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Protein Ontology report - ptx homeobox protein
PR:000000022 - http://purl.obolibrary.org/obo/PR_000000022
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000022   
  PRO nameptx homeobox protein 
  Definition"A protein that has a core domain composition consisting of an N-terminal K50 class Homeobox domain (Pfam:PF00046) and a C-terminal OAR domain (Pfam:PF03826). The homeobox domain consists of a self-folding, stable protein domain of 60 amino acids in which position 50 can confer a distinct DNA binding specificity. The K50 class of homeodomains recognizes a consensus DNA sequence of TAATCC. Homeodomain-containing proteins are known to play important roles in such diverse activities as embryonic pattern formation, cell-type specification, and differentiation." [PMID:15895993] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 12                                        
         Sequence5                                                  Organism-Sequence 24                                        
         Modification0                                                  Organism-Modification 0                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000563
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000022 ptx homeobox protein
NOG
Yes
gene


PR:000000117 pituitary homeobox 2
PITX2

organism-gene


PR:O93385 pituitary homeobox 2 (chicken)
chick-PITX2

organism-sequence


PR:O93385-1 pituitary homeobox 2 isoform Ptx2C (chicken)
chick-PITX2/iso:Ptx2C

organism-sequence


PR:O93385-2 pituitary homeobox 2 isoform Ptx2A (chicken)
chick-PITX2/iso:Ptx2A

organism-gene


PR:P97474 pituitary homeobox 2 (mouse)
mPITX2

organism-sequence


PR:000036295 pituitary homeobox 2 isoform 4 (mouse)
mPITX2/iso:4

organism-sequence


PR:P97474-1 pituitary homeobox 2 isoform Ptx2B (mouse)
mPITX2/iso:Ptx2B
Yes
organism-sequence


PR:P97474-2 pituitary homeobox 2 isoform Ptx2C (mouse)
mPITX2/iso:Ptx2C
Yes
organism-sequence


PR:P97474-3 pituitary homeobox 2 isoform Ptx2A (mouse)
mPITX2/iso:Ptx2A
Yes
organism-sequence


PR:P97474-4 pituitary homeobox 2 isoform Ptx2Calpha (mouse)
mPITX2/iso:Ptx2Calpha

organism-sequence


PR:P97474-5 pituitary homeobox 2 isoform Ptx2Cbeta (mouse)
mPITX2/iso:Ptx2Cbeta

organism-gene


PR:Q99697 pituitary homeobox 2 (human)
hPITX2

organism-sequence


PR:000000298 pituitary homeobox 2 sequence variant R89W (human)
hPITX2/var:R89W
Yes
organism-sequence


PR:000000299 pituitary homeobox 2 sequence variant L100Q (human)
hPITX2/var:L100Q
Yes
organism-sequence


PR:000000300 pituitary homeobox 2 sequence variant T114P (human)
hPITX2/var:T114P
Yes
organism-sequence


PR:000000301 pituitary homeobox 2 sequence variant R115H (human)
hPITX2/var:R115H
Yes
organism-sequence


PR:000000302 pituitary homeobox 2 sequence variant R137P (human)
hPITX2/var:R137P
Yes
organism-sequence


PR:000036294 pituitary homeobox 2 isoform 4 (human)
hPITX2/iso:4
Yes
organism-sequence


PR:Q99697-1 pituitary homeobox 2 isoform Ptx2B (human)
hPITX2/iso:Ptx2B
Yes
organism-sequence


PR:Q99697-2 pituitary homeobox 2 isoform Ptx2C (human)
hPITX2/iso:Ptx2C
Yes
organism-sequence


PR:Q99697-3 pituitary homeobox 2 isoform Ptx2A (human)
hPITX2/iso:Ptx2A
Yes
organism-gene


PR:Q9R0W1 pituitary homeobox 2 (rat)
rPITX2

organism-sequence


PR:Q9R0W1-1 pituitary homeobox 2 isoform Ptx2C (rat)
rPITX2/iso:Ptx2C

organism-sequence


PR:Q9R0W1-2 pituitary homeobox 2 isoform Ptx2A (rat)
rPITX2/iso:Ptx2A

organism-gene


PR:Q9W5Z2 pituitary homeobox 2 (zebrafish)
z-PITX2

organism-sequence


PR:Q9W5Z2-1 pituitary homeobox 2 isoform c (zebrafish)
z-PITX2/iso:c

organism-sequence


PR:Q9W5Z2-2 pituitary homeobox 2 isoform a (zebrafish)
z-PITX2/iso:a

sequence


PR:000000294 pituitary homeobox 2 isoform Ptx2A
PITX2/iso:Ptx2A

organism-sequence


PR:O93385-2 pituitary homeobox 2 isoform Ptx2A (chicken)
chick-PITX2/iso:Ptx2A

organism-sequence


PR:P97474-3 pituitary homeobox 2 isoform Ptx2A (mouse)
mPITX2/iso:Ptx2A
Yes
organism-sequence


PR:Q99697-3 pituitary homeobox 2 isoform Ptx2A (human)
hPITX2/iso:Ptx2A
Yes
organism-sequence


PR:Q9R0W1-2 pituitary homeobox 2 isoform Ptx2A (rat)
rPITX2/iso:Ptx2A

sequence


PR:000000295 pituitary homeobox 2 isoform Ptx2B
PITX2/iso:Ptx2B

organism-sequence


PR:P97474-1 pituitary homeobox 2 isoform Ptx2B (mouse)
mPITX2/iso:Ptx2B
Yes
organism-sequence


PR:Q99697-1 pituitary homeobox 2 isoform Ptx2B (human)
hPITX2/iso:Ptx2B
Yes
sequence


PR:000000296 pituitary homeobox 2 isoform Ptx2C
PITX2/iso:Ptx2C

organism-sequence


PR:O93385-1 pituitary homeobox 2 isoform Ptx2C (chicken)
chick-PITX2/iso:Ptx2C

organism-sequence


PR:P97474-2 pituitary homeobox 2 isoform Ptx2C (mouse)
mPITX2/iso:Ptx2C
Yes
organism-sequence


PR:Q99697-2 pituitary homeobox 2 isoform Ptx2C (human)
hPITX2/iso:Ptx2C
Yes
organism-sequence


PR:Q9R0W1-1 pituitary homeobox 2 isoform Ptx2C (rat)
rPITX2/iso:Ptx2C

sequence


PR:000000297 pituitary homeobox 2 isoform 4
PITX2/iso:4

organism-sequence


PR:000036294 pituitary homeobox 2 isoform 4 (human)
hPITX2/iso:4
Yes
organism-sequence


PR:000036295 pituitary homeobox 2 isoform 4 (mouse)
mPITX2/iso:4

gene


PR:000012760 pituitary homeobox 1
PITX1

organism-gene


PR:P70314 pituitary homeobox 1 (mouse)
mPITX1

organism-gene


PR:P78337 pituitary homeobox 1 (human)
hPITX1

organism-gene


PR:Q99NA7 pituitary homeobox 1 (rat)
rPITX1

gene


PR:000012761 pituitary homeobox 3
PITX3

organism-gene


PR:O35160 pituitary homeobox 3 (mouse)
mPITX3

organism-sequence


PR:O35160-1 pituitary homeobox 3 isoform 1 (mouse)
mPITX3/iso:1

organism-gene


PR:O75364 pituitary homeobox 3 (human)
hPITX3

organism-sequence


PR:O75364-1 pituitary homeobox 3 isoform 1 (human)
hPITX3/iso:1

organism-gene


PR:P81062 pituitary homeobox 3 (rat)
rPITX3

organism-sequence


PR:P81062-1 pituitary homeobox 3 isoform 1 (rat)
rPITX3/iso:1

organism-gene


PR:Q24256 homeobox protein B-H2 (fruit fly)
fly-PITX3

sequence


PR:000038343 pituitary homeobox 3 isoform 1
PITX3/iso:1

organism-sequence


PR:O35160-1 pituitary homeobox 3 isoform 1 (mouse)
mPITX3/iso:1

organism-sequence


PR:O75364-1 pituitary homeobox 3 isoform 1 (human)
hPITX3/iso:1

organism-sequence


PR:P81062-1 pituitary homeobox 3 isoform 1 (rat)
rPITX3/iso:1

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000022 NOG
Homeodomain-containing proteins are known to play important roles in such diverse activities as embryonic pattern formation, cell-type specification, and differentiation		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PIRSF:PIRSF000563
GO:0007275 multicellular organism development PIRSF:PIRSF000563
enablesGO:0003700 DNA-binding transcription factor activity PIRSF:PIRSF000563
PR:000000298 hPITX2/var:R89W
Example: UniProtKB:Q99697-1, Arg-89, CHEBI:29954		 associated_with_disease_progressionDO:0050786 iridogoniodysgenesis syndrome PMID:9437321
PR:000000299 hPITX2/var:L100Q
Example: UniProtKB:Q99697-1, Leu-100, CHEBI:30011		 associated_with_disease_progressionDO:14686 Axenfeld-Rieger syndrome PMID:8944018
PR:000000300 hPITX2/var:T114P
Example: UniProtKB:Q99697-1, Thr-114, CHEBI:50342		 associated_with_disease_progressionDO:14686 Axenfeld-Rieger syndrome PMID:8944018
PR:000000301 hPITX2/var:R115H
Example: UniProtKB:Q99697-1, Arg-115, CHEBI:29979		 associated_with_disease_progressionDO:0050786 iridogoniodysgenesis syndrome PMID:9618168
PR:000000302 hPITX2/var:R137P
Example: UniProtKB:Q99697-1, Arg-137, CHEBI:50342		 associated_with_disease_progressionDO:14686 Axenfeld-Rieger syndrome PMID:8944018
PR:000036294 hPITX2/iso:4 acts_upstream_of_or_withinGO:0043433 negative regulation of DNA-binding transcription factor activity PMID:11948188
enablesNOT GO:0003677 DNA binding PMID:11948188
GO:0005515 protein binding with PR:Q99697-3 PMID:11948188
GO:0005515 protein binding PMID:11948188
PR:P97474-1 mPITX2/iso:Ptx2B acts_upstream_of_or_withinGO:0007368 determination of left/right symmetry PMID:12397115
GO:0016055 Wnt signaling pathway PMID:12464179
located_inGO:0005667 transcription factor complex PMID:12464179; PMID:15385555
PR:P97474-2 mPITX2/iso:Ptx2C acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:10585561
GO:0007368 determination of left/right symmetry PMID:9708732
GO:0007520 myoblast fusion MGI_ref:3686567; PMID:16958127
GO:0009887 animal organ morphogenesis PMID:10585561
GO:2000288 positive regulation of myoblast proliferation MGI_ref:3686567; PMID:16958127
PR:P97474-3 mPITX2/iso:Ptx2A acts_upstream_of_or_withinGO:0007266 Rho protein signal transduction PMID:11854422
NOT GO:0007368 determination of left/right symmetry PMID:10585561
GO:0030036 actin cytoskeleton organization PMID:11854422
GO:0043388 positive regulation of DNA binding MGI_ref:3796777; PMID:18458156
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific MGI_ref:3796777; PMID:18458156
GO:0003677 DNA binding MGI_ref:3796777; PMID:18458156
GO:0003712 transcription coregulator activity MGI_ref:3796777; PMID:18458156
GO:0005515 protein binding MGI_ref:3796777; PMID:18458156
GO:0008134 transcription factor binding PMID:15385555
located_inGO:0005634 nucleus PMID:11854422
GO:0005634 nucleus PMID:11854422
PR:Q99697-1 hPITX2/iso:Ptx2B acts_upstream_of_or_withinGO:0007368 determination of left/right symmetry PMID:9708732
GO:0009887 animal organ morphogenesis PMID:9618168
enablesGO:0005515 protein binding with PR:Q99697-2 PMID:11948188
GO:0005515 protein binding with PR:Q99697-3 PMID:11948188
PR:Q99697-2 hPITX2/iso:Ptx2C acts_upstream_of_or_withinGO:0007507 heart development PMID:11948188
enablesGO:0003677 DNA binding PMID:11948188
GO:0005515 protein binding with PR:Q99697-3 PMID:11948188
GO:0005515 protein binding PMID:11948188
PR:Q99697-3 hPITX2/iso:Ptx2A enablesGO:0005515 protein binding with PR:Q99697-2 PMID:11948188
GO:0008134 transcription factor binding PMID:16449236
located_inGO:0005634 nucleus PMID:16449236