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Protein Ontology report - BMP receptor type-1A
PR:000000035 - http://purl.obolibrary.org/obo/PR_000000035
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000035   
  PRO nameBMP receptor type-1A 
  Synonyms
PRO-Short-label: EXACT:BMPR1A
Gene-based: RELATED:ACVRLK3 | ALK3 | Bmpr
Other: EXACT:activin receptor-like kinase 3 | ALK-3 | BMP type-1A receptor | BMP-2/BMP-4 receptor | BMPR-1A | CD292 | serine/threonine-protein kinase receptor R5 | SKR5
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 10                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1786
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000035

BMP receptor type-1A

BMPR1A


"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1A gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2 and BMP4." [PRO:CNA]


organism-gene



PR:P36894

bone morphogenetic protein receptor type-1A (human)

hBMPR1A


"A BMP receptor type-1A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36894]


organism-sequence



PR:000000137

BMP receptor type-1A sequence variant Y62D (human)

hBMPR1A/var:Y62D


"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Tyr-62 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Tyr-62, CHEBI:29958." [PMID:12417513, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000138

BMP receptor type-1A sequence variant C82Y (human)

hBMPR1A/var:C82Y


"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-82 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-82, CHEBI:46858." [PMID:12417513, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000139

BMP receptor type-1A sequence variant C124R (human)

hBMPR1A/var:C124R


"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-124 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-124, CHEBI:29952." [PMID:11536076, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000140

BMP receptor type-1A sequence variant C130R (human)

hBMPR1A/var:C130R


"A bone morphogenetic protein receptor type-1A (human) that has an Arg residue at the position equivalent to Cys-130 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-130, CHEBI:29952." [PMID:12136244, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000141

BMP receptor type-1A sequence variant A338D (human)

hBMPR1A/var:A338D


"A bone morphogenetic protein receptor type-1A (human) that has an Asp residue at the position equivalent to Ala-338 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Ala-338, CHEBI:29958." [PMID:11536076, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000142

BMP receptor type-1A sequence variant C376Y (human)

hBMPR1A/var:C376Y


"A bone morphogenetic protein receptor type-1A (human) that has a Tyr residue at the position equivalent to Cys-376 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Cys-376, CHEBI:46858." [PMID:11536076, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000143

BMP receptor type-1A sequence variant R443C (human)

hBMPR1A/var:R443C


"A bone morphogenetic protein receptor type-1A (human) that has a Cys residue at the position equivalent to Arg-443 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Arg-443, CHEBI:29950." [PMID:12417513, PMID:17344846, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000144

BMP receptor type-1A sequence variant M470T (human)

hBMPR1A/var:M470T


"A bone morphogenetic protein receptor type-1A (human) that has a Thr residue at the position equivalent to Met-470 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, Met-470, CHEBI:30013." [PMID:12630959, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P36894-1

bone morphogenetic protein receptor type-1A isoform 1 (human)

hBMPR1A/iso:1


"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036422

BMP receptor type-1A isoform 1 phosphorylated 1 (human)

hBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]

Yes

organism-modification



PR:000036424

BMP receptor type-1A isoform 1 phosphorylated 2 (human)

hBMPR1A/iso:1/Phos:2


"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]


organism-modification



PR:000046493

bone morphogenetic protein receptor type-1A, signal peptide removed form (human)

hBMPR1A/SigPep-


"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed. UniProtKB:P36894, 24-532." [PRO:DNx, Reactome:R-HSA-201480]


organism-modification



PR:000046494

bone morphogenetic protein receptor type-1A, signal peptide removed phosphorylated 2 (human)

hBMPR1A/SigPep-/Phos:2


"A bone morphogenetic protein receptor type-1A (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 215, 216, 218 and 220 of the amino acid sequence represented by UniProtKB:P36894. UniProtKB:P36894, 24-532, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PRO:DNx, Reactome:R-HSA-201448]


organism-gene



PR:P36895

bone morphogenetic protein receptor type-1A (mouse)

mBMPR1A


"A BMP receptor type-1A that is encoded in the genome of mouse." [OMA:P36895, PRO:DNx]


organism-sequence



PR:P36895-1

bone morphogenetic protein receptor type-1A isoform 1 (mouse)

mBMPR1A/iso:1


"A BMP receptor type-1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036423

BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)

mBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]

Yes

organism-gene



PR:Q78EA7

bone morphogenetic protein receptor type-1A (rat)

rBMPR1A


"A BMP receptor type-1A that is encoded in the genome of rat." [OMA:Q78EA7, PRO:DNx]


sequence



PR:000000136

BMP receptor type-1A isoform 1

BMPR1A/iso:1


"A BMP receptor type-1A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36894-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P36894-1

bone morphogenetic protein receptor type-1A isoform 1 (human)

hBMPR1A/iso:1


"A BMP receptor type-1A isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036422

BMP receptor type-1A isoform 1 phosphorylated 1 (human)

hBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]

Yes

organism-modification



PR:000036424

BMP receptor type-1A isoform 1 phosphorylated 2 (human)

hBMPR1A/iso:1/Phos:2


"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]


organism-sequence



PR:P36895-1

bone morphogenetic protein receptor type-1A isoform 1 (mouse)

mBMPR1A/iso:1


"A BMP receptor type-1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036423

BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)

mBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]

Yes

modification



PR:000000382

BMP receptor type-1A isoform 1 phosphorylated form

BMPR1A/iso:1/PhosRes+


"A BMP receptor type-1A isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000498

BMP receptor type-1A isoform 1 phosphorylated 1

BMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated form in which the phosphorylation occurs within the GS-motif by BMP receptor type-2 upon BMP ligand binding." [PMID:12829744, PRO:CNA]


organism-modification



PR:000036422

BMP receptor type-1A isoform 1 phosphorylated 1 (human)

hBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in human." [PMID:10712517, PMID:12065756, PMID:12829744, PMID:15940369, PRO:CNA]

Yes

organism-modification



PR:000036423

BMP receptor type-1A isoform 1 phosphorylated 1 (mouse)

mBMPR1A/iso:1/Phos:1


"A BMP receptor type-1A isoform 1 phosphorylated 1 in mouse." [PMID:10814522, PMID:9738003, PRO:CNA]

Yes

modification



PR:000000499

BMP receptor type-1A isoform 1 phosphorylated 2

BMPR1A/iso:1/Phos:2


"A BMP receptor type-1A isoform 1 phosphorylated form in which the phosphorylation occurs upon EGF induction. Example: UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA, PRO:DAN]


organism-modification



PR:000036424

BMP receptor type-1A isoform 1 phosphorylated 2 (human)

hBMPR1A/iso:1/Phos:2


"A BMP receptor type-1A isoform 1 phosphorylated 2 in human. UniProtKB:P36894-1, Ser-215/Ser-216/Ser-218/Ser-220, MOD:00046." [PMID:17081983, PRO:CNA]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000137 hBMPR1A/var:Y62D
UniProtKB:P36894, Tyr-62, CHEBI:29958
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000138 hBMPR1A/var:C82Y
UniProtKB:P36894, Cys-82, CHEBI:46858
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513
PR:000000139 hBMPR1A/var:C124R
UniProtKB:P36894, Cys-124, CHEBI:29952
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000140 hBMPR1A/var:C130R
UniProtKB:P36894, Cys-130, CHEBI:29952
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12136244
PR:000000141 hBMPR1A/var:A338D
UniProtKB:P36894, Ala-338, CHEBI:29958
associated_with_disease_progressionDO:6457 Cowden syndrome PMID:11536076
PR:000000142 hBMPR1A/var:C376Y
UniProtKB:P36894, Cys-376, CHEBI:46858
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:11536076
PR:000000143 hBMPR1A/var:R443C
UniProtKB:P36894, Arg-443, CHEBI:29950
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12417513; PMID:17344846
PR:000000144 hBMPR1A/var:M470T
UniProtKB:P36894, Met-470, CHEBI:30013
associated_with_disease_progressionDO:0050787 juvenile polyposis syndrome PMID:12630959
PR:000036422 hBMPR1A/iso:1/Phos:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:12065756
GO:0030509 BMP signaling pathway PMID:12829744
enablesGO:0004674 protein serine/threonine kinase activity PMID:12829744
located_inGO:0009986 cell surface PMID:10712517
GO:0043235 receptor complex PMID:12829744; PMID:15940369
PR:000036423 mBMPR1A/iso:1/Phos:1 enablesGO:0046332 SMAD binding PMID:10814522; PMID:9738003
PR:P36894-1 hBMPR1A/iso:1 located_inGO:0016020 membrane PMID:8397373
GO:0043235 receptor complex PMID:15940369
PR:P36895-1 mBMPR1A/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:10814522