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Protein Ontology report - ribosomal protein S6 kinase beta
PR:000000025 - http://purl.obolibrary.org/obo/PR_000000025
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000025   
  PRO nameribosomal protein S6 kinase beta 
  Definition"A protein that specifically phosphorylates ribosomal protein S6 in response to insulin and other mitogens. It has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433)." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 7                                        
         Sequence3                                                  Organism-Sequence 12                                        
         Modification6                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF000605
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000025

ribosomal protein S6 kinase beta

NOG


"A protein that specifically phosphorylates ribosomal protein S6 in response to insulin and other mitogens. It has a core domain composition consisting of a Protein kinase domain (Pfam:PF00069) followed by a Protein kinase C terminal domain (Pfam:PF00433)." [PRO:CNA]

Yes

gene



PR:000000123

ribosomal protein S6 kinase beta-1

RPS6KB1


"A ribosomal protein S6 kinase beta that is a translation product of the human RPS6KB1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P23443

ribosomal protein S6 kinase beta-1 (human)

hRPS6KB1


"A ribosomal protein S6 kinase beta-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P23443]


organism-sequence



PR:P23443-1

ribosomal protein S6 kinase beta-1 isoform Alpha I (human)

hRPS6KB1/iso:Alpha I


"A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036480

ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 (human)

hRPS6KB1/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 in human. UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062, PRO:CNA]

Yes

organism-sequence



PR:P23443-2

ribosomal protein S6 kinase beta-1 isoform Alpha II (human)

hRPS6KB1/iso:Alpha II


"A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036481

ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 (human)

hRPS6KB1/iso:2/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 in human." [PMID:1922062, PRO:CNA]

Yes

organism-sequence



PR:P23443-3

ribosomal protein S6 kinase beta-1 isoform h2 (human)

hRPS6KB1/iso:h2


"A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-3." [PRO:DNx, UniProtKB:P23443]


organism-sequence



PR:P23443-4

ribosomal protein S6 kinase beta-1 isoform h3 (human)

hRPS6KB1/iso:h3


"A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-4." [PRO:DNx, UniProtKB:P23443]


organism-sequence



PR:P23443-5

ribosomal protein S6 kinase beta-1 isoform h4 (human)

hRPS6KB1/iso:h4


"A ribosomal protein S6 kinase beta-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-5." [PRO:DNx, UniProtKB:P23443]


organism-modification



PR:000049135

ribosomal protein S6 kinase beta-1 phosphorylated 2 (human)

hRPS6KB1/Phos:2


"A ribosomal protein S6 kinase beta-1 (human) that has been phosphorylated on residues at the positions equivalent to Ser-394 and Thr-412 of the amino acid sequence represented by UniProtKB:P23443. UniProtKB:P23443, Ser-394, MOD:00046|Thr-412, MOD:00047." [PRO:DAN]


organism-modification



PR:000069158

ribosomal protein S6 kinase beta-1 cysteinylated 1 (human)

hRPS6KB1/Cyst:1


"A ribosomal protein S6 kinase beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-308 of the amino acid sequence represented by UniProtKB:P23443-1. Example: UniProtKB:P23443-1, Cys-308, MOD:00765." [IEDB_epitope:1027122, PRO:DNx]


organism-modification



PR:000071099

ribosomal protein S6 kinase beta-1 phosphorylated 1 (human)

hRPS6KB1/Phos:1


"A ribosomal protein S6 kinase beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-447 of the amino acid sequence represented by UniProtKB:P23443-1. Example: UniProtKB:P23443-1, Ser-447, MOD:00046." [IEDB_epitope:912584, PRO:DNx]


organism-modification



PR:000082924

ribosomal protein S6 kinase beta-1 cysteinylated 2 (human)

hRPS6KB1/Cyst:2


"A ribosomal protein S6 kinase beta-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-196 of the amino acid sequence represented by UniProtKB:P23443-1. Example: UniProtKB:P23443-1, Cys-196, MOD:00765." [IEDB_epitope:1020483, IEDB_epitope:1562799, PRO:DNx]


organism-modification



PR:000085996

ribosomal protein S6 kinase beta-1 phosphorylated 3 (human)

hRPS6KB1/Phos:3


"A ribosomal protein S6 kinase beta-1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-412 of the amino acid sequence represented by UniProtKB:P23443-1. Example: UniProtKB:P23443-1, Thr-412, MOD:00047." [PRO:DNx, Reactome:R-HSA-165714]


organism-gene



PR:P67999

ribosomal protein S6 kinase beta-1 (rat)

rRPS6KB1


"A ribosomal protein S6 kinase beta-1 that is encoded in the genome of rat." [OMA:P67999, PRO:DNx]


organism-sequence



PR:P67999-1

ribosomal protein S6 kinase beta-1 isoform Alpha I (rat)

rRPS6KB1/iso:Alpha I


"A ribosomal protein S6 kinase beta-1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P67999-1." [PRO:DNx, UniProtKB:P67999]


organism-sequence



PR:P67999-2

ribosomal protein S6 kinase beta-1 isoform Alpha II (rat)

rRPS6KB1/iso:Alpha II


"A ribosomal protein S6 kinase beta-1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P67999-2." [PRO:DNx, UniProtKB:P67999]


organism-gene



PR:Q8BSK8

ribosomal protein S6 kinase beta-1 (mouse)

mRPS6KB1


"A ribosomal protein S6 kinase beta-1 that is encoded in the genome of mouse." [OMA:Q8BSK8, PRO:DNx]


organism-sequence



PR:Q8BSK8-1

ribosomal protein S6 kinase beta-1 isoform Alpha I (mouse)

mRPS6KB1/iso:Alpha I


"A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:Q8BSK8-2

ribosomal protein S6 kinase beta-1 isoform Alpha II (mouse)

mRPS6KB1/iso:Alpha II


"A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000310

ribosomal protein S6 kinase beta-1 isoform 1

RPS6KB1/iso:1


"A ribosomal protein S6 kinase beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P23443-1

ribosomal protein S6 kinase beta-1 isoform Alpha I (human)

hRPS6KB1/iso:Alpha I


"A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036480

ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 (human)

hRPS6KB1/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 in human. UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062, PRO:CNA]

Yes

organism-sequence



PR:Q8BSK8-1

ribosomal protein S6 kinase beta-1 isoform Alpha I (mouse)

mRPS6KB1/iso:Alpha I


"A ribosomal protein S6 kinase beta-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000463

ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated form

RPS6KB1/iso:1/PhosRes+


"A ribosomal protein S6 kinase beta-1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000567

ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1

RPS6KB1/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated form in which the phosphorylation occurs within the AGC-kinase C-terminal domain. Example: UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062]


organism-modification



PR:000036480

ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 (human)

hRPS6KB1/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 1 phosphorylated 1 in human. UniProtKB:P23443-1, Ser-441/Ser-447, MOD:00046|Thr-444, MOD:00047." [PMID:1922062, PRO:CNA]

Yes

sequence



PR:000000311

ribosomal protein S6 kinase beta-1 isoform 2

RPS6KB1/iso:2


"A ribosomal protein S6 kinase beta-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23443-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P23443-2

ribosomal protein S6 kinase beta-1 isoform Alpha II (human)

hRPS6KB1/iso:Alpha II


"A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036481

ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 (human)

hRPS6KB1/iso:2/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 in human." [PMID:1922062, PRO:CNA]

Yes

organism-sequence



PR:Q8BSK8-2

ribosomal protein S6 kinase beta-1 isoform Alpha II (mouse)

mRPS6KB1/iso:Alpha II


"A ribosomal protein S6 kinase beta-1 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000464

ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated form

RPS6KB1/iso:2/PhosRes+


"A ribosomal protein S6 kinase beta-1 isoform 2 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000568

ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1

RPS6KB1/iso:2/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated form in which the phosphorylation occurs within the AGC-kinase C-terminal domain. These sites serve as phosphorylation-regulated switches to control both intra- and inter-molecular interactions. Without these priming phosphorylations, the kinases are catalytically inactive." [PMID:1922062]


organism-modification



PR:000036481

ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 (human)

hRPS6KB1/iso:2/Phos:1


"A ribosomal protein S6 kinase beta-1 isoform 2 phosphorylated 1 in human." [PMID:1922062, PRO:CNA]

Yes

gene



PR:000000124

ribosomal protein S6 kinase beta-2

RPS6KB2


"A ribosomal protein S6 kinase beta that is a translation product of the human RPS6KB2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q8MYF1

probable serine/threonine-protein kinase DDB_G0277449 (Dictyostelium discoideum)

Dicty-RPS6KB2


"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of Dictyostelium discoideum." [OMA:Q8MYF1, PRO:CNA]


organism-gene



PR:Q9NAH6

ribosomal protein S6 kinase beta (worm)

RPS6KB2 (worm)


"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of worm." [OMA:Q9NAH6, PRO:DNx]


organism-gene



PR:Q9UBS0

ribosomal protein S6 kinase beta-2 (human)

hRPS6KB2


"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UBS0]


organism-sequence



PR:Q9UBS0-1

ribosomal protein S6 kinase beta-2 isoform 1 (human)

hRPS6KB2/iso:1


"A ribosomal protein S6 kinase beta-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026339

ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 (human)

hRPS6KB2/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBS0-1, Ser-15/Ser-356, MOD:00046." [PRO:DNx, UniProtKB:Q9UBS0]


organism-sequence



PR:Q9UBS0-2

ribosomal protein S6 kinase beta-2 isoform h2 (human)

hRPS6KB2/iso:h2


"A ribosomal protein S6 kinase beta-2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBS0-2." [PRO:DNx, UniProtKB:Q9UBS0]


organism-modification



PR:000068932

ribosomal protein S6 kinase beta-2 phosphorylated 1 (human)

hRPS6KB2/Phos:1


"A ribosomal protein S6 kinase beta-2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-423 of the amino acid sequence represented by UniProtKB:Q9UBS0-1. Example: UniProtKB:Q9UBS0-1, Ser-423, MOD:00046." [IEDB_epitope:612396, PRO:DNx]


organism-modification



PR:000080961

ribosomal protein S6 kinase beta-2 phosphorylated 2 (human)

hRPS6KB2/Phos:2


"A ribosomal protein S6 kinase beta-2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-417 of the amino acid sequence represented by UniProtKB:Q9UBS0-1. Example: UniProtKB:Q9UBS0-1, Ser-417, MOD:00046." [IEDB_epitope:612395, PRO:DNx]


organism-gene



PR:Q9Z1M4

ribosomal protein S6 kinase beta-2 (mouse)

mRPS6KB2


"A ribosomal protein S6 kinase beta-2 that is encoded in the genome of mouse." [OMA:Q9Z1M4, PRO:DNx]


organism-sequence



PR:Q9Z1M4-1

ribosomal protein S6 kinase beta-2 isoform 1 (mouse)

mRPS6KB2/iso:1


"A ribosomal protein S6 kinase beta-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000312

ribosomal protein S6 kinase beta-2 isoform 1

RPS6KB2/iso:1


"A ribosomal protein S6 kinase beta-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBS0-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UBS0-1

ribosomal protein S6 kinase beta-2 isoform 1 (human)

hRPS6KB2/iso:1


"A ribosomal protein S6 kinase beta-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026339

ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 (human)

hRPS6KB2/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBS0-1, Ser-15/Ser-356, MOD:00046." [PRO:DNx, UniProtKB:Q9UBS0]


organism-sequence



PR:Q9Z1M4-1

ribosomal protein S6 kinase beta-2 isoform 1 (mouse)

mRPS6KB2/iso:1


"A ribosomal protein S6 kinase beta-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000000465

ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated form

RPS6KB2/iso:1/PhosRes+


"A ribosomal protein S6 kinase beta-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000569

ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1

RPS6KB2/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated form in which the phosphorylation occurs upon activation of the EGF receptor signaling pathway." [PMID:17081983]


organism-modification



PR:000026339

ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 (human)

hRPS6KB2/iso:1/Phos:1


"A ribosomal protein S6 kinase beta-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBS0-1, Ser-15/Ser-356, MOD:00046." [PRO:DNx, UniProtKB:Q9UBS0]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006412 translationPR:Q9UBS0-1 hRPS6KB2/iso:1 PMID:9804755
GO:0006468 protein phosphorylationPR:000000025 NOG PANTHER:PTHR24351; PIRSF:PIRSF000605
GO:0007165 signal transductionPR:000036480 hRPS6KB1/iso:1/Phos:1 PMID:1922062
PR:000036481 hRPS6KB1/iso:2/Phos:1 PMID:1922062
PR:P23443-1 hRPS6KB1/iso:Alpha I PMID:1922062
PR:P23443-2 hRPS6KB1/iso:Alpha II PMID:1922062
PR:Q9UBS0-1 hRPS6KB2/iso:1 PMID:9804755

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004672 protein kinase activityPR:000000025 NOG PANTHER:PTHR24351; PIRSF:PIRSF000605
PR:000036480 hRPS6KB1/iso:1/Phos:1 PMID:1922062
PR:000036481 hRPS6KB1/iso:2/Phos:1 PMID:1922062
NOT GO:0004672 protein kinase activityPR:P23443-1 hRPS6KB1/iso:Alpha I PMID:1922062
PR:P23443-2 hRPS6KB1/iso:Alpha II PMID:1922062
GO:0004674 protein serine/threonine kinase activityPR:Q9Z1M4-1 mRPS6KB2/iso:1 PMID:15249583
GO:0004711 ribosomal protein S6 kinase activityPR:000000025 NOG PANTHER:PTHR24351; PIRSF:PIRSF000605