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Protein Ontology report - Rho-associated protein kinase
PR:000000024 - http://purl.obolibrary.org/obo/PR_000000024
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000024   
  PRO nameRho-associated protein kinase 
  Definition"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence3                                                  Organism-Sequence 8                                        
         Modification11                                                  Organism-Modification 13                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037568
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000024 Rho-associated protein kinase
NOG
Yes
gene


PR:000000120 Rho-associated protein kinase 1
ROCK1

organism-gene


PR:P70335 Rho-associated protein kinase 1 (mouse)
mROCK1

organism-sequence


PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse)
mROCK1/iso:1

organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
organism-sequence


PR:P70335-2 Rho-associated protein kinase 1 isoform m2 (mouse)
mROCK1/iso:m2

organism-gene


PR:Q13464 Rho-associated protein kinase 1 (human)
hROCK1

organism-sequence


PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human)
hROCK1/iso:1
Yes
organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
organism-modification


PR:000061208 Rho-associated protein kinase 1, initiator methionine removed form (human)
hROCK1/InitMet-

organism-modification


PR:000070060 Rho-associated protein kinase 1 deaminated 1 (human)
hROCK1/Deam:1

organism-modification


PR:000070524 Rho-associated protein kinase 1 phosphorylated 1 (human)
hROCK1/Phos:1

organism-modification


PR:000082399 Rho-associated protein kinase 1 deaminated 2 (human)
hROCK1/Deam:2

organism-gene


PR:Q63644 Rho-associated protein kinase 1 (rat)
rROCK1

organism-sequence


PR:Q63644-1 Rho-associated protein kinase 1 isoform r1 (rat)
rROCK1/iso:r1

organism-sequence


PR:Q63644-2 Rho-associated protein kinase 1 isoform r2 (rat)
rROCK1/iso:r2

sequence


PR:000000307 Rho-associated protein kinase 1 isoform 1
ROCK1/iso:1

organism-sequence


PR:P70335-1 Rho-associated protein kinase 1 isoform 1 (mouse)
mROCK1/iso:1

organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
organism-sequence


PR:Q13464-1 Rho-associated protein kinase 1 isoform 1 (human)
hROCK1/iso:1
Yes
organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
modification


PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1
ROCK1/iso:1/Clv:1

organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
modification


PR:000002529 Rho-associated protein kinase 1 isoform 1 unmodified form
ROCK1/iso:1/UnMod

organism-modification


PR:000044586 Rho-associated protein kinase 1 isoform 1 unmodified form (human)
hROCK1/iso:1/UnMod
Yes
modification


PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form
ROCK1/iso:1/InitMet-

modification


PR:000018280 Rho-associated protein kinase 1, initiator methionine removed form
ROCK1/InitMet-

modification


PR:000026574 Rho-associated protein kinase 1 isoform 1, initiator methionine removed form
ROCK1/iso:1/InitMet-

organism-modification


PR:000061208 Rho-associated protein kinase 1, initiator methionine removed form (human)
hROCK1/InitMet-

modification


PR:000025435 Rho-associated protein kinase 1 proteolytic cleavage product
ROCK1/ClvPrd

modification


PR:000000563 Rho-associated protein kinase 1 isoform 1 cleaved 1
ROCK1/iso:1/Clv:1

organism-modification


PR:000026340 Rho-associated protein kinase 1 isoform 1 cleaved 1 (human)
hROCK1/iso:1/Clv:1
Yes
organism-modification


PR:000036476 Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse)
mROCK1/iso:1/Clv:1
Yes
gene


PR:000000121 Rho-associated protein kinase 2
ROCK2

organism-gene


PR:O75116 Rho-associated protein kinase 2 (human)
hROCK2

organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human)
hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
hROCK2/iso:1/Phos:2
Yes
organism-modification


PR:000066276 Rho-associated protein kinase 2 methylated 1 (human)
hROCK2/Me:1

organism-modification


PR:000071951 Rho-associated protein kinase 2 methylated 2 (human)
hROCK2/Me:2

organism-modification


PR:000074887 Rho-associated protein kinase 2 phosphorylated 1 (human)
hROCK2/Phos:1

organism-gene


PR:P70336 Rho-associated protein kinase 2 (mouse)
mROCK2

organism-sequence


PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse)
mROCK2/iso:1

organism-sequence


PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse)
mROCK2/iso:2
Yes
organism-gene


PR:Q62868 Rho-associated protein kinase 2 (rat)
rROCK2

sequence


PR:000000308 Rho-associated protein kinase 2 isoform 1
ROCK2/iso:1

organism-sequence


PR:O75116-1 Rho-associated protein kinase 2 isoform 1 (human)
hROCK2/iso:1
Yes
organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
hROCK2/iso:1/Phos:1
Yes
organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
hROCK2/iso:1/Phos:2
Yes
organism-sequence


PR:P70336-1 Rho-associated protein kinase 2 isoform 1 (mouse)
mROCK2/iso:1

modification


PR:000000462 Rho-associated protein kinase 2 isoform 1 phosphorylated form
ROCK2/iso:1/PhosRes+

modification


PR:000000565 Rho-associated protein kinase 2 isoform 1 phosphorylated 1
ROCK2/iso:1/Phos:1

organism-modification


PR:000036478 Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)
hROCK2/iso:1/Phos:1
Yes
modification


PR:000000566 Rho-associated protein kinase 2 isoform 1 phosphorylated 2
ROCK2/iso:1/Phos:2

organism-modification


PR:000036479 Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)
hROCK2/iso:1/Phos:2
Yes
modification


PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1
ROCK2/iso:1/Clv:1

organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
modification


PR:000002530 Rho-associated protein kinase 2 isoform 1 unmodified form
ROCK2/iso:1/UnMod

sequence


PR:000000309 Rho-associated protein kinase 2 isoform 2
ROCK2/iso:2

organism-sequence


PR:P70336-2 Rho-associated protein kinase 2 isoform 2 (mouse)
mROCK2/iso:2
Yes
modification


PR:000025436 Rho-associated protein kinase 2 proteolytic cleavage product
ROCK2/ClvPrd

modification


PR:000000564 Rho-associated protein kinase 2 isoform 1 cleaved 1
ROCK2/iso:1/Clv:1

organism-modification


PR:000036477 Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)
hROCK2/iso:1/Clv:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006468 protein phosphorylationPR:000000024 NOG PANTHER:PTHR22988; PIRSF:PIRSF037568
PR:000026340 hROCK1/iso:1/Clv:1 PMID:11283607
PR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1 PMID:17446864
PR:O75116-1 hROCK2/iso:1 PMID:9933571
PR:P70336-2 mROCK2/iso:2 PMID:17606625
PR:Q13464-1 hROCK1/iso:1 PMID:10436159
GO:0007266 Rho protein signal transductionPR:000000024 NOG PANTHER:PTHR22988; PIRSF:PIRSF037568
PR:Q13464-1 hROCK1/iso:1 PMID:8798490
GO:0010659 cardiac muscle cell apoptotic processPR:000036476 mROCK1/iso:1/Clv:1 PMID:16983089
GO:0030036 actin cytoskeleton organizationPR:000036476 mROCK1/iso:1/Clv:1 PMID:11283607; PMID:16983089
PR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:Q13464-1 hROCK1/iso:1 PMID:10436159
GO:0042770 signal transduction in response to DNA damagePR:000036479 hROCK2/iso:1/Phos:2 PMID:17525332
GO:0051149 positive regulation of muscle cell differentiationPR:P70336-2 mROCK2/iso:2 PMID:17606625
GO:0051260 protein homooligomerizationPR:O75116-1 hROCK2/iso:1 PMID:15291762
PR:Q13464-1 hROCK1/iso:1 PMID:15291762

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004672 protein kinase activityPR:000000024 NOG PANTHER:PTHR22988; PIRSF:PIRSF037568
GO:0004674 protein serine/threonine kinase activityPR:000000024 NOG PANTHER:PTHR22988; PIRSF:PIRSF037568
PR:000026340 hROCK1/iso:1/Clv:1 PMID:11283607
PR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1 PMID:17446864
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:000044586 hROCK1/iso:1/UnMod PMID:15699075
PR:O75116-1 hROCK2/iso:1 PMID:9933571
PR:P70336-2 mROCK2/iso:2 PMID:17606625
PR:Q13464-1 hROCK1/iso:1 PMID:8798490
GO:0031267 small GTPase bindingPR:O75116-1 hROCK2/iso:1 PMID:11350930
PR:Q13464-1 hROCK1/iso:1 PMID:14660612; PMID:15475352

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005622 intracellular anatomical structurePR:000036477 hROCK2/iso:1/Clv:1 PMID:15699075
PR:O75116-1 hROCK2/iso:1 PMID:16574662
GO:0005634 nucleusPR:000036478 hROCK2/iso:1/Phos:1 PMID:15302935