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Protein Ontology report - BMP receptor-regulated smad protein
PR:000000038 - http://purl.obolibrary.org/obo/PR_000000038
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000038   
  PRO nameBMP receptor-regulated smad protein 
  Synonyms
PRO-Short-label: EXACT:R-SMAD(BMP)
  Definition"A smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways." [PMID:11532220
  PRO Categoryfamily 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene3                                                  Organism-Gene 11                                        
         Sequence5                                                  Organism-Sequence 10                                        
         Modification13                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500500
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000038

BMP receptor-regulated smad protein

R-SMAD(BMP)


"A smad protein that mediates signal transduction through activation of bone morphogenetic protein (BMP) or anti-Mullerian hormone pathways." [PMID:11532220]

Yes

gene



PR:000000363

smad1

SMAD1


"A BMP receptor-regulated smad protein that is a translation product of the human SMAD1 gene or a 1:1 ortholog thereof." [PMID:10708949, PRO:CNA]


organism-gene



PR:P70340

mothers against decapentaplegic homolog 1 (mouse)

mSMAD1


"A smad1 that is encoded in the genome of mouse." [OMA:P70340, PRO:DNx]


organism-sequence



PR:P70340-1

mothers against decapentaplegic homolog 1 isoform 1 (mouse)

mSMAD1/iso:1


"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000026724

smad1 isoform 1 phosphorylated 1 (mouse)

mSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]

Yes

organism-gene



PR:P97588

mothers against decapentaplegic homolog 1 (rat)

rSMAD1


"A smad1 that is encoded in the genome of rat." [OMA:P97588, PRO:DNx]


organism-gene



PR:Q15797

mothers against decapentaplegic homolog 1 (human)

hSMAD1


"A smad1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q15797]


organism-sequence



PR:Q15797-1

mothers against decapentaplegic homolog 1 isoform 1 (human)

hSMAD1/iso:1


"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026334

smad1 isoform 1 phosphorylated 1 (human)

hSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]

Yes

organism-modification



PR:000036553

smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q15797-2

mothers against decapentaplegic homolog 1 isoform h2 (human)

hSMAD1/iso:h2


"A mothers against decapentaplegic homolog 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-2." [PRO:DNx, UniProtKB:Q15797]


organism-modification



PR:000049280

mothers against decapentaplegic homolog 1 ubiquitinated form (human)

hSMAD1/UbiqLys+


"A mothers against decapentaplegic homolog 1 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q15797, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782768]


organism-modification



PR:000036553

smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000050147

smad1 phosphorylated 1 (human)

hSMAD1/Phos:1


"A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]


sequence



PR:000000467

smad1 isoform 1

SMAD1/iso:1


"A smad1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15797-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P70340-1

mothers against decapentaplegic homolog 1 isoform 1 (mouse)

mSMAD1/iso:1


"A smad1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000026724

smad1 isoform 1 phosphorylated 1 (mouse)

mSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]

Yes

organism-sequence



PR:Q15797-1

mothers against decapentaplegic homolog 1 isoform 1 (human)

hSMAD1/iso:1


"A smad1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026334

smad1 isoform 1 phosphorylated 1 (human)

hSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]

Yes

organism-modification



PR:000036553

smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000570

smad1 isoform 1 phosphorylated and ubiquitinated form

SMAD1/iso:1/PhosUbiq+


"A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]


modification



PR:000000648

smad1 isoform 1 phosphorylated and ubiquitinated 1

SMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]


organism-modification



PR:000036553

smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000571

smad1 isoform 1 phosphorylated form

SMAD1/iso:1/PhosRes+


"A smad1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000570

smad1 isoform 1 phosphorylated and ubiquitinated form

SMAD1/iso:1/PhosUbiq+


"A smad1 isoform 1 that includes at least one phosphorylated residue and at least one ubiquitinated lysine." [PRO:CNA]


modification



PR:000000648

smad1 isoform 1 phosphorylated and ubiquitinated 1

SMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated form that has been phosphorylated at the two last C-terminal SSxS motif and has been ubiquitinated by E3 ubiquitin-protein ligase SMURF1 (PR:000000466). Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]


organism-modification



PR:000036553

smad1 isoform 1 phosphorylated and ubiquitinated 1 (human)

hSMAD1/iso:1/PhosUbiq:1


"A smad1 isoform 1 phosphorylated and ubiquitinated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148." [PMID:12857866, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000647

smad1 isoform 1 phosphorylated 1

SMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PMID:9136927]

Yes

organism-modification



PR:000026334

smad1 isoform 1 phosphorylated 1 (human)

hSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in human. UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046." [PRO:DAN, Reactome:R-HSA-201464, Reactome:R-HSA-201483]

Yes

organism-modification



PR:000026724

smad1 isoform 1 phosphorylated 1 (mouse)

mSMAD1/iso:1/Phos:1


"A smad1 isoform 1 phosphorylated 1 in mouse. UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:12151307, PMID:12370310]

Yes

modification



PR:000050148

smad1 phosphorylated 1

SMAD1/Phos:1


"A smad1 that has been phosphorylated on the last two Ser residues within the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]


organism-modification



PR:000050147

smad1 phosphorylated 1 (human)

hSMAD1/Phos:1


"A smad1 phosphorylated 1 in human. UniProtKB:Q15797, Ser-463/Ser-465, MOD:00046." [PRO:DAN]


gene



PR:000000372

smad5

SMAD5


"A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof." [PMID:10708949]


organism-gene



PR:P97454

mothers against decapentaplegic homolog 5 (mouse)

mSMAD5


"A smad5 that is encoded in the genome of mouse." [OMA:P97454, PRO:DNx]


organism-sequence



PR:P97454-1

mothers against decapentaplegic homolog 5 isoform 1 (mouse)

mSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

organism-gene



PR:Q56I99

mothers against decapentaplegic homolog 5 (chicken)

chick-SMAD5


"A smad5 that is encoded in the genome of chicken." [OMA:Q56I99, PRO:DNx, UniProtKB:Q56I99]


organism-gene



PR:Q99717

mothers against decapentaplegic homolog 5 (human)

hSMAD5


"A smad5 that is encoded in the genome of human." []


organism-sequence



PR:000029962

smad5 isoform 2 (human)

hSMAD5/iso:2


"A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]

Yes

organism-sequence



PR:Q99717-1

mothers against decapentaplegic homolog 5 isoform 1 (human)

hSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

organism-modification



PR:000049289

mothers against decapentaplegic homolog 5, initiator methionine removed form (human)

hSMAD5/InitMet-


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]


organism-modification



PR:000049290

mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)

hSMAD5/InitMet-/Phos:1


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]


organism-gene



PR:Q9R1V3

mothers against decapentaplegic homolog 5 (rat)

rSMAD5


"A smad5 that is encoded in the genome of rat." [OMA:Q9R1V3, PRO:DNx]


organism-gene



PR:Q9W7E7

mothers against decapentaplegic homolog 5 (zebrafish)

z-SMAD5


"A smad5 that is encoded in the genome of zebrafish." [OMA:Q9W7E7, PRO:DNx]


sequence



PR:000000477

smad5 isoform 1

SMAD5/iso:1


"A smad5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99717-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P97454-1

mothers against decapentaplegic homolog 5 isoform 1 (mouse)

mSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

organism-sequence



PR:Q99717-1

mothers against decapentaplegic homolog 5 isoform 1 (human)

hSMAD5/iso:1


"A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

modification



PR:000000580

smad5 isoform 1 phosphorylated form

SMAD5/iso:1/PhosRes+


"A smad5 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000661

smad5 isoform 1 phosphorylated 1

SMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600]


organism-modification



PR:000036562

smad5 isoform 1 phosphorylated 1 (human)

hSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]

Yes

organism-modification



PR:000036563

smad5 isoform 1 phosphorylated 1 (mouse)

mSMAD5/iso:1/Phos:1


"A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]

Yes

modification



PR:000026652

smad5 isoform 1, initiator methionine removed form

SMAD5/iso:1/InitMet-


"A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


sequence



PR:000000478

smad5 isoform 2

SMAD5/iso:2


"A smad5 that is a translation product of a transcript comprising intron 6 generating a C-terminus truncated MH2 domain and a unique C-terminus sequence lacking the SSxS motif necessary for SMAD activation." [EST:AA169504, PMID:10845932, PRO:CNA, PRO:DAN]


organism-sequence



PR:000029962

smad5 isoform 2 (human)

hSMAD5/iso:2


"A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]

Yes

modification



PR:000018297

smad5, initiator methionine removed form

SMAD5/InitMet-


"A smad5 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026652

smad5 isoform 1, initiator methionine removed form

SMAD5/iso:1/InitMet-


"A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000049289

mothers against decapentaplegic homolog 5, initiator methionine removed form (human)

hSMAD5/InitMet-


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]


organism-modification



PR:000049290

mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)

hSMAD5/InitMet-/Phos:1


"A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]


gene



PR:000000375

smad9

SMAD9


"A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof." [PMID:10708948]


organism-gene



PR:O15198

mothers against decapentaplegic homolog 9 (human)

hSMAD9


"A smad9 that is encoded in the genome of human." []


organism-sequence



PR:000029959

smad9 isoform 3 (human)

hSMAD9/iso:3


"A mothers against decapentaplegic homolog 9 (human) that is a translation product of a transcript that lacks the last exon." [PMID:10583507, PRO:DAN]

Yes

organism-sequence



PR:O15198-1

mothers against decapentaplegic homolog 9 isoform A (human)

hSMAD9/iso:A


"A smad9 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


organism-sequence



PR:O15198-2

mothers against decapentaplegic homolog 9 isoform B (human)

hSMAD9/iso:B


"A smad9 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000049291

mothers against decapentaplegic homolog 9 phosphorylated 1 (human)

hSMAD9/Phos:1


"A mothers against decapentaplegic homolog 9 (human) that has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:O15198. UniProtKB:O15198, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-201441, Reactome:R-HSA-201474]


organism-modification



PR:000067869

mothers against decapentaplegic homolog 9 methylated 1 (human)

hSMAD9/Me:1


"A mothers against decapentaplegic homolog 9 (human) that has been methylated on the residue at the position equivalent to Cys-436 of the amino acid sequence represented by UniProtKB:O15198-1. Example: UniProtKB:O15198-1, Cys-436, MOD:00660." [IEDB_epitope:1054906, PRO:DNx]


organism-modification



PR:000085152

mothers against decapentaplegic homolog 9 methylated 2 (human)

hSMAD9/Me:2


"A mothers against decapentaplegic homolog 9 (human) that has been methylated on the residue at the position equivalent to Cys-412 of the amino acid sequence represented by UniProtKB:O15198-1. Example: UniProtKB:O15198-1, Cys-412, MOD:00660." [IEDB_epitope:1008595, PRO:DNx]


organism-gene



PR:O54835

mothers against decapentaplegic homolog 9 (rat)

rSMAD9


"A smad9 that is encoded in the genome of rat." [OMA:O54835, PRO:DNx]


organism-gene



PR:Q9JIW5

mothers against decapentaplegic homolog 9 (mouse)

mSMAD9


"A smad9 that is encoded in the genome of mouse." [OMA:Q9JIW5, PRO:DNx]


organism-sequence



PR:Q9JIW5-1

mothers against decapentaplegic homolog 9 isoform 1 (mouse)

mSMAD9/iso:1


"A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

sequence



PR:000000482

smad9 isoform 1

SMAD9/iso:1


"A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JIW5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O15198-2

mothers against decapentaplegic homolog 9 isoform B (human)

hSMAD9/iso:B


"A smad9 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-sequence



PR:Q9JIW5-1

mothers against decapentaplegic homolog 9 isoform 1 (mouse)

mSMAD9/iso:1


"A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

modification



PR:000000585

smad9 isoform 1 phosphorylated form

SMAD9/iso:1/PhosRes+


"A smad9 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000666

smad9 isoform 1 phosphorylated 1

SMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:15542835]


organism-modification



PR:000036567

smad9 isoform 1 phosphorylated 1 (mouse)

mSMAD9/iso:1/Phos:1


"A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]

Yes

sequence



PR:000000484

smad9 isoform 3

SMAD9/iso:3


"A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15198-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O15198-1

mothers against decapentaplegic homolog 9 isoform A (human)

hSMAD9/iso:A


"A smad9 isoform 3 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


modification



PR:000000586

smad9 isoform 3 phosphorylated form

SMAD9/iso:3/PhosRes+


"A smad9 isoform 3 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000667

smad9 isoform 3 phosphorylated 1

SMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif. Example: UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PMID:17081983, PRO:CNA, PRO:DAN]


organism-modification



PR:000028350

smad9 isoform 3 phosphorylated 1 (human)

hSMAD9/iso:3/Phos:1


"A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000038 R-SMAD(BMP) acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PANTHER:PTHR13703; PIRSF:PIRSF500500
PR:000000647 SMAD1/iso:1/Phos:1
Example: UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
PR:000026334 hSMAD1/iso:1/Phos:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0007165 signal transduction PMID:9759503
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0046332 SMAD binding with PR:Q13485 deletion target in pancreatic carcinoma 4 (human) PMID:9136927
located_inGO:0005634 nucleus PMID:11509558; PMID:9759503
PR:000026724 mSMAD1/iso:1/Phos:1
UniProtKB:P70340-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15899870
GO:0030509 BMP signaling pathway PMID:12370310; PMID:15198985
enablesGO:0005515 protein binding with PR:Q04211 BTG family member 2 (mouse) PMID:14633973
GO:0005515 protein binding with PR:Q8BGV5 mZNF8 PMID:14633973
GO:0005515 protein binding with PR:Q9QZH6 Ecsit PMID:14633973
located_inGO:0005634 nucleus PMID:10504300; PMID:12151307; PMID:12370310
GO:0005667 transcription factor complex PMID:14633973
GO:0005769 early endosome PMID:17592637
PR:000029959 hSMAD9/iso:3 acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:10583507
enablesGO:0046332 SMAD binding PMID:10583507
located_inGO:0005737 cytoplasm PMID:10583507
PR:000029962 hSMAD5/iso:2 enablesNOT GO:0046332 SMAD binding PMID:10845932
PR:000036553 hSMAD1/iso:1/PhosUbiq:1
UniProtKB:Q15797-1, Ser-463/Ser-465, MOD:00046|MOD:01148
acts_upstream_of_or_withinGO:0030514 negative regulation of BMP signaling pathway PMID:12857866
PR:000036562 hSMAD5/iso:1/Phos:1
UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8637600
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:000036563 mSMAD5/iso:1/Phos:1
UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:16522160
located_inGO:0005634 nucleus PMID:10504300; PMID:9759503
PR:000036567 mSMAD9/iso:1/Phos:1
UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046
acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:11163184; PMID:15542835
enablesGO:0005515 protein binding PMID:11163184; PMID:15542835
located_inGO:0005634 nucleus PMID:10814522
PR:P70340-1 mSMAD1/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:15198985; PMID:15331632; PMID:17356069
located_inGO:0005737 cytoplasm PMID:10504300; PMID:17356069
PR:P97454-1 mSMAD5/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:16765933
GO:0030509 BMP signaling pathway PMID:16522160; PMID:16765933
located_inGO:0005737 cytoplasm PMID:10504300
PR:Q15797-1 hSMAD1/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:8637600
GO:0030509 BMP signaling pathway PMID:8653785
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:10708949
GO:0005102 signaling receptor binding PMID:9136927; PMID:9748228
GO:0005515 protein binding PMID:17356069
located_inGO:0005737 cytoplasm PMID:11509558
PR:Q99717-1 hSMAD5/iso:1 acts_upstream_of_or_withinGO:0030509 BMP signaling pathway PMID:8673135
enablesGO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific PMID:8673135
PR:Q9JIW5-1 mSMAD9/iso:1 acts_upstream_of_or_withinGO:0048856 anatomical structure development PMID:15899870
located_inGO:0005622 intracellular anatomical structure PMID:10814522