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Protein Ontology report - S-phase kinase-associated protein 1A
PR:000000045 - http://purl.obolibrary.org/obo/PR_000000045
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000045   
  PRO nameS-phase kinase-associated protein 1A 
  Synonyms
PRO-Short-label: EXACT:SKP1
Gene-based: RELATED:EMC19 | OCP2 | SKP1A | TCEB1L
Other: EXACT:cyclin-A/CDK2-associated protein p19 | OCP-2 | OCP-II | organ of Corti protein 2 | organ of Corti protein II | p19A | p19skp1 | RNA polymerase II elongation factor-like protein | SIII | transcription elongation factor B
  Definition"An E3 ubiquitin ligase SFC complex Skp1 subunit that is a translation product of the human SKP1 gene or a 1:1 ortholog thereof. This gene has 5 conserved protein coding exons." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000002 E3 ubiquitin ligase SFC complex Skp1 subunit
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000045

S-phase kinase-associated protein 1A

SKP1


"An E3 ubiquitin ligase SFC complex Skp1 subunit that is a translation product of the human SKP1 gene or a 1:1 ortholog thereof. This gene has 5 conserved protein coding exons." [PRO:CNA]


organism-gene



PR:P52286

suppressor of kinetochore protein 1 (yeast)

ySKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of yeast." [OMA:P52286, PRO:DNx]


organism-gene



PR:P63208

S-phase kinase-associated protein 1 (human)

hSKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of human." [PRO:CNA, UniProtKB:P63208]


organism-sequence



PR:P63208-1

S-phase kinase-associated protein 1 isoform 1 (human)

hSKP1/iso:1


"An S-phase kinase-associated protein 1A isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:P63208-2

S-phase kinase-associated protein 1 isoform 2 (human)

hSKP1/iso:2


"An S-phase kinase-associated protein 1A isoform 2 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026755

S-phase kinase-associated protein 1A, initiator methionine removed form (human)

hSKP1/InitMet-


"An S-phase kinase-associated protein 1A, initiator methionine removed form in human. UniProtKB:P63208, 2-163." [PRO:DNx]


Yes
organism-modification



PR:000066666

S-phase kinase-associated protein 1 methylated 1 (human)

hSKP1/Me:1


"An S-phase kinase-associated protein 1 (human) that has been methylated on the residue at the position equivalent to Cys-120 of the amino acid sequence represented by UniProtKB:P63208. UniProtKB:P63208, Cys-120, MOD:00660." [IEDB_epitope:1015744, IEDB_epitope:1029875, PRO:DNx]


organism-modification



PR:000067768

S-phase kinase-associated protein 1 deaminated 1 (human)

hSKP1/Deam:1


"An S-phase kinase-associated protein 1 (human) that has been deaminated on the residue at the position equivalent to Asn-157 of the amino acid sequence represented by UniProtKB:P63208. UniProtKB:P63208, Asn-157, MOD:00684." [IEDB_epitope:771730, PRO:DNx]


organism-modification



PR:000082662

S-phase kinase-associated protein 1 deaminated 2 (human)

hSKP1/Deam:2


"An S-phase kinase-associated protein 1 (human) that has been deaminated on the residue at the position equivalent to Gln-152 of the amino acid sequence represented by UniProtKB:P63208. UniProtKB:P63208, Gln-152, MOD:00685." [IEDB_epitope:771731, PRO:DNx]


organism-gene



PR:Q5ZKF5

S-phase kinase-associated protein 1 (chicken)

chick-SKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of chicken." [OMA:Q5ZKF5, PRO:DNx]


organism-gene



PR:Q6PEC4

S-phase kinase-associated protein 1 (rat)

rSKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of rat." [OMA:Q6PEC4, PRO:DNx]


organism-gene



PR:Q9WTX5

S-phase kinase-associated protein 1 (mouse)

mSKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of mouse." [OMA:Q9WTX5, PRO:DNx]


organism-sequence



PR:Q9WTX5-1

S-phase kinase-associated protein 1 isoform 1 (mouse)

mSKP1/iso:1


"An S-phase kinase-associated protein 1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q9Y709

suppressor of kinetochore protein 1 (Schizosaccharomyces pombe 972h-)

Spom972h-SKP1


"An S-phase kinase-associated protein 1A that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q9Y709, PRO:DNx]


sequence



PR:000000180

S-phase kinase-associated protein 1A isoform 1

SKP1/iso:1


"An S-phase kinase-associated protein 1A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P63208-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P63208-1

S-phase kinase-associated protein 1 isoform 1 (human)

hSKP1/iso:1


"An S-phase kinase-associated protein 1A isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q9WTX5-1

S-phase kinase-associated protein 1 isoform 1 (mouse)

mSKP1/iso:1


"An S-phase kinase-associated protein 1A isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000026647

S-phase kinase-associated protein 1A isoform 1, initiator methionine removed form

SKP1/iso:1/InitMet-


"An S-phase kinase-associated protein 1A isoform 1 that has had the initiator methionine removed." [PRO:DNx]


sequence



PR:000000181

S-phase kinase-associated protein 1A isoform 2

SKP1/iso:2


"An S-phase kinase-associated protein 1A that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P63208-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P63208-2

S-phase kinase-associated protein 1 isoform 2 (human)

hSKP1/iso:2


"An S-phase kinase-associated protein 1A isoform 2 that is encoded in the genome of human." [PRO:CNA]


modification



PR:000018274

S-phase kinase-associated protein 1A, initiator methionine removed form

SKP1/InitMet-


"An S-phase kinase-associated protein 1A that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026647

S-phase kinase-associated protein 1A isoform 1, initiator methionine removed form

SKP1/iso:1/InitMet-


"An S-phase kinase-associated protein 1A isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000026755

S-phase kinase-associated protein 1A, initiator methionine removed form (human)

hSKP1/InitMet-


"An S-phase kinase-associated protein 1A, initiator methionine removed form in human. UniProtKB:P63208, 2-163." [PRO:DNx]


Yes
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SKP1 forms found in complexes   

SKP1 Component
Complexes
PR:000026755 hSKP1/InitMet- PR:000026771 SCF beta-TrCP complex (human)
PR:000026772 SCF(Skp2) complex (human)
PR:000037513 FBXO4:CRYAB:Skp1:Cul1:Rbx1 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:P63208-1 hSKP1/iso:1 enablesGO:0005515 protein binding with PR:Q13616-1 PMID:12609982
located_inGO:0019005 SCF ubiquitin ligase complex PMID:11961546; PMID:12481031; PMID:16797541; PMID:17098746
PR:Q9WTX5-1 mSKP1/iso:1 enablesGO:0005515 protein binding with PR:P62137-1 PMID:17274640
GO:0005515 protein binding with PR:P63087-1 PMID:17274640
located_inGO:0019005 SCF ubiquitin ligase complex PMID:12665572