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Protein Ontology report - TGF-beta receptor type-1
PR:000000047 -
http://purl.obolibrary.org/obo/PR_000000047
Protein Forms
Complex
Annotations
Ontology Information
Show OBO stanza
PRO ID
PR:000000047
PRO name
TGF-beta receptor type-1
Synonyms
PRO-Short-label
:
EXACT:
TGFBR1
Gene-based
:
RELATED:
ALK5 | SKR4
Other
:
EXACT:
activin receptor-like kinase 5 | ALK-5 | ESK2 | serine/threonine-protein kinase receptor R4
Definition
"A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA]
PRO Category
gene
Parent
PR:000000006
TGF-beta superfamily receptor type-1
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Gene
1
Organism-Gene
3
Sequence
1
Organism-Sequence
16
Modification
6
Organism-Modification
15
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
IUPHARobj:1788
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Protein Forms
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Compact View
Category
PRO ID
Name
Short Name
Definition
Ann.
Has Annotation?
Comp.
In Complex?
gene
PR:000000047
TGF-beta receptor type-1
TGFBR1
"A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA]
organism-gene
PR:P36897
TGF-beta receptor type-1 (human)
hTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897]
organism-sequence
PR:000000186
TGF-beta receptor type-1 sequence variant T200I (human)
hTGFBR1/var:T200I
"A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000187
TGF-beta receptor type-1 sequence variant 10 (human)
hTGFBR1/var:10
"A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000188
TGF-beta receptor type-1 sequence variant 11 (human)
hTGFBR1/var:11
"A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000189
TGF-beta receptor type-1 sequence variant K232E (human)
hTGFBR1/var:K232E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000190
TGF-beta receptor type-1 sequence variant S241L (human)
hTGFBR1/var:S241L
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000191
TGF-beta receptor type-1 sequence variant N267H (human)
hTGFBR1/var:N267H
"A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000192
TGF-beta receptor type-1 sequence variant M318R (human)
hTGFBR1/var:M318R
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000193
TGF-beta receptor type-1 sequence variant D400G (human)
hTGFBR1/var:D400G
"A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000194
TGF-beta receptor type-1 sequence variant R487P (human)
hTGFBR1/var:R487P
"A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000195
TGF-beta receptor type-1 sequence variant R487E (human)
hTGFBR1/var:R487E
"A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:000000196
TGF-beta receptor type-1 sequence variant R487W (human)
hTGFBR1/var:R487W
"A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN]
Yes
organism-sequence
PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-sequence
PR:P36897-2
TGF-beta receptor type-1 isoform h2 (human)
hTGFBR1/iso:h2
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897]
organism-sequence
PR:P36897-3
TGF-beta receptor type-1 isoform h3 (human)
hTGFBR1/iso:h3
"A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897]
organism-modification
PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]
organism-modification
PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]
organism-modification
PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]
organism-modification
PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]
organism-modification
PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]
organism-modification
PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]
organism-modification
PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000067321
TGF-beta receptor type-1 methylated 1 (human)
hTGFBR1/Me:1
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-474 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-474, MOD:00660." [IEDB_epitope:1046772, PRO:DNx]
organism-modification
PR:000070298
TGF-beta receptor type-1 methylated 2 (human)
hTGFBR1/Me:2
"A TGF-beta receptor type-1 (human) that has been methylated on the residue at the position equivalent to Cys-461 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-461, MOD:00660." [IEDB_epitope:1039294, PRO:DNx]
organism-modification
PR:000075184
TGF-beta receptor type-1 cysteinylated 1 (human)
hTGFBR1/Cyst:1
"A TGF-beta receptor type-1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-71 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Cys-71, MOD:00765." [IEDB_epitope:2129187, IEDB_epitope:2129188, PRO:DNx]
organism-gene
PR:P80204
TGF-beta receptor type-1 (rat)
rTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of rat." [OMA:P80204, PRO:DNx]
organism-gene
PR:Q64729
TGF-beta receptor type-1 (mouse)
mTGFBR1
"A TGF-beta receptor type-1 that is encoded in the genome of mouse." [OMA:Q64729, PRO:DNx]
organism-sequence
PR:Q64729-1
TGF-beta receptor type-1 isoform 1 (mouse)
mTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
organism-sequence
PR:Q64729-2
TGF-beta receptor type-1 isoform m2 (mouse)
mTGFBR1/iso:m2
"A TGF-beta receptor type-1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64729-2." [PRO:DNx, UniProtKB:Q64729]
sequence
PR:000000185
TGF-beta receptor type-1 isoform 1
TGFBR1/iso:1
"A TGF-beta receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
organism-sequence
PR:P36897-1
TGF-beta receptor type-1 isoform 1 (human)
hTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-sequence
PR:Q64729-1
TGF-beta receptor type-1 isoform 1 (mouse)
mTGFBR1/iso:1
"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification
PR:000000522
TGF-beta receptor type-1 isoform 1, signal peptide removed form
TGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
TGFBR1/iso:1/SigPep-/PhosRes+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]
modification
PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
modification
PR:000025411
TGF-beta receptor type-1 proteolytic cleavage product
TGFBR1/ClvPrd
"A TGF-beta receptor type-1 that has been processed by proteolytic cleavage." [PRO:DNx]
modification
PR:000025932
TGF-beta receptor type-1, signal peptide removed form
TGFBR1/SigPep-
"A TGF-beta receptor type-1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000522
TGF-beta receptor type-1 isoform 1, signal peptide removed form
TGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]
modification
PR:000000408
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form
TGFBR1/iso:1/SigPep-/PhosRes+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]
modification
PR:000000523
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1
TGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000036434
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]
Yes
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
modification
PR:000003173
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form
TGFBR1/iso:1/SigPep-/PhosUbiq+
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049432
TGF-beta receptor type-1, signal peptide removed form (human)
hTGFBR1/SigPep-
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839]
organism-modification
PR:000036432
TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)
hTGFBR1/iso:1/SigPep-
"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]
Yes
organism-modification
PR:000025959
TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hTGFBR1/iso:1/SigPep-/Phos:1
"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]
Yes
Yes
organism-modification
PR:000049433
TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human)
hTGFBR1/SigPep-/UbiqLys+
"A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461]
organism-modification
PR:000060809
TGF-beta receptor type-1 sequence variant G52R, signal peptide removed form (human)
hTGFBR1/var:G52R/SigPep-
"A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Gly-52 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Gly-52, CHEBI:29952." [PRO:DNx, Reactome:R-HSA-3656368]
organism-modification
PR:000060890
TGF-beta receptor type-1 sequence variant R414*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:R414*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Arg-413 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-413, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656508]
organism-modification
PR:000061254
TGF-beta receptor type-1 sequence variant P83L, signal peptide removed form (human)
hTGFBR1/var:P83L/SigPep-
"A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:30006." [PRO:DNx, Reactome:R-HSA-3656341]
organism-modification
PR:000061891
TGF-beta receptor type-1 sequence variant P83S, signal peptide removed form (human)
hTGFBR1/var:P83S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Pro-83 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Pro-83, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656326]
organism-modification
PR:000063489
TGF-beta receptor type-1 sequence variant C41Y, signal peptide removed form (human)
hTGFBR1/var:C41Y/SigPep-
"A TGF-beta receptor type-1 (human) that has a Tyr residue at the position equivalent to Cys-41 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Cys-41, CHEBI:46858." [PRO:DNx, Reactome:R-HSA-3656328]
organism-modification
PR:000063569
TGF-beta receptor type-1 sequence variant N45S, signal peptide removed form (human)
hTGFBR1/var:N45S/SigPep-
"A TGF-beta receptor type-1 (human) that has a Ser residue at the position equivalent to Asn-45 of the amino acid sequence represented by UniProtKB:P36897-1 and that has had the signal peptide removed. Example: UniProtKB:P36897-1, 34-503, Asn-45, CHEBI:29999." [PRO:DNx, Reactome:R-HSA-3656348]
organism-modification
PR:000064307
TGF-beta receptor type-1 sequence variant W242*, signal peptide removed phosphorylated 1 (human)
hTGFBR1/var:W242*/SigPep-/Phos:1
"A TGF-beta receptor type-1 (human) that has has been truncated after the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1, that has had the signal peptide removed, and that has been phosphorylated on the residues at the positions equivalent to Ser-165, Thr-185, Thr-186, Ser-187, Ser-189, and Ser-191. Example: UniProtKB:P36897-1, 34-241, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PRO:DNx, Reactome:R-HSA-3656504]
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TGFBR1
forms found in complexes
TGFBR1
Component
Complexes
PR:000000523
TGFBR1/iso:1/SigPep-/Phos:1
PR:000025975
transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
PR:000025961
transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (PRO-centric view)
Switch to
GO Centric View
PRO Term
GO Annotation
Evidence
PR:000000186
hTGFBR1/var:T200I
UniProtKB:P36897, Thr-200, CHEBI:30009
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000187
hTGFBR1/var:10
located_in
SO:0001605
amino_acid_insertion
PMID:9661882
PR:000000188
hTGFBR1/var:11
UniProtKB:P36897, 1-23, 27-503
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:9661882
GO:0007179
transforming growth factor beta receptor signaling pathway
PMID:9661882
PR:000000189
hTGFBR1/var:K232E
Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16928994
PR:000000190
hTGFBR1/var:S241L
Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16596670
;
PMID:16791849
PR:000000191
hTGFBR1/var:N267H
Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
PR:000000192
hTGFBR1/var:M318R
Example: UniProtKB:P36897-1, Met-318, CHEBI:29952
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000193
hTGFBR1/var:D400G
Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:15731757
PR:000000194
hTGFBR1/var:R487P
Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:15731757
;
PMID:16928994
PR:000000195
hTGFBR1/var:R487E
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972
associated_with_disease_progression
DO:0050466
Loeys-Dietz syndrome
PMID:16791849
;
PMID:16928994
PR:000000196
hTGFBR1/var:R487W
Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954
associated_with_disease_progression
DO:14756
vascular type Ehlers-Danlos syndrome
PMID:16928994
PR:000025959
hTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:7774578
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8947046
enables
GO:0005025
transforming growth factor beta receptor activity, type I
PMID:7774578
;
PMID:8947046
located_in
GO:0005886
plasma membrane
PMID:8947046
PR:000036432
hTGFBR1/iso:1/SigPep-
UniProtKB:P36897-1, 34-503
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
GO:0007181
transforming growth factor beta receptor complex assembly
PMID:8242743
located_in
GO:0005886
plasma membrane
PMID:8242743
PR:000036434
mTGFBR1/iso:1/SigPep-/Phos:1
UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047
acts_upstream_of_or_within
GO:0006468
protein phosphorylation
PMID:12065756
PR:P36897-1
hTGFBR1/iso:1
acts_upstream_of_or_within
GO:0007165
signal transduction
PMID:8242743
