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Protein Ontology report - RING-box protein 2
PR:000000044 - http://purl.obolibrary.org/obo/PR_000000044
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000044   
  PRO nameRING-box protein 2 
  Synonyms
PRO-Short-label: EXACT:RNF7
Gene-based: RELATED:RBX2 | ROC2 | SAG
Other: EXACT:CKBBP1 | CKII beta-binding protein 1 | rbx2 | regulator of cullins 2 | RING finger protein 7 | sensitive to apoptosis gene protein
  Definition"A RING-box protein that is a translation product of the human RNF7 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000004 RING-box protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 2                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification4                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500725
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000044

RING-box protein 2

RNF7


"A RING-box protein that is a translation product of the human RNF7 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:Q9M9L0

anaphase-promoting complex subunit 11 (Arabidopsis thaliana)

At-RNF7


"A RING-box protein 2 that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9M9L0, PRO:DNx]


organism-gene



PR:Q9UBF6

RING-box protein 2 (human)

hRNF7


"A RING-box protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9UBF6]


organism-sequence



PR:Q9UBF6-1

RING-box protein 2 isoform 1 (human)

hRNF7/iso:1


"A RING-box protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036431

RING-box protein 2 isoform 1 phosphorylated 1 (human)

hRNF7/iso:1/Phos:1


"A RING-box protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBF6-1, Thr-10, MOD:00047." [PMID:12748192, PRO:CNA]

Yes

organism-sequence



PR:Q9UBF6-2

RING-box protein 2 isoform 2 (human)

hRNF7/iso:2


"A RING-box protein 2 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UBF6]

Yes

organism-sequence



PR:Q9UBF6-3

RING-box protein 2 isoform h3 (human)

hRNF7/iso:h3


"A RING-box protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBF6-3." [PRO:DNx, UniProtKB:Q9UBF6]


organism-sequence



PR:Q9UBF6-4

RING-box protein 2 isoform h4 (human)

hRNF7/iso:h4


"A RING-box protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBF6-4." [PRO:DNx, UniProtKB:Q9UBF6]


organism-modification



PR:000049057

RING-box protein 2, initiator methionine removed form (human)

hRNF7/InitMet-


"A RING-box protein 2 (human) that has had the initiator methionine removed. UniProtKB:Q9UBF6, 2-113." [PRO:DNx, Reactome:R-HSA-8863132]


organism-modification



PR:000068715

RING-box protein 2 methylated 1 (human)

hRNF7/Me:1


"A RING-box protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-80 of the amino acid sequence represented by UniProtKB:Q9UBF6-1. Example: UniProtKB:Q9UBF6-1, Cys-80, MOD:00660." [IEDB_epitope:1060008, PRO:DNx]


organism-modification



PR:000071162

RING-box protein 2 methylated 2 (human)

hRNF7/Me:2


"A RING-box protein 2 (human) that has been methylated on the residue at the position equivalent to Cys-73 of the amino acid sequence represented by UniProtKB:Q9UBF6-1. Example: UniProtKB:Q9UBF6-1, Cys-73, MOD:00660." [IEDB_epitope:1026019, PRO:DNx]


sequence



PR:000000178

RING-box protein 2 isoform 1

RNF7/iso:1


"A RING-box protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBF6-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UBF6-1

RING-box protein 2 isoform 1 (human)

hRNF7/iso:1


"A RING-box protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036431

RING-box protein 2 isoform 1 phosphorylated 1 (human)

hRNF7/iso:1/Phos:1


"A RING-box protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBF6-1, Thr-10, MOD:00047." [PMID:12748192, PRO:CNA]

Yes

organism-sequence



PR:Q9WTZ1-1

RING-box protein 2 isoform 1 (mouse)

mRNF7/iso:1


"A RING-box protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000000396

RING-box protein 2 isoform 1 phosphorylated form

RNF7/iso:1/PhosRes+


"A RING-box protein 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000511

RING-box protein 2 isoform 1 phosphorylated 1

RNF7/iso:1/Phos:1


"A RING-box protein 2 isoform 1 phosphorylated form in which the phosphorylation occurs at the most N-terminal Thr residue by CK2. Example: UniProtKB:Q9UBF6-1, Thr-10, MOD:00047." [PMID:12748192, PRO:CNA, PRO:DAN]


organism-modification



PR:000036431

RING-box protein 2 isoform 1 phosphorylated 1 (human)

hRNF7/iso:1/Phos:1


"A RING-box protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q9UBF6-1, Thr-10, MOD:00047." [PMID:12748192, PRO:CNA]

Yes

modification



PR:000026651

RING-box protein 2 isoform 1, initiator methionine removed form

RNF7/iso:1/InitMet-


"A RING-box protein 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


sequence



PR:000000179

RING-box protein 2 isoform 2

RNF7/iso:2


"A RING-box protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UBF6-2 or a 1:1 ortholog thereof." [PMID:11506706, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q9UBF6-2

RING-box protein 2 isoform 2 (human)

hRNF7/iso:2


"A RING-box protein 2 isoform 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UBF6]

Yes

modification



PR:000018273

RING-box protein 2, initiator methionine removed form

RNF7/InitMet-


"A RING-box protein 2 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026651

RING-box protein 2 isoform 1, initiator methionine removed form

RNF7/iso:1/InitMet-


"A RING-box protein 2 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000049057

RING-box protein 2, initiator methionine removed form (human)

hRNF7/InitMet-


"A RING-box protein 2 (human) that has had the initiator methionine removed. UniProtKB:Q9UBF6, 2-113." [PRO:DNx, Reactome:R-HSA-8863132]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stressPR:Q9WTZ1-1 mRNF7/iso:1 PMID:10082581
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processPR:000000044 RNF7 PIRSF:PIRSF500725

Cellular Location GO Term

Protein Forms & Complexes

Evidence
NOT GO:0000151 ubiquitin ligase complexPR:Q9UBF6-2 hRNF7/iso:2 PMID:11506706
GO:0005634 nucleusPR:000036431 hRNF7/iso:1/Phos:1 PMID:12748192
PR:Q9WTZ1-1 mRNF7/iso:1 PMID:10082581
GO:0005737 cytoplasmPR:000036431 hRNF7/iso:1/Phos:1 PMID:12748192
PR:Q9WTZ1-1 mRNF7/iso:1 PMID:10082581
GO:0019005 SCF ubiquitin ligase complexPR:000000044 RNF7 PIRSF:PIRSF500725