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Protein Ontology report - inhibitory smad protein
PR:000000099 - http://purl.obolibrary.org/obo/PR_000000099
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000099   
  PRO nameinhibitory smad protein 
  Definition"A smad protein that is an antagonist of the transforming growth factor beta (TGF-beta) superfamily signaling pathways. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads." [PMID:11532220] 
  PRO Categoryfamily 
  ParentPR:000000027 smad protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence4                                                  Organism-Sequence 9                                        
         Modification8                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500412
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
family


PR:000000099 inhibitory smad protein
FST/iso:2
Yes
gene


PR:000000373 smad6
SMAD6

organism-gene


PR:O35182 mothers against decapentaplegic homolog 6 (mouse)
mSMAD6

organism-sequence


PR:O35182-1 mothers against decapentaplegic homolog 6 isoform 1 (mouse)
mSMAD6/iso:1
Yes
organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
organism-gene


PR:O43541 mothers against decapentaplegic homolog 6 (human)
hSMAD6

organism-sequence


PR:O43541-1 mothers against decapentaplegic homolog 6 isoform A (human)
hSMAD6/iso:A
Yes
organism-sequence


PR:O43541-2 mothers against decapentaplegic homolog 6 isoform B (human)
hSMAD6/iso:B
Yes
organism-sequence


PR:O43541-4 mothers against decapentaplegic homolog 6 isoform D (human)
hSMAD6/iso:D

organism-gene


PR:Q9W734 mothers against decapentaplegic homolog 6 (chicken)
chick-SMAD6

sequence


PR:000000479 smad6 isoform 1
SMAD6/iso:1

organism-sequence


PR:O35182-1 mothers against decapentaplegic homolog 6 isoform 1 (mouse)
mSMAD6/iso:1
Yes
organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
organism-sequence


PR:O43541-1 mothers against decapentaplegic homolog 6 isoform A (human)
hSMAD6/iso:A
Yes
modification


PR:000000581 smad6 isoform 1 dimethylated form
SMAD6/iso:1/Me2Res+

modification


PR:000000662 smad6 isoform 1 dimethylated 1
SMAD6/iso:1/Me2:1

organism-modification


PR:000036564 smad6 isoform 1 dimethylated 1 (mouse)
mSMAD6/iso:1/Me2:1
Yes
sequence


PR:000000480 smad6 isoform 2
SMAD6/iso:2

organism-sequence


PR:O43541-2 mothers against decapentaplegic homolog 6 isoform B (human)
hSMAD6/iso:B
Yes
gene


PR:000000374 smad7
SMAD7

organism-gene


PR:O15105 mothers against decapentaplegic homolog 7 (human)
hSMAD7

organism-sequence


PR:O15105-1 mothers against decapentaplegic homolog 7 isoform 1 (human)
hSMAD7/iso:1
Yes
organism-modification


PR:000036565 smad7 isoform 1 acetylated 1 (human)
hSMAD7/iso:1/Ac:1
Yes
organism-modification


PR:000036566 smad7 isoform 1 phosphorylated 1 (human)
hSMAD7/iso:1/Phos:1

organism-sequence


PR:O15105-2 mothers against decapentaplegic homolog 7 isoform h2 (human)
hSMAD7/iso:h2

organism-sequence


PR:O15105-3 mothers against decapentaplegic homolog 7 isoform 3 (human)
hSMAD7/iso:3

organism-gene


PR:O35253 mothers against decapentaplegic homolog 7 (mouse)
mSMAD7

organism-sequence


PR:O35253-1 mothers against decapentaplegic homolog 7 isoform A (mouse)
mSMAD7/iso:A

organism-modification


PR:000036932 smad7 isoform 1 phosphorylated 1 (mouse)
mSMAD7/iso:1/Phos:1
Yes
organism-modification


PR:000049801 mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
mSMAD7/iso:A/Me1:1

organism-modification


PR:000049802 mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
mSMAD7/iso:A/UnMe:1

organism-sequence


PR:O35253-2 mothers against decapentaplegic homolog 7 isoform B (mouse)
mSMAD7/iso:B

organism-gene


PR:O88406 mothers against decapentaplegic homolog 7 (rat)
rSMAD7

sequence


PR:000000481 smad7 isoform 1
SMAD7/iso:1

organism-sequence


PR:O15105-1 mothers against decapentaplegic homolog 7 isoform 1 (human)
hSMAD7/iso:1
Yes
organism-modification


PR:000036565 smad7 isoform 1 acetylated 1 (human)
hSMAD7/iso:1/Ac:1
Yes
organism-modification


PR:000036566 smad7 isoform 1 phosphorylated 1 (human)
hSMAD7/iso:1/Phos:1

organism-sequence


PR:O35253-1 mothers against decapentaplegic homolog 7 isoform A (mouse)
mSMAD7/iso:A

organism-modification


PR:000036932 smad7 isoform 1 phosphorylated 1 (mouse)
mSMAD7/iso:1/Phos:1
Yes
organism-modification


PR:000049801 mothers against decapentaplegic homolog 7 isoform A monomethylated 1 (mouse)
mSMAD7/iso:A/Me1:1

organism-modification


PR:000049802 mothers against decapentaplegic homolog 7 isoform A unmethylated 1 (mouse)
mSMAD7/iso:A/UnMe:1

modification


PR:000000582 smad7 isoform 1 acetylated form
SMAD7/iso:1/AcRes+

modification


PR:000000663 smad7 isoform 1 acetylated 1
SMAD7/iso:1/Ac:1

organism-modification


PR:000036565 smad7 isoform 1 acetylated 1 (human)
hSMAD7/iso:1/Ac:1
Yes
modification


PR:000000583 smad7 isoform 1 phosphorylated form
SMAD7/iso:1/PhosRes+

modification


PR:000000664 smad7 isoform 1 phosphorylated 1
SMAD7/iso:1/Phos:1

organism-modification


PR:000036566 smad7 isoform 1 phosphorylated 1 (human)
hSMAD7/iso:1/Phos:1

organism-modification


PR:000036932 smad7 isoform 1 phosphorylated 1 (mouse)
mSMAD7/iso:1/Phos:1
Yes
modification


PR:000000584 smad7 isoform 1 ubiquitinated form
SMAD7/iso:1/UbiqLys+

modification


PR:000000665 smad7 isoform 1 ubiquitinated 1
SMAD7/iso:1/Ubiq:1

sequence


PR:000038037 smad7 isoform 3
SMAD7/iso:3

organism-sequence


PR:O15105-3 mothers against decapentaplegic homolog 7 isoform 3 (human)
hSMAD7/iso:3

organism-sequence


PR:O35253-2 mothers against decapentaplegic homolog 7 isoform B (mouse)
mSMAD7/iso:B

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000099 FST/iso:2
It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation that is present in the receptor-regulated smads		 acts_upstream_of_or_withinGO:0009968 negative regulation of signal transduction PIRSF:PIRSF500412
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway PIRSF:PIRSF500412
GO:0030514 negative regulation of BMP signaling pathway PIRSF:PIRSF500412
PR:000036564 mSMAD6/iso:1/Me2:1
UniProtKB:O35182-1, Arg-74, MOD:00783		 enablesGO:0140416 transcription regulator inhibitor activity PMID:17118358
PR:000036565 hSMAD7/iso:1/Ac:1
UniProtKB:O15105-1, Lys-64/Lys-70, MOD:00064		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:12408818
enablesGO:0140416 transcription regulator inhibitor activity PMID:12408818
located_inGO:0005634 nucleus PMID:11278814
PR:000036932 mSMAD7/iso:1/Phos:1
UniProtKB:O35253-1, Ser-249, MOD:00046		 acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:11278814
enablesGO:0140416 transcription regulator inhibitor activity PMID:11278814
located_inGO:0005634 nucleus PMID:11278814
PR:O15105-1 hSMAD7/iso:1 acts_upstream_of_or_withinGO:0006950 response to stress PMID:9256479
GO:0007179 transforming growth factor beta receptor signaling pathway PMID:10823886; PMID:9215638
enablesGO:0005515 protein binding PMID:9256479
GO:0140416 transcription regulator inhibitor activity PMID:9215638
located_inGO:0005634 nucleus PMID:11278814
PR:O35182-1 mSMAD6/iso:1 enablesGO:0140416 transcription regulator inhibitor activity PMID:17118358
PR:O43541-1 hSMAD6/iso:A enablesGO:0005515 protein binding with PR:000026334 hSMAD1/iso:1/Phos:1 PMID:9436979
GO:0140416 transcription regulator inhibitor activity PMID:9436979
PR:O43541-2 hSMAD6/iso:B enablesGO:0005515 protein binding PMID:11284962
GO:0140416 transcription regulator inhibitor activity PMID:11284962