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Protein Ontology report - sara-type zinc finger FYVE domain-containing protein
PR:000000026 - http://purl.obolibrary.org/obo/PR_000000026
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000026   
  PRO namesara-type zinc finger FYVE domain-containing protein 
  Definition"A protein that has a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex." [PMID:17356069
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 5                                        
         Sequence3                                                  Organism-Sequence 7                                        
         Modification1                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037289
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000026

sara-type zinc finger FYVE domain-containing protein

NOG


"A protein that has a core domain composition consisting of a FYVE zinc finger (Pfam:PF01363) domain and a smad-binding domain that is involved in recruiting and presenting receptor-regulated smads to the receptor complex." [PMID:17356069]

Yes

gene



PR:000000125

zinc finger FYVE domain-containing protein 9

ZFYVE9


"A sara-type zinc finger FYVE domain-containing protein that is a translation product of the human ZFYVE9 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

Yes
organism-gene



PR:000029965

zinc finger FYVE domain-containing protein 9 (mouse)

mZFYVE9


"A zinc finger FYVE domain-containing protein 9 that is encoded in the genome of mouse." [PRO:DAN]


organism-sequence



PR:A2A8R0

zinc finger FYVE domain-containing protein 9 isoform 1 (mouse)

mZFYVE9/iso:1


"A zinc finger FYVE domain-containing protein 9 isoform 1 that is encoded in the genome of mouse." [PRO:DAN]


organism-sequence



PR:A8Y5G5

zinc finger FYVE domain-containing protein 9 isoform 2 (mouse)

mZFYVE9/iso:2


"A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of mouse." [PRO:DAN]


organism-gene



PR:O95405

zinc finger FYVE domain-containing protein 9 (human)

hZFYVE9


"A zinc finger FYVE domain-containing protein 9 that is encoded in the genome of human." [PRO:CNA]


Yes
organism-sequence



PR:O95405-1

zinc finger FYVE domain-containing protein 9 isoform 1 (human)

hZFYVE9/iso:1


"A zinc finger FYVE domain-containing protein 9 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O95405-2

zinc finger FYVE domain-containing protein 9 isoform 2 (human)

hZFYVE9/iso:2


"A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:O95405-3

zinc finger FYVE domain-containing protein 9 isoform 3 (human)

hZFYVE9/iso:3


"A zinc finger FYVE domain-containing protein 9 isoform 3 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000313

zinc finger FYVE domain-containing protein 9 isoform 1

ZFYVE9/iso:1


"A zinc finger FYVE domain-containing protein 9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95405-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:A2A8R0

zinc finger FYVE domain-containing protein 9 isoform 1 (mouse)

mZFYVE9/iso:1


"A zinc finger FYVE domain-containing protein 9 isoform 1 that is encoded in the genome of mouse." [PRO:DAN]


organism-sequence



PR:O95405-1

zinc finger FYVE domain-containing protein 9 isoform 1 (human)

hZFYVE9/iso:1


"A zinc finger FYVE domain-containing protein 9 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000002535

zinc finger FYVE domain-containing protein 9 isoform 1 unmodified form

ZFYVE9/iso:1/UnMod


"A zinc finger FYVE domain-containing protein 9 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000314

zinc finger FYVE domain-containing protein 9 isoform 2

ZFYVE9/iso:2


"A zinc finger FYVE domain-containing protein 9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95405-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:A8Y5G5

zinc finger FYVE domain-containing protein 9 isoform 2 (mouse)

mZFYVE9/iso:2


"A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of mouse." [PRO:DAN]


organism-sequence



PR:O95405-2

zinc finger FYVE domain-containing protein 9 isoform 2 (human)

hZFYVE9/iso:2


"A zinc finger FYVE domain-containing protein 9 isoform 2 that is encoded in the genome of human." [PRO:CNA]

Yes

sequence



PR:000000315

zinc finger FYVE domain-containing protein 9 isoform 3

ZFYVE9/iso:3


"A zinc finger FYVE domain-containing protein 9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95405-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O95405-3

zinc finger FYVE domain-containing protein 9 isoform 3 (human)

hZFYVE9/iso:3


"A zinc finger FYVE domain-containing protein 9 isoform 3 that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000017658

zinc finger FYVE domain-containing protein 16

ZFYVE16


"A sara-type zinc finger FYVE domain-containing protein that is a translation product of the human ZFYVE16 gene or a 1:1 ortholog thereof." [PRO:DNx]


organism-gene



PR:E1C1H1

uncharacterized protein, LOC768418 translation product (chicken)

chick-ZFYVE16


"A zinc finger FYVE domain-containing protein 16 that is encoded in the genome of chicken." [PRO:DNx]


organism-gene



PR:Q7Z3T8

zinc finger FYVE domain-containing protein 16 (human)

hZFYVE16


"A zinc finger FYVE domain-containing protein 16 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q7Z3T8]


organism-sequence



PR:Q7Z3T8-1

zinc finger FYVE domain-containing protein 16 isoform h1 (human)

hZFYVE16/iso:h1


"A zinc finger FYVE domain-containing protein 16 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z3T8-1." [PRO:DNx, UniProtKB:Q7Z3T8]


organism-sequence



PR:Q7Z3T8-3

zinc finger FYVE domain-containing protein 16 isoform h2 (human)

hZFYVE16/iso:h2


"A zinc finger FYVE domain-containing protein 16 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q7Z3T8-3." [PRO:DNx, UniProtKB:Q7Z3T8]


organism-modification



PR:000068710

zinc finger FYVE domain-containing protein 16 methylated 1 (human)

hZFYVE16/Me:1


"A zinc finger FYVE domain-containing protein 16 (human) that has been methylated on the residue at the position equivalent to Cys-1463 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Cys-1463, MOD:00660." [IEDB_epitope:1000214, PRO:DNx]


organism-modification



PR:000072595

zinc finger FYVE domain-containing protein 16 deaminated 1 (human)

hZFYVE16/Deam:1


"A zinc finger FYVE domain-containing protein 16 (human) that has been deaminated on the residue at the position equivalent to Asn-1241 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Asn-1241, MOD:00684." [IEDB_epitope:1986641, PRO:DNx]


organism-modification



PR:000074201

zinc finger FYVE domain-containing protein 16 phosphorylated 1 (human)

hZFYVE16/Phos:1


"A zinc finger FYVE domain-containing protein 16 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-998 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Tyr-998, MOD:00048." [IEDB_epitope:2147778, PRO:DNx]


organism-modification



PR:000075206

zinc finger FYVE domain-containing protein 16 methylated 2 (human)

hZFYVE16/Me:2


"A zinc finger FYVE domain-containing protein 16 (human) that has been methylated on the residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Cys-41, MOD:00660." [IEDB_epitope:1035375, PRO:DNx]


organism-modification



PR:000075419

zinc finger FYVE domain-containing protein 16 deaminated 2 (human)

hZFYVE16/Deam:2


"A zinc finger FYVE domain-containing protein 16 (human) that has been deaminated on the residue at the position equivalent to Gln-1094 of the amino acid sequence represented by UniProtKB:Q7Z3T8-1. Example: UniProtKB:Q7Z3T8-1, Gln-1094, MOD:00685." [IEDB_epitope:1980285, PRO:DNx]


organism-gene



PR:Q80U44

zinc finger FYVE domain-containing protein 16 (mouse)

mZFYVE16


"A zinc finger FYVE domain-containing protein 16 that is encoded in the genome of mouse." [OMA:Q80U44, PRO:DNx]


organism-modification



PR:000079565

zinc finger FYVE domain-containing protein 16 cysteinylated 1 (mouse)

mZFYVE16/Cyst:1


"A zinc finger FYVE domain-containing protein 16 (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-287 of the amino acid sequence represented by UniProtKB:Q80U44. UniProtKB:Q80U44, Cys-287, MOD:00765." [IEDB_epitope:2112247, PRO:DNx]


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NOG forms found in complexes   

NOG Component
Complexes
PR:000000125 ZFYVE9 PR:000025974 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex
PR:O95405 hZFYVE9 PR:000025965 TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:SMAD2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000026 NOG acts_upstream_of_or_withinGO:0008104 intracellular protein localization PIRSF:PIRSF037289
PR:000000125 ZFYVE9 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PANTHER:PTHR22835
PR:O95405-1 hZFYVE9/iso:1 acts_upstream_of_or_withinGO:0006897 endocytosis PMID:12809483
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:10615055
GO:0060390 regulation of SMAD protein signal transduction PMID:11877415; PMID:12356868
GO:0060395 SMAD protein signal transduction PMID:11877415; PMID:12356868
enablesGO:0005515 protein binding with PR:000025960 hSMAD2/iso:[Long/Short]/UnPhos:1 PMID:17693260
GO:0005515 protein binding with PR:P08100 hRHO PMID:17693260
located_inGO:0005769 early endosome PMID:11877415; PMID:12356868; PMID:12432064
PR:O95405-2 hZFYVE9/iso:2 located_inGO:0005615 extracellular space PMID:9582421
PR:O95405-3 hZFYVE9/iso:3 located_inGO:0005615 extracellular space PMID:9582421