back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

|   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - Muellerian-inhibiting factor
PR:000000073 - http://purl.obolibrary.org/obo/PR_000000073
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000073   
  PRO nameMuellerian-inhibiting factor 
  Synonyms
PRO-Short-label: EXACT:AMH
Gene-based: RELATED:MIF
Other: EXACT:anti-Muellerian hormone | Muellerian-inhibiting substance
RELATED:MIS
  Definition"A TGF-beta-like cystine-knot cytokine that is a translation product of the human AMH gene or a 1:1 ortholog thereof. Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000008 TGF-beta-like cystine-knot cytokine
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 10                                        
         Modification5                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Related Cross References

  Db identifiers
PIRSF:PIRSF037270
Back to top
Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000073

Muellerian-inhibiting factor

AMH


"A TGF-beta-like cystine-knot cytokine that is a translation product of the human AMH gene or a 1:1 ortholog thereof. Related to the transforming growth factor-beta, activin/inhibin, and bone morphogenic protein families which are all involved in the regulation of cell growth and differentiation." [PRO:CNA]

Yes

organism-gene



PR:P03971

Muellerian-inhibiting factor (human)

hAMH


"A Muellerian-inhibiting factor that is encoded in the genome of human." [PRO:CNA, UniProtKB:P03971]


organism-sequence



PR:000000221

Muellerian-inhibiting factor sequence variant V12G (human)

hAMH/var:V12G


"A Muellerian-inhibiting factor (human) that has a Gly residue at the position equivalent to Val-12 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-12, CHEBI:29947." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000222

Muellerian-inhibiting factor sequence variant L70P (human)

hAMH/var:L70P


"A Muellerian-inhibiting factor (human) that has a Pro residue at the position equivalent to Leu-70 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Leu-70, CHEBI:50342." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000223

Muellerian-inhibiting factor sequence variant G101V (human)

hAMH/var:G101V


"A Muellerian-inhibiting factor (human) that has a Val residue at the position equivalent to Gly-101 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Gly-101, CHEBI:30015." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000224

Muellerian-inhibiting factor sequence variant R123W (human)

hAMH/var:R123W


"A Muellerian-inhibiting factor (human) that has a Trp residue at the position equivalent to Arg-123 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-123, CHEBI:29954." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000225

Muellerian-inhibiting factor sequence variant Y167C (human)

hAMH/var:Y167C


"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Tyr-167 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Tyr-167, CHEBI:29950." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000226

Muellerian-inhibiting factor sequence variant R194C (human)

hAMH/var:R194C


"A Muellerian-inhibiting factor (human) that has a Cys residue at the position equivalent to Arg-194 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Arg-194, CHEBI:29950." [PMID:14673134, PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:000000227

Muellerian-inhibiting factor sequence variant V477A (human)

hAMH/var:V477A


"A Muellerian-inhibiting factor (human) that has an Ala residue at the position equivalent to Val-477 of the amino acid sequence represented by UniProtKB:P03971. UniProtKB:P03971, Val-477, CHEBI:46217." [PMID:8162013, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P03971-1

Muellerian-inhibiting factor isoform 1 (human)

hAMH/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036605

Muellerian-inhibiting factor isoform 1 mature form (human)

hAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in human. UniProtKB:P03971-1, 451-560." [PMID:14673134, PRO:CNA]

Yes

organism-modification



PR:000036444

Muellerian-inhibiting factor isoform 1 mature N-glycosylated 2 (human)

hAMH/iso:1/mature/NGlyco:2


"A Muellerian-inhibiting factor isoform 1 mature glycosylated 2 in human. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000053160

Muellerian-inhibiting factor O-glycosylated 1 (human)

hAMH/OGlyco:1


"A Muellerian-inhibiting factor (human) that has been O-glycosylated at the residue equivalent to Thr-353 of the amino acid sequence represented by UniProtKB:P03971-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P03971-1, Thr-353, MOD:00005~GNO:G43417UB." [GlyGen:P03971-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000053161

Muellerian-inhibiting factor O-glycosylated 2 (human)

hAMH/OGlyco:2


"A Muellerian-inhibiting factor (human) that has been O-glycosylated at the residue equivalent to Thr-367 of the amino acid sequence represented by UniProtKB:P03971-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P03971-1, Thr-367, MOD:00005~GNO:G43417UB." [GlyGen:P03971-1, PMID:30459171, PRO:DNx]


organism-gene



PR:P27106

Muellerian-inhibiting factor (mouse)

mAmh


"A Muellerian-inhibiting factor that is encoded in the genome of mouse." [OMA:P27106, PRO:DAN]


organism-sequence



PR:P27106-1

Muellerian-inhibiting factor isoform 1 (mouse)

mAmh/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-gene



PR:P49000

Muellerian-inhibiting factor (rat)

rAMH


"A Muellerian-inhibiting factor that is encoded in the genome of rat." [OMA:P49000, PRO:DNx]


organism-sequence



PR:P49000-1

Muellerian-inhibiting factor isoform 1 (rat)

rAMH/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-modification



PR:000036606

Muellerian-inhibiting factor isoform 1 mature form (rat)

rAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in rat. UniProtKB:P49000-1, 446-553." [PMID:8755541, PRO:CNA]

Yes

sequence



PR:000000220

Muellerian-inhibiting factor isoform 1

AMH/iso:1


"A Muellerian-inhibiting factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27106-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P03971-1

Muellerian-inhibiting factor isoform 1 (human)

hAMH/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036605

Muellerian-inhibiting factor isoform 1 mature form (human)

hAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in human. UniProtKB:P03971-1, 451-560." [PMID:14673134, PRO:CNA]

Yes

organism-modification



PR:000036444

Muellerian-inhibiting factor isoform 1 mature N-glycosylated 2 (human)

hAMH/iso:1/mature/NGlyco:2


"A Muellerian-inhibiting factor isoform 1 mature glycosylated 2 in human. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:P27106-1

Muellerian-inhibiting factor isoform 1 (mouse)

mAmh/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P49000-1

Muellerian-inhibiting factor isoform 1 (rat)

rAMH/iso:1


"A Muellerian-inhibiting factor isoform 1 that is encoded in the genome of rat." [PRO:CNA]


organism-modification



PR:000036606

Muellerian-inhibiting factor isoform 1 mature form (rat)

rAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in rat. UniProtKB:P49000-1, 446-553." [PMID:8755541, PRO:CNA]

Yes

modification



PR:000021919

Muellerian-inhibiting factor isoform 1, signal peptide removed form

AMH/iso:1/SigPep-


"A Muellerian-inhibiting factor isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000001277

Muellerian-inhibiting factor isoform 1 mature form

AMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1, signal peptide removed form that has had the propeptide removed." [PMID:8755541, PRO:CNA]


modification



PR:000000419

Muellerian-inhibiting factor isoform 1 mature glycosylated form

AMH/iso:1/mature/Glyco+


"A Muellerian-inhibiting factor isoform 1 mature form that includes at least one glycosylated residue." [PRO:CNA, PRO:DAN]


modification



PR:000000534

Muellerian-inhibiting factor isoform 1 mature glycosylated 2

complex:AMH/iso:1/mature/Glyco:2


"A Muellerian-inhibiting factor isoform 1 mature glycosylated form that has the cleaved N-terminal propeptide joined with the C-terminal 'main' chain via disulfide bonds." [PMID:14673134, PRO:CNA, PRO:DAN]


organism-modification



PR:000036444

Muellerian-inhibiting factor isoform 1 mature N-glycosylated 2 (human)

hAMH/iso:1/mature/NGlyco:2


"A Muellerian-inhibiting factor isoform 1 mature glycosylated 2 in human. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036605

Muellerian-inhibiting factor isoform 1 mature form (human)

hAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in human. UniProtKB:P03971-1, 451-560." [PMID:14673134, PRO:CNA]

Yes

organism-modification



PR:000036444

Muellerian-inhibiting factor isoform 1 mature N-glycosylated 2 (human)

hAMH/iso:1/mature/NGlyco:2


"A Muellerian-inhibiting factor isoform 1 mature glycosylated 2 in human. UniProtKB:P03971-1, 26-450, 451-560, MOD:00160." [PMID:12834017, PMID:14673134, PMID:14750901, PMID:3754790, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036606

Muellerian-inhibiting factor isoform 1 mature form (rat)

rAMH/iso:1/mature


"A Muellerian-inhibiting factor isoform 1 mature form in rat. UniProtKB:P49000-1, 446-553." [PMID:8755541, PRO:CNA]

Yes

modification



PR:000001276

Muellerian-inhibiting factor proteolytic cleavage product

AMH/ClvPrd


"A Muellerian-inhibiting factor that has been processed by proteolytic cleavage." [PRO:DAN]


Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0001880 Mullerian duct regressionPR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:14750901; PMID:3754790
PR:P03971-1 hAMH/iso:1 PMID:14750901
GO:0007267 cell-cell signalingPR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:3754790
GO:0007548 sex differentiationPR:000000073 AMH PIRSF:PIRSF037270
PR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:12834017
PR:P03971-1 hAMH/iso:1 PMID:12834017
GO:0008406 gonad developmentPR:000000073 AMH PIRSF:PIRSF037270

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:0050791 persistent Mullerian duct syndromePR:000000221 hAMH/var:V12G PMID:8162013
PR:000000222 hAMH/var:L70P PMID:8162013
PR:000000223 hAMH/var:G101V PMID:8162013
PR:000000224 hAMH/var:R123W PMID:8162013
PR:000000225 hAMH/var:Y167C PMID:8162013
PR:000000226 hAMH/var:R194C PMID:14673134; PMID:8162013

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005102 signaling receptor bindingPR:000000073 AMH PIRSF:PIRSF037270
PR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:14750901
GO:0005179 hormone activityPR:000000073 AMH PIRSF:PIRSF037270
PR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:14750901
GO:0046983 protein dimerization activityPR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:14673134
PR:000036605 hAMH/iso:1/mature PMID:14673134

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005576 extracellular regionPR:000036444 hAMH/iso:1/mature/NGlyco:2 PMID:14750901; PMID:3754790
PR:000036606 rAMH/iso:1/mature PMID:8755541
SO:0001555 decreased_translational_product_levelPR:000000226 hAMH/var:R194C PMID:14673134; PMID:8162013
SO:0001558 polypeptide_localization_variantPR:000000226 hAMH/var:R194C PMID:14673134; PMID:8162013
PR:000000227 hAMH/var:V477A PMID:8162013