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Protein Ontology report - DNA-binding protein inhibitor ID-2
PR:000000040 - http://purl.obolibrary.org/obo/PR_000000040
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000040   
  PRO nameDNA-binding protein inhibitor ID-2 
  Synonyms
PRO-Short-label: EXACT:ID2
Gene-based: RELATED:BHLHB26 | Id-2 | Idb2
Other: EXACT:bHLHb26 | class B basic helix-loop-helix protein 26 | inhibitor of differentiation 2 | inhibitor of DNA binding 2
  Definition"An HLH DNA-binding protein inhibitor that is a translation product of the human ID2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000003 HLH DNA-binding protein inhibitor
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500498
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000040
DNA-binding protein inhibitor ID-2
ID2
"An HLH DNA-binding protein inhibitor that is a translation product of the human ID2 gene or a 1:1 ortholog thereof." [PRO:CNA]
Yes
organism-gene


PR:P41136
DNA-binding protein inhibitor ID-2 (mouse)
mID2
"A DNA-binding protein inhibitor ID-2 that is encoded in the genome of mouse." [OMA:P41136, PRO:DNx]

organism-sequence


PR:P41136-1
DNA-binding protein inhibitor ID-2 isoform 1 (mouse)
mID2/iso:1
"A DNA-binding protein inhibitor ID-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000045376
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in mouse. UniProtKB:P41136-1, Ser-5, PR:000026291." [PRO:CNA]

organism-gene


PR:P41137
DNA-binding protein inhibitor ID-2 (rat)
rID2
"A DNA-binding protein inhibitor ID-2 that is encoded in the genome of rat." [OMA:P41137, PRO:DNx]

organism-modification


PR:000036428
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat)
rID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 in rat. UniProtKB:P41137-1, Ser-5, MOD:00046." [PMID:11706002, PRO:CNA]
Yes
organism-modification


PR:000045377
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat)
rID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in rat. UniProtKB:P41137-1, Ser-5, PR:000026291." [PMID:11706002, PRO:CNA]
Yes
organism-gene


PR:Q02363
DNA-binding protein inhibitor ID-2 (human)
hID2
"A DNA-binding protein inhibitor ID-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q02363]

organism-sequence


PR:Q02363-1
DNA-binding protein inhibitor ID-2 isoform 1 (human)
hID2/iso:1
"A DNA-binding protein inhibitor ID-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036427
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, MOD:00046." [PMID:9029153, PRO:CNA]
Yes
organism-modification


PR:000045368
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, PR:000026291." [PMID:9029153, PRO:CNA]
Yes
organism-modification


PR:000069807
DNA-binding protein inhibitor ID-2 sulfated 1 (human)
hID2/Sulf:1
"A DNA-binding protein inhibitor ID-2 (human) that has been sulfated on the residue at the position equivalent to Ser-5 of the amino acid sequence represented by UniProtKB:Q02363. UniProtKB:Q02363, Ser-5, MOD:00366." [IEDB_epitope:1392990, PRO:DNx]

organism-modification


PR:000079087
DNA-binding protein inhibitor ID-2 phosphorylated 1 (human)
hID2/Phos:1
"A DNA-binding protein inhibitor ID-2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-5 of the amino acid sequence represented by UniProtKB:Q02363. UniProtKB:Q02363, Ser-5, MOD:00046." [IEDB_epitope:845632, PRO:DNx]

sequence


PR:000000173
DNA-binding protein inhibitor ID-2 isoform 1
ID2/iso:1
"A DNA-binding protein inhibitor ID-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q02363-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P41136-1
DNA-binding protein inhibitor ID-2 isoform 1 (mouse)
mID2/iso:1
"A DNA-binding protein inhibitor ID-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000045376
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in mouse. UniProtKB:P41136-1, Ser-5, PR:000026291." [PRO:CNA]

organism-sequence


PR:Q02363-1
DNA-binding protein inhibitor ID-2 isoform 1 (human)
hID2/iso:1
"A DNA-binding protein inhibitor ID-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

organism-modification


PR:000036427
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, MOD:00046." [PMID:9029153, PRO:CNA]
Yes
organism-modification


PR:000045368
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, PR:000026291." [PMID:9029153, PRO:CNA]
Yes
modification


PR:000000392
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated form
ID2/iso:1/PhosRes+
"A DNA-binding protein inhibitor ID-2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000507
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1
ID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue in the N-terminal SPVR motif. Example: UniProtKB:Q02363-1, Ser-5, MOD:00046." [PMID:9029153]

organism-modification


PR:000036427
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (human)
hID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, MOD:00046." [PMID:9029153, PRO:CNA]
Yes
organism-modification


PR:000036428
DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 (rat)
rID2/iso:1/Phos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 phosphorylated 1 in rat. UniProtKB:P41137-1, Ser-5, MOD:00046." [PMID:11706002, PRO:CNA]
Yes
modification


PR:000045375
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1
ID2/iso:1/PhosRes-
"A DNA-binding protein inhibitor ID-2 isoform 1 that lacks phosphorylation on the N-terminal SPVR motif. Example: UniProtKB:Q02363-1, Ser-5, PR:000026291." [PMID:11706002, PMID:9029153, PRO:CNA]

organism-modification


PR:000045368
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (human)
hID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in human. UniProtKB:Q02363-1, Ser-5, PR:000026291." [PMID:9029153, PRO:CNA]
Yes
organism-modification


PR:000045376
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (mouse)
mID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in mouse. UniProtKB:P41136-1, Ser-5, PR:000026291." [PRO:CNA]

organism-modification


PR:000045377
DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 (rat)
rID2/iso:1/UnPhos:1
"A DNA-binding protein inhibitor ID-2 isoform 1 unphosphorylated 1 in rat. UniProtKB:P41137-1, Ser-5, PR:000026291." [PMID:11706002, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0045892 negative regulation of DNA-templated transcriptionPR:000000040 ID2 PIRSF:PIRSF500478
PR:000045368 hID2/iso:1/UnPhos:1 PMID:14627819; PMID:9029153
GO:0051726 regulation of cell cyclePR:000036427 hID2/iso:1/Phos:1 PMID:9029153

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0046983 protein dimerization activityPR:P41136-1 mID2/iso:1 PMID:10891368

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000036428 rID2/iso:1/Phos:1 PMID:11706002
PR:P41136-1 mID2/iso:1 PMID:12878164
GO:0005737 cytoplasmPR:000045377 rID2/iso:1/UnPhos:1 PMID:11706002
PR:P41136-1 mID2/iso:1 PMID:12878164; PMID:15563451