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family
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PR:000000102 |
lefty protein
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LTBP1
|
"A TGF-beta-like cystine-knot cytokine that is an antagonist of nodal signaling. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]
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Yes |
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gene
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PR:000000287 |
lefty 1
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LEFTY1
|
"A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O75610 |
left-right determination factor 1 (human)
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hLEFTY1
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"A lefty 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75610]
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organism-sequence
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PR:O75610-1 |
left-right determination factor 1 isoform 1 (human)
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hLEFTY1/iso:1
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"A lefty 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000036546 |
lefty 1 isoform 1 cleaved 1 (human)
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hLEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
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PR:000036548 |
lefty 1 isoform 1 cleaved 2 (human)
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hLEFTY1/iso:1/Clv:2
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"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
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PR:000077301 |
left-right determination factor 1 phosphorylated 1 (human)
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hLEFTY1/Phos:1
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"A left-right determination factor 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-61 of the amino acid sequence represented by UniProtKB:O75610. UniProtKB:O75610, Tyr-61, MOD:00048." [IEDB_epitope:2149845, PRO:DNx]
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sequence
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PR:000000450 |
lefty 1 isoform 1
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LEFTY1/iso:1
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"A lefty 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75610-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
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PR:O75610-1 |
left-right determination factor 1 isoform 1 (human)
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hLEFTY1/iso:1
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"A lefty 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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organism-modification
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PR:000036546 |
lefty 1 isoform 1 cleaved 1 (human)
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hLEFTY1/iso:1/Clv:1
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"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
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PR:000036548 |
lefty 1 isoform 1 cleaved 2 (human)
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hLEFTY1/iso:1/Clv:2
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"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-sequence
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PR:Q64280-1 |
left-right determination factor 1 isoform 1 (mouse)
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mLEFTY1/iso:1
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"A lefty 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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Yes |
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organism-modification
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PR:000036547 |
lefty 1 isoform 1 cleaved 1 (mouse)
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mLEFTY1/iso:1/Clv:1
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"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]
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Yes |
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modification
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PR:000000643 |
lefty 1 isoform 1 cleaved 1
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LEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PMID:11278322, PMID:18039650]
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organism-modification
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PR:000036546 |
lefty 1 isoform 1 cleaved 1 (human)
|
hLEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
|
|
PR:000036547 |
lefty 1 isoform 1 cleaved 1 (mouse)
|
mLEFTY1/iso:1/Clv:1
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"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]
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Yes |
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modification
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PR:000000644 |
lefty 1 isoform 1 cleaved 2
|
LEFTY1/iso:1/Clv:2
|
"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PMID:11278322]
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organism-modification
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PR:000036548 |
lefty 1 isoform 1 cleaved 2 (human)
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hLEFTY1/iso:1/Clv:2
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"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]
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Yes |
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modification
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PR:000025431 |
lefty 1 proteolytic cleavage product
|
LEFTY1/ClvPrd
|
"A lefty 1 that has been processed by proteolytic cleavage." [PRO:DNx]
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modification
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PR:000000643 |
lefty 1 isoform 1 cleaved 1
|
LEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PMID:11278322, PMID:18039650]
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organism-modification
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PR:000036546 |
lefty 1 isoform 1 cleaved 1 (human)
|
hLEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
|
|
PR:000036547 |
lefty 1 isoform 1 cleaved 1 (mouse)
|
mLEFTY1/iso:1/Clv:1
|
"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]
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Yes |
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modification
|
|
PR:000000644 |
lefty 1 isoform 1 cleaved 2
|
LEFTY1/iso:1/Clv:2
|
"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PMID:11278322]
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organism-modification
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PR:000036548 |
lefty 1 isoform 1 cleaved 2 (human)
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hLEFTY1/iso:1/Clv:2
|
"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]
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Yes |
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gene
|
|
PR:000000288 |
lefty 2
|
LEFTY2
|
"A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof." [PRO:CNA]
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organism-gene
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PR:O00292 |
left-right determination factor 2 (human)
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hLEFTY2
|
"A lefty 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O00292]
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organism-sequence
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PR:000000452 |
lefty 2 sequence variant S342N (human)
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hLEFTY2/var:S342N
|
"A left-right determination factor 2 (human) that has an Asn residue at the position equivalent to Ser-342 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347." [PMID:10053005, PRO:CNA, PRO:DAN]
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Yes |
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organism-sequence
|
|
PR:O00292-1 |
left-right determination factor 2 isoform 1 (human)
|
hLEFTY2/iso:1
|
"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
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Yes |
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organism-modification
|
|
PR:000036549 |
lefty 2 isoform 1 cleaved 1 (human)
|
hLEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
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Yes |
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organism-modification
|
|
PR:000036550 |
lefty 2 isoform 1 cleaved 2 (human)
|
hLEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
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Yes |
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organism-sequence
|
|
PR:O00292-2 |
left-right determination factor 2 isoform h2 (human)
|
hLEFTY2/iso:h2
|
"A left-right determination factor 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-2." [PRO:DNx, UniProtKB:O00292]
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organism-modification
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PR:000048185 |
left-right determination factor 2, signal peptide removed form (human)
|
hLEFTY2/SigPep-
|
"A left-right determination factor 2 (human) that has had the signal peptide removed. UniProtKB:O00292, 22-366." [PRO:DNx, Reactome:R-HSA-114708]
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organism-modification
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PR:000083292 |
left-right determination factor 2 phosphorylated 1 (human)
|
hLEFTY2/Phos:1
|
"A left-right determination factor 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-213 of the amino acid sequence represented by UniProtKB:O00292-1. Example: UniProtKB:O00292-1, Ser-213, MOD:00046." [IEDB_epitope:2149881, PRO:DNx]
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sequence
|
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PR:000000451 |
lefty 2 isoform 1
|
LEFTY2/iso:1
|
"A lefty 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O00292-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
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organism-sequence
|
|
PR:O00292-1 |
left-right determination factor 2 isoform 1 (human)
|
hLEFTY2/iso:1
|
"A lefty 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
|
Yes |
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organism-modification
|
|
PR:000036549 |
lefty 2 isoform 1 cleaved 1 (human)
|
hLEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
|
Yes |
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organism-modification
|
|
PR:000036550 |
lefty 2 isoform 1 cleaved 2 (human)
|
hLEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
|
Yes |
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| |
organism-sequence
|
|
PR:P57785-1 |
left-right determination factor 2 isoform 1 (mouse)
|
mLEFTY2/iso:1
|
"A lefty 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
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modification
|
|
PR:000000645 |
lefty 2 isoform 1 cleaved 1
|
LEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]
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organism-modification
|
|
PR:000036549 |
lefty 2 isoform 1 cleaved 1 (human)
|
hLEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
|
Yes |
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| |
modification
|
|
PR:000000646 |
lefty 2 isoform 1 cleaved 2
|
LEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]
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organism-modification
|
|
PR:000036550 |
lefty 2 isoform 1 cleaved 2 (human)
|
hLEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
|
Yes |
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modification
|
|
PR:000025432 |
lefty 2 proteolytic cleavage product
|
LEFTY2/ClvPrd
|
"A lefty 2 that has been processed by proteolytic cleavage." [PRO:DNx]
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modification
|
|
PR:000000645 |
lefty 2 isoform 1 cleaved 1
|
LEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]
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organism-modification
|
|
PR:000036549 |
lefty 2 isoform 1 cleaved 1 (human)
|
hLEFTY2/iso:1/Clv:1
|
"A lefty 2 isoform 1 cleaved 1 in human. UniProtKB:O00292-1, 77-366." [PMID:10053005, PMID:11278322, PRO:CNA]
|
Yes |
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modification
|
|
PR:000000646 |
lefty 2 isoform 1 cleaved 2
|
LEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PRO:CNA, PRO:DAN]
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organism-modification
|
|
PR:000036550 |
lefty 2 isoform 1 cleaved 2 (human)
|
hLEFTY2/iso:1/Clv:2
|
"A lefty 2 isoform 1 cleaved 2 in human. UniProtKB:O00292-1, 135-366." [PMID:11278322, PRO:CNA]
|
Yes |
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|
