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Protein Ontology report - mitogen-activated protein kinase
PR:000000019 - http://purl.obolibrary.org/obo/PR_000000019
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000019   
  PRO namemitogen-activated protein kinase 
  Synonyms
Other: EXACT:MAPK
RELATED:kinase-related transforming protein
  Definition"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 8                                        
         Sequence2                                                  Organism-Sequence 11                                        
         Modification10                                                  Organism-Modification 26                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF501110
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000019

mitogen-activated protein kinase

IFNG


"A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase]

Yes

gene



PR:000000103

mitogen-activated protein kinase 1

MAPK1


"A mitogen-activated protein kinase that is a translation product of the human MAPK1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P28482

mitogen-activated protein kinase 1 (human)

hMAPK1


"A mitogen-activated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P28482]


organism-sequence



PR:P28482-1

mitogen-activated protein kinase 1 isoform 1 (human)

hMAPK1/iso:1


"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026341

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)

hMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]

Yes

organism-sequence



PR:P28482-2

mitogen-activated protein kinase 1 isoform h2 (human)

hMAPK1/iso:h2


"A mitogen-activated protein kinase 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-2." [PRO:DNx, UniProtKB:P28482]


organism-modification



PR:000045734

mitogen-activated protein kinase 1 phosphorylated 1 (human)

hMAPK1/Phos:1


"A mitogen-activated protein kinase 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-29 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Ser-29, MOD:00046." [iPTMnet:P28482, PMID:19447520]


organism-modification



PR:000048313

mitogen-activated protein kinase 1, initiator methionine removed form (human)

hMAPK1/InitMet-


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]


organism-modification



PR:000048314

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)

hMAPK1/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]


organism-modification



PR:000060366

mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]


organism-modification



PR:000060482

mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]


organism-modification



PR:000061403

mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58G/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Gly residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:29947|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652802]


organism-modification



PR:000061840

mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E81K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-81 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Glu-81, CHEBI:29967|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652799]


organism-modification



PR:000062009

mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652797]


organism-modification



PR:000062395

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)

hMAPK1/InitMet-/Phos:2


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-185 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635773]


organism-modification



PR:000062794

mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321N/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652785]


organism-modification



PR:000062965

mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652806]


organism-modification



PR:000063285

mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:S142L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Ser-142 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Ser-142, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652808]


organism-modification



PR:000063321

mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322A/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Ala residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9652794]


organism-modification



PR:000083225

mitogen-activated protein kinase 1 cysteinylated 1 (human)

hMAPK1/Cyst:1


"A mitogen-activated protein kinase 1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00765." [IEDB_epitope:1573500, PRO:DNx]


organism-modification



PR:000083581

mitogen-activated protein kinase 1 methylated 1 (human)

hMAPK1/Me:1


"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-166 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-166, MOD:00660." [IEDB_epitope:1024100, PRO:DNx]


organism-modification



PR:000084106

mitogen-activated protein kinase 1 methylated 2 (human)

hMAPK1/Me:2


"A mitogen-activated protein kinase 1 (human) that has been methylated on the residue at the position equivalent to Cys-127 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, Cys-127, MOD:00660." [IEDB_epitope:1018447, PRO:DNx]


organism-gene



PR:P39745

mitogen-activated protein kinase mpk-1 (worm)

MAPK1 (worm)


"A mitogen-activated protein kinase 1 that is encoded in the genome of worm." [OMA:P39745, PRO:DNx]


organism-sequence



PR:P39745-1

mitogen-activated protein kinase mpk-1 isoform b (worm)

MAPK1/iso:b (worm)


"A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-1." [PRO:DNx, UniProtKB:P39745]


organism-sequence



PR:P39745-2

mitogen-activated protein kinase mpk-1 isoform a (worm)

MAPK1/iso:a (worm)


"A mitogen-activated protein kinase mpk-1 (worm) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P39745-2." [PRO:DNx, UniProtKB:P39745]


organism-gene



PR:P42525

extracellular signal-regulated kinase 1 (Dictyostelium discoideum)

Dicty-MAPK1


"A mitogen-activated protein kinase 1 that is encoded in the genome of Dictyostelium discoideum." [PRO:CNA]


organism-gene



PR:P63085

mitogen-activated protein kinase 1 (mouse)

mMAPK1


"A mitogen-activated protein kinase 1 that is encoded in the genome of mouse." [OMA:P63085, PRO:DNx]


organism-sequence



PR:P63085-1

mitogen-activated protein kinase 1 isoform 1 (mouse)

mMAPK1/iso:1


"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036464

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)

mMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]

Yes

organism-gene



PR:P63086

mitogen-activated protein kinase 1 (rat)

rMAPK1


"A mitogen-activated protein kinase 1 that is encoded in the genome of rat." [OMA:P63086, PRO:DNx]


organism-modification



PR:000036466

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)

rMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA]

Yes

sequence



PR:000000289

mitogen-activated protein kinase 1 isoform 1

MAPK1/iso:1


"A mitogen-activated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28482-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P28482-1

mitogen-activated protein kinase 1 isoform 1 (human)

hMAPK1/iso:1


"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026341

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)

hMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]

Yes

organism-sequence



PR:P63085-1

mitogen-activated protein kinase 1 isoform 1 (mouse)

mMAPK1/iso:1


"A mitogen-activated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036464

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)

mMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]

Yes

modification



PR:000000454

mitogen-activated protein kinase 1 isoform 1 phosphorylated form

MAPK1/iso:1/PhosRes+


"A mitogen-activated protein kinase 1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000556

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1

MAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated form that is phosphorylated at both Thr and Tyr of the TxY motif within the protein kinase domain. Example: UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PMID:17192257, PMID:1849075, PRO:CNA]


organism-modification



PR:000026341

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (human)

hMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in human. UniProtKB:P28482-1, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, UniProtKB:P28482]

Yes

organism-modification



PR:000036464

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (mouse)

mMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P63085-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:11684667, PMID:11726647, PMID:12223545, PMID:12925581, PMID:14744933, PMID:15284227, PMID:15314156, PMID:16251435, PMID:8626447, PRO:CNA]

Yes

organism-modification



PR:000036466

mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 (rat)

rMAPK1/iso:1/Phos:1


"A mitogen-activated protein kinase 1 isoform 1 phosphorylated 1 in rat. UniProtKB:P63086-1, Thr-183, MOD:00047|Tyr-185, MOD:00048." [PMID:9604935, PRO:CNA]

Yes

modification



PR:000025465

mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form

MAPK1/iso:1/InitMet-


"A mitogen-activated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000000453

mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form

MAPK1/iso:1/InitMet-/AcRes+


"A mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form that includes at least one acetylated residue." [PMID:12665801, PRO:CNA]


modification



PR:000018278

mitogen-activated protein kinase 1, initiator methionine removed form

MAPK1/InitMet-


"A mitogen-activated protein kinase 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000025465

mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form

MAPK1/iso:1/InitMet-


"A mitogen-activated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000000453

mitogen-activated protein kinase 1 isoform 1, initiator methionine removed acetylated form

MAPK1/iso:1/InitMet-/AcRes+


"A mitogen-activated protein kinase 1 isoform 1, initiator methionine removed form that includes at least one acetylated residue." [PMID:12665801, PRO:CNA]


organism-modification



PR:000048313

mitogen-activated protein kinase 1, initiator methionine removed form (human)

hMAPK1/InitMet-


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed. UniProtKB:P28482, 2-360." [PRO:DNx, Reactome:R-HSA-199960, Reactome:R-HSA-59282]


organism-modification



PR:000048314

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 1 (human)

hMAPK1/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 185, and phosphotyrosine at position 187 of the amino acid sequence represented by UniProtKB:P28482. UniProtKB:P28482, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-109853, Reactome:R-HSA-112354]


organism-modification



PR:000060366

mitogen-activated protein kinase 1 sequence variant D321V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652791]


organism-modification



PR:000060482

mitogen-activated protein kinase 1 sequence variant E322K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:29967." [PRO:DNx, Reactome:R-HSA-9652175]


organism-modification



PR:000061403

mitogen-activated protein kinase 1 sequence variant P58G, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58G/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Gly residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:29947|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652802]


organism-modification



PR:000061840

mitogen-activated protein kinase 1 sequence variant E81K, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E81K/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Lys residue at the position equivalent to Glu-81 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Glu-81, CHEBI:29967|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652799]


organism-modification



PR:000062009

mitogen-activated protein kinase 1 sequence variant E322V, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322V/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Val residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:30015." [PRO:DNx, Reactome:R-HSA-9652797]


organism-modification



PR:000062395

mitogen-activated protein kinase 1, initiator methionine removed phosphorylated 2 (human)

hMAPK1/InitMet-/Phos:2


"A mitogen-activated protein kinase 1 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-185 of the amino acid sequence represented by UniProtKB:P28482-1. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635773]


organism-modification



PR:000062794

mitogen-activated protein kinase 1 sequence variant D321N, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:D321N/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Asn residue at the position equivalent to Asp-321 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Asp-321, CHEBI:50347." [PRO:DNx, Reactome:R-HSA-9652785]


organism-modification



PR:000062965

mitogen-activated protein kinase 1 sequence variant P58L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:P58L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Pro-58 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Pro-58, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652806]


organism-modification



PR:000063285

mitogen-activated protein kinase 1 sequence variant S142L, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:S142L/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has a Leu residue at the position equivalent to Ser-142 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Ser-142, CHEBI:30006|Thr-185, MOD:00047|Tyr-187, MOD:00048." [PRO:DNx, Reactome:R-HSA-9652808]


organism-modification



PR:000063321

mitogen-activated protein kinase 1 sequence variant E322A, initiator methionine removed phosphorylated 1 (human)

hMAPK1/var:E322A/InitMet-/Phos:1


"A mitogen-activated protein kinase 1 (human) that has an Ala residue at the position equivalent to Glu-322 of the amino acid sequence represented by UniProtKB:P28482-1, that has had the initiator methionine removed, and that has been phosphorylated on the residues at the positions equivalent to Thr-185 and Tyr-187. Example: UniProtKB:P28482-1, 2-360, Thr-185, MOD:00047|Tyr-187, MOD:00048|Glu-322, CHEBI:46217." [PRO:DNx, Reactome:R-HSA-9652794]


modification



PR:000025458

mitogen-activated protein kinase 1 proteolytic cleavage product

MAPK1/ClvPrd


"A mitogen-activated protein kinase 1 that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000000104

mitogen-activated protein kinase 3

MAPK3


"A mitogen-activated protein kinase that is a translation product of the human MAPK3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P21708

mitogen-activated protein kinase 3 (rat)

rMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of rat." [OMA:P21708, PRO:DNx]


organism-sequence



PR:P21708-1

mitogen-activated protein kinase 3 isoform r1 (rat)

rMAPK3/iso:r1


"A mitogen-activated protein kinase 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21708-1." [PRO:DNx, UniProtKB:P21708]


organism-sequence



PR:P21708-2

mitogen-activated protein kinase 3 isoform r2 (rat)

rMAPK3/iso:r2


"A mitogen-activated protein kinase 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21708-2." [PRO:DNx, UniProtKB:P21708]


organism-gene



PR:P27361

mitogen-activated protein kinase 3 (human)

hMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P27361]


organism-sequence



PR:P27361-1

mitogen-activated protein kinase 3 isoform 1 (human)

hMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-sequence



PR:P27361-2

mitogen-activated protein kinase 3 isoform h2 (human)

hMAPK3/iso:h2


"A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-2." [PRO:DNx, UniProtKB:P27361]


organism-sequence



PR:P27361-3

mitogen-activated protein kinase 3 isoform h3 (human)

hMAPK3/iso:h3


"A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-3." [PRO:DNx, UniProtKB:P27361]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


organism-modification



PR:000048321

mitogen-activated protein kinase 3, initiator methionine removed form (human)

hMAPK3/InitMet-


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed. UniProtKB:P27361, 2-379." [PRO:DNx, Reactome:R-HSA-59284, Reactome:R-HSA-73724]


organism-modification



PR:000048322

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 202, and phosphotyrosine at position 204 of the amino acid sequence represented by UniProtKB:P27361. UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-109842, Reactome:R-HSA-112359]


organism-modification



PR:000060765

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 2 (human)

hMAPK3/InitMet-/Phos:2


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-202 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, 2-379, Thr-202, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635775]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


organism-modification



PR:000065834

mitogen-activated protein kinase 3 methylated 1 (human)

hMAPK3/Me:1


"A mitogen-activated protein kinase 3 (human) that has been methylated on the residue at the position equivalent to Cys-144 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, Cys-144, MOD:00660." [IEDB_epitope:1031789, PRO:DNx]


organism-gene



PR:Q63844

mitogen-activated protein kinase 3 (mouse)

mMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of mouse." [OMA:Q63844, PRO:DNx]


organism-sequence



PR:Q63844-1

mitogen-activated protein kinase 3 isoform 1 (mouse)

mMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

sequence



PR:000000290

mitogen-activated protein kinase 3 isoform 1

MAPK3/iso:1


"A mitogen-activated protein kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27361-1

mitogen-activated protein kinase 3 isoform 1 (human)

hMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-sequence



PR:Q63844-1

mitogen-activated protein kinase 3 isoform 1 (mouse)

mMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

modification



PR:000000455

mitogen-activated protein kinase 3 isoform 1 phosphorylated form

MAPK3/iso:1/PhosRes+


"A mitogen-activated protein kinase 3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000557

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1

MAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated form that is phosphorylated at both Thr and Tyr of the TxY motif within the protein kinase domain. Example: UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]


organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

modification



PR:000026627

mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form

MAPK3/iso:1/InitMet-


"A mitogen-activated protein kinase 3 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018279

mitogen-activated protein kinase 3, initiator methionine removed form

MAPK3/InitMet-


"A mitogen-activated protein kinase 3 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026627

mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form

MAPK3/iso:1/InitMet-


"A mitogen-activated protein kinase 3 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048321

mitogen-activated protein kinase 3, initiator methionine removed form (human)

hMAPK3/InitMet-


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed. UniProtKB:P27361, 2-379." [PRO:DNx, Reactome:R-HSA-59284, Reactome:R-HSA-73724]


organism-modification



PR:000048322

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 202, and phosphotyrosine at position 204 of the amino acid sequence represented by UniProtKB:P27361. UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-109842, Reactome:R-HSA-112359]


organism-modification



PR:000060765

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 2 (human)

hMAPK3/InitMet-/Phos:2


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-202 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, 2-379, Thr-202, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635775]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0000165 MAPK cascadePR:000036464 mMAPK1/iso:1/Phos:1 PMID:8626447
GO:0006468 protein phosphorylationPR:000000019 IFNG PIRSF:PIRSF501110
PR:000026189 hMAPK3/iso:1/Phos:1 PMID:7687743
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:15284227
PR:000036468 mMAPK3/iso:1/Phos:1 PMID:11841548; PMID:15383658
GO:0006915 apoptotic processPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10958679
GO:0006935 chemotaxisPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:P28482-1 hMAPK1/iso:1 PMID:10706854
GO:0006950 response to stressPR:P28482-1 hMAPK1/iso:1 PMID:10958679
GO:0007165 signal transductionPR:000026341 hMAPK1/iso:1/Phos:1 PMID:1540184
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:11684667
GO:0007268 chemical synaptic transmissionPR:P28482-1 hMAPK1/iso:1 PMID:10706854
GO:0051726 regulation of cell cyclePR:000026189 hMAPK3/iso:1/Phos:1 PMID:7687743
PR:P27361-1 hMAPK3/iso:1 PMID:7687743

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004672 protein kinase activityPR:000000019 IFNG PIRSF:PIRSF501110
PR:000026189 hMAPK3/iso:1/Phos:1 PMID:16581800
PR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:14744933
PR:000036468 mMAPK3/iso:1/Phos:1 PMID:11684667; PMID:15314156
GO:0004707 MAP kinase activityPR:000026341 hMAPK1/iso:1/Phos:1 PMID:10706854
PR:000036464 mMAPK1/iso:1/Phos:1 PMID:11684667; PMID:12223545; PMID:15314156; PMID:8626447
PR:000036468 mMAPK3/iso:1/Phos:1 PMID:15314156
NOT GO:0004707 MAP kinase activityPR:P28482-1 hMAPK1/iso:1 PMID:10706854
GO:0005515 protein bindingPR:000026341 hMAPK1/iso:1/Phos:1 PMID:16291755
PR:Q63844-1 mMAPK3/iso:1 PMID:15118098
GO:0042803 protein homodimerization activityPR:000036466 rMAPK1/iso:1/Phos:1 PMID:9604935

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005634 nucleusPR:000036464 mMAPK1/iso:1/Phos:1 PMID:11726647; PMID:12925581; PMID:16251435
PR:000036468 mMAPK3/iso:1/Phos:1 PMID:11726647
GO:0005737 cytoplasmPR:P63085-1 mMAPK1/iso:1 PMID:11726647; PMID:12223545
PR:Q63844-1 mMAPK3/iso:1 PMID:11726647; PMID:12223545