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Protein Ontology report - activin receptor type-2B
PR:000000071 - http://purl.obolibrary.org/obo/PR_000000071
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000071   
  PRO nameactivin receptor type-2B 
  Synonyms
PRO-Short-label: EXACT:ACVR2B
Other: EXACT:activin receptor type IIB | ACTR-IIB
  Definition"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000007 TGF-beta superfamily receptor type-2 with activin receptor domain
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence5                                                  Organism-Sequence 9                                        
         Modification2                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500456;IUPHARobj:1792
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000071

activin receptor type-2B

ACVR2B


"A TGF-beta superfamily receptor type-2 with activin receptor domain that is a translation product of the human ACVR2B gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P27040

activin receptor type-2B (mouse)

mACVR2B


"An activin receptor type-2B that is encoded in the genome of mouse." [OMA:P27040, PRO:DNx]


organism-sequence



PR:P27040-1

activin receptor type-2B isoform ActR-IIB1 (mouse)

mACVR2B/iso:ActR-IIB1


"An activin receptor type-2B isoform ActR-IIB1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:P27040-2

activin receptor type-2B isoform ActR-IIB2 (mouse)

mACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036442

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)

mACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:1326537, PMID:16991118, PMID:8721982, PRO:CNA]

Yes

organism-sequence



PR:P27040-3

activin receptor type-2B isoform ActR-IIB3 (mouse)

mACVR2B/iso:ActR-IIB3


"An activin receptor type-2B isoform ActR-IIB3 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:P27040-4

activin receptor type-2B isoform ActR-IIB4 (mouse)

mACVR2B/iso:ActR-IIB4


"An activin receptor type-2B isoform ActR-IIB4 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:P38445

activin receptor type-2B (rat)

rACVR2B


"An activin receptor type-2B that is encoded in the genome of rat." [OMA:P38445, PRO:DNx]


organism-gene



PR:Q13705

activin receptor type-2B (human)

hACVR2B


"An activin receptor type-2B that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13705]


organism-sequence



PR:000000214

activin receptor type-2B sequence variant R40H (human)

hACVR2B/var:R40H


"An activin receptor type-2B (human) that has a His residue at the position equivalent to Arg-40 of the amino acid sequence represented by UniProtKB:Q13705-1. This variation is within the extracellular domain. Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979." [PMID:9916847, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000215

activin receptor type-2B sequence variant V494I (human)

hACVR2B/var:V494I


"An activin receptor type-2B (human) that has an Ile residue at the position equivalent to Val-494 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009." [PMID:9916847, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q13705-1

activin receptor type-2B isoform ActR-IIB2 (human)

hACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036443

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)

hACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q13705-2

activin receptor type-2B isoform ActR-IIBtrunc (human)

hACVR2B/iso:ActR-IIB1


"An activin receptor type-2B isoform ActR-IIBtrunc that is encoded in the genome of human." [PMID:9916847, PRO:DNx, UniProtKB:Q13705]

Yes

organism-modification



PR:000046259

activin receptor type-2B, signal peptide removed form (human)

hACVR2B/SigPep-


"An activin receptor type-2B (human) that has had the signal peptide removed. UniProtKB:Q13705, 19-512." [PRO:DNx, Reactome:R-HSA-201656]


organism-modification



PR:000076998

activin receptor type-2B phosphorylated 1 (human)

hACVR2B/Phos:1


"An activin receptor type-2B (human) that has been phosphorylated on the residue at the position equivalent to Tyr-387 of the amino acid sequence represented by UniProtKB:Q13705-1. Example: UniProtKB:Q13705-1, Tyr-387, MOD:00048." [IEDB_epitope:2146498, PRO:DNx]


organism-gene



PR:Q90670

activin receptor type-2B (chicken)

chick-ACVR2B


"An activin receptor type-2B that is encoded in the genome of chicken." [OMA:Q90670, PRO:DNx]


organism-sequence



PR:Q90670-1

activin receptor type-2B isoform ActR-IIB2 (chicken)

chick-ACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of chicken." [PRO:CNA]


sequence



PR:000000209

activin receptor type-2B isoform ActR-IIB2

ACVR2B/iso:ActR-IIB2


"An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27040-2

activin receptor type-2B isoform ActR-IIB2 (mouse)

mACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036442

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)

mACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:1326537, PMID:16991118, PMID:8721982, PRO:CNA]

Yes

organism-sequence



PR:Q13705-1

activin receptor type-2B isoform ActR-IIB2 (human)

hACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036443

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)

hACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q90670-1

activin receptor type-2B isoform ActR-IIB2 (chicken)

chick-ACVR2B/iso:ActR-IIB2


"An activin receptor type-2B isoform ActR-IIB2 that is encoded in the genome of chicken." [PRO:CNA]


modification



PR:000000415

activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form

ACVR2B/iso:ActR-IIB2/GlycoPhos+


"An activin receptor type-2B isoform ActR-IIB2 that includes at least one glycosylated residue and at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000529

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1

ACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 glycosylated and phosphorylated form in which the phosphorylation occurs at Ser/Thr residues within the GS-motif, and constitutes an active activin receptor subunit." [PRO:CNA]


organism-modification



PR:000036442

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (mouse)

mACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in mouse." [PMID:10452853, PMID:11459935, PMID:12414726, PMID:1326537, PMID:16991118, PMID:8721982, PRO:CNA]

Yes

organism-modification



PR:000036443

activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 (human)

hACVR2B/iso:ActR-IIB2/NGlycoPhos:1


"An activin receptor type-2B isoform ActR-IIB2 N-glycosylated and phosphorylated 1 in human." [PMID:11279102, PMID:24337809, PMID:8161782, PMID:8622651, PMID:9872992, PRO:CNA, PRO:DAN]

Yes

sequence



PR:000000210

activin receptor type-2B isoform ActR-IIBtrunc

ACVR2B/iso:ActR-IIBtrunc


"An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13705-2 or a 1:1 ortholog thereof." [PMID:9916847, PRO:CNA, PRO:DAN]


organism-sequence



PR:Q13705-2

activin receptor type-2B isoform ActR-IIBtrunc (human)

hACVR2B/iso:ActR-IIB1


"An activin receptor type-2B isoform ActR-IIBtrunc that is encoded in the genome of human." [PMID:9916847, PRO:DNx, UniProtKB:Q13705]

Yes

sequence



PR:000000211

activin receptor type-2B isoform ActR-IIB1

ACVR2B/iso:ActR-IIB1


"An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-1 or a 1:1 ortholog thereof." [PMID:1310075, PRO:CNA, PRO:DAN]


organism-sequence



PR:P27040-1

activin receptor type-2B isoform ActR-IIB1 (mouse)

mACVR2B/iso:ActR-IIB1


"An activin receptor type-2B isoform ActR-IIB1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000212

activin receptor type-2B isoform ActR-IIB3

ACVR2B/iso:ActR-IIB3


"An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-3 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27040-3

activin receptor type-2B isoform ActR-IIB3 (mouse)

mACVR2B/iso:ActR-IIB3


"An activin receptor type-2B isoform ActR-IIB3 that is encoded in the genome of mouse." [PRO:CNA]

Yes

sequence



PR:000000213

activin receptor type-2B isoform ActR-IIB4

ACVR2B/iso:ActR-IIB4


"An activin receptor type-2B that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27040-4 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27040-4

activin receptor type-2B isoform ActR-IIB4 (mouse)

mACVR2B/iso:ActR-IIB4


"An activin receptor type-2B isoform ActR-IIB4 that is encoded in the genome of mouse." [PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000071 ACVR2B acts_upstream_of_or_withinGO:0032924 activin receptor signaling pathway PIRSF:PIRSF500456
enablesGO:0048185 activin binding PIRSF:PIRSF500456
PR:000000214 hACVR2B/var:R40H
Example: UniProtKB:Q13705-1, Arg-40, CHEBI:29979
associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000000215 hACVR2B/var:V494I
Example: UniProtKB:Q13705-1, Val-494, CHEBI:30009
associated_with_disease_progressionDO:0050545 visceral heterotaxy PMID:9916847
PR:000036442 mACVR2B/iso:ActR-IIB2/NGlycoPhos:1 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8721982
GO:0009952 anterior/posterior pattern specification PMID:10452853; PMID:16991118
GO:0032925 regulation of activin receptor signaling pathway PMID:8721982
enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:1326537
GO:0019838 growth factor binding PMID:11459935; PMID:12414726
NOT GO:0050431 transforming growth factor beta binding PMID:1326537
PR:000036443 hACVR2B/iso:ActR-IIB2/NGlycoPhos:1 enablesGO:0004675 transmembrane receptor protein serine/threonine kinase activity PMID:8622651
GO:0005515 protein binding PMID:11279102; PMID:9872992
GO:0016362 activin receptor activity, type II PMID:8622651
located_inGO:0005886 plasma membrane PMID:8161782
GO:0048179 activin receptor complex PMID:8622651
PR:P27040-1 mACVR2B/iso:ActR-IIB1 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:P27040-3 mACVR2B/iso:ActR-IIB3 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:P27040-4 mACVR2B/iso:ActR-IIB4 located_inGO:0005886 plasma membrane PMID:1310075
GO:0048179 activin receptor complex PMID:1310075
PR:Q13705-1 hACVR2B/iso:ActR-IIB2 acts_upstream_of_or_withinGO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway PMID:8161782
PR:Q13705-2 hACVR2B/iso:ActR-IIB1 enablesNOT GO:0016362 activin receptor activity, type II PMID:9916847
located_inSO:0001587 stop_gained PMID:9916847