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Protein Ontology report - Rho-associated protein kinase 2
PR:000000121 - http://purl.obolibrary.org/obo/PR_000000121
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000121   
  PRO nameRho-associated protein kinase 2 
  Synonyms
PRO-Short-label: EXACT:ROCK2
Gene-based: RELATED:KIAA0619
Other: EXACT:p164 ROCK-2 | rho kinase 2 | rho-associated, coiled-coil-containing protein kinase 2 | Rho-associated, coiled-coil-containing protein kinase II | ROCK-II
  Definition"A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000024 Rho-associated protein kinase
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 3                                        
         Modification6                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
IUPHARobj:1504
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000121

Rho-associated protein kinase 2

ROCK2


"A Rho-associated protein kinase that is a translation product of the human ROCK2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O75116

Rho-associated protein kinase 2 (human)

hROCK2


"A Rho-associated protein kinase 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75116]


organism-sequence



PR:O75116-1

Rho-associated protein kinase 2 isoform 1 (human)

hROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

organism-modification



PR:000036478

Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]

Yes

organism-modification



PR:000036479

Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]

Yes

organism-modification



PR:000066276

Rho-associated protein kinase 2 methylated 1 (human)

hROCK2/Me:1


"A Rho-associated protein kinase 2 (human) that has been methylated on the residue at the position equivalent to Cys-236 of the amino acid sequence represented by UniProtKB:O75116. UniProtKB:O75116, Cys-236, MOD:00660." [IEDB_epitope:1024569, PRO:DNx]


organism-modification



PR:000071951

Rho-associated protein kinase 2 methylated 2 (human)

hROCK2/Me:2


"A Rho-associated protein kinase 2 (human) that has been methylated on the residue at the position equivalent to Cys-1315 of the amino acid sequence represented by UniProtKB:O75116. UniProtKB:O75116, Cys-1315, MOD:00660." [IEDB_epitope:1020710, PRO:DNx]


organism-modification



PR:000074887

Rho-associated protein kinase 2 phosphorylated 1 (human)

hROCK2/Phos:1


"A Rho-associated protein kinase 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1379 of the amino acid sequence represented by UniProtKB:O75116. UniProtKB:O75116, Ser-1379, MOD:00046." [IEDB_epitope:2147201, PRO:DNx]


organism-gene



PR:P70336

Rho-associated protein kinase 2 (mouse)

mROCK2


"A Rho-associated protein kinase 2 that is encoded in the genome of mouse." [OMA:P70336, PRO:DNx]


organism-sequence



PR:P70336-1

Rho-associated protein kinase 2 isoform 1 (mouse)

mROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-sequence



PR:P70336-2

Rho-associated protein kinase 2 isoform 2 (mouse)

mROCK2/iso:2


"A Rho-associated protein kinase 2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-gene



PR:Q62868

Rho-associated protein kinase 2 (rat)

rROCK2


"A Rho-associated protein kinase 2 that is encoded in the genome of rat." [OMA:Q62868, PRO:DNx]


sequence



PR:000000308

Rho-associated protein kinase 2 isoform 1

ROCK2/iso:1


"A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75116-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O75116-1

Rho-associated protein kinase 2 isoform 1 (human)

hROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

organism-modification



PR:000036478

Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]

Yes

organism-modification



PR:000036479

Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]

Yes

organism-sequence



PR:P70336-1

Rho-associated protein kinase 2 isoform 1 (mouse)

mROCK2/iso:1


"A Rho-associated protein kinase 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000462

Rho-associated protein kinase 2 isoform 1 phosphorylated form

ROCK2/iso:1/PhosRes+


"A Rho-associated protein kinase 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000565

Rho-associated protein kinase 2 isoform 1 phosphorylated 1

ROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated form in which the phosphorylation occurs within the C-terminal region by the action of serine/threonine-protein kinase PLK1." [PMID:17446864]


organism-modification



PR:000036478

Rho-associated protein kinase 2 isoform 1 phosphorylated 1 (human)

hROCK2/iso:1/Phos:1


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 1 in human. UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046." [PMID:15302935, PMID:17446864, PRO:CNA]

Yes

modification



PR:000000566

Rho-associated protein kinase 2 isoform 1 phosphorylated 2

ROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated form that has been induced by DNA damage. Example: UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA, PRO:DAN]


organism-modification



PR:000036479

Rho-associated protein kinase 2 isoform 1 phosphorylated 2 (human)

hROCK2/iso:1/Phos:2


"A Rho-associated protein kinase 2 isoform 1 phosphorylated 2 in human. UniProtKB:O75116-1, Thr-1078, MOD:00047." [PMID:17525332, PRO:CNA]

Yes

modification



PR:000000564

Rho-associated protein kinase 2 isoform 1 cleaved 1

ROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 that has been cleaved in the granzyme B consensus motif [IVL][GE]xD located between the Rho binding and the PH domains, removing the C-terminus." [PRO:CNA]


organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

modification



PR:000002530

Rho-associated protein kinase 2 isoform 1 unmodified form

ROCK2/iso:1/UnMod


"A Rho-associated protein kinase 2 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx]


sequence



PR:000000309

Rho-associated protein kinase 2 isoform 2

ROCK2/iso:2


"A Rho-associated protein kinase 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70336-2 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P70336-2

Rho-associated protein kinase 2 isoform 2 (mouse)

mROCK2/iso:2


"A Rho-associated protein kinase 2 isoform 2 that is encoded in the genome of mouse." [PRO:CNA]

Yes

modification



PR:000025436

Rho-associated protein kinase 2 proteolytic cleavage product

ROCK2/ClvPrd


"A Rho-associated protein kinase 2 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000564

Rho-associated protein kinase 2 isoform 1 cleaved 1

ROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 that has been cleaved in the granzyme B consensus motif [IVL][GE]xD located between the Rho binding and the PH domains, removing the C-terminus." [PRO:CNA]


organism-modification



PR:000036477

Rho-associated protein kinase 2 isoform 1 cleaved 1 (human)

hROCK2/iso:1/Clv:1


"A Rho-associated protein kinase 2 isoform 1 cleaved 1 in human. UniProtKB:O75116-1, 1-1131." [PMID:15699075, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036477 hROCK2/iso:1/Clv:1
UniProtKB:O75116-1, 1-1131
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:15699075
GO:0030036 actin cytoskeleton organization PMID:15699075
enablesincreased GO:0004674 protein serine/threonine kinase activity relative to PR:000002530 ROCK2/iso:1/UnMod PMID:15699075
located_inGO:0005622 intracellular anatomical structure PMID:15699075
PR:000036478 hROCK2/iso:1/Phos:1
UniProtKB:O75116-1, Ser-1134/Ser-1137, MOD:00046
acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17446864
enablesGO:0004674 protein serine/threonine kinase activity PMID:17446864
located_inGO:0005634 nucleus PMID:15302935
PR:000036479 hROCK2/iso:1/Phos:2
UniProtKB:O75116-1, Thr-1078, MOD:00047
acts_upstream_of_or_withinGO:0042770 signal transduction in response to DNA damage PMID:17525332
PR:O75116-1 hROCK2/iso:1 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:9933571
GO:0051260 protein homooligomerization PMID:15291762
enablesGO:0004674 protein serine/threonine kinase activity PMID:9933571
GO:0031267 small GTPase binding PMID:11350930
located_inGO:0005622 intracellular anatomical structure PMID:16574662
PR:P70336-2 mROCK2/iso:2 acts_upstream_of_or_withinGO:0006468 protein phosphorylation PMID:17606625
GO:0051149 positive regulation of muscle cell differentiation PMID:17606625
enablesGO:0004674 protein serine/threonine kinase activity PMID:17606625