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Protein Ontology report - nodal protein

PR:000000105 - http://purl.obolibrary.org/obo/PR_000000105

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000105

PRO name

nodal protein

Synonyms

PRO-Short-label:

EXACT:

NODAL

Definition

"A TGF-beta-like cystine-knot cytokine that is a translation product of the human NODAL gene or a 1:1 ortholog thereof. The nodal and lefty genes form positive and negative regulatory loops that resemble the reaction-diffusion system. As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation." [PRO:CNA]

PRO Category

gene

Parent

PR:000000008 TGF-beta-like cystine-knot cytokine

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	2
Sequence	1	Organism-Sequence	3
Modification	2	Organism-Modification	3

Term Hierarchy
Visualization

DAG:

OLS:

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Related Cross References
Db identifiers	PIRSF:PIRSF037400

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000105 nodal protein

NODAL

Yes

organism-gene

PR:P43021 nodal (mouse)

mNODAL

organism-sequence

PR:P43021-1 nodal isoform 1 (mouse)

mNODAL/iso:1

Yes

organism-modification

PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-

Yes

organism-gene

PR:Q96S42 nodal homolog (human)

hNODAL

organism-sequence

PR:000000292 nodal protein sequence variant R183Q (human)

hNODAL/var:R183Q

Yes

organism-sequence

PR:Q96S42-1 nodal homolog isoform 1 (human)

hNODAL/iso:1

organism-modification

PR:000048620 nodal homolog, signal peptide removed form (human)

hNODAL/SigPep-

organism-modification

PR:000084052 nodal homolog, mature form (human)

hNODAL/mature

organism-modification

PR:000084052 nodal homolog, mature form (human)

hNODAL/mature

sequence

PR:000000291 nodal protein isoform 1

NODAL/iso:1

organism-sequence

PR:P43021-1 nodal isoform 1 (mouse)

mNODAL/iso:1

Yes

organism-modification

PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-

Yes

organism-sequence

PR:Q96S42-1 nodal homolog isoform 1 (human)

hNODAL/iso:1

modification

PR:000000558 nodal protein isoform 1, signal peptide removed form

NODAL/iso:1/SigPep-

organism-modification

PR:000036469 nodal protein isoform 1, signal peptide removed form (mouse)

mNODAL/iso:1/SigPep-

Yes

modification

PR:000025433 nodal protein proteolytic cleavage product

NODAL/ClvPrd

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000105 NODAL As a pair, these genes control various events of vertebrate embryonic patterning, including left-right specification and mesoderm formation	acts_upstream_of_or_within	GO:0007368 determination of left/right symmetry	PIRSF:PIRSF037400
	enables	GO:0016015 morphogen activity	PIRSF:PIRSF037400
PR:000000292 hNODAL/var:R183Q UniProtKB:Q96S42, Arg-183, CHEBI:30011	associated_with_disease_progression	DO:0050545 visceral heterotaxy	PMID:9354794
PR:000036469 mNODAL/iso:1/SigPep- UniProtKB:P43021-1, 27-354	acts_upstream_of_or_within	GO:0007368 determination of left/right symmetry	PMID:12654299
	acts_upstream_of_or_within	GO:0009952 anterior/posterior pattern specification	PMID:15004567
	enables	GO:0042803 protein homodimerization activity	PMID:15649361
	located_in	GO:0005615 extracellular space	PMID:15649361
PR:P43021-1 mNODAL/iso:1	acts_upstream_of_or_within	GO:0007368 determination of left/right symmetry	PMID:12654299
	acts_upstream_of_or_within	GO:0009952 anterior/posterior pattern specification	PMID:15004567
	enables	GO:0042803 protein homodimerization activity	PMID:15649361
	located_in	GO:0005615 extracellular space	PMID:15649361