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Protein Ontology report - BMP receptor type-1A
PR:000000035 - http://purl.obolibrary.org/obo/PR_000000035
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000035   
  PRO nameBMP receptor type-1A 
  Synonyms
PRO-Short-label: EXACT:BMPR1A
Gene-based: RELATED:ACVRLK3 | ALK3 | Bmpr
Other: EXACT:activin receptor-like kinase 3 | ALK-3 | BMP type-1A receptor | BMP-2/BMP-4 receptor | BMPR-1A | CD292 | serine/threonine-protein kinase receptor R5 | SKR5
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1786
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000035 BMP receptor type-1A
BMPR1A

organism-gene


PR:P36894 bone morphogenetic protein receptor type-1A (human)
hBMPR1A

organism-sequence


PR:000000137 BMP receptor type-1A sequence variant Y62D (human)
hBMPR1A/var:Y62D
Yes
organism-sequence


PR:000000138 BMP receptor type-1A sequence variant C82Y (human)
hBMPR1A/var:C82Y
Yes
organism-sequence


PR:000000139 BMP receptor type-1A sequence variant C124R (human)
hBMPR1A/var:C124R
Yes
organism-sequence


PR:000000140 BMP receptor type-1A sequence variant C130R (human)
hBMPR1A/var:C130R
Yes
organism-sequence


PR:000000141 BMP receptor type-1A sequence variant A338D (human)
hBMPR1A/var:A338D
Yes
organism-sequence


PR:000000142 BMP receptor type-1A sequence variant C376Y (human)
hBMPR1A/var:C376Y
Yes
organism-sequence


PR:000000143 BMP receptor type-1A sequence variant R443C (human)
hBMPR1A/var:R443C
Yes
organism-sequence


PR:000000144 BMP receptor type-1A sequence variant M470T (human)
hBMPR1A/var:M470T
Yes
organism-sequence


PR:P36894-1 bone morphogenetic protein receptor type-1A isoform 1 (human)
hBMPR1A/iso:1
Yes
organism-modification


PR:000036422 BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
Yes
organism-modification


PR:000036424 BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2

organism-modification


PR:000046493 bone morphogenetic protein receptor type-1A, signal peptide removed form (human)
hBMPR1A/SigPep-

organism-modification


PR:000046494 bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human)
hBMPR1A/SigPep-/Phos:2

organism-gene


PR:P36895 bone morphogenetic protein receptor type-1A (mouse)
mBMPR1A

organism-sequence


PR:P36895-1 bone morphogenetic protein receptor type-1A isoform 1 (mouse)
mBMPR1A/iso:1
Yes
organism-modification


PR:000036423 BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
Yes
organism-gene


PR:Q78EA7 bone morphogenetic protein receptor type-1A (rat)
rBMPR1A

sequence


PR:000000136 BMP receptor type-1A isoform 1
BMPR1A/iso:1

organism-sequence


PR:P36894-1 bone morphogenetic protein receptor type-1A isoform 1 (human)
hBMPR1A/iso:1
Yes
organism-modification


PR:000036422 BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
Yes
organism-modification


PR:000036424 BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2

organism-sequence


PR:P36895-1 bone morphogenetic protein receptor type-1A isoform 1 (mouse)
mBMPR1A/iso:1
Yes
organism-modification


PR:000036423 BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
Yes
modification


PR:000000382 BMP receptor type-1A isoform 1 phosphorylated form
BMPR1A/iso:1/PhosRes+

modification


PR:000000498 BMP receptor type-1A isoform 1 phosphorylated 1
BMPR1A/iso:1/Phos:1

organism-modification


PR:000036422 BMP receptor type-1A isoform 1 phosphorylated 1 (human)
hBMPR1A/iso:1/Phos:1
Yes
organism-modification


PR:000036423 BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)
mBMPR1A/iso:1/Phos:1
Yes
modification


PR:000000499 BMP receptor type-1A isoform 1 phosphorylated 2
BMPR1A/iso:1/Phos:2

organism-modification


PR:000036424 BMP receptor type-1A isoform 1 phosphorylated 2 (human)
hBMPR1A/iso:1/Phos:2

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000137 hBMPR1A/var:Y62D
UniProtKB:P36894, Tyr-62, CHEBI:29958		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000138 hBMPR1A/var:C82Y
UniProtKB:P36894, Cys-82, CHEBI:46858		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000139 hBMPR1A/var:C124R
UniProtKB:P36894, Cys-124, CHEBI:29952		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000140 hBMPR1A/var:C130R
UniProtKB:P36894, Cys-130, CHEBI:29952		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12136244
PR:000000141 hBMPR1A/var:A338D
UniProtKB:P36894, Ala-338, CHEBI:29958		 associated_with_disease_progressionDO:6457 Cowden syndrome PMID:11536076
PR:000000142 hBMPR1A/var:C376Y
UniProtKB:P36894, Cys-376, CHEBI:46858		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000143 hBMPR1A/var:R443C
UniProtKB:P36894, Arg-443, CHEBI:29950		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513; PMID:17344846
PR:000000144 hBMPR1A/var:M470T
UniProtKB:P36894, Met-470, CHEBI:30013		 associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12630959
PR:000036422 hBMPR1A/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
GO:0030509 BMP signaling pathway PMID:12829744
enablesGO:0004674 protein serine/threonine kinase activity PMID:12829744
located_inGO:0009986 cell surface PMID:10712517
GO:0043235 receptor complex PMID:12829744; PMID:15940369
PR:000036423 mBMPR1A/iso:1/Phos:1 enablesGO:0046332 SMAD binding PMID:10814522; PMID:9738003
PR:P36894-1 hBMPR1A/iso:1 located_inGO:0016020 membrane PMID:8397373
GO:0043235 receptor complex PMID:15940369
PR:P36895-1 mBMPR1A/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10814522