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Protein Ontology report - activin receptor type-2A
PR:000000070 - http://purl.obolibrary.org/obo/PR_000000070
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000070   
  PRO nameactivin receptor type-2A 
  Synonyms
PRO-Short-label: EXACT:ACVR2A
Gene-based: RELATED:ACVR2
Other: EXACT:activin receptor type IIA | ACTR-IIA | ACTRIIA
  Definition"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2A gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification2                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500457;IUPHARobj:1791
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000070 activin receptor type-2A
ACVR2A
Yes
organism-gene


PR:P27037 activin receptor type-2A (human)
hACVR2A

organism-sequence


PR:P27037-1 activin receptor type-2A isoform 1 (human)
hACVR2A/iso:1

organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
organism-sequence


PR:P27037-2 activin receptor type-2A isoform h2 (human)
hACVR2A/iso:h2

organism-modification


PR:000046258 activin receptor type-2A, signal peptide removed form (human)
hACVR2A/SigPep-

organism-gene


PR:P27038 activin receptor type-2A (mouse)
mACVR2A

organism-sequence


PR:P27038-1 activin receptor type-2A isoform 1 (mouse)
mACVR2A/iso:1
Yes
organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
organism-gene


PR:P38444 activin receptor type-2A (rat)
rACVR2A

organism-gene


PR:Q90669 activin receptor type-2A (chicken)
chick-ACVR2A

sequence


PR:000000208 activin receptor type-2A isoform 1
ACVR2A/iso:1

organism-sequence


PR:P27037-1 activin receptor type-2A isoform 1 (human)
hACVR2A/iso:1

organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
organism-sequence


PR:P27038-1 activin receptor type-2A isoform 1 (mouse)
mACVR2A/iso:1
Yes
organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
modification


PR:000000414 activin receptor type-2A isoform 1 glycosylated and phosphorylated form
ACVR2A/iso:1/GlycoPhos+

modification


PR:000000528 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1
ACVR2A/iso:1/GlycoPhos:1

organism-modification


PR:000036440 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (mouse)
mACVR2A/iso:1/GlycoPhos:1
Yes
organism-modification


PR:000036441 activin receptor type-2A isoform 1 glycosylated and phosphorylated 1 (human)
hACVR2A/iso:1/GlycoPhos:1
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathwayPR:000036441 hACVR2A/iso:1/GlycoPhos:1 PMID:1314589
PR:P27038-1 mACVR2A/iso:1 PMID:8395525
GO:0008584 male gonad developmentPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:7885474
GO:0009952 anterior/posterior pattern specificationPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:10452853; PMID:16991118
GO:0032924 activin receptor signaling pathwayPR:000000070 ACVR2A PIRSF:PIRSF500457

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004675 transmembrane receptor protein serine/threonine kinase activityPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:8395525
GO:0016362 activin receptor activity, type IIPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:8395525
PR:000036441 hACVR2A/iso:1/GlycoPhos:1 PMID:12665502
GO:0019838 growth factor bindingPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:11459935; PMID:12414726
GO:0042803 protein homodimerization activityPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:8612709
GO:0048185 activin bindingPR:000000070 ACVR2A PIRSF:PIRSF500457

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005886 plasma membranePR:000036441 hACVR2A/iso:1/GlycoPhos:1 PMID:1314589
GO:0048179 activin receptor complexPR:000036440 mACVR2A/iso:1/GlycoPhos:1 PMID:8395525
PR:000036441 hACVR2A/iso:1/GlycoPhos:1 PMID:8622651