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Protein Ontology report - tumor necrosis factor, TNF-like
PR:000000033 - http://purl.obolibrary.org/obo/PR_000000033
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000033   
  PRO nametumor necrosis factor, TNF-like 
  Definition"A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229)." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000001 protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family2                                                  Organism-Family 0                                        
         Gene6                                                  Organism-Gene 17                                        
         Sequence12                                                  Organism-Sequence 20                                        
         Modification15                                                  Organism-Modification 21                                        
  Term Hierarchy
  Visualization
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Related Cross References

  Db identifiers
PIRSF:PIRSF001873
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000033

tumor necrosis factor, TNF-like

fam:CBP-p300


"A protein that has a core domain composition consisting of an N-terminal cytosolic domain, a type II transmembrane domain and a C-terminal TNF domain (Pfam:PF00229)." [PRO:CNA]

Yes

gene



PR:000000095

tumor necrosis factor ligand superfamily member 6

FASLG


"A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P36940

tumor necrosis factor ligand superfamily member 6 (rat)

rFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of rat." [OMA:P36940, PRO:DNx]


organism-gene



PR:P41047

tumor necrosis factor ligand superfamily member 6 (mouse)

mFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of mouse." [OMA:P41047, PRO:DNx]


organism-sequence



PR:P41047-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)

mFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P41047-2

tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)

mFASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 isoform FasLS that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:P48023

tumor necrosis factor ligand superfamily member 6 (human)

hFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023]


organism-sequence



PR:P48023-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (human)

hFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

organism-sequence



PR:P48023-2

tumor necrosis factor ligand superfamily member 6 isoform h2 (human)

hFASLG/iso:h2


"A tumor necrosis factor ligand superfamily member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-2." [PRO:DNx, UniProtKB:P48023]


sequence



PR:000000276

tumor necrosis factor ligand superfamily member 6 isoform FasL

FASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


sequence



PR:000000278

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L

FASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that has a Leu residue at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. Example: UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:CNA, PRO:DAN]


organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P41047-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)

mFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P48023-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (human)

hFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

modification



PR:000000432

tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form

FASLG/iso:FasL/GlycoRes+


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000546

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1

FASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form that has been N-glycosylated at the Asn residues within the N-glycosylation sites located in the C-terminal extracellular region. Example: UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425]


organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000547

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form

FASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is the soluble N-terminal portion after ADAM10 processing." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

sequence



PR:000000277

tumor necrosis factor ligand superfamily member 6 isoform FasLS

FASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41047-2 or a 1:1 ortholog thereof." [PMID:10552956, PRO:CNA, PRO:DAN]


organism-sequence



PR:P41047-2

tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)

mFASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 isoform FasLS that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000018277

tumor necrosis factor ligand superfamily member 6 proteolytic cleavage product

FASLG/ClvPrd


"A tumor necrosis factor ligand superfamily member 6 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000547

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form

FASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is the soluble N-terminal portion after ADAM10 processing." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

gene



PR:000000134

tumor necrosis factor

TNF


"A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA]


organism-gene



PR:P01375

tumor necrosis factor (human)

hTNF


"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]


Yes
organism-sequence



PR:P01375-1

tumor necrosis factor isoform 1 (human)

hTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036507

tumor necrosis factor isoform 1 myristoylated 1 (human)

hTNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]

Yes

organism-modification



PR:000036508

tumor necrosis factor isoform 1 phosphorylated 1 (human)

hTNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]

Yes

organism-modification



PR:000051774

tumor necrosis factor O-glycosylated 1 (human)

hTNF/OGlyco:1


"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]


organism-modification



PR:000051775

tumor necrosis factor O-glycosylated 2 (human)

hTNF/OGlyco:2


"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G56682BC. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]


organism-gene



PR:P06804

tumor necrosis factor (mouse)

mTNF


"A tumor necrosis factor that is encoded in the genome of mouse." [OMA:P06804, PRO:DNx]


organism-sequence



PR:P06804-1

tumor necrosis factor isoform 1 (mouse)

mTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

organism-gene



PR:P16599

tumor necrosis factor (rat)

rTNF


"A tumor necrosis factor that is encoded in the genome of rat." [OMA:P16599, PRO:DNx]


sequence



PR:000000381

tumor necrosis factor isoform 1

TNF/iso:1


"A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P01375-1

tumor necrosis factor isoform 1 (human)

hTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036507

tumor necrosis factor isoform 1 myristoylated 1 (human)

hTNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]

Yes

organism-modification



PR:000036508

tumor necrosis factor isoform 1 phosphorylated 1 (human)

hTNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]

Yes

organism-sequence



PR:P06804-1

tumor necrosis factor isoform 1 (mouse)

mTNF/iso:1


"A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

modification



PR:000000496

tumor necrosis factor isoform 1 myristoylated form

TNF/iso:1/MyrRes+


"A tumor necrosis factor isoform 1 that includes at least one myristoylated residue." [PRO:CNA]


modification



PR:000000606

tumor necrosis factor isoform 1 myristoylated 1

TNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated form that has been modified at the N-epsilon-NH2 groups of the most N-terminal Lys within the cytoplasmic domain. Example: UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651]


organism-modification



PR:000036507

tumor necrosis factor isoform 1 myristoylated 1 (human)

hTNF/iso:1/Myr:1


"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]

Yes

modification



PR:000000497

tumor necrosis factor isoform 1 phosphorylated form

TNF/iso:1/PhosRes+


"A tumor necrosis factor isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000607

tumor necrosis factor isoform 1 phosphorylated 1

TNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Ser within the ST[EK]S motif in the cytoplasmic domain. Example: UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166]


organism-modification



PR:000036508

tumor necrosis factor isoform 1 phosphorylated 1 (human)

hTNF/iso:1/Phos:1


"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]

Yes

modification



PR:000000604

tumor necrosis factor isoform 1 cleaved 1

TNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]


organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

modification



PR:000000605

tumor necrosis factor isoform 1 cleaved 2

TNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]


organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

modification



PR:000018285

tumor necrosis factor proteolytic cleavage product

TNF/ClvPrd


"A tumor necrosis factor that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000604

tumor necrosis factor isoform 1 cleaved 1

TNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]


organism-modification



PR:000036504

tumor necrosis factor isoform 1 cleaved 1 (human)

hTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]

Yes

organism-modification



PR:000036505

tumor necrosis factor isoform 1 cleaved 1 (mouse)

mTNF/iso:1/Clv:1


"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]

Yes

modification



PR:000000605

tumor necrosis factor isoform 1 cleaved 2

TNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]


organism-modification



PR:000036506

tumor necrosis factor isoform 1 cleaved 2 (mouse)

mTNF/iso:1/Clv:2


"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]

Yes

gene



PR:000002222

tumor necrosis factor ligand superfamily member 14

TNFSF14


"A tumor necrosis factor, TNF-like that is a translation product of the human TNFSF14 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O43557

tumor necrosis factor ligand superfamily member 14 (human)

hTNFSF14


"A tumor necrosis factor ligand superfamily member 14 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O43557]


organism-sequence



PR:O43557-1

tumor necrosis factor ligand superfamily member 14 isoform 1 (human)

hTNFSF14/iso:1


"A tumor necrosis factor ligand superfamily member 14 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:O43557-2

tumor necrosis factor ligand superfamily member 14 isoform 2 (human)

hTNFSF14/iso:2


"A tumor necrosis factor ligand superfamily member 14 isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000065924

tumor necrosis factor ligand superfamily member 14 deaminated 1 (human)

hTNFSF14/Deam:1


"A tumor necrosis factor ligand superfamily member 14 (human) that has been deaminated on the residue at the position equivalent to Gln-117 of the amino acid sequence represented by UniProtKB:O43557-1. Example: UniProtKB:O43557-1, Gln-117, MOD:00685." [IEDB_epitope:1811726, IEDB_epitope:1835319, PRO:DNx]


organism-modification



PR:000082240

tumor necrosis factor ligand superfamily member 14 phosphorylated 1 (human)

hTNFSF14/Phos:1


"A tumor necrosis factor ligand superfamily member 14 (human) that has been phosphorylated on the residue at the position equivalent to Thr-22 of the amino acid sequence represented by UniProtKB:O43557-1. Example: UniProtKB:O43557-1, Thr-22, MOD:00047." [IEDB_epitope:2149651, PRO:DNx]


organism-gene



PR:Q9QYH9

tumor necrosis factor ligand superfamily member 14 (mouse)

mTNFSF14


"A tumor necrosis factor ligand superfamily member 14 that is encoded in the genome of mouse." [OMA:Q9QYH9, PRO:DNx]


organism-sequence



PR:Q9QYH9-1

tumor necrosis factor ligand superfamily member 14 isoform 1 (mouse)

mTNFSF14/iso:1


"A tumor necrosis factor ligand superfamily member 14 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002353

tumor necrosis factor ligand superfamily member 14 isoform 1

TNFSF14/iso:1


"A tumor necrosis factor ligand superfamily member 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43557-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O43557-1

tumor necrosis factor ligand superfamily member 14 isoform 1 (human)

hTNFSF14/iso:1


"A tumor necrosis factor ligand superfamily member 14 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q9QYH9-1

tumor necrosis factor ligand superfamily member 14 isoform 1 (mouse)

mTNFSF14/iso:1


"A tumor necrosis factor ligand superfamily member 14 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002354

tumor necrosis factor ligand superfamily member 14 isoform 2

TNFSF14/iso:2


"A tumor necrosis factor ligand superfamily member 14 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43557-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O43557-2

tumor necrosis factor ligand superfamily member 14 isoform 2 (human)

hTNFSF14/iso:2


"A tumor necrosis factor ligand superfamily member 14 isoform 2 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000018755

tumor necrosis factor ligand superfamily member 14 proteolytic cleavage product

TNFSF14/ClvPrd


"A tumor necrosis factor ligand superfamily member 14 that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000002223

tumor necrosis factor ligand superfamily member 15

TNFSF15


"A tumor necrosis factor, TNF-like that is a translation product of the human TNFSF15 gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:O95150

tumor necrosis factor ligand superfamily member 15 (human)

hTNFSF15


"A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of human." [PRO:WCB, UniProtKB:O95150]


organism-sequence



PR:O95150-1

tumor necrosis factor ligand superfamily member 15 isoform 1 (human)

hTNFSF15/iso:1


"A tumor necrosis factor ligand superfamily member 15 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:O95150-2

tumor necrosis factor ligand superfamily member 15 isoform 2 (human)

hTNFSF15/iso:2


"A tumor necrosis factor ligand superfamily member 15 isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:O95150-3

tumor necrosis factor ligand superfamily member 15 isoform 3 (human)

hTNFSF15/iso:3


"A tumor necrosis factor ligand superfamily member 15 isoform 3 that is encoded in the genome of human." [PRO:JAN]


organism-gene



PR:Q50L61

TL1A (chicken)

chick-TNFSF15


"A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of chicken." [PANTHER:PTHR11471:SF10, PRO:DNx]


organism-gene



PR:Q5UBV8

tumor necrosis factor ligand superfamily member 15 (mouse)

mTNFSF15


"A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of mouse." [OMA:Q5UBV8, PRO:DNx]


organism-sequence



PR:Q5UBV8-1

tumor necrosis factor ligand superfamily member 15 isoform 1 (mouse)

mTNFSF15/iso:1


"A tumor necrosis factor ligand superfamily member 15 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:Q8K3Y7

tumor necrosis factor ligand superfamily member 15 (rat)

rTNFSF15


"A tumor necrosis factor ligand superfamily member 15 that is encoded in the genome of rat." [OMA:Q8K3Y7, PRO:DNx]


sequence



PR:000002355

tumor necrosis factor ligand superfamily member 15 isoform 1

TNFSF15/iso:1


"A tumor necrosis factor ligand superfamily member 15 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q5UBV8-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O95150-1

tumor necrosis factor ligand superfamily member 15 isoform 1 (human)

hTNFSF15/iso:1


"A tumor necrosis factor ligand superfamily member 15 isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q5UBV8-1

tumor necrosis factor ligand superfamily member 15 isoform 1 (mouse)

mTNFSF15/iso:1


"A tumor necrosis factor ligand superfamily member 15 isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002356

tumor necrosis factor ligand superfamily member 15 isoform 2

TNFSF15/iso:2


"A tumor necrosis factor ligand superfamily member 15 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95150-2 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O95150-2

tumor necrosis factor ligand superfamily member 15 isoform 2 (human)

hTNFSF15/iso:2


"A tumor necrosis factor ligand superfamily member 15 isoform 2 that is encoded in the genome of human." [PRO:JAN]


sequence



PR:000002357

tumor necrosis factor ligand superfamily member 15 isoform 3

TNFSF15/iso:3


"A tumor necrosis factor ligand superfamily member 15 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O95150-3 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:O95150-3

tumor necrosis factor ligand superfamily member 15 isoform 3 (human)

hTNFSF15/iso:3


"A tumor necrosis factor ligand superfamily member 15 isoform 3 that is encoded in the genome of human." [PRO:JAN]


modification



PR:000018756

tumor necrosis factor ligand superfamily member 15 proteolytic cleavage product

TNFSF15/ClvPrd


"A tumor necrosis factor ligand superfamily member 15 that has been processed by proteolytic cleavage." [PRO:DNx]


family



PR:000050043

lymphotoxin

fam:LT


"A tumor necrosis factor, TNF-like that is a translation product of the human LTA or LTB genes, or 1:1 orthologs thereof." [PRO:DAN]


gene



PR:000002204

lymphotoxin-alpha

LTA


"A lymphotoxin that is a translation product of the human LTA gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P01374

lymphotoxin-alpha (human)

hLTA


"A lymphotoxin-alpha that is encoded in the genome of human." [PRO:WCB, UniProtKB:P01374]


organism-sequence



PR:P01374-1

lymphotoxin-alpha isoform 1 (human)

hLTA/iso:1


"A lymphotoxin-alpha isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-modification



PR:000048265

lymphotoxin-alpha, signal peptide removed form (human)

hLTA/SigPep-


"A lymphotoxin-alpha (human) that has had the signal peptide removed. UniProtKB:P01374, 35-205." [PRO:DNx, Reactome:R-HSA-5667153]


organism-modification



PR:000051768

lymphotoxin-alpha N-glycosylated 1 (human)

hLTA/NGlyco:1


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G29228MX. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G29228MX." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000051769

lymphotoxin-alpha N-glycosylated 2 (human)

hLTA/NGlyco:2


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G45359RY. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G45359RY." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000051770

lymphotoxin-alpha N-glycosylated 3 (human)

hLTA/NGlyco:3


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G52038JM. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G52038JM." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000051771

lymphotoxin-alpha N-glycosylated 4 (human)

hLTA/NGlyco:4


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G63889NK. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G63889NK." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000051772

lymphotoxin-alpha N-glycosylated 5 (human)

hLTA/NGlyco:5


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G78059CC. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G78059CC." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000051773

lymphotoxin-alpha N-glycosylated 6 (human)

hLTA/NGlyco:6


"A lymphotoxin-alpha (human) that has been N-glycosylated at the residue equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374-1, in which the glycan structure is represented by GlyTouCan:G86357DX. Example: UniProtKB:P01374-1, Asn-96, MOD:00160~GNO:G86357DX." [GlyGen:P01374-1, PMID:8323280, PRO:DNx]


organism-modification



PR:000066956

lymphotoxin-alpha deaminated 1 (human)

hLTA/Deam:1


"A lymphotoxin-alpha (human) that has been deaminated on the residue at the position equivalent to Asn-96 of the amino acid sequence represented by UniProtKB:P01374. UniProtKB:P01374, Asn-96, MOD:00684." [IEDB_epitope:838045, PRO:DNx]


organism-modification



PR:000073774

lymphotoxin-alpha methylated 1 (human)

hLTA/Me:1


"A lymphotoxin-alpha (human) that has been methylated on the residue at the position equivalent to Ser-43 of the amino acid sequence represented by UniProtKB:P01374. UniProtKB:P01374, Ser-43, MOD:01799." [IEDB_epitope:1859056, PRO:DNx]


organism-modification



PR:000074173

lymphotoxin-alpha deaminated 2 (human)

hLTA/Deam:2


"A lymphotoxin-alpha (human) that has been deaminated on the residue at the position equivalent to Gln-112 of the amino acid sequence represented by UniProtKB:P01374. UniProtKB:P01374, Gln-112, MOD:00685." [IEDB_epitope:1585188, PRO:DNx]


organism-gene



PR:P09225

lymphotoxin-alpha (mouse)

mLTA


"A lymphotoxin-alpha that is encoded in the genome of mouse." [OMA:P09225, PRO:DNx]


organism-sequence



PR:P09225-1

lymphotoxin-alpha isoform 1 (mouse)

mLTA/iso:1


"A lymphotoxin-alpha isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:Q06332

lymphotoxin-alpha (rat)

rLTA


"A lymphotoxin-alpha that is encoded in the genome of rat." [OMA:Q06332, PRO:DNx]


sequence



PR:000002331

lymphotoxin-alpha isoform 1

LTA/iso:1


"A lymphotoxin-alpha that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09225-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P01374-1

lymphotoxin-alpha isoform 1 (human)

hLTA/iso:1


"A lymphotoxin-alpha isoform 1 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:P09225-1

lymphotoxin-alpha isoform 1 (mouse)

mLTA/iso:1


"A lymphotoxin-alpha isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


modification



PR:000026648

lymphotoxin-alpha isoform 1, signal peptide removed form

LTA/iso:1/SigPep-


"A lymphotoxin-alpha isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000018753

lymphotoxin-alpha, signal peptide removed form

LTA/SigPep-


"A lymphotoxin-alpha that has had the signal peptide removed." [PRO:DNx]


modification



PR:000026648

lymphotoxin-alpha isoform 1, signal peptide removed form

LTA/iso:1/SigPep-


"A lymphotoxin-alpha isoform 1 that has had the signal peptide removed." [PRO:DNx]


organism-modification



PR:000048265

lymphotoxin-alpha, signal peptide removed form (human)

hLTA/SigPep-


"A lymphotoxin-alpha (human) that has had the signal peptide removed. UniProtKB:P01374, 35-205." [PRO:DNx, Reactome:R-HSA-5667153]


gene



PR:000002205

lymphotoxin-beta

LTB


"A lymphotoxin that is a translation product of the human LTB gene or a 1:1 ortholog thereof." [PRO:WCB]


organism-gene



PR:P41155

lymphotoxin-beta (mouse)

mLTB


"A lymphotoxin-beta that is encoded in the genome of mouse." [OMA:P41155, PRO:DNx]


organism-sequence



PR:P41155-1

lymphotoxin-beta isoform 1 (mouse)

mLTB/iso:1


"A lymphotoxin-beta isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


organism-gene



PR:Q06643

lymphotoxin-beta (human)

hLTB


"A lymphotoxin-beta that is encoded in the genome of human." [PRO:WCB, UniProtKB:Q06643]


organism-sequence



PR:Q06643-1

lymphotoxin-beta isoform 1 (human)

hLTB/iso:1


"A lymphotoxin-beta isoform 2 that is encoded in the genome of human." [PRO:JAN]


organism-sequence



PR:Q06643-2

lymphotoxin-beta isoform h2 (human)

hLTB/iso:h2


"A lymphotoxin-beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06643-2." [PRO:DNx, UniProtKB:Q06643]


sequence



PR:000002332

lymphotoxin-beta isoform 1

LTB/iso:1


"A lymphotoxin-beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41155-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:P41155-1

lymphotoxin-beta isoform 1 (mouse)

mLTB/iso:1


"A lymphotoxin-beta isoform 1 that is encoded in the genome of mouse." [PRO:JAN]


sequence



PR:000002333

lymphotoxin-beta isoform 2

LTB/iso:2


"A lymphotoxin-beta that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q06643-1 or a 1:1 ortholog thereof." [PRO:JAN]


organism-sequence



PR:Q06643-1

lymphotoxin-beta isoform 1 (human)

hLTB/iso:1


"A lymphotoxin-beta isoform 2 that is encoded in the genome of human." [PRO:JAN]


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fam:CBP-p300 forms found in complexes   

fam:CBP-p300 Component
Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006355 regulation of DNA-templated transcriptionPR:000036505 mTNF/iso:1/Clv:1 PMID:9305915
GO:0006915 apoptotic processPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
PR:000036504 hTNF/iso:1/Clv:1 PMID:3856324
PR:P01375-1 hTNF/iso:1 PMID:3856324
PR:P41047-1 mFASLG/iso:FasL PMID:16365167
GO:0007165 signal transductionPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
GO:0007267 cell-cell signalingPR:000000095 FASLG PANTHER:PTHR11471
GO:0043066 negative regulation of apoptotic processPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9396774
PR:P41047-1 mFASLG/iso:FasL MGI_ref:76989; PMID:7595210
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0043123 positive regulation of canonical NF-kappaB signal transductionPR:P48023-1 hFASLG/iso:FasL PMID:12761501
GO:0097190 apoptotic signaling pathwayPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:15039234

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:6688 autoimmune lymphoproliferative syndromePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005102 signaling receptor bindingPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
GO:0005125 cytokine activityPR:000000033 fam:CBP-p300 PIRSF:PIRSF001873
NOT GO:0005125 cytokine activityPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005164 tumor necrosis factor receptor bindingPR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
GO:0042802 identical protein bindingPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672; PMID:9228058; PMID:9405425
PR:000036504 hTNF/iso:1/Clv:1 PMID:14512626
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005576 extracellular regionPR:000036506 mTNF/iso:1/Clv:2 PMID:2777790
GO:0005615 extracellular spacePR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672
PR:000036505 mTNF/iso:1/Clv:1 PMID:10089307
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0005886 plasma membranePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745
PR:P01375-1 hTNF/iso:1 PMID:3349526
PR:P41047-1 mFASLG/iso:FasL PMID:16973387
GO:0009986 cell surfacePR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:16973387
GO:0016020 membranePR:000036507 hTNF/iso:1/Myr:1 PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1 PMID:10205166