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Protein Ontology report - interferon gamma
PR:000000017 - http://purl.obolibrary.org/obo/PR_000000017
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000017   
  PRO nameinterferon gamma 
  Synonyms
PRO-Short-label: EXACT:IFNG
Other: EXACT:IFN-gamma | immune interferon
  Definition"A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000024990 type II interferon
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF001936
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000017 interferon gamma
IFNG
Yes
organism-gene


PR:P01579 interferon gamma (human)
hIFNG

organism-sequence


PR:P01579-1 interferon gamma isoform 1 (human)
hIFNG/iso:1

organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000068116 interferon gamma, mature form (human)
hIFNG/mature

organism-gene


PR:P01580 interferon gamma (mouse)
mIFNG

organism-sequence


PR:P01580-1 interferon gamma isoform 1 (mouse)
mIFNG/iso:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-gene


PR:P01581 interferon gamma (rat)
rIFNG

organism-gene


PR:P49708 interferon gamma (chicken)
chick-IFNG

sequence


PR:000000100 interferon gamma isoform 1
IFNG/iso:1

organism-sequence


PR:P01579-1 interferon gamma isoform 1 (human)
hIFNG/iso:1

organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-sequence


PR:P01580-1 interferon gamma isoform 1 (mouse)
mIFNG/iso:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
modification


PR:000000445 interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-

modification


PR:000000446 interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+

modification


PR:000000447 interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2

organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
modification


PR:000018270 interferon gamma, signal peptide removed form
IFNG/SigPep-

modification


PR:000000445 interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-

modification


PR:000000446 interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+

modification


PR:000000447 interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2

organism-modification


PR:000036420 interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000036419 interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
Yes
organism-modification


PR:000036418 interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
Yes
organism-modification


PR:000036407 interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
Yes
organism-modification


PR:000068116 interferon gamma, mature form (human)
hIFNG/mature

modification


PR:000018271 interferon gamma proteolytic cleavage product
IFNG/ClvPrd

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000017 IFNG
It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions		 acts_upstream_of_or_withinGO:0006955 immune response PIRSF:PIRSF001936
GO:0032722 positive regulation of chemokine production PIRSF:PIRSF001936
PR:000036407 mIFNG/iso:1/SigPep-/GlycoRes+
UniProtKB:P01580-1, 23-155, MOD:00693		 acts_upstream_of_or_withinGO:0050776 regulation of immune response PMID:12882831
enablesGO:0005125 cytokine activity PMID:11027433; PMID:12925700; PMID:15240719
located_inGO:0005615 extracellular space PMID:11057672; PMID:11728336; PMID:15240714
PR:000036418 mIFNG/iso:1/SigPep-
UniProtKB:P01580-1, 23-155		 acts_upstream_of_or_withinGO:0050776 regulation of immune response PMID:11441112
enablesGO:0005125 cytokine activity PMID:11441112
PR:000036419 hIFNG/iso:1/SigPep-/NGlyco:1
UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160		 enablesGO:0005133 type II interferon receptor binding PMID:10986460
GO:0042803 protein homodimerization activity PMID:3109913
located_inGO:0005615 extracellular space PMID:6427223
PR:000036420 hIFNG/iso:1/ClvNGlyco:2
UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160		 enablesGO:0042803 protein homodimerization activity PMID:1902591
PR:P01580-1 mIFNG/iso:1 acts_upstream_of_or_withinGO:0032722 positive regulation of chemokine production PMID:12925700
GO:0042742 defense response to bacterium PMID:17661079