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Protein Ontology report - activin receptor type-1B
PR:000000068 - http://purl.obolibrary.org/obo/PR_000000068
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000068   
  PRO nameactivin receptor type-1B 
  Synonyms
PRO-Short-label: EXACT:ACVR1B
Gene-based: RELATED:ACVRLK4 | ALK4
Other: EXACT:activin receptor type IB | activin receptor-like kinase 4 | ACTR-IB | ALK-4 | serine/threonine-protein kinase receptor R2 | SKR2
  Definition"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1B gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000006 TGF-beta superfamily receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1787
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000068
activin receptor type-1B
ACVR1B
"A TGF-beta superfamily receptor type-1 that is a translation product of the human ACVR1B gene or a 1:1 ortholog thereof." [PRO:CNA]

organism-gene


PR:P36896
activin receptor type-1B (human)
hACVR1B
"An activin receptor type-1B that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36896]

organism-sequence


PR:P36896-1
activin receptor type-1B isoform 1 (human)
hACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

organism-sequence


PR:P36896-2
activin receptor type-1B isoform 2 (human)
hACVR1B/iso:2
"An activin receptor type-1B isoform 2 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:P36896-3
activin receptor type-1B isoform 3 (human)
hACVR1B/iso:3
"An activin receptor type-1B isoform 3 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-sequence


PR:P36896-4
activin receptor type-1B isoform h4 (human)
hACVR1B/iso:h4
"An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-4." [PRO:DNx, UniProtKB:P36896]

organism-sequence


PR:P36896-5
activin receptor type-1B isoform h5 (human)
hACVR1B/iso:h5
"An activin receptor type-1B (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-5." [PRO:DNx, UniProtKB:P36896]

organism-modification


PR:000046256
activin receptor type-1B, signal peptide removed form (human)
hACVR1B/SigPep-
"An activin receptor type-1B (human) that has had the signal peptide removed. UniProtKB:P36896, 24-505." [PRO:DNx, Reactome:R-HSA-205867]

organism-modification


PR:000046257
activin receptor type-1B, signal peptide removed phosphorylated 3 (human)
hACVR1B/SigPep-/Phos:3
"An activin receptor type-1B (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 187, 189, 191 and 193, and phosphothreonine at positions 188 and 206 of the amino acid sequence represented by UniProtKB:P36896. UniProtKB:P36896, 24-505, Ser-187/Ser-189/Ser-191/Ser-193, MOD:00046|Thr-188/Thr-206, MOD:00047." [PRO:DNx, Reactome:R-HSA-205780]

organism-gene


PR:P80202
activin receptor type-1B (rat)
rACVR1B
"An activin receptor type-1B that is encoded in the genome of rat." [OMA:P80202, PRO:DNx]

organism-gene


PR:Q61271
activin receptor type-1B (mouse)
mACVR1B
"An activin receptor type-1B that is encoded in the genome of mouse." [OMA:Q61271, PRO:DNx]

organism-sequence


PR:Q61271-1
activin receptor type-1B isoform 1 (mouse)
mACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

sequence


PR:000000201
activin receptor type-1B isoform 1
ACVR1B/iso:1
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-1
activin receptor type-1B isoform 1 (human)
hACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

organism-sequence


PR:Q61271-1
activin receptor type-1B isoform 1 (mouse)
mACVR1B/iso:1
"An activin receptor type-1B isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

modification


PR:000000412
activin receptor type-1B isoform 1 phosphorylated form
ACVR1B/iso:1/PhosRes+
"An activin receptor type-1B isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000525
activin receptor type-1B isoform 1 phosphorylated 1
ACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated at Ser/Thr residues in the GS-motif region (GSGSGLP and surrounding sequence) by activated activin receptor type-2, and constitutes an active receptor subunit." [PMID:8622651, PMID:8721982, PRO:CNA]

organism-modification


PR:000036437
activin receptor type-1B isoform 1 phosphorylated 1 (human)
hACVR1B/iso:1/Phos:1
"An activin receptor type-1B isoform 1 phosphorylated 1 in human." [PMID:12065756, PMID:12665502, PMID:8397373, PMID:8622651, PRO:CNA]
Yes
modification


PR:000000526
activin receptor type-1B isoform 1 phosphorylated 2
ACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated form that is phosphorylated on a Tyr residue within the protein kinase domain, as a result of platelet activation. Example: UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA, PRO:DAN]

organism-modification


PR:000036438
activin receptor type-1B isoform 1 phosphorylated 2 (human)
hACVR1B/iso:1/Phos:2
"An activin receptor type-1B isoform 1 phosphorylated 2 in human. UniProtKB:P36896-1, Tyr-380, MOD:00048." [PMID:12112843, PRO:CNA]

sequence


PR:000000202
activin receptor type-1B isoform 2
ACVR1B/iso:2
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-2 or a 1:1 ortholog thereof." [PMID:11117535, PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-2
activin receptor type-1B isoform 2 (human)
hACVR1B/iso:2
"An activin receptor type-1B isoform 2 that is encoded in the genome of human." [PRO:CNA]
Yes
sequence


PR:000000203
activin receptor type-1B isoform 3
ACVR1B/iso:3
"An activin receptor type-1B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36896-3 or a 1:1 ortholog thereof." [PMID:11117535, PRO:CNA, PRO:DAN]

organism-sequence


PR:P36896-3
activin receptor type-1B isoform 3 (human)
hACVR1B/iso:3
"An activin receptor type-1B isoform 3 that is encoded in the genome of human." [PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006468 protein phosphorylationPR:000036437 hACVR1B/iso:1/Phos:1 PMID:12065756
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:P36896-1 hACVR1B/iso:1 PMID:11069203

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0016361 activin receptor activity, type IPR:000036437 hACVR1B/iso:1/Phos:1 PMID:8622651
NOT GO:0016361 activin receptor activity, type IPR:P36896-2 hACVR1B/iso:2 PMID:11117535; PMID:8636304
PR:P36896-3 hACVR1B/iso:3 PMID:11117535; PMID:8636304
GO:0046332 SMAD bindingPR:000036437 hACVR1B/iso:1/Phos:1 PMID:12065756

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000036437 hACVR1B/iso:1/Phos:1 PMID:8397373
PR:P36896-2 hACVR1B/iso:2 PMID:11117535; PMID:8636304
PR:P36896-3 hACVR1B/iso:3 PMID:11117535; PMID:8636304
GO:0009986 cell surfacePR:000036437 hACVR1B/iso:1/Phos:1 PMID:12665502