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Protein Ontology report - TGF-beta receptor type-1
PR:000000047 - http://purl.obolibrary.org/obo/PR_000000047
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000047   
  PRO nameTGF-beta receptor type-1 
  Synonyms
PRO-Short-label: EXACT:TGFBR1
Gene-based: RELATED:ALK5 | SKR4
Other: EXACT:activin receptor-like kinase 5 | ALK-5 | ESK2 | serine/threonine-protein kinase receptor R4
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 16                                        
         Modification6                                                  Organism-Modification 15                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1788
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000047

TGF-beta receptor type-1

TGFBR1


"A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P36897

TGF-beta receptor type-1 (human)

hTGFBR1


"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897]


organism-sequence



PR:000000186

TGF-beta receptor type-1 sequence variant T200I (human)

hTGFBR1/var:T200I


"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000187

TGF-beta receptor type-1 sequence variant 10 (human)

hTGFBR1/var:10


"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000188

TGF-beta receptor type-1 sequence variant 11 (human)

hTGFBR1/var:11


"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000189

TGF-beta receptor type-1 sequence variant K232E (human)

hTGFBR1/var:K232E


"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000190

TGF-beta receptor type-1 sequence variant S241L (human)

hTGFBR1/var:S241L


"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000191

TGF-beta receptor type-1 sequence variant N267H (human)

hTGFBR1/var:N267H


"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000192

TGF-beta receptor type-1 sequence variant M318R (human)

hTGFBR1/var:M318R


"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000193

TGF-beta receptor type-1 sequence variant D400G (human)

hTGFBR1/var:D400G


"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000194

TGF-beta receptor type-1 sequence variant R487P (human)

hTGFBR1/var:R487P


"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000195

TGF-beta receptor type-1 sequence variant R487E (human)

hTGFBR1/var:R487E


"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000196

TGF-beta receptor type-1 sequence variant R487W (human)

hTGFBR1/var:R487W


"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P36897-1

TGF-beta receptor type-1 isoform 1 (human)

hTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-sequence



PR:P36897-2

TGF-beta receptor type-1 isoform h2 (human)

hTGFBR1/iso:h2


"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897]


organism-sequence



PR:P36897-3

TGF-beta receptor type-1 isoform h3 (human)

hTGFBR1/iso:h3


"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897]


organism-modification



PR:000049432

TGF-beta receptor type-1, signal peptide removed form (human)

hTGFBR1/SigPep-


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000049433

TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]


organism-modification



PR:000060809

TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)

hTGFBR1/var:G52R/SigPep-


"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]


organism-modification



PR:000060890

TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:R414*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]


organism-modification



PR:000061254

TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)

hTGFBR1/var:P83L/SigPep-


"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]


organism-modification



PR:000061891

TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)

hTGFBR1/var:P83S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]


organism-modification



PR:000063489

TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)

hTGFBR1/var:C41Y/SigPep-


"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]


organism-modification



PR:000063569

TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)

hTGFBR1/var:N45S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]


organism-modification



PR:000064307

TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:W242*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]


organism-modification



PR:000049433

TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]


organism-modification



PR:000067321

TGF-beta receptor type-1 methylated 1 (human)

hTGFBR1/Me:1


"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-474 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-474, MOD:00660." [IEDB_epitope:1046772, PRO:DNx]


organism-modification



PR:000070298

TGF-beta receptor type-1 methylated 2 (human)

hTGFBR1/Me:2


"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-461 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-461, MOD:00660." [IEDB_epitope:1039294, PRO:DNx]


organism-modification



PR:000075184

TGF-beta receptor type-1 cysteinylated 1 (human)

hTGFBR1/Cyst:1


"A TGF-beta receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-71, MOD:00765." [IEDB_epitope:2129187, IEDB_epitope:2129188, PRO:DNx]


organism-gene



PR:P80204

TGF-beta receptor type-1 (rat)

rTGFBR1


"A TGF-beta receptor type-1 that is encoded in the genome of rat." [OMA:P80204, PRO:DNx]


organism-gene



PR:Q64729

TGF-beta receptor type-1 (mouse)

mTGFBR1


"A TGF-beta receptor type-1 that is encoded in the genome of mouse." [OMA:Q64729, PRO:DNx]


organism-sequence



PR:Q64729-1

TGF-beta receptor type-1 isoform 1 (mouse)

mTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

organism-sequence



PR:Q64729-2

TGF-beta receptor type-1 isoform m2 (mouse)

mTGFBR1/iso:m2


"A TGF-beta receptor type-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64729-2." [PRO:DNx, UniProtKB:Q64729]


sequence



PR:000000185

TGF-beta receptor type-1 isoform 1

TGFBR1/iso:1


"A TGF-beta receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P36897-1

TGF-beta receptor type-1 isoform 1 (human)

hTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-sequence



PR:Q64729-1

TGF-beta receptor type-1 isoform 1 (mouse)

mTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

modification



PR:000000522

TGF-beta receptor type-1 isoform 1, signal peptide removed form

TGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]


modification



PR:000000408

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form

TGFBR1/iso:1/SigPep-/PhosRes+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000523

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1

TGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]


Yes
organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
modification



PR:000025411

TGF-beta receptor type-1 proteolytic cleavage product

TGFBR1/ClvPrd


"A TGF-beta receptor type-1 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000025932

TGF-beta receptor type-1, signal peptide removed form

TGFBR1/SigPep-


"A TGF-beta receptor type-1 that has had the signal peptide removed." [PRO:CNA]


modification



PR:000000522

TGF-beta receptor type-1 isoform 1, signal peptide removed form

TGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]


modification



PR:000000408

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form

TGFBR1/iso:1/SigPep-/PhosRes+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000523

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1

TGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]


Yes
organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000049432

TGF-beta receptor type-1, signal peptide removed form (human)

hTGFBR1/SigPep-


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000049433

TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)

hTGFBR1/SigPep-/UbiqLys+


"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]


organism-modification



PR:000060809

TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)

hTGFBR1/var:G52R/SigPep-


"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]


organism-modification



PR:000060890

TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:R414*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]


organism-modification



PR:000061254

TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)

hTGFBR1/var:P83L/SigPep-


"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]


organism-modification



PR:000061891

TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)

hTGFBR1/var:P83S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]


organism-modification



PR:000063489

TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)

hTGFBR1/var:C41Y/SigPep-


"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]


organism-modification



PR:000063569

TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)

hTGFBR1/var:N45S/SigPep-


"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]


organism-modification



PR:000064307

TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)

hTGFBR1/var:W242*/SigPep-/Phos:1


"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]


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TGFBR1 forms found in complexes   

TGFBR1 Component
Complexes
PR:000000523 TGFBR1/iso:1/SigPep-/Phos:1 PR:000025975 transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006468 protein phosphorylationPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578
PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12065756
GO:0007165 signal transductionPR:000000188 hTGFBR1/var:11 PMID:9661882
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8242743
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743
PR:P36897-1 hTGFBR1/iso:1 PMID:8242743
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000000188 hTGFBR1/var:11 PMID:9661882
GO:0007181 transforming growth factor beta receptor complex assemblyPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050466 Loeys-Dietz syndromePR:000000186 hTGFBR1/var:T200I PMID:15731757
PR:000000189 hTGFBR1/var:K232E PMID:16928994
PR:000000190 hTGFBR1/var:S241L PMID:16596670; PMID:16791849
PR:000000191 hTGFBR1/var:N267H PMID:16791849
PR:000000192 hTGFBR1/var:M318R PMID:15731757
PR:000000193 hTGFBR1/var:D400G PMID:15731757
PR:000000195 hTGFBR1/var:R487E PMID:16791849; PMID:16928994
DO:14756 vascular type Ehlers-Danlos syndromePR:000000194 hTGFBR1/var:R487P PMID:15731757; PMID:16928994
PR:000000196 hTGFBR1/var:R487W PMID:16928994

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005025 transforming growth factor beta receptor activity, type IPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578; PMID:8947046

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743
SO:0001605 amino_acid_insertionPR:000000187 hTGFBR1/var:10 PMID:9661882