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Protein Ontology report - activin/inhibin beta subunit
PR:000000072 - http://purl.obolibrary.org/obo/PR_000000072
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000072   
  PRO nameactivin/inhibin beta subunit 
  Definition"A TGF-beta-like cystine-knot cytokine that is the beta subunit of inhibin and activin complexes. Related to the transforming growth factor-beta, anti-Muellerian hormone, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene4                                                  Organism-Gene 14                                        
         Sequence4                                                  Organism-Sequence 8                                        
         Modification12                                                  Organism-Modification 10                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF037268
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000072

activin/inhibin beta subunit

ACVR2B


"A TGF-beta-like cystine-knot cytokine that is the beta subunit of inhibin and activin complexes. Related to the transforming growth factor-beta, anti-Muellerian hormone, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA]

Yes

gene



PR:000000216

activin/inhibin beta A chain

INHBA


"An activin/inhibin beta subunit that is a translation product of the human INHBA gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P08476

inhibin beta A chain (human)

hINHBA


"An activin/inhibin beta A chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P08476]


organism-sequence



PR:P08476-1

inhibin beta A chain isoform 1 (human)

hINHBA/iso:1


"An activin/inhibin beta A chain isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036540

activin/inhibin beta A chain isoform 1 mature form (human)

hINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in human. UniProtKB:P08476-1, 311-426." [PMID:10320815, PMID:12213882, PMID:12456957, PMID:12960042, PMID:1537316, PMID:17456790, PMID:2575216, PMID:7890768, PMID:9884026, PRO:CNA]

Yes

organism-modification



PR:000054446

inhibin beta A chain O-glycosylated 1 (human)

hINHBA/OGlyco:1


"An inhibin beta A chain (human) that has been O-glycosylated at the residue equivalent to Ser-30 of the amino acid sequence represented by UniProtKB:P08476-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P08476-1, Ser-30, MOD:00002~GNO:G43417UB." [GlyGen:P08476-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P18331

inhibin beta A chain (rat)

rINHBA


"An activin/inhibin beta A chain that is encoded in the genome of rat." [OMA:P18331, PRO:DNx]


organism-gene



PR:P27092

inhibin beta A chain (chicken)

chick-INHBA


"An activin/inhibin beta A chain that is encoded in the genome of chicken." [OMA:P27092, PRO:DNx]


organism-gene



PR:Q04998

inhibin beta A chain (mouse)

mINHBA


"An activin/inhibin beta A chain that is encoded in the genome of mouse." [OMA:Q04998, PRO:DNx]


organism-sequence



PR:Q04998-1

inhibin beta A chain isoform 1 (mouse)

mINHBA/iso:1


"An activin/inhibin beta A chain isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036539

activin/inhibin beta A chain isoform 1 mature form (mouse)

mINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in mouse. UniProtKB:Q04998-1, 309-424." [PMID:1646080, PMID:2133547, PMID:7577669, PRO:CNA]

Yes

sequence



PR:000000416

activin/inhibin beta A chain isoform 1

INHBA/iso:1


"An activin/inhibin beta A chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08476-1 or a 1:1 ortholog thereof." [PMID:15319829, PRO:CNA, PRO:DAN]


organism-sequence



PR:P08476-1

inhibin beta A chain isoform 1 (human)

hINHBA/iso:1


"An activin/inhibin beta A chain isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036540

activin/inhibin beta A chain isoform 1 mature form (human)

hINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in human. UniProtKB:P08476-1, 311-426." [PMID:10320815, PMID:12213882, PMID:12456957, PMID:12960042, PMID:1537316, PMID:17456790, PMID:2575216, PMID:7890768, PMID:9884026, PRO:CNA]

Yes

organism-sequence



PR:Q04998-1

inhibin beta A chain isoform 1 (mouse)

mINHBA/iso:1


"An activin/inhibin beta A chain isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036539

activin/inhibin beta A chain isoform 1 mature form (mouse)

mINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in mouse. UniProtKB:Q04998-1, 309-424." [PMID:1646080, PMID:2133547, PMID:7577669, PRO:CNA]

Yes

modification



PR:000021911

activin/inhibin beta A chain isoform 1, signal peptide removed form

INHBA/iso:1/SigPep-


"An activin/inhibin beta A chain isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000637

activin/inhibin beta A chain isoform 1 mature form

INHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide. It is a subunit of inhibin A and activin A complexes. Inhibin A complex is a dimer of INHA and INHBA, whereas activin A complex is a homodimer of INHBA." [PMID:15948132]


organism-modification



PR:000036539

activin/inhibin beta A chain isoform 1 mature form (mouse)

mINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in mouse. UniProtKB:Q04998-1, 309-424." [PMID:1646080, PMID:2133547, PMID:7577669, PRO:CNA]

Yes

organism-modification



PR:000036540

activin/inhibin beta A chain isoform 1 mature form (human)

hINHBA/iso:1/mature


"An activin/inhibin beta A chain isoform 1 mature form in human. UniProtKB:P08476-1, 311-426." [PMID:10320815, PMID:12213882, PMID:12456957, PMID:12960042, PMID:1537316, PMID:17456790, PMID:2575216, PMID:7890768, PMID:9884026, PRO:CNA]

Yes

modification



PR:000018295

activin/inhibin beta A chain proteolytic cleavage product

INHBA/ClvPrd


"An activin/inhibin beta A chain that has been processed by proteolytic cleavage." [PRO:DNx]


gene



PR:000000217

activin/inhibin beta B chain

INHBB


"An activin/inhibin beta subunit that is a translation product of the human INHBB gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P09529

inhibin beta B chain (human)

hINHBB


"An activin/inhibin beta B chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P09529]


organism-sequence



PR:P09529-1

inhibin beta B chain isoform 1 (human)

hINHBB/iso:1


"An activin/inhibin beta B chain isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09529]


organism-modification



PR:000036541

activin/inhibin beta B chain isoform 1 mature form (human)

hINHBB/iso:1/mature


"An activin/inhibin beta B chain isoform 1 mature form in human. UniProtKB:P09529-1, 293-407." [PMID:10320815, PMID:2575216, PMID:3122219, PMID:3754442, PRO:CNA]

Yes

organism-modification



PR:000054651

inhibin beta B chain O-glycosylated 1 (human)

hINHBB/OGlyco:1


"An inhibin beta B chain (human) that has been O-glycosylated at the residue equivalent to Ser-47 of the amino acid sequence represented by UniProtKB:P09529-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P09529-1, Ser-47, MOD:00002~GNO:G43417UB." [GlyGen:P09529-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000054652

inhibin beta B chain O-glycosylated 2 (human)

hINHBB/OGlyco:2


"An inhibin beta B chain (human) that has been O-glycosylated at the residue equivalent to Thr-35 of the amino acid sequence represented by UniProtKB:P09529-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P09529-1, Thr-35, MOD:00005~GNO:G43417UB." [GlyGen:P09529-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P17491

inhibin beta B chain (rat)

rINHBB


"An activin/inhibin beta B chain that is encoded in the genome of rat." [OMA:P17491, PRO:DNx]


organism-gene



PR:P27093

inhibin beta B chain (chicken)

chick-INHBB


"An activin/inhibin beta B chain that is encoded in the genome of chicken." [OMA:P27093, PRO:DNx]


organism-gene



PR:Q04999

inhibin beta B chain (mouse)

mINHBB


"An activin/inhibin beta B chain that is encoded in the genome of mouse." [OMA:Q04999, PRO:DNx]


organism-sequence



PR:Q04999-1

inhibin beta B chain isoform 1 (mouse)

mINHBB/iso:1


"An activin/inhibin beta B chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q04999]


sequence



PR:000000417

activin/inhibin beta B chain isoform 1

INHBB/iso:1


"An activin/inhibin beta B chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P09529-1 or a 1:1 ortholog thereof." [PMID:15319829, PRO:CNA, PRO:DAN]


organism-sequence



PR:P09529-1

inhibin beta B chain isoform 1 (human)

hINHBB/iso:1


"An activin/inhibin beta B chain isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P09529]


organism-modification



PR:000036541

activin/inhibin beta B chain isoform 1 mature form (human)

hINHBB/iso:1/mature


"An activin/inhibin beta B chain isoform 1 mature form in human. UniProtKB:P09529-1, 293-407." [PMID:10320815, PMID:2575216, PMID:3122219, PMID:3754442, PRO:CNA]

Yes

organism-sequence



PR:Q04999-1

inhibin beta B chain isoform 1 (mouse)

mINHBB/iso:1


"An activin/inhibin beta B chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:Q04999]


modification



PR:000021912

activin/inhibin beta B chain isoform 1, signal peptide removed form

INHBB/iso:1/SigPep-


"An activin/inhibin beta B chain isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000638

activin/inhibin beta B chain isoform 1 mature form

INHBB/iso:1/mature


"An activin/inhibin beta B chain isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide. It is a subunit of activin B, inhibin B and activin AB complexes. Activin B is a homodimer of INHBB. Inhibin B is a dimer of INHA and INHBB. Activin AB is a dimer of INHBA and INHBB." [PMID:3754442]


organism-modification



PR:000036541

activin/inhibin beta B chain isoform 1 mature form (human)

hINHBB/iso:1/mature


"An activin/inhibin beta B chain isoform 1 mature form in human. UniProtKB:P09529-1, 293-407." [PMID:10320815, PMID:2575216, PMID:3122219, PMID:3754442, PRO:CNA]

Yes

modification



PR:000021927

activin/inhibin beta B chain proteolytic cleavage product

INHBB/ClvPrd


"An activin/inhibin beta B chain that has been processed by proteolytic cleavage." [PRO:DAN]


gene



PR:000000218

activin/inhibin beta C chain

INHBC


"An activin/inhibin beta subunit that is a translation product of the human INHBC gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P55103

inhibin beta C chain (human)

hINHBC


"An activin/inhibin beta C chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P55103]


organism-sequence



PR:P55103-1

inhibin beta C chain isoform 1 (human)

hINHBC/iso:1


"An inhibin beta C chain isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036545

inhibin beta C chain isoform 1 mature form (human)

hINHBC/iso:1/mature


"An inhibin beta C chain isoform 1 mature form in human. UniProtKB:P55103-1, 237-352." [PMID:11134153, PMID:12960042, PMID:16627954, PMID:7826378, PRO:CNA]

Yes

organism-gene



PR:P55104

inhibin beta C chain (mouse)

mINHBC


"An activin/inhibin beta C chain that is encoded in the genome of mouse." [OMA:P55104, PRO:DNx]


organism-sequence



PR:P55104-1

inhibin beta C chain isoform 1 (mouse)

mINHBC/iso:1


"An inhibin beta C chain isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:Q9WUK5

inhibin beta C chain (rat)

rINHBC


"An activin/inhibin beta C chain that is encoded in the genome of rat." [OMA:Q9WUK5, PRO:DNx]


sequence



PR:000000444

inhibin beta C chain isoform 1

INHBC/iso:1


"An activin/inhibin beta C chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P55103-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P55103-1

inhibin beta C chain isoform 1 (human)

hINHBC/iso:1


"An inhibin beta C chain isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036545

inhibin beta C chain isoform 1 mature form (human)

hINHBC/iso:1/mature


"An inhibin beta C chain isoform 1 mature form in human. UniProtKB:P55103-1, 237-352." [PMID:11134153, PMID:12960042, PMID:16627954, PMID:7826378, PRO:CNA]

Yes

organism-sequence



PR:P55104-1

inhibin beta C chain isoform 1 (mouse)

mINHBC/iso:1


"An inhibin beta C chain isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000021916

inhibin beta C chain isoform 1, signal peptide removed form

INHBC/iso:1/SigPep-


"An inhibin beta C chain isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000642

inhibin beta C chain isoform 1 mature form

INHBC/iso:1/mature


"An inhibin beta C chain isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide. It can form heterodimers with INHBB or INHBA." [PMID:11134153]


organism-modification



PR:000036545

inhibin beta C chain isoform 1 mature form (human)

hINHBC/iso:1/mature


"An inhibin beta C chain isoform 1 mature form in human. UniProtKB:P55103-1, 237-352." [PMID:11134153, PMID:12960042, PMID:16627954, PMID:7826378, PRO:CNA]

Yes

modification



PR:000021933

activin/inhibin beta C chain proteolytic cleavage product

INHBC/ClvPrd


"An activin/inhibin beta C chain that has been processed by proteolytic cleavage." [PRO:DAN]


gene



PR:000000219

activin/inhibin beta E chain

INHBE


"An activin/inhibin beta subunit that is a translation product of the human INHBE gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O08717

inhibin beta E chain (mouse)

mINHBE


"An activin/inhibin beta E chain that is encoded in the genome of mouse." [OMA:O08717, PRO:DNx]


organism-sequence



PR:O08717-1

inhibin beta E chain isoform 1 (mouse)

mINHBE/iso:1


"An activin/inhibin beta E chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O08717]


organism-modification



PR:000036542

activin/inhibin beta E chain isoform 1 mature form (mouse)

mINHBE/iso:1/mature


"An activin/inhibin beta E chain isoform 1 mature form in mouse. UniProtKB:O08717-1, 237-350." [PMID:15863943, PRO:CNA]

Yes

organism-gene



PR:O88959

inhibin beta E chain (rat)

rINHBE


"An activin/inhibin beta E chain that is encoded in the genome of rat." [OMA:O88959, PRO:DNx]


organism-gene



PR:P58166

inhibin beta E chain (human)

hINHBE


"An activin/inhibin beta E chain that is encoded in the genome of human." [PRO:CNA, UniProtKB:P58166]


organism-sequence



PR:P58166-1

inhibin beta E chain isoform 1 (human)

hINHBE/iso:1


"An activin/inhibin beta E chain isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P58166]


organism-modification



PR:000056664

inhibin beta E chain O-glycosylated 1 (human)

hINHBE/OGlyco:1


"An inhibin beta E chain (human) that has been O-glycosylated at the residue equivalent to Thr-239 of the amino acid sequence represented by UniProtKB:P58166-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P58166-1, Thr-239, MOD:00005~GNO:G43417UB." [GlyGen:P58166-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000077206

inhibin beta E chain, mature form (human)

hINHBE/mature


"An inhibin beta E chain (human) that has had the signal peptide and propeptide removed. UniProtKB:P58166, 237-350." [PRO:DNx, Reactome:R-HSA-1449700]


sequence



PR:000000418

activin/inhibin beta E chain isoform 1

INHBE/iso:1


"An activin/inhibin beta E chain that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P58166-1 or a 1:1 ortholog thereof." [PMID:11134153, PRO:CNA, PRO:DAN]


organism-sequence



PR:O08717-1

inhibin beta E chain isoform 1 (mouse)

mINHBE/iso:1


"An activin/inhibin beta E chain isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O08717]


organism-modification



PR:000036542

activin/inhibin beta E chain isoform 1 mature form (mouse)

mINHBE/iso:1/mature


"An activin/inhibin beta E chain isoform 1 mature form in mouse. UniProtKB:O08717-1, 237-350." [PMID:15863943, PRO:CNA]

Yes

organism-sequence



PR:P58166-1

inhibin beta E chain isoform 1 (human)

hINHBE/iso:1


"An activin/inhibin beta E chain isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P58166]


modification



PR:000021913

activin/inhibin beta E chain isoform 1, signal peptide removed form

INHBE/iso:1/SigPep-


"An activin/inhibin beta E chain isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000639

activin/inhibin beta E chain isoform 1 mature form

INHBE/iso:1/mature


"An activin/inhibin beta E chain isoform 1, signal peptide removed form that has been processed by subsequent removal of the propeptide." [PMID:1286533, PRO:CNA]


organism-modification



PR:000036542

activin/inhibin beta E chain isoform 1 mature form (mouse)

mINHBE/iso:1/mature


"An activin/inhibin beta E chain isoform 1 mature form in mouse. UniProtKB:O08717-1, 237-350." [PMID:15863943, PRO:CNA]

Yes

modification



PR:000021928

activin/inhibin beta E chain proteolytic cleavage product

INHBE/ClvPrd


"An activin/inhibin beta E chain that has been processed by proteolytic cleavage." [PRO:DAN]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0001541 ovarian follicle developmentPR:P08476-1 hINHBA/iso:1 PMID:9166111
GO:0007165 signal transductionPR:P08476-1 hINHBA/iso:1 PMID:3267209
GO:0007166 cell surface receptor signaling pathwayPR:000036540 hINHBA/iso:1/mature PMID:12456957
GO:0007267 cell-cell signalingPR:000036540 hINHBA/iso:1/mature PMID:12456957
PR:P08476-1 hINHBA/iso:1 PMID:12456957
GO:0007399 nervous system developmentPR:P08476-1 hINHBA/iso:1 PMID:10320815
GO:0009605 response to external stimulusPR:000036540 hINHBA/iso:1/mature PMID:10320815
GO:0030154 cell differentiationPR:000036540 hINHBA/iso:1/mature PMID:12456957
PR:000036541 hINHBB/iso:1/mature PMID:10320815
PR:P08476-1 hINHBA/iso:1 PMID:12456957
GO:0032925 regulation of activin receptor signaling pathwayPR:000036540 hINHBA/iso:1/mature PMID:9884026
GO:0032926 negative regulation of activin receptor signaling pathwayPR:000036545 hINHBC/iso:1/mature PMID:12960042; PMID:16627954
GO:0043065 positive regulation of apoptotic processPR:000036542 mINHBE/iso:1/mature PMID:15863943
GO:0046880 regulation of follicle-stimulating hormone secretionPR:000036541 hINHBB/iso:1/mature PMID:3122219
GO:0050789 regulation of biological processPR:P08476-1 hINHBA/iso:1 PMID:12419948; PMID:3122219

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005102 signaling receptor bindingPR:000000072 ACVR2B PIRSF:PIRSF037268
contributes_to GO:0005102 signaling receptor bindingPR:000036539 mINHBA/iso:1/mature PMID:1646080; PMID:7577669
PR:000036540 hINHBA/iso:1/mature PMID:7890768
PR:000036541 hINHBB/iso:1/mature PMID:3754442
contributes_to GO:0005160 transforming growth factor beta receptor bindingPR:000036545 hINHBC/iso:1/mature PMID:7826378
GO:0005515 protein bindingPR:000036541 hINHBB/iso:1/mature PMID:2575216
GO:0046983 protein dimerization activityPR:000036539 mINHBA/iso:1/mature PMID:2133547
PR:000036540 hINHBA/iso:1/mature PMID:1537316
PR:000036541 hINHBB/iso:1/mature PMID:2575216
PR:000036542 mINHBE/iso:1/mature PMID:15863943
PR:000036545 hINHBC/iso:1/mature PMID:11134153

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005576 extracellular regionPR:000036540 hINHBA/iso:1/mature PMID:12213882; PMID:2575216
PR:000036541 hINHBB/iso:1/mature PMID:3122219
PR:000036542 mINHBE/iso:1/mature PMID:15863943
PR:000036545 hINHBC/iso:1/mature PMID:16627954; PMID:7826378
GO:0032991 protein-containing complexPR:000036540 hINHBA/iso:1/mature PMID:12960042
PR:000036545 hINHBC/iso:1/mature PMID:11134153; PMID:12960042
GO:0043509 activin A complexPR:000036540 hINHBA/iso:1/mature PMID:7890768
GO:0043512 inhibin A complexPR:000036540 hINHBA/iso:1/mature PMID:17456790; PMID:7890768
GO:0048180 activin complexPR:000036542 mINHBE/iso:1/mature PMID:15863943