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Protein Ontology report - BMP receptor type-1B
PR:000000036 - http://purl.obolibrary.org/obo/PR_000000036
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000036   
  PRO nameBMP receptor type-1B 
  Synonyms
PRO-Short-label: EXACT:BMPR1B
Gene-based: RELATED:Acvrlk6
Other: EXACT:activin receptor-like kinase 6 | ALK-6 | BMP type-1B receptor | BMPR-1B | CDw293 | serine/threonine-protein kinase receptor R6 | SKR6
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 5                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1789
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000036

BMP receptor type-1B

BMPR1B


"A TGF-beta superfamily receptor type-1 that is a translation product of the human BMPR1B gene or a 1:1 ortholog thereof. Bone morphogenetic protein (BMP) signals are transmitted by type 2 and type 1 serine/threonine kinase receptors. Type 2 receptors phosphorylate and activate type 1 receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1." [PRO:CNA]


organism-gene



PR:O00238

bone morphogenetic protein receptor type-1B (human)

hBMPR1B


"A BMP receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00238]


organism-sequence



PR:000000146

BMP receptor type-1B sequence variant I200K (human)

hBMPR1B/var:I200K


"A bone morphogenetic protein receptor type-1B (human) that has a Lys residue at the position equivalent to Ile-200 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Ile-200, CHEBI:29967." [PMID:14523231, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000147

BMP receptor type-1B sequence variant R486W (human)

hBMPR1B/var:R486W


"A bone morphogenetic protein receptor type-1B (human) that has a Trp residue at the position equivalent to Arg-486 of the amino acid sequence represented by UniProtKB:O00238-1. Example: UniProtKB:O00238-1, Arg-486, CHEBI:29954." [PMID:14523231, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:O00238-1

bone morphogenetic protein receptor type-1B isoform 1 (human)

hBMPR1B/iso:1


"A BMP receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036426

BMP receptor type-1B isoform 1 phosphorylated 1 (human)

hBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]

Yes

organism-sequence



PR:O00238-2

bone morphogenetic protein receptor type-1B isoform h2 (human)

hBMPR1B/iso:h2


"A bone morphogenetic protein receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-2." [PRO:DNx, UniProtKB:O00238]


organism-modification



PR:000046495

bone morphogenetic protein receptor type-1B, signal peptide removed form (human)

hBMPR1B/SigPep-


"A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed. UniProtKB:O00238, 14-502." [PRO:DNx, Reactome:R-HSA-201657]


organism-modification



PR:000046496

bone morphogenetic protein receptor type-1B, signal peptide removed phosphoserine(4+) form (human)

hBMPR1B/SigPep-/PhosSer(4+)


"A bone morphogenetic protein receptor type-1B (human) that has had the signal peptide removed and that includes at least four phosphorylated serines. UniProtKB:O00238, 14-502, MOD:00046(4+)." [PRO:DNx, Reactome:R-HSA-201814]


organism-gene



PR:P36898

bone morphogenetic protein receptor type-1B (mouse)

mBMPR1B


"A BMP receptor type-1B that is encoded in the genome of mouse." [OMA:P36898, PRO:DNx]


organism-sequence



PR:P36898-1

bone morphogenetic protein receptor type-1B isoform 1 (mouse)

mBMPR1B/iso:1


"A BMP receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036425

BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)

mBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]

Yes

organism-gene



PR:Q05438

bone morphogenetic protein receptor type-1B (chicken)

chick-BMPR1B


"A BMP receptor type-1B that is encoded in the genome of chicken." [OMA:Q05438, PRO:DNx]


organism-gene



PR:Q09488

serine/threonine-protein kinase receptor sma-6 (worm)

BMPR1B (worm)


"A BMP receptor type-1B that is encoded in the genome of worm." [OMA:Q09488, PRO:DNx]


organism-gene



PR:Q569A5

receptor protein serine/threonine kinase (rat)

rBMPR1B


"A BMP receptor type-1B that is encoded in the genome of rat." [PANTHER:PTHR23255:SF35, PRO:DNx]


sequence



PR:000000145

BMP receptor type-1B isoform 1

BMPR1B/iso:1


"A BMP receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00238-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:O00238-1

bone morphogenetic protein receptor type-1B isoform 1 (human)

hBMPR1B/iso:1


"A BMP receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036426

BMP receptor type-1B isoform 1 phosphorylated 1 (human)

hBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]

Yes

organism-sequence



PR:P36898-1

bone morphogenetic protein receptor type-1B isoform 1 (mouse)

mBMPR1B/iso:1


"A BMP receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036425

BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)

mBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]

Yes

modification



PR:000000383

BMP receptor type-1B isoform 1 phosphorylated form

BMPR1B/iso:1/PhosRes+


"A BMP receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000500

BMP receptor type-1B isoform 1 phosphorylated 1

BMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated form in which the phosphorylation occurs within the GS-motif by the BMP receptor type-2 upon BMP ligand binding." [PRO:CNA]


organism-modification



PR:000036425

BMP receptor type-1B isoform 1 phosphorylated 1 (mouse)

mBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in mouse." [PMID:10631181, PMID:10712517, PMID:14523231, PRO:CNA]

Yes

organism-modification



PR:000036426

BMP receptor type-1B isoform 1 phosphorylated 1 (human)

hBMPR1B/iso:1/Phos:1


"A BMP receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:10051328, PMID:14523231, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0001501 skeletal system developmentPR:000036425 mBMPR1B/iso:1/Phos:1 PMID:14523231
PR:P36898-1 mBMPR1B/iso:1 PMID:14523231
GO:0001502 cartilage condensationPR:000036425 mBMPR1B/iso:1/Phos:1 PMID:10631181; PMID:14523231
PR:P36898-1 mBMPR1B/iso:1 PMID:14523231
GO:0030509 BMP signaling pathwayPR:000036426 hBMPR1B/iso:1/Phos:1 PMID:10051328
PR:O00238-1 hBMPR1B/iso:1 PMID:10051328
GO:0035108 limb morphogenesisPR:000036425 mBMPR1B/iso:1/Phos:1 PMID:14523231
PR:P36898-1 mBMPR1B/iso:1 PMID:14523231
GO:0045597 positive regulation of cell differentiationPR:000036426 hBMPR1B/iso:1/Phos:1 PMID:14523231

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050581 brachydactylyPR:000000146 hBMPR1B/var:I200K PMID:14523231
PR:000000147 hBMPR1B/var:R486W PMID:14523231

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004674 protein serine/threonine kinase activityPR:000000147 hBMPR1B/var:R486W PMID:14523231
NOT GO:0004674 protein serine/threonine kinase activityPR:000000146 hBMPR1B/var:I200K PMID:14523231

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0009986 cell surfacePR:000000146 hBMPR1B/var:I200K PMID:14523231
PR:000000147 hBMPR1B/var:R486W PMID:14523231
PR:000036425 mBMPR1B/iso:1/Phos:1 PMID:10712517; PMID:14523231
PR:P36898-1 mBMPR1B/iso:1 PMID:10712517
GO:0043235 receptor complexPR:000036425 mBMPR1B/iso:1/Phos:1 PMID:10712517