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Protein Ontology report - mitogen-activated protein kinase 3
PR:000000104 - http://purl.obolibrary.org/obo/PR_000000104
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000104   
  PRO namemitogen-activated protein kinase 3 
  Synonyms
PRO-Short-label: EXACT:MAPK3
Gene-based: RELATED:ERK1 | PRKM3
Other: EXACT:ERK-1 | ERT2 | extracellular signal-regulated kinase 1 | insulin-stimulated MAP2 kinase | MAP kinase 3 | MAP kinase isoform p44 | MAPK 3 | microtubule-associated protein 2 kinase | MNK1 | p44-ERK1 | p44-MAPK
RELATED:MAP kinase 1 | MAPK 1 | mitogen-activated protein kinase 1
  Definition"A mitogen-activated protein kinase that is a translation product of the human MAPK3 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000019 mitogen-activated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 6                                        
         Modification4                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1494
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000104

mitogen-activated protein kinase 3

MAPK3


"A mitogen-activated protein kinase that is a translation product of the human MAPK3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P21708

mitogen-activated protein kinase 3 (rat)

rMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of rat." [OMA:P21708, PRO:DNx]


organism-sequence



PR:P21708-1

mitogen-activated protein kinase 3 isoform r1 (rat)

rMAPK3/iso:r1


"A mitogen-activated protein kinase 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21708-1." [PRO:DNx, UniProtKB:P21708]


organism-sequence



PR:P21708-2

mitogen-activated protein kinase 3 isoform r2 (rat)

rMAPK3/iso:r2


"A mitogen-activated protein kinase 3 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21708-2." [PRO:DNx, UniProtKB:P21708]


organism-gene



PR:P27361

mitogen-activated protein kinase 3 (human)

hMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P27361]


organism-sequence



PR:P27361-1

mitogen-activated protein kinase 3 isoform 1 (human)

hMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-sequence



PR:P27361-2

mitogen-activated protein kinase 3 isoform h2 (human)

hMAPK3/iso:h2


"A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-2." [PRO:DNx, UniProtKB:P27361]


organism-sequence



PR:P27361-3

mitogen-activated protein kinase 3 isoform h3 (human)

hMAPK3/iso:h3


"A mitogen-activated protein kinase 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-3." [PRO:DNx, UniProtKB:P27361]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


organism-modification



PR:000048321

mitogen-activated protein kinase 3, initiator methionine removed form (human)

hMAPK3/InitMet-


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed. UniProtKB:P27361, 2-379." [PRO:DNx, Reactome:R-HSA-59284, Reactome:R-HSA-73724]


organism-modification



PR:000048322

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 202, and phosphotyrosine at position 204 of the amino acid sequence represented by UniProtKB:P27361. UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-109842, Reactome:R-HSA-112359]


organism-modification



PR:000060765

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 2 (human)

hMAPK3/InitMet-/Phos:2


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-202 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, 2-379, Thr-202, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635775]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


organism-modification



PR:000065834

mitogen-activated protein kinase 3 methylated 1 (human)

hMAPK3/Me:1


"A mitogen-activated protein kinase 3 (human) that has been methylated on the residue at the position equivalent to Cys-144 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, Cys-144, MOD:00660." [IEDB_epitope:1031789, PRO:DNx]


organism-gene



PR:Q63844

mitogen-activated protein kinase 3 (mouse)

mMAPK3


"A mitogen-activated protein kinase 3 that is encoded in the genome of mouse." [OMA:Q63844, PRO:DNx]


organism-sequence



PR:Q63844-1

mitogen-activated protein kinase 3 isoform 1 (mouse)

mMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

sequence



PR:000000290

mitogen-activated protein kinase 3 isoform 1

MAPK3/iso:1


"A mitogen-activated protein kinase 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P27361-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27361-1

mitogen-activated protein kinase 3 isoform 1 (human)

hMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-sequence



PR:Q63844-1

mitogen-activated protein kinase 3 isoform 1 (mouse)

mMAPK3/iso:1


"A mitogen-activated protein kinase 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

modification



PR:000000455

mitogen-activated protein kinase 3 isoform 1 phosphorylated form

MAPK3/iso:1/PhosRes+


"A mitogen-activated protein kinase 3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000557

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1

MAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated form that is phosphorylated at both Thr and Tyr of the TxY motif within the protein kinase domain. Example: UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]


organism-modification



PR:000026189

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (human)

hMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in human. UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PMID:17192257, PRO:CNA]

Yes

organism-modification



PR:000036468

mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 (mouse)

mMAPK3/iso:1/Phos:1


"A mitogen-activated protein kinase 3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048." [PMID:11684667, PMID:11726647, PMID:11841548, PMID:15314156, PMID:15383658, PRO:CNA]

Yes

modification



PR:000026627

mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form

MAPK3/iso:1/InitMet-


"A mitogen-activated protein kinase 3 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000018279

mitogen-activated protein kinase 3, initiator methionine removed form

MAPK3/InitMet-


"A mitogen-activated protein kinase 3 that has had the initiator methionine removed." [PRO:DNx]


modification



PR:000026627

mitogen-activated protein kinase 3 isoform 1, initiator methionine removed form

MAPK3/iso:1/InitMet-


"A mitogen-activated protein kinase 3 isoform 1 that has had the initiator methionine removed." [PRO:DNx]


organism-modification



PR:000048321

mitogen-activated protein kinase 3, initiator methionine removed form (human)

hMAPK3/InitMet-


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed. UniProtKB:P27361, 2-379." [PRO:DNx, Reactome:R-HSA-59284, Reactome:R-HSA-73724]


organism-modification



PR:000048322

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 202, and phosphotyrosine at position 204 of the amino acid sequence represented by UniProtKB:P27361. UniProtKB:P27361, 2-379, Thr-202, MOD:00047|Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-109842, Reactome:R-HSA-112359]


organism-modification



PR:000060765

mitogen-activated protein kinase 3, initiator methionine removed phosphorylated 2 (human)

hMAPK3/InitMet-/Phos:2


"A mitogen-activated protein kinase 3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-202 of the amino acid sequence represented by UniProtKB:P27361-1. Example: UniProtKB:P27361-1, 2-379, Thr-202, MOD:00047." [PRO:DNx, Reactome:R-HSA-9635775]


organism-modification



PR:000063126

mitogen-activated protein kinase 3 isoform h3, initiator methionine removed phosphorylated 1 (human)

hMAPK3/iso:h3/InitMet-/Phos:1


"A mitogen-activated protein kinase 3 isoform h3 (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Tyr-204 of the amino acid sequence represented by UniProtKB:P27361-3. UniProtKB:P27361-3, 2-357, Tyr-204, MOD:00048." [PRO:DNx, Reactome:R-HSA-2422448]


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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000026189 hMAPK3/iso:1/Phos:1
UniProtKB:P27361-1, Thr-202, MOD:00047|Tyr-204, MOD:00048
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:7687743
GO:0051726 regulation of cell cycle PMID:7687743
enablesGO:0004672 protein kinase activity PMID:16581800
PR:000036468 mMAPK3/iso:1/Phos:1
UniProtKB:Q63844-1, Thr-203, MOD:00047|Tyr-205, MOD:00048
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:11841548; PMID:15383658
enablesGO:0004672 protein kinase activity PMID:11684667; PMID:15314156
GO:0004707 MAP kinase activity PMID:15314156
located_inGO:0005634 nucleus PMID:11726647
PR:P27361-1 hMAPK3/iso:1 acts_upstream_of_or_withinGO:0051726 regulation of cell cycle PMID:7687743
PR:Q63844-1 mMAPK3/iso:1 enablesGO:0005515 protein binding with PR:Q9DAJ4 MAPK organizer 1 (mouse) PMID:15118098
located_inGO:0005737 cytoplasm PMID:11726647; PMID:12223545