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Protein Ontology report - tumor necrosis factor ligand superfamily member 6
PR:000000095 - http://purl.obolibrary.org/obo/PR_000000095
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000095   
  PRO nametumor necrosis factor ligand superfamily member 6 
  Synonyms
PRO-Short-label: EXACT:FASLG
Gene-based: RELATED:APT1LG1 | CD95L | FASL | gld | TNFSF6
Other: EXACT:apoptosis antigen ligand | APTL | CD178 | CD95 ligand | CD95-L | fas antigen ligand | fas ligand | fas ligand, TNF-like
  Definition"A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000033 tumor necrosis factor, TNF-like
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification4                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000095 tumor necrosis factor ligand superfamily member 6
FASLG
Yes
organism-gene


PR:P36940 tumor necrosis factor ligand superfamily member 6 (rat)
rFASLG

organism-gene


PR:P41047 tumor necrosis factor ligand superfamily member 6 (mouse)
mFASLG

organism-sequence


PR:P41047-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)
mFASLG/iso:FasL
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P41047-2 tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)
mFASLG/iso:FasLS
Yes
organism-gene


PR:P48023 tumor necrosis factor ligand superfamily member 6 (human)
hFASLG

organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
organism-sequence


PR:P48023-2 tumor necrosis factor ligand superfamily member 6 isoform h2 (human)
hFASLG/iso:h2

sequence


PR:000000276 tumor necrosis factor ligand superfamily member 6 isoform FasL
FASLG/iso:FasL

sequence


PR:000000278 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L
FASLG/iso:FasL/var:F273L

organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P41047-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)
mFASLG/iso:FasL
Yes
organism-sequence


PR:000036783 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)
mFASLG/iso:FasL/var:F273L
Yes
organism-sequence


PR:P48023-1 tumor necrosis factor ligand superfamily member 6 isoform FasL (human)
hFASLG/iso:FasL
Yes
organism-sequence


PR:000036782 tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)
hFASLG/iso:FasL/var:F273L
Yes
organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
modification


PR:000000432 tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form
FASLG/iso:FasL/GlycoRes+

modification


PR:000000546 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1
FASLG/iso:FasL/NGlyco:1

organism-modification


PR:000036458 tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)
hFASLG/iso:FasL/NGlyco:1
Yes
modification


PR:000000547 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form
FASLG/iso:FasL/Clv:soluble

organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
sequence


PR:000000277 tumor necrosis factor ligand superfamily member 6 isoform FasLS
FASLG/iso:FasLS

organism-sequence


PR:P41047-2 tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)
mFASLG/iso:FasLS
Yes
modification


PR:000018277 tumor necrosis factor ligand superfamily member 6 proteolytic cleavage product
FASLG/ClvPrd

modification


PR:000000547 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form
FASLG/iso:FasL/Clv:soluble

organism-modification


PR:000036459 tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)
hFASLG/iso:FasL/Clv:soluble
Yes
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000095 FASLG acts_upstream_of_or_withinGO:0007267 cell-cell signaling PANTHER:PTHR11471
PR:000036458 hFASLG/iso:FasL/NGlyco:1
UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160		 acts_upstream_of_or_withinGO:0097190 apoptotic signaling pathway PMID:9405425
enablesGO:0005102 signaling receptor binding PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble
UniProtKB:P48023-1, 130-281		 acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:9396774
enablesGO:0005102 signaling receptor binding PMID:9405425
GO:0042802 identical protein binding PMID:7536672; PMID:9228058; PMID:9405425
located_inGO:0005615 extracellular space PMID:7536672
PR:000036782 hFASLG/iso:FasL/var:F273L
UniProtKB:P48023-1, Phe-275, CHEBI:30006		 enablesaltered GO:0005102 signaling receptor binding with PR:P25445 apo-1 antigen (human) PMID:9405425
GO:0042802 identical protein binding PMID:9405425
located_inGO:0009986 cell surface PMID:9405425
PR:000036783 mFASLG/iso:FasL/var:F273L
UniProtKB:P41047-1, Phe-273, CHEBI:30006		 associated_with_disease_progressionDO:6688 autoimmune lymphoproliferative syndrome PMID:7495745
located_inGO:0005886 plasma membrane PMID:7495745
PR:P41047-1 mFASLG/iso:FasL acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:16365167
GO:0043066 negative regulation of apoptotic process MGI_ref:76989; PMID:7595210
GO:0097190 apoptotic signaling pathway PMID:15039234
located_inGO:0005886 plasma membrane PMID:16973387
GO:0009986 cell surface PMID:16973387
PR:P41047-2 mFASLG/iso:FasLS acts_upstream_of_or_withinGO:0043066 negative regulation of apoptotic process PMID:10552956
located_inGO:0005615 extracellular space PMID:10552956
PR:P48023-1 hFASLG/iso:FasL acts_upstream_of_or_withinGO:0043123 positive regulation of canonical NF-kappaB signal transduction PMID:12761501