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Protein Ontology report - tumor necrosis factor ligand superfamily member 6
PR:000000095 - http://purl.obolibrary.org/obo/PR_000000095
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000095   
  PRO nametumor necrosis factor ligand superfamily member 6 
  Synonyms
PRO-Short-label: EXACT:FASLG
Gene-based: RELATED:APT1LG1 | CD95L | FASL | gld | TNFSF6
Other: EXACT:apoptosis antigen ligand | APTL | CD178 | CD95 ligand | CD95-L | fas antigen ligand | fas ligand | fas ligand, TNF-like
  Definition"A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000033 tumor necrosis factor, TNF-like
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence3                                                  Organism-Sequence 6                                        
         Modification4                                                  Organism-Modification 2                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000095

tumor necrosis factor ligand superfamily member 6

FASLG


"A tumor necrosis factor, TNF-like that is a translation product of the human FASLG gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P36940

tumor necrosis factor ligand superfamily member 6 (rat)

rFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of rat." [OMA:P36940, PRO:DNx]


organism-gene



PR:P41047

tumor necrosis factor ligand superfamily member 6 (mouse)

mFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of mouse." [OMA:P41047, PRO:DNx]


organism-sequence



PR:P41047-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)

mFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P41047-2

tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)

mFASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 isoform FasLS that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:P48023

tumor necrosis factor ligand superfamily member 6 (human)

hFASLG


"A tumor necrosis factor ligand superfamily member 6 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P48023]


organism-sequence



PR:P48023-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (human)

hFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

organism-sequence



PR:P48023-2

tumor necrosis factor ligand superfamily member 6 isoform h2 (human)

hFASLG/iso:h2


"A tumor necrosis factor ligand superfamily member 6 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-2." [PRO:DNx, UniProtKB:P48023]


sequence



PR:000000276

tumor necrosis factor ligand superfamily member 6 isoform FasL

FASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P48023-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


sequence



PR:000000278

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L

FASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that has a Leu residue at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. Example: UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:CNA, PRO:DAN]


organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P41047-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (mouse)

mFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:000036783

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (mouse)

mFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of mouse. The variation occurs at the position equivalent to Phe-273 of the amino acid sequence represented by UniProtKB:P41047-1. UniProtKB:P41047-1, Phe-273, CHEBI:30006." [PMID:7495745, PRO:DAN]

Yes

organism-sequence



PR:P48023-1

tumor necrosis factor ligand superfamily member 6 isoform FasL (human)

hFASLG/iso:FasL


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is encoded in the genome of human." [PRO:CNA]

Yes

organism-sequence



PR:000036782

tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L (human)

hFASLG/iso:FasL/var:F273L


"A tumor necrosis factor ligand superfamily member 6 isoform FasL sequence variant F273L that is encoded in the genome of human. The variation occurs at the position equivalent to Phe-275 of the amino acid sequence represented by UniProtKB:P48023-1. UniProtKB:P48023-1, Phe-275, CHEBI:30006." [PRO:DAN]

Yes

organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

modification



PR:000000432

tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form

FASLG/iso:FasL/GlycoRes+


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that includes at least one glycosylated residue." [PRO:CNA]


modification



PR:000000546

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1

FASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL glycosylated form that has been N-glycosylated at the Asn residues within the N-glycosylation sites located in the C-terminal extracellular region. Example: UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425]


organism-modification



PR:000036458

tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 (human)

hFASLG/iso:FasL/NGlyco:1


"A tumor necrosis factor ligand superfamily member 6 isoform FasL N-glycosylated 1 in human. UniProtKB:P48023-1, Asn-184/Asn-250/Asn-260, MOD:00160." [PMID:9405425, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000547

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form

FASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is the soluble N-terminal portion after ADAM10 processing." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

sequence



PR:000000277

tumor necrosis factor ligand superfamily member 6 isoform FasLS

FASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P41047-2 or a 1:1 ortholog thereof." [PMID:10552956, PRO:CNA, PRO:DAN]


organism-sequence



PR:P41047-2

tumor necrosis factor ligand superfamily member 6 isoform FasLS (mouse)

mFASLG/iso:FasLS


"A tumor necrosis factor ligand superfamily member 6 isoform FasLS that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000018277

tumor necrosis factor ligand superfamily member 6 proteolytic cleavage product

FASLG/ClvPrd


"A tumor necrosis factor ligand superfamily member 6 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000547

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form

FASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL that is the soluble N-terminal portion after ADAM10 processing." [PRO:CNA, PRO:DAN]


organism-modification



PR:000036459

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form (human)

hFASLG/iso:FasL/Clv:soluble


"A tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form in human. UniProtKB:P48023-1, 130-281." [PMID:7536672, PMID:9228058, PMID:9396774, PMID:9405425, PRO:CNA]

Yes

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006915 apoptotic processPR:P41047-1 mFASLG/iso:FasL PMID:16365167
GO:0007267 cell-cell signalingPR:000000095 FASLG PANTHER:PTHR11471
GO:0043066 negative regulation of apoptotic processPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9396774
PR:P41047-1 mFASLG/iso:FasL MGI_ref:76989; PMID:7595210
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0043123 positive regulation of canonical NF-kappaB signal transductionPR:P48023-1 hFASLG/iso:FasL PMID:12761501
GO:0097190 apoptotic signaling pathwayPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:15039234

Disease Associated GO Term

Protein Forms & Complexes

Evidence
DO:6688 autoimmune lymphoproliferative syndromePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005102 signaling receptor bindingPR:000036458 hFASLG/iso:FasL/NGlyco:1 PMID:9405425
PR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
GO:0042802 identical protein bindingPR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672; PMID:9228058; PMID:9405425
PR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005615 extracellular spacePR:000036459 hFASLG/iso:FasL/Clv:soluble PMID:7536672
PR:P41047-2 mFASLG/iso:FasLS PMID:10552956
GO:0005886 plasma membranePR:000036783 mFASLG/iso:FasL/var:F273L PMID:7495745
PR:P41047-1 mFASLG/iso:FasL PMID:16973387
GO:0009986 cell surfacePR:000036782 hFASLG/iso:FasL/var:F273L PMID:9405425
PR:P41047-1 mFASLG/iso:FasL PMID:16973387