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Protein Ontology report - CREB-binding protein
PR:000000090 - http://purl.obolibrary.org/obo/PR_000000090
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000090   
  PRO nameCREB-binding protein 
  Synonyms
PRO-Short-label: EXACT:CREBBP
Gene-based: RELATED:CBP
Other: EXACT:protein lactyltransferas CREBBP | protein-lysine acetyltransferase CREBBP
  Definition"A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000031 transcription adapter with TAZ, KIX and bromo-domains
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification4                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2734
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000090 CREB-binding protein
CREBBP

organism-gene


PR:P45481 histone lysine acetyltransferase CREBBP (mouse)
mCREBBP

organism-sequence


PR:P45481-1 CREB-binding protein isoform 1 (mouse)
mCREBBP/iso:1
Yes
organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
organism-modification


PR:000077765 histone lysine acetyltransferase CREBBP cysteinylated 1 (mouse)
mCREBBP/Cyst:1

organism-gene


PR:Q6JHU9 histone lysine acetyltransferase CREBBP (rat)
rCREBBP

organism-gene


PR:Q92793 CREB-binding protein (human)
hCREBBP

organism-sequence


PR:000000266 CREB-binding protein sequence variant R1378P (human)
hCREBBP/var:R1378P
Yes
organism-sequence


PR:Q92793-1 CREB-binding protein isoform 1 (human)
hCREBBP/iso:1
Yes
organism-sequence


PR:Q92793-2 CREB-binding protein isoform h2 (human)
hCREBBP/iso:h2

organism-modification


PR:000064816 CREB-binding protein sumoylated 1 (human)
hCREBBP/Sumo:1

organism-modification


PR:000067783 CREB-binding protein phosphorylated 1 (human)
hCREBBP/Phos:1

organism-modification


PR:000080126 CREB-binding protein phosphorylated 2 (human)
hCREBBP/Phos:2

sequence


PR:000000265 CREB-binding protein isoform 1
CREBBP/iso:1

organism-sequence


PR:P45481-1 CREB-binding protein isoform 1 (mouse)
mCREBBP/iso:1
Yes
organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
organism-sequence


PR:Q92793-1 CREB-binding protein isoform 1 (human)
hCREBBP/iso:1
Yes
modification


PR:000000426 CREB-binding protein isoform 1 methylated form
CREBBP/iso:1/MeRes+

modification


PR:000000541 CREB-binding protein isoform 1 methylated 1
CREBBP/iso:1/Me:1

organism-modification


PR:000036453 CREB-binding protein isoform 1 methylated 1 (mouse)
mCREBBP/iso:1/Me:1
Yes
modification


PR:000026573 CREB-binding protein isoform 1, initiator methionine removed form
CREBBP/iso:1/InitMet-

modification


PR:000018275 CREB-binding protein, initiator methionine removed form
CREBBP/InitMet-

modification


PR:000026573 CREB-binding protein isoform 1, initiator methionine removed form
CREBBP/iso:1/InitMet-

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000266 hCREBBP/var:R1378P
Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342		 associated_with_disease_progressionDO:1933 Rubinstein-Taybi syndrome PMID:11331617
enablesNOT GO:0004402 histone acetyltransferase activity PMID:11331617
located_inSO:0001559 polypeptide_loss_of_function_variant PMID:11331617
PR:000036453 mCREBBP/iso:1/Me:1
UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658		 located_inNOT GO:0000123 histone acetyltransferase complex PMID:11701890
GO:0005634 nucleus PMID:11701890
PR:P45481-1 mCREBBP/iso:1 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:15464984
enablesGO:0004402 histone acetyltransferase activity PMID:11867645
GO:0005515 protein binding with PR:P88946 orfK9 (tax435895) PMID:12496368
GO:0005515 protein binding with PR:Q60749 GAP-associated tyrosine phosphoprotein p62 (mouse) PMID:12496368
GO:0005515 protein binding PMID:12496368
GO:0016407 acetyltransferase activity PMID:12496368
located_inGO:0005634 nucleus PMID:11963968; PMID:12496368
PR:Q92793-1 hCREBBP/iso:1 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12169688; PMID:7913207
GO:0045893 positive regulation of DNA-templated transcription PMID:11742995
enablesGO:0003713 transcription coactivator activity PMID:10733899; PMID:10893273; PMID:12169688; PMID:12586840; PMID:8684459
GO:0004402 histone acetyltransferase activity PMID:11742995
GO:0005515 protein binding with PR:P42858 HD PMID:11799127
GO:0005515 protein binding with PR:P55209 hNAP1L1 PMID:11799127
GO:0005515 protein binding with PR:Q04206 hRELA PMID:11799127
GO:0005515 protein binding with PR:Q14686 activating signal cointegrator 2 (human) PMID:11799127
GO:0005515 protein binding with PR:Q16665 ARNT-interacting protein (human) PMID:11799127
GO:0005515 protein binding with PR:Q92793 CBP PMID:11799127
GO:0005515 protein binding with PR:Q99967-1 PMID:11799127
GO:0005515 protein binding with PR:Q9UER7 BING2 PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0016407 acetyltransferase activity PMID:11742995
located_inGO:0000123 histone acetyltransferase complex PMID:9742083
GO:0005634 nucleus PMID:7913207