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Protein Ontology report - CREB-binding protein
PR:000000090 - http://purl.obolibrary.org/obo/PR_000000090
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000090   
  PRO nameCREB-binding protein 
  Synonyms
PRO-Short-label: EXACT:CREBBP
Gene-based: RELATED:CBP
Other: EXACT:protein lactyltransferas CREBBP | protein-lysine acetyltransferase CREBBP
  Definition"A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000031 transcription adapter with TAZ, KIX and bromo-domains
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 4                                        
         Modification4                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:2734
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000090

CREB-binding protein

CREBBP


"A transcription adapter with TAZ, KIX and bromo-domains that is a translation product of the human CREBBP gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P45481

histone lysine acetyltransferase CREBBP (mouse)

mCREBBP


"A CREB-binding protein that is encoded in the genome of mouse." [OMA:P45481, PMID:8413673]


organism-sequence



PR:P45481-1

CREB-binding protein isoform 1 (mouse)

mCREBBP/iso:1


"A CREB-binding protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1


"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

organism-modification



PR:000077765

histone lysine acetyltransferase CREBBP cysteinylated 1 (mouse)

mCREBBP/Cyst:1


"A histone lysine acetyltransferase CREBBP (mouse) that has been cysteinylated on the residue at the position equivalent to Cys-1179 of the amino acid sequence represented by UniProtKB:P45481. UniProtKB:P45481, Cys-1179, MOD:00765." [IEDB_epitope:2106235, PRO:DNx]


organism-gene



PR:Q6JHU9

histone lysine acetyltransferase CREBBP (rat)

rCREBBP


"A CREB-binding protein that is encoded in the genome of rat." [OMA:Q6JHU9, PRO:DNx]


organism-gene



PR:Q92793

CREB-binding protein (human)

hCREBBP


"A CREB-binding protein that is encoded in the genome of human." [PMID:11331617]


organism-sequence



PR:000000266

CREB-binding protein sequence variant R1378P (human)

hCREBBP/var:R1378P


"A CREB-binding protein (human) that has a Pro residue at the position equivalent to Arg-1378 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342." [PMID:11331617, PRO:CNA, PRO:DAN]

Yes

organism-sequence



PR:Q92793-1

CREB-binding protein isoform 1 (human)

hCREBBP/iso:1


"A CREB-binding protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:Q92793-2

CREB-binding protein isoform h2 (human)

hCREBBP/iso:h2


"A CREB-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92793-2." [PRO:DNx, UniProtKB:Q92793]


organism-modification



PR:000064816

CREB-binding protein sumoylated 1 (human)

hCREBBP/Sumo:1


"A CREB-binding protein (human) that has been sumoylated on the residues at the positions equivalent to Lys-998, Lys-1033, and Lys-1056 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Lys-998/Lys-1033/Lys-1056, MOD:01149." [PRO:DNx, Reactome:R-HSA-3927877]


organism-modification



PR:000067783

CREB-binding protein phosphorylated 1 (human)

hCREBBP/Phos:1


"A CREB-binding protein (human) that has been phosphorylated on the residue at the position equivalent to Ser-868 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Ser-868, MOD:00046." [IEDB_epitope:1372378, PRO:DNx]


organism-modification



PR:000080126

CREB-binding protein phosphorylated 2 (human)

hCREBBP/Phos:2


"A CREB-binding protein (human) that has been phosphorylated on the residue at the position equivalent to Tyr-1539 of the amino acid sequence represented by UniProtKB:Q92793-1. Example: UniProtKB:Q92793-1, Tyr-1539, MOD:00048." [IEDB_epitope:2149301, PRO:DNx]


sequence



PR:000000265

CREB-binding protein isoform 1

CREBBP/iso:1


"A CREB-binding protein that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q92793-1 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:P45481-1

CREB-binding protein isoform 1 (mouse)

mCREBBP/iso:1


"A CREB-binding protein isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1


"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

organism-sequence



PR:Q92793-1

CREB-binding protein isoform 1 (human)

hCREBBP/iso:1


"A CREB-binding protein isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

modification



PR:000000426

CREB-binding protein isoform 1 methylated form

CREBBP/iso:1/MeRes+


"A CREB-binding protein isoform 1 that includes at least one methylated residue." [PRO:CNA]


modification



PR:000000541

CREB-binding protein isoform 1 methylated 1

CREBBP/iso:1/Me:1


"A CREB-binding protein isoform 1 methylated form that has been methylated at arginine residues within the KIX domain. Example: UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890]


organism-modification



PR:000036453

CREB-binding protein isoform 1 methylated 1 (mouse)

mCREBBP/iso:1/Me:1


"A CREB-binding protein isoform 1 methylated 1 in mouse. UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658." [PMID:11701890, PRO:CNA]

Yes

modification



PR:000026573

CREB-binding protein isoform 1, initiator methionine removed form

CREBBP/iso:1/InitMet-


"A CREB-binding protein isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018275

CREB-binding protein, initiator methionine removed form

CREBBP/InitMet-


"A CREB-binding protein that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026573

CREB-binding protein isoform 1, initiator methionine removed form

CREBBP/iso:1/InitMet-


"A CREB-binding protein isoform 1 that has had the initiator methionine removed." [PRO:DNx]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000266 hCREBBP/var:R1378P
Example: UniProtKB:Q92793-1, Arg-1378, CHEBI:50342
associated_with_disease_progressionDO:1933 Rubinstein-Taybi syndrome PMID:11331617
enablesNOT GO:0004402 histone acetyltransferase activity PMID:11331617
located_inSO:0001559 polypeptide_loss_of_function_variant PMID:11331617
PR:000036453 mCREBBP/iso:1/Me:1
UniProtKB:P45481-1, Arg-600/Arg-624, MOD:00658
located_inNOT GO:0000123 histone acetyltransferase complex PMID:11701890
GO:0005634 nucleus PMID:11701890
PR:P45481-1 mCREBBP/iso:1 acts_upstream_of_or_withinGO:0045893 positive regulation of DNA-templated transcription PMID:15464984
enablesGO:0004402 histone acetyltransferase activity PMID:11867645
GO:0005515 protein binding with PR:P88946 orfK9 (tax435895) PMID:12496368
GO:0005515 protein binding with PR:Q60749 GAP-associated tyrosine phosphoprotein p62 (mouse) PMID:12496368
GO:0005515 protein binding PMID:12496368
GO:0016407 acetyltransferase activity PMID:12496368
located_inGO:0005634 nucleus PMID:11963968; PMID:12496368
PR:Q92793-1 hCREBBP/iso:1 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:12169688; PMID:7913207
GO:0045893 positive regulation of DNA-templated transcription PMID:11742995
enablesGO:0003713 transcription coactivator activity PMID:10733899; PMID:10893273; PMID:12169688; PMID:12586840; PMID:8684459
GO:0004402 histone acetyltransferase activity PMID:11742995
GO:0005515 protein binding with PR:P42858 HD PMID:11799127
GO:0005515 protein binding with PR:P55209 hNAP1L1 PMID:11799127
GO:0005515 protein binding with PR:Q04206 hRELA PMID:11799127
GO:0005515 protein binding with PR:Q14686 activating signal cointegrator 2 (human) PMID:11799127
GO:0005515 protein binding with PR:Q16665 ARNT-interacting protein (human) PMID:11799127
GO:0005515 protein binding with PR:Q92793 CBP PMID:11799127
GO:0005515 protein binding with PR:Q99967-1 PMID:11799127
GO:0005515 protein binding with PR:Q9UER7 BING2 PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0005515 protein binding PMID:11799127
GO:0016407 acetyltransferase activity PMID:11742995
located_inGO:0000123 histone acetyltransferase complex PMID:9742083
GO:0005634 nucleus PMID:7913207