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Protein Ontology report - retinoblastoma-like protein
PR:000000023 - http://purl.obolibrary.org/obo/PR_000000023
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000023   
  PRO nameretinoblastoma-like protein 
  Definition"A protein that has a core domain composition consisting of a Retinoblastoma-associated protein A domain (Pfam:PF01858) followed by a Retinoblastoma-associated protein B domain (Pfam:PF01857). The retinoblastoma-like proteins are key regulators of entry into cell division. They are directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence4                                                  Organism-Sequence 7                                        
         Modification6                                                  Organism-Modification 8                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037408
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000023 retinoblastoma-like protein
NOG
Yes
gene


PR:000000118 retinoblastoma-like protein 1
RBL1

organism-gene


PR:D3ZS28 retinoblastoma-like protein 1 (rat)
rRBL1

organism-gene


PR:P28749 retinoblastoma-like protein 1 (human)
hRBL1

organism-sequence


PR:P28749-1 retinoblastoma-like protein 1 isoform 1 (human)
hRBL1/iso:1
Yes
organism-modification


PR:000036470 retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
Yes
organism-sequence


PR:P28749-2 retinoblastoma-like protein 1 isoform 2 (human)
hRBL1/iso:2

organism-modification


PR:000049024 retinoblastoma-like protein 1 phosphorylated 1 (human)
hRBL1/Phos:1

organism-gene


PR:Q24472 retinoblastoma family protein (fruit fly)
fly-RBL1

organism-gene


PR:Q64701 retinoblastoma-like protein 1 (mouse)
mRBL1

organism-sequence


PR:Q64701-1 retinoblastoma-like protein 1 isoform Long (mouse)
mRBL1/iso:Long

organism-sequence


PR:Q64701-2 retinoblastoma-like protein 1 isoform Short (mouse)
mRBL1/iso:Short

sequence


PR:000000303 retinoblastoma-like protein 1 isoform 1
RBL1/iso:1

organism-sequence


PR:P28749-1 retinoblastoma-like protein 1 isoform 1 (human)
hRBL1/iso:1
Yes
organism-modification


PR:000036470 retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
Yes
organism-sequence


PR:Q64701-1 retinoblastoma-like protein 1 isoform Long (mouse)
mRBL1/iso:Long

modification


PR:000000458 retinoblastoma-like protein 1 isoform 1 phosphorylated form
RBL1/iso:1/PhosRes+

modification


PR:000000559 retinoblastoma-like protein 1 isoform 1 phosphorylated 1
RBL1/iso:1/Phos:1

organism-modification


PR:000036470 retinoblastoma-like protein 1 isoform 1 phosphorylated 1 (human)
hRBL1/iso:1/Phos:1
Yes
sequence


PR:000000304 retinoblastoma-like protein 1 isoform 2
RBL1/iso:2

organism-sequence


PR:P28749-2 retinoblastoma-like protein 1 isoform 2 (human)
hRBL1/iso:2

sequence


PR:000000305 retinoblastoma-like protein 1 isoform 3
RBL1/iso:3

organism-sequence


PR:Q64701-2 retinoblastoma-like protein 1 isoform Short (mouse)
mRBL1/iso:Short

gene


PR:000000119 retinoblastoma-like protein 2
RBL2

organism-gene


PR:O55081 retinoblastoma-like protein 2 (rat)
rRBL2

organism-gene


PR:Q08999 retinoblastoma-like protein 2 (human)
hRBL2

organism-sequence


PR:Q08999-1 retinoblastoma-like protein 2 isoform 1 (human)
hRBL2/iso:1
Yes
organism-modification


PR:000036471 retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
Yes
organism-modification


PR:000036472 retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
Yes
organism-modification


PR:000036473 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
Yes
organism-sequence


PR:Q08999-2 retinoblastoma-like protein 2 isoform h2 (human)
hRBL2/iso:h2

organism-modification


PR:000049025 retinoblastoma-like protein 2 phosphorylated 4 (human)
hRBL2/Phos:4

organism-modification


PR:000068308 retinoblastoma-like protein 2 phosphorylated 1 (human)
hRBL2/Phos:1

organism-gene


PR:Q64700 retinoblastoma-like protein 2 (mouse)
mRBL2

organism-sequence


PR:Q64700-1 retinoblastoma-like protein 2 isoform 1 (mouse)
mRBL2/iso:1
Yes
organism-modification


PR:000036474 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
Yes
sequence


PR:000000306 retinoblastoma-like protein 2 isoform 1
RBL2/iso:1

organism-sequence


PR:Q08999-1 retinoblastoma-like protein 2 isoform 1 (human)
hRBL2/iso:1
Yes
organism-modification


PR:000036471 retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
Yes
organism-modification


PR:000036472 retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
Yes
organism-modification


PR:000036473 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
Yes
organism-sequence


PR:Q64700-1 retinoblastoma-like protein 2 isoform 1 (mouse)
mRBL2/iso:1
Yes
organism-modification


PR:000036474 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
Yes
modification


PR:000000459 retinoblastoma-like protein 2 isoform 1 phosphorylated form
RBL2/iso:1/PhosRes+

modification


PR:000000560 retinoblastoma-like protein 2 isoform 1 phosphorylated 1
RBL2/iso:1/Phos:1

organism-modification


PR:000036471 retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human)
hRBL2/iso:1/Phos:1
Yes
modification


PR:000000561 retinoblastoma-like protein 2 isoform 1 phosphorylated 2
RBL2/iso:1/Phos:2

organism-modification


PR:000036472 retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human)
hRBL2/iso:1/Phos:2
Yes
modification


PR:000000562 retinoblastoma-like protein 2 isoform 1 phosphorylated 3
RBL2/iso:1/Phos:3

organism-modification


PR:000036473 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human)
hRBL2/iso:1/Phos:3
Yes
organism-modification


PR:000036474 retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse)
mRBL2/iso:1/Phos:3
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000023 NOG
They are directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PIRSF:PIRSF037408
enablesGO:0005515 protein binding PIRSF:PIRSF037408
PR:000036470 hRBL1/iso:1/Phos:1
UniProtKB:P28749-1, Thr-369, MOD:00047|Ser-640/Ser-964/Ser-975, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11884610
enablesGO:0005515 protein binding PMID:11884610
NOT GO:0030308 negative regulation of cell growth PMID:11884610
PR:000036471 hRBL2/iso:1/Phos:1
UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11042701; PMID:11157749; PMID:8710362
enablesNOT GO:0005515 protein binding PMID:11157749
NOT GO:0030308 negative regulation of cell growth PMID:11157749
PR:000036472 hRBL2/iso:1/Phos:2
UniProtKB:Q08999-1, Ser-672, MOD:00046		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:12006580
enablesGO:0005515 protein binding with PR:Q13309 cyclin-A/CDK2-associated protein p45 (human) PMID:12006580
NOT GO:0030308 negative regulation of cell growth PMID:12006580
PR:000036473 hRBL2/iso:1/Phos:3
UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047		 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:11042701; PMID:11157749; PMID:8710362
enablesGO:0005515 protein binding with PR:Q16254 E2F-4 (human) PMID:11042701; PMID:11157749
PR:000036474 mRBL2/iso:1/Phos:3 located_inGO:0005667 transcription factor complex PMID:10082561
PR:P28749-1 hRBL1/iso:1 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:8319904
enablesGO:0005515 protein binding PMID:11884610
GO:0030308 negative regulation of cell growth PMID:11884610
PR:Q08999-1 hRBL2/iso:1 enablesGO:0005515 protein binding PMID:8361765
PR:Q64700-1 mRBL2/iso:1 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:10082561
enablesGO:0030308 negative regulation of cell growth PMID:10082561
located_inGO:0005634 nucleus PMID:10082561