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Protein Ontology report - interferon gamma
PR:000000017 -
http://purl.obolibrary.org/obo/PR_000000017
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000017
PRO name
interferon gamma
Synonyms
PRO-Short-label
:
EXACT:
IFNG
Other
:
EXACT:
IFN-gamma | immune interferon
Definition
"A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (
Pfam:PF00714
) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA]
PRO Category
gene
Parent
PR:000024990
type II interferon
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
4
Sequence
1
Organism-Sequence
2
Modification
5
Organism-Modification
5
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF001936
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Protein Forms
Switch to
Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000017
interferon gamma
IFNG
"A type II interferon that is a translation product of the human IFNG gene or a 1:1 ortholog thereof. The core domain structure consists of an Interferon gamma domain (Pfam:PF00714) that is four-helical cytokine domain with an additional helix in one of the crossover connections. It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions." [PRO:CNA]
Yes
organism-gene
PR:P01579
interferon gamma (human)
hIFNG
"An interferon gamma that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01579]
organism-sequence
PR:P01579-1
interferon gamma isoform 1 (human)
hIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000068116
interferon gamma, mature form (human)
hIFNG/mature
"An interferon gamma (human) that has had the signal peptide and propeptide removed. UniProtKB:P01579, 24-161." [PRO:DNx, Reactome:R-HSA-629621]
organism-gene
PR:P01580
interferon gamma (mouse)
mIFNG
"An interferon gamma that is encoded in the genome of mouse." [OMA:P01580, PRO:DNx]
organism-sequence
PR:P01580-1
interferon gamma isoform 1 (mouse)
mIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-gene
PR:P01581
interferon gamma (rat)
rIFNG
"An interferon gamma that is encoded in the genome of rat." [OMA:P01581, PRO:DNx]
organism-gene
PR:P49708
interferon gamma (chicken)
chick-IFNG
"An interferon gamma that is encoded in the genome of chicken." [OMA:P49708, PRO:DNx]
sequence
PR:000000100
interferon gamma isoform 1
IFNG/iso:1
"An interferon gamma that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01579-1 or a 1:1 ortholog thereof." [PRO:CNA]
organism-sequence
PR:P01579-1
interferon gamma isoform 1 (human)
hIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of human." [PRO:CNA]
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-sequence
PR:P01580-1
interferon gamma isoform 1 (mouse)
mIFNG/iso:1
"An interferon gamma isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
modification
PR:000000445
interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-
"An interferon gamma isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000446
interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PMID:3109913, PRO:CNA]
modification
PR:000000447
interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1, signal peptide removed glycosylated form that is a mature protein with N-linked glycosylation and partial proteolytic degradation of the C-terminus. Example: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PRO:CNA, PRO:DAN]
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
modification
PR:000018270
interferon gamma, signal peptide removed form
IFNG/SigPep-
"An interferon gamma that has had the signal peptide removed." [PRO:DNx]
modification
PR:000000445
interferon gamma isoform 1, signal peptide removed form
IFNG/iso:1/SigPep-
"An interferon gamma isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000446
interferon gamma isoform 1, signal peptide removed glycosylated form
IFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed form that includes at least one glycosylated residue." [PMID:3109913, PRO:CNA]
modification
PR:000000447
interferon gamma isoform 1 cleaved and N-glycosylated 2
IFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1, signal peptide removed glycosylated form that is a mature protein with N-linked glycosylation and partial proteolytic degradation of the C-terminus. Example: UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PRO:CNA, PRO:DAN]
organism-modification
PR:000036420
interferon gamma isoform 1 cleaved and N-glycosylated 2 (human)
hIFNG/iso:1/ClvNGlyco:2
"An interferon gamma isoform 1 cleaved and N-glycosylated 2 in human. UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160." [PMID:1902591, PMID:6427223, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000036419
interferon gamma isoform 1, signal peptide removed N-glycosylated 1 (human)
hIFNG/iso:1/SigPep-/NGlyco:1
"An interferon gamma isoform 1, signal peptide removed glycosylated form in human in which N-linked glycosylation occurs at Asn-48 and Asn-120. UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160." [PMID:10986460, PMID:3109913, PMID:6427223, PRO:CNA, PRO:DAN]
Yes
organism-modification
PR:000036418
interferon gamma isoform 1, signal peptide removed form (mouse)
mIFNG/iso:1/SigPep-
"An interferon gamma isoform 1, signal peptide removed form in mouse. UniProtKB:P01580-1, 23-155." [PMID:11441112, PRO:CNA]
Yes
organism-modification
PR:000036407
interferon gamma isoform 1, signal peptide removed glycosylated form (mouse)
mIFNG/iso:1/SigPep-/GlycoRes+
"An interferon gamma isoform 1, signal peptide removed glycosylated form in mouse. UniProtKB:P01580-1, 23-155, MOD:00693." [PMID:11027433, PMID:11057672, PMID:11728336, PMID:12882831, PMID:12925700, PMID:15240714, PMID:15240719, PRO:CNA]
Yes
organism-modification
PR:000068116
interferon gamma, mature form (human)
hIFNG/mature
"An interferon gamma (human) that has had the signal peptide and propeptide removed. UniProtKB:P01579, 24-161." [PRO:DNx, Reactome:R-HSA-629621]
modification
PR:000018271
interferon gamma proteolytic cleavage product
IFNG/ClvPrd
"An interferon gamma that has been processed by proteolytic cleavage." [PRO:DNx]
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000017
IFNG
It is a cytokine produced by lymphocytes activated by specific antigens or mitogens that has important immunoregulatory functions
acts_upstream_of_or_within
GO:0006955
immune response
PIRSF:PIRSF001936
GO:0032722
positive regulation of chemokine production
PIRSF:PIRSF001936
PR:000036407
mIFNG/iso:1/SigPep-/GlycoRes+
UniProtKB:P01580-1, 23-155, MOD:00693
acts_upstream_of_or_within
GO:0050776
regulation of immune response
PMID:12882831
enables
GO:0005125
cytokine activity
PMID:11027433
;
PMID:12925700
;
PMID:15240719
located_in
GO:0005615
extracellular space
PMID:11057672
;
PMID:11728336
;
PMID:15240714
PR:000036418
mIFNG/iso:1/SigPep-
UniProtKB:P01580-1, 23-155
acts_upstream_of_or_within
GO:0050776
regulation of immune response
PMID:11441112
enables
GO:0005125
cytokine activity
PMID:11441112
PR:000036419
hIFNG/iso:1/SigPep-/NGlyco:1
UniProtKB:P01579-1, 24-157, Asn-48/Asn-120, MOD:00160
enables
GO:0005133
type II interferon receptor binding
PMID:10986460
GO:0042803
protein homodimerization activity
PMID:3109913
located_in
GO:0005615
extracellular space
PMID:6427223
PR:000036420
hIFNG/iso:1/ClvNGlyco:2
UniProtKB:P01579-1, 24-161, Asn-48/Asn-120, MOD:00160
enables
GO:0042803
protein homodimerization activity
PMID:1902591
PR:P01580-1
mIFNG/iso:1
acts_upstream_of_or_within
GO:0032722
positive regulation of chemokine production
PMID:12925700
GO:0042742
defense response to bacterium
PMID:17661079
