back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - activin receptor type-1
PR:000000067 - http://purl.obolibrary.org/obo/PR_000000067
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000067   
  PRO nameactivin receptor type-1 
  Synonyms
PRO-Short-label: EXACT:ACVR1
Gene-based: RELATED:ACVRLK2 | Tgfb1
Other: EXACT:activin receptor type I | activin receptor-like kinase 2 | ACTR-I | ALK-2 | serine/threonine-protein kinase receptor R1 | SKR1 | TSK-7L
RELATED:TGF-B superfamily receptor type I | TSR-I
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
IUPHARobj:1785
Back to top
Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000067 activin receptor type-1
ACVR1

organism-gene


PR:P37172 activin receptor type-1 (mouse)
mACVR1

organism-sequence


PR:P37172-1 activin receptor type-1 isoform 1 (mouse)
mACVR1/iso:1

organism-modification


PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
Yes
organism-gene


PR:P80201 activin receptor type-1 (rat)
rACVR1

organism-gene


PR:Q04771 activin receptor type-1 (human)
hACVR1

organism-sequence


PR:000000200 activin receptor type-1 sequence variant R206H (human)
hACVR1/var:R206H
Yes
organism-sequence


PR:Q04771-1 activin receptor type-1 isoform 1 (human)
hACVR1/iso:1

organism-modification


PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000068633 activin receptor type-1 cysteinylated 1 (human)
hACVR1/Cyst:1

organism-gene


PR:Q90ZK6 activin receptor type-1 (chicken)
chick-ACVR1

sequence


PR:000000199 activin receptor type-1 isoform 1
ACVR1/iso:1

organism-sequence


PR:P37172-1 activin receptor type-1 isoform 1 (mouse)
mACVR1/iso:1

organism-modification


PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
Yes
organism-sequence


PR:Q04771-1 activin receptor type-1 isoform 1 (human)
hACVR1/iso:1

organism-modification


PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
Yes
modification


PR:000021938 activin receptor type-1 isoform 1, signal peptide removed form
ACVR1/iso:1/SigPep-

modification


PR:000000411 activin receptor type-1 isoform 1, signal peptide removed phosphorylated form
ACVR1/iso:1/SigPep-/PhosRes+

modification


PR:000000524 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1
ACVR1/iso:1/SigPep-/Phos:1

organism-modification


PR:000036435 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)
hACVR1/iso:1/SigPep-/Phos:1
Yes
organism-modification


PR:000036436 activin receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)
mACVR1/iso:1/SigPep-/Phos:1
Yes
Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742; PMID:8389764
PR:000036436 mACVR1/iso:1/SigPep-/Phos:1 PMID:11376112

Disease Associated GO Term
Protein Forms & Complexes
Evidence
DO:13374 fibrodysplasia ossificans progressivaPR:000000200 hACVR1/var:R206H PMID:8397373

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004675 transmembrane receptor protein serine/threonine kinase activityPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8389764
GO:0048185 activin bindingPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000000200 hACVR1/var:R206H PMID:8397373
PR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742; PMID:8397373
GO:0048179 activin receptor complexPR:000036435 hACVR1/iso:1/SigPep-/Phos:1 PMID:8242742