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Protein Ontology report - cyclin-dependent kinase inhibitor
PR:000000014 - http://purl.obolibrary.org/obo/PR_000000014
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000014   
  PRO namecyclin-dependent kinase inhibitor 
  Definition"A protein that has a core domain composition consisting of four ankyrin repeats, and that functions as negative regulator of cyclin-dependent kinases." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 10                                        
         Modification2                                                  Organism-Modification 1                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF036346
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000014

cyclin-dependent kinase inhibitor

CHRD


"A protein that has a core domain composition consisting of four ankyrin repeats, and that functions as negative regulator of cyclin-dependent kinases." [PRO:CNA]

Yes

gene



PR:000000093

cyclin-dependent kinase 4 inhibitor B

CDKN2B


"A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2B gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P42772

cyclin-dependent kinase 4 inhibitor B (human)

hCDKN2B


"A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P42772]


organism-sequence



PR:000000269

cyclin-dependent kinase 4 inhibitor B sequence variant G47E (human)

hCDKN2B/var:G47E


"A cyclin-dependent kinase 4 inhibitor B (human) that has a Glu residue at the position equivalent to Gly-47 of the amino acid sequence represented by UniProtKB:P42772-1. Example: UniProtKB:P42772-1, Gly-47, CHEBI:29972." [PMID:7882351, PRO:CNA, PRO:DAN]


organism-sequence



PR:000000270

cyclin-dependent kinase 4 inhibitor B sequence variant A50V (human)

hCDKN2B/var:A50V


"A cyclin-dependent kinase 4 inhibitor B (human) that has a Val residue at the position equivalent to Ala-50 of the amino acid sequence represented by UniProtKB:P42772-1. Example: UniProtKB:P42772-1, Ala-50, CHEBI:30015." [PMID:7882351, PRO:CNA, PRO:DAN]


organism-sequence



PR:P42772-1

cyclin-dependent kinase 4 inhibitor B isoform 1 (human)

hCDKN2B/iso:1


"A cyclin-dependent kinase 4 inhibitor B isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P42772-2

cyclin-dependent kinase 4 inhibitor B isoform h2 (human)

hCDKN2B/iso:h2


"A cyclin-dependent kinase 4 inhibitor B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42772-2." [PRO:DNx, UniProtKB:P42772]


organism-gene



PR:P55271

cyclin-dependent kinase 4 inhibitor B (mouse)

mCDKN2B


"A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036455

cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 (mouse)

mCDKN2B/iso:1/Phos:1


"A cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 in mouse. UniProtKB:P55271-1, Thr-12, MOD:00047." [PMID:15345747, PRO:CNA]


organism-gene



PR:P55272

cyclin-dependent kinase 4 inhibitor B (rat)

rCDKN2B


"A cyclin-dependent kinase 4 inhibitor B that is encoded in the genome of rat." [PRO:CNA]


organism-sequence



PR:P55272-1

cyclin-dependent kinase 4 inhibitor B isoform Long (rat)

rCDKN2B/iso:Long


"A cyclin-dependent kinase 4 inhibitor B (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55272-1." [PRO:DNx, UniProtKB:P55272]


organism-sequence



PR:P55272-2

cyclin-dependent kinase 4 inhibitor B isoform Short (rat)

rCDKN2B/iso:Short


"A cyclin-dependent kinase 4 inhibitor B (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55272-2." [PRO:DNx, UniProtKB:P55272]


sequence



PR:000000268

cyclin-dependent kinase 4 inhibitor B isoform 1

CDKN2B/iso:1


"A cyclin-dependent kinase 4 inhibitor B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42772-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P42772-1

cyclin-dependent kinase 4 inhibitor B isoform 1 (human)

hCDKN2B/iso:1


"A cyclin-dependent kinase 4 inhibitor B isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000000428

cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form

CDKN2B/iso:1/PhosRes+


"A cyclin-dependent kinase 4 inhibitor B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000543

cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1

CDKN2B/iso:1/Phos:1


"A cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated form in which the phosphorylation occurs on a residue equivalent to Thr-12 of the amino acid sequence represented by UniProtKB:P55271-1. Example: UniProtKB:P55271-1, Thr-12, MOD:00047." [UniProtKB:P55271]


organism-modification



PR:000036455

cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 (mouse)

mCDKN2B/iso:1/Phos:1


"A cyclin-dependent kinase 4 inhibitor B isoform 1 phosphorylated 1 in mouse. UniProtKB:P55271-1, Thr-12, MOD:00047." [PMID:15345747, PRO:CNA]


gene



PR:000005278

cyclin-dependent kinase 4 inhibitor C

CDKN2C


"A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2C gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P42773

cyclin-dependent kinase 4 inhibitor C (human)

hCDKN2C


"A cyclin-dependent kinase 4 inhibitor C that is encoded in the genome of human." [PRO:DNx, UniProtKB:P42773]


organism-sequence



PR:P42773-1

cyclin-dependent kinase 4 inhibitor C isoform 1 (human)

hCDKN2C/iso:1


"A cyclin-dependent kinase 4 inhibitor C isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q60772

cyclin-dependent kinase 4 inhibitor C (mouse)

mCDKN2C


"A cyclin-dependent kinase 4 inhibitor C that is encoded in the genome of mouse." [OMA:Q60772, PRO:DNx]


organism-sequence



PR:Q60772-1

cyclin-dependent kinase 4 inhibitor C isoform 1 (mouse)

mCDKN2C/iso:1


"A cyclin-dependent kinase 4 inhibitor C isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000039444

cyclin-dependent kinase 4 inhibitor C isoform 1

CDKN2C/iso:1


"A cyclin-dependent kinase 4 inhibitor C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P42773-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P42773-1

cyclin-dependent kinase 4 inhibitor C isoform 1 (human)

hCDKN2C/iso:1


"A cyclin-dependent kinase 4 inhibitor C isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q60772-1

cyclin-dependent kinase 4 inhibitor C isoform 1 (mouse)

mCDKN2C/iso:1


"A cyclin-dependent kinase 4 inhibitor C isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


gene



PR:000005279

cyclin-dependent kinase 4 inhibitor D

CDKN2D


"A cyclin-dependent kinase inhibitor that is a translation product of the human CDKN2D gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P55273

cyclin-dependent kinase 4 inhibitor D (human)

hCDKN2D


"A cyclin-dependent kinase 4 inhibitor D that is encoded in the genome of human." [PRO:DNx, UniProtKB:P55273]


organism-sequence



PR:P55273-1

cyclin-dependent kinase 4 inhibitor D isoform 1 (human)

hCDKN2D/iso:1


"A cyclin-dependent kinase 4 inhibitor D isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-gene



PR:Q60773

cyclin-dependent kinase 4 inhibitor D (mouse)

mCDKN2D


"A cyclin-dependent kinase 4 inhibitor D that is encoded in the genome of mouse." [OMA:Q60773, PRO:DNx]


organism-sequence



PR:Q60773-1

cyclin-dependent kinase 4 inhibitor D isoform 1 (mouse)

mCDKN2D/iso:1


"A cyclin-dependent kinase 4 inhibitor D isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000039795

cyclin-dependent kinase 4 inhibitor D isoform 1

CDKN2D/iso:1


"A cyclin-dependent kinase 4 inhibitor D that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55273-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:P55273-1

cyclin-dependent kinase 4 inhibitor D isoform 1 (human)

hCDKN2D/iso:1


"A cyclin-dependent kinase 4 inhibitor D isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q60773-1

cyclin-dependent kinase 4 inhibitor D isoform 1 (mouse)

mCDKN2D/iso:1


"A cyclin-dependent kinase 4 inhibitor D isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000014 CHRD acts_upstream_of_or_withinGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity PIRSF:PIRSF036346
GO:0008285 negative regulation of cell population proliferation PIRSF:PIRSF036346
GO:0051726 regulation of cell cycle PIRSF:PIRSF036346
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PIRSF:PIRSF036346
PR:000000093 CDKN2B acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PANTHER:PTHR24144
PR:P42772-1 hCDKN2B/iso:1 acts_upstream_of_or_withinGO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity PMID:8078588
GO:0008285 negative regulation of cell population proliferation PMID:8078588
GO:0051726 regulation of cell cycle PMID:8078588
enablesGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity PMID:8078588
GO:0005515 protein binding PMID:16169070