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Protein Ontology report - HECT domain-containing E3 ubiquitin-protein ligase with WW domains
PR:000000016 - http://purl.obolibrary.org/obo/PR_000000016
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000016   
  PRO nameHECT domain-containing E3 ubiquitin-protein ligase with WW domains 
  Definition"A protein that has a core domain composition consisting of the C-terminal HECT-domain (ubiquitin-transferase) (Pfam:PF00632), which is catalytically involved in the attachment of ubiquitin to substrate proteins, and an N-terminal extension with a C2 domain (Pfam:PF00168) and two to three copies of the WW domain (Pfam:PF00397) that mediate the substrate specificity." [PMID:18047743
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene7                                                  Organism-Gene 19                                        
         Sequence3                                                  Organism-Sequence 41                                        
         Modification1                                                  Organism-Modification 22                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF001569
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000016

HECT domain-containing E3 ubiquitin-protein ligase with WW domains

FST


"A protein that has a core domain composition consisting of the C-terminal HECT-domain (ubiquitin-transferase) (Pfam:PF00632), which is catalytically involved in the attachment of ubiquitin to substrate proteins, and an N-terminal extension with a C2 domain (Pfam:PF00168) and two to three copies of the WW domain (Pfam:PF00397) that mediate the substrate specificity." [PMID:18047743]

Yes

family



PR:000000127

smad ubiquitination regulatory factor

ACVRL1


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA]

Yes

gene



PR:000000361

E3 ubiquitin-protein ligase SMURF1

SMURF1


"A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q9CUN6

E3 ubiquitin-protein ligase SMURF1 (mouse)

mSMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of mouse." [OMA:Q9CUN6, PRO:DNx]

Yes

organism-sequence



PR:Q9CUN6-1

E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)

mSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000049754

E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse)

mSMURF1/Phos:1


"An E3 ubiquitin-protein ligase SMURF1 (mouse) that has been phosphorylated on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, MOD:00046." [MGI:1923038, PMID:27052174, PRO:HJD]


organism-modification



PR:000049755

E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse)

mSMURF1/UnPhos:1


"An E3 ubiquitin-protein ligase SMURF1 (mouse) that lacks phosphorylation on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, PR:000026291." [MGI:1923038, PMID:27052174, PRO:HJD]


organism-gene



PR:Q9HCE7

E3 ubiquitin-protein ligase SMURF1 (human)

hSMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7]

Yes

organism-sequence



PR:Q9HCE7-1

E3 ubiquitin-protein ligase SMURF1 isoform Long (human)

hSMURF1/iso:Long


"An E3 ubiquitin-protein ligase SMURF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-1." [PRO:DNx, UniProtKB:Q9HCE7]


organism-sequence



PR:Q9HCE7-2

E3 ubiquitin-protein ligase SMURF1 isoform Short (human)

hSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000075773

E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)

hSMURF1/Cyst:1


"An E3 ubiquitin-protein ligase SMURF1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-725 of the amino acid sequence represented by UniProtKB:Q9HCE7-1. Example: UniProtKB:Q9HCE7-1, Cys-725, MOD:00765." [IEDB_epitope:1582149, PRO:DNx]


organism-gene



PR:Q9V853

E3 ubiquitin-protein ligase Smurf1 (fruit fly)

fly-SMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of fruit fly." [PRO:DAN]


sequence



PR:000000466

E3 ubiquitin-protein ligase SMURF1 isoform Short

SMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q9CUN6-1

E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)

mSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9HCE7-2

E3 ubiquitin-protein ligase SMURF1 isoform Short (human)

hSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000000362

E3 ubiquitin-protein ligase SMURF2

SMURF2


"A smad ubiquitination regulatory factor that is a translation product of the human SMURF2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A2A5Z6

E3 ubiquitin-protein ligase SMURF2 (mouse)

mSMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of mouse." [OMA:A2A5Z6, PRO:DNx]


organism-sequence



PR:A2A5Z6-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)

mSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:A2A5Z6-2

E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse)

mSMURF2/iso:m2


"An E3 ubiquitin-protein ligase SMURF2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2A5Z6-2." [PRO:DNx, UniProtKB:A2A5Z6]


organism-gene



PR:A9JRZ0

E3 ubiquitin-protein ligase SMURF2 (zebrafish)

z-SMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of zebrafish." [OMA:A9JRZ0, PRO:DNx]


organism-gene



PR:Q9HAU4

E3 ubiquitin-protein ligase SMURF2 (human)

hSMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HAU4]

Yes

organism-sequence



PR:Q9HAU4-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)

hSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


sequence



PR:000043363

E3 ubiquitin-protein ligase SMURF2 isoform 1

SMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HAU4-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:A2A5Z6-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)

mSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9HAU4-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)

hSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


gene



PR:000003174

NEDD4-like E3 ubiquitin-protein ligase WWP1

WWP1


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human WWP1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8BZZ3

NEDD4-like E3 ubiquitin-protein ligase WWP1 (mouse)

mWWP1


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 that is encoded in the genome of mouse." [OMA:Q8BZZ3, PRO:DNx]


organism-gene



PR:Q9H0M0

NEDD4-like E3 ubiquitin-protein ligase WWP1 (human)

hWWP1


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-1

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h1 (human)

hWWP1/iso:h1


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-1." [PRO:DNx, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-2

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h2 (human)

hWWP1/iso:h2


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-2." [PRO:DNx, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-3

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h3 (human)

hWWP1/iso:h3


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-3." [PRO:DNx, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-4

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h4 (human)

hWWP1/iso:h4


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-4." [PRO:DNx, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-5

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h5 (human)

hWWP1/iso:h5


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-5." [PRO:DNx, UniProtKB:Q9H0M0]


organism-sequence



PR:Q9H0M0-6

NEDD4-like E3 ubiquitin-protein ligase WWP1 isoform h6 (human)

hWWP1/iso:h6


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9H0M0-6." [PRO:DNx, UniProtKB:Q9H0M0]


organism-modification



PR:000081799

NEDD4-like E3 ubiquitin-protein ligase WWP1 deaminated 1 (human)

hWWP1/Deam:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 (human) that has been deaminated on the residue at the position equivalent to Asn-478 of the amino acid sequence represented by UniProtKB:Q9H0M0-1. Example: UniProtKB:Q9H0M0-1, Asn-478, MOD:00684." [IEDB_epitope:1735032, PRO:DNx]


organism-gene



PR:Q9N2Z7

E3 ubiquitin-protein ligase wwp-1 (worm)

WWP1 (worm)


"A NEDD4-like E3 ubiquitin-protein ligase WWP1 that is encoded in the genome of worm." [OMA:Q9N2Z7, PRO:DNx]


organism-sequence



PR:Q9N2Z7-1

E3 ubiquitin-protein ligase wwp-1 isoform a (worm)

WWP1/iso:a (worm)


"An E3 ubiquitin-protein ligase wwp-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9N2Z7-1." [PRO:DNx, UniProtKB:Q9N2Z7]


organism-sequence



PR:Q9N2Z7-2

E3 ubiquitin-protein ligase wwp-1 isoform b (worm)

WWP1/iso:b (worm)


"An E3 ubiquitin-protein ligase wwp-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9N2Z7-2." [PRO:DNx, UniProtKB:Q9N2Z7]


organism-sequence



PR:Q9N2Z7-3

E3 ubiquitin-protein ligase wwp-1 isoform c (worm)

WWP1/iso:c (worm)


"An E3 ubiquitin-protein ligase wwp-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9N2Z7-3." [PRO:DNx, UniProtKB:Q9N2Z7]


organism-sequence



PR:Q9N2Z7-4

E3 ubiquitin-protein ligase wwp-1 isoform d (worm)

WWP1/iso:d (worm)


"An E3 ubiquitin-protein ligase wwp-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9N2Z7-4." [PRO:DNx, UniProtKB:Q9N2Z7]


gene



PR:000003191

E3 ubiquitin-protein ligase NEDD4-like

NEDD4L


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human NEDD4L gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8CFI0

E3 ubiquitin-protein ligase NEDD4-like (mouse)

mNEDD4L


"An E3 ubiquitin-protein ligase NEDD4-like that is encoded in the genome of mouse." [OMA:Q8CFI0, PRO:DNx]


organism-sequence



PR:Q8CFI0-1

E3 ubiquitin-protein ligase NEDD4-like isoform m1 (mouse)

mNEDD4L/iso:m1


"An E3 ubiquitin-protein ligase NEDD4-like (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFI0-1." [PRO:DNx, UniProtKB:Q8CFI0]


organism-sequence



PR:Q8CFI0-2

E3 ubiquitin-protein ligase NEDD4-like isoform m2 (mouse)

mNEDD4L/iso:m2


"An E3 ubiquitin-protein ligase NEDD4-like (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFI0-2." [PRO:DNx, UniProtKB:Q8CFI0]


organism-sequence



PR:Q8CFI0-3

E3 ubiquitin-protein ligase NEDD4-like isoform m3 (mouse)

mNEDD4L/iso:m3


"An E3 ubiquitin-protein ligase NEDD4-like (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8CFI0-3." [PRO:DNx, UniProtKB:Q8CFI0]


organism-modification



PR:000079739

E3 ubiquitin-protein ligase NEDD4-like cysteinylated 1 (mouse)

mNEDD4L/Cyst:1


"An E3 ubiquitin-protein ligase NEDD4-like (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-731 of the amino acid sequence represented by UniProtKB:Q8CFI0-1. Example: UniProtKB:Q8CFI0-1, Cys-731, MOD:00765." [IEDB_epitope:2107385, PRO:DNx]


organism-gene



PR:Q96PU5

E3 ubiquitin-protein ligase NEDD4-like (human)

hNEDD4L


"An E3 ubiquitin-protein ligase NEDD4-like that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-1

E3 ubiquitin-protein ligase NEDD4-like isoform h1 (human)

hNEDD4L/iso:h1


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-1." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-2

E3 ubiquitin-protein ligase NEDD4-like isoform h2 (human)

hNEDD4L/iso:h2


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-2." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-3

E3 ubiquitin-protein ligase NEDD4-like isoform h3 (human)

hNEDD4L/iso:h3


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-3." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-4

E3 ubiquitin-protein ligase NEDD4-like isoform h4 (human)

hNEDD4L/iso:h4


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-4." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-5

E3 ubiquitin-protein ligase NEDD4-like isoform h5 (human)

hNEDD4L/iso:h5


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-5." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-6

E3 ubiquitin-protein ligase NEDD4-like isoform h6 (human)

hNEDD4L/iso:h6


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-6." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-7

E3 ubiquitin-protein ligase NEDD4-like isoform h7 (human)

hNEDD4L/iso:h7


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-7." [PRO:DNx, UniProtKB:Q96PU5]


organism-sequence



PR:Q96PU5-9

E3 ubiquitin-protein ligase NEDD4-like isoform h8 (human)

hNEDD4L/iso:h8


"An E3 ubiquitin-protein ligase NEDD4-like (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96PU5-9." [PRO:DNx, UniProtKB:Q96PU5]


organism-modification



PR:000070849

E3 ubiquitin-protein ligase NEDD4-like phosphorylated 1 (human)

hNEDD4L/Phos:1


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been phosphorylated on the residue at the position equivalent to Ser-448 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Ser-448, MOD:00046." [IEDB_epitope:848351, IEDB_epitope:912480, IEDB_epitope:912518, PRO:DNx]


organism-modification



PR:000071377

E3 ubiquitin-protein ligase NEDD4-like phosphorylated 2 (human)

hNEDD4L/Phos:2


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been phosphorylated on the residue at the position equivalent to Ser-446 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Ser-446, MOD:00046." [IEDB_epitope:611231, PRO:DNx]


organism-modification



PR:000072127

E3 ubiquitin-protein ligase NEDD4-like deaminated 1 (human)

hNEDD4L/Deam:1


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been deaminated on the residue at the position equivalent to Asn-83 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Asn-83, MOD:00684." [IEDB_epitope:1738433, PRO:DNx]


organism-modification



PR:000081384

E3 ubiquitin-protein ligase NEDD4-like methylated 1 (human)

hNEDD4L/Me:1


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been methylated on the residue at the position equivalent to Cys-874 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Cys-874, MOD:00660." [IEDB_epitope:1017173, PRO:DNx]


organism-modification



PR:000084556

E3 ubiquitin-protein ligase NEDD4-like phosphorylated 3 (human)

hNEDD4L/Phos:3


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been phosphorylated on the residue at the position equivalent to Ser-867 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Ser-867, MOD:00046." [IEDB_epitope:2070245, PRO:DNx]


organism-modification



PR:000084704

E3 ubiquitin-protein ligase NEDD4-like phosphorylated 4 (human)

hNEDD4L/Phos:4


"An E3 ubiquitin-protein ligase NEDD4-like (human) that has been phosphorylated on the residue at the position equivalent to Tyr-680 of the amino acid sequence represented by UniProtKB:Q96PU5-1. Example: UniProtKB:Q96PU5-1, Tyr-680, MOD:00048." [IEDB_epitope:990551, PRO:DNx]


modification



PR:000018788

E3 ubiquitin-protein ligase NEDD4-like, initiator methionine removed form

NEDD4L/InitMet-


"An E3 ubiquitin-protein ligase NEDD4-like that has had the initiator methionine removed." [PRO:DNx]


gene



PR:000003192

E3 ubiquitin-protein ligase Itchy

ITCH


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human ITCH gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8C863

E3 ubiquitin-protein ligase Itchy (mouse)

mITCH


"An E3 ubiquitin-protein ligase Itchy that is encoded in the genome of mouse." [OMA:Q8C863, PRO:DNx]


organism-sequence



PR:Q8C863-1

E3 ubiquitin-protein ligase Itchy isoform m1 (mouse)

mITCH/iso:m1


"An E3 ubiquitin-protein ligase Itchy (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C863-1." [PRO:DNx, UniProtKB:Q8C863]


organism-sequence



PR:Q8C863-2

E3 ubiquitin-protein ligase Itchy isoform m2 (mouse)

mITCH/iso:m2


"An E3 ubiquitin-protein ligase Itchy (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8C863-2." [PRO:DNx, UniProtKB:Q8C863]


organism-gene



PR:Q96J02

E3 ubiquitin-protein ligase Itchy homolog (human)

hITCH


"An E3 ubiquitin-protein ligase Itchy that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q96J02]


organism-sequence



PR:Q96J02-1

E3 ubiquitin-protein ligase Itchy homolog isoform h1 (human)

hITCH/iso:h1


"An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-1." [PRO:DNx, UniProtKB:Q96J02]


organism-sequence



PR:Q96J02-2

E3 ubiquitin-protein ligase Itchy homolog isoform h2 (human)

hITCH/iso:h2


"An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-2." [PRO:DNx, UniProtKB:Q96J02]


organism-sequence



PR:Q96J02-3

E3 ubiquitin-protein ligase Itchy homolog isoform h3 (human)

hITCH/iso:h3


"An E3 ubiquitin-protein ligase Itchy homolog (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96J02-3." [PRO:DNx, UniProtKB:Q96J02]


organism-modification



PR:000066127

E3 ubiquitin-protein ligase Itchy homolog deaminated 1 (human)

hITCH/Deam:1


"An E3 ubiquitin-protein ligase Itchy homolog (human) that has been deaminated on the residue at the position equivalent to Asn-625 of the amino acid sequence represented by UniProtKB:Q96J02-1. Example: UniProtKB:Q96J02-1, Asn-625, MOD:00684." [IEDB_epitope:1768402, PRO:DNx]


organism-modification



PR:000069402

E3 ubiquitin-protein ligase Itchy homolog deaminated 2 (human)

hITCH/Deam:2


"An E3 ubiquitin-protein ligase Itchy homolog (human) that has been deaminated on the residue at the position equivalent to Gln-794 of the amino acid sequence represented by UniProtKB:Q96J02-1. Example: UniProtKB:Q96J02-1, Gln-794, MOD:00685." [IEDB_epitope:1584912, PRO:DNx]


organism-modification



PR:000072373

E3 ubiquitin-protein ligase Itchy homolog deaminated 3 (human)

hITCH/Deam:3


"An E3 ubiquitin-protein ligase Itchy homolog (human) that has been deaminated on the residue at the position equivalent to Asn-321 of the amino acid sequence represented by UniProtKB:Q96J02-1. Example: UniProtKB:Q96J02-1, Asn-321, MOD:00684." [IEDB_epitope:1578081, PRO:DNx]


organism-modification



PR:000072566

E3 ubiquitin-protein ligase Itchy homolog deaminated 4 (human)

hITCH/Deam:4


"An E3 ubiquitin-protein ligase Itchy homolog (human) that has been deaminated on the residue at the position equivalent to Asn-460 of the amino acid sequence represented by UniProtKB:Q96J02-1. Example: UniProtKB:Q96J02-1, Asn-460, MOD:00684." [IEDB_epitope:1757874, PRO:DNx]


organism-modification



PR:000080509

E3 ubiquitin-protein ligase Itchy homolog deaminated 5 (human)

hITCH/Deam:5


"An E3 ubiquitin-protein ligase Itchy homolog (human) that has been deaminated on the residue at the position equivalent to Asn-451 of the amino acid sequence represented by UniProtKB:Q96J02-1. Example: UniProtKB:Q96J02-1, Asn-451, MOD:00684." [IEDB_epitope:1364869, IEDB_epitope:1581585, PRO:DNx]


gene



PR:000011115

E3 ubiquitin-protein ligase NEDD4

NEDD4


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human NEDD4 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:P46934

E3 ubiquitin-protein ligase NEDD4 (human)

hNEDD4


"An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P46934]


organism-sequence



PR:P46934-1

E3 ubiquitin-protein ligase NEDD4 isoform h1 (human)

hNEDD4/iso:h1


"An E3 ubiquitin-protein ligase NEDD4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46934-1." [PRO:DNx, UniProtKB:P46934]


organism-sequence



PR:P46934-2

E3 ubiquitin-protein ligase NEDD4 isoform h2 (human)

hNEDD4/iso:h2


"An E3 ubiquitin-protein ligase NEDD4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46934-2." [PRO:DNx, UniProtKB:P46934]


organism-sequence



PR:P46934-3

E3 ubiquitin-protein ligase NEDD4 isoform h3 (human)

hNEDD4/iso:h3


"An E3 ubiquitin-protein ligase NEDD4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46934-3." [PRO:DNx, UniProtKB:P46934]


organism-sequence



PR:P46934-4

E3 ubiquitin-protein ligase NEDD4 isoform h4 (human)

hNEDD4/iso:h4


"An E3 ubiquitin-protein ligase NEDD4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P46934-4." [PRO:DNx, UniProtKB:P46934]


organism-modification



PR:000081259

E3 ubiquitin-protein ligase NEDD4 phosphorylated 1 (human)

hNEDD4/Phos:1


"An E3 ubiquitin-protein ligase NEDD4 (human) that has been phosphorylated on the residue at the position equivalent to Ser-747 of the amino acid sequence represented by UniProtKB:P46934-1. Example: UniProtKB:P46934-1, Ser-747, MOD:00046." [IEDB_epitope:912503, PRO:DNx]


organism-gene



PR:P46935

E3 ubiquitin-protein ligase NEDD4 (mouse)

mNEDD4


"An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of mouse." [OMA:P46935, PRO:DNx]


organism-gene



PR:Q62940

E3 ubiquitin-protein ligase NEDD4 (rat)

rNEDD4


"An E3 ubiquitin-protein ligase NEDD4 that is encoded in the genome of rat." [OMA:Q62940, PRO:DNx]


gene



PR:000017465

NEDD4-like E3 ubiquitin-protein ligase WWP2

WWP2


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that is a translation product of the human WWP2 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:O00308

NEDD4-like E3 ubiquitin-protein ligase WWP2 (human)

hWWP2


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O00308]


organism-sequence



PR:O00308-1

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (human)

hWWP2/iso:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:O00308-2

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h2 (human)

hWWP2/iso:h2


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00308-2." [PRO:DNx, UniProtKB:O00308]


organism-sequence



PR:O00308-3

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h3 (human)

hWWP2/iso:h3


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00308-3." [PRO:DNx, UniProtKB:O00308]


organism-sequence



PR:O00308-4

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform h4 (human)

hWWP2/iso:h4


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00308-4." [PRO:DNx, UniProtKB:O00308]


organism-modification



PR:000070658

NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 1 (human)

hWWP2/Deam:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that has been deaminated on the residue at the position equivalent to Asn-598 of the amino acid sequence represented by UniProtKB:O00308-1. Example: UniProtKB:O00308-1, Asn-598, MOD:00684." [IEDB_epitope:1345232, PRO:DNx]


organism-modification



PR:000073586

NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 2 (human)

hWWP2/Deam:2


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that has been deaminated on the residue at the position equivalent to Asn-424 of the amino acid sequence represented by UniProtKB:O00308-1. Example: UniProtKB:O00308-1, Asn-424, MOD:00684." [IEDB_epitope:1732934, IEDB_epitope:1757881, IEDB_epitope:1757883, IEDB_epitope:1800715, PRO:DNx]


organism-modification



PR:000074527

NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 3 (human)

hWWP2/Deam:3


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that has been deaminated on the residue at the position equivalent to Asn-426 of the amino acid sequence represented by UniProtKB:O00308-1. Example: UniProtKB:O00308-1, Asn-426, MOD:00684." [IEDB_epitope:1757882, IEDB_epitope:1757884, IEDB_epitope:1800714, PRO:DNx]


organism-modification



PR:000082029

NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 4 (human)

hWWP2/Deam:4


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that has been deaminated on the residue at the position equivalent to Asn-417 of the amino acid sequence represented by UniProtKB:O00308-1. Example: UniProtKB:O00308-1, Asn-417, MOD:00684." [IEDB_epitope:1322359, IEDB_epitope:1322361, IEDB_epitope:1732933, IEDB_epitope:1800710, IEDB_epitope:1800711, PRO:DNx]


organism-modification



PR:000082609

NEDD4-like E3 ubiquitin-protein ligase WWP2 deaminated 5 (human)

hWWP2/Deam:5


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 (human) that has been deaminated on the residue at the position equivalent to Gln-431 of the amino acid sequence represented by UniProtKB:O00308-1. Example: UniProtKB:O00308-1, Gln-431, MOD:00685." [IEDB_epitope:1757886, PRO:DNx]


organism-gene



PR:P39940

E3 ubiquitin-protein ligase RSP5 (yeast)

yWWP2


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of yeast." [PRO:DNx]


organism-gene



PR:Q9DBH0

NEDD4-like E3 ubiquitin-protein ligase WWP2 (mouse)

mWWP2


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is encoded in the genome of mouse." [OMA:Q9DBH0, PRO:DNx]


organism-sequence



PR:Q9DBH0-1

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (mouse)

mWWP2/iso:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


sequence



PR:000037914

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1

WWP2/iso:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00308-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:O00308-1

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (human)

hWWP2/iso:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


organism-sequence



PR:Q9DBH0-1

NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 (mouse)

mWWP2/iso:1


"A NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000016 FST enablesGO:0004842 ubiquitin-protein transferase activity PIRSF:PIRSF001569
PR:000000127 ACVRL1 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PIRSF:PIRSF500454
GO:0007398 ectoderm development PIRSF:PIRSF500454
GO:0009968 negative regulation of signal transduction PIRSF:PIRSF500454
PR:Q9CUN6 mSMURF1 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:14711801
PR:Q9CUN6-1 mSMURF1/iso:Short located_inGO:0005622 intracellular anatomical structure PMID:14711801
PR:Q9HAU4 hSMURF2 acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:14755250
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway PMID:11016919; PMID:11158580; PMID:11163210; PMID:15862290
enablesGO:0004842 ubiquitin-protein transferase activity PMID:14755250
GO:0005515 protein binding PMID:14755250
PR:Q9HCE7 hSMURF1 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10458166
PR:Q9HCE7-2 hSMURF1/iso:Short acts_upstream_of_or_withinGO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0006511 ubiquitin-dependent protein catabolic process PMID:12857866
GO:0036211 protein modification process PMID:10458166
enablesGO:0004842 ubiquitin-protein transferase activity PMID:10458166
GO:0005515 protein binding PMID:11278251; PMID:16299379
located_inGO:0005622 intracellular anatomical structure PMID:10458166