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Protein Ontology report - smad ubiquitination regulatory factor
PR:000000127 -
http://purl.obolibrary.org/obo/PR_000000127
Protein Forms
Annotations
Ontology Information
Show OBO stanza
/
PAF
PRO ID
PR:000000127
PRO name
smad ubiquitination regulatory factor
Synonyms
Other
:
EXACT:
smurf
Definition
"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA]
PRO Category
family
Parent
PR:000000016
HECT domain-containing E3 ubiquitin-protein ligase with WW domains
Terms by PRO Category
Organism-Independent
Organism-Specific
Category
Number of Terms
Category
Number of Terms
Family
1
Organism-Family
0
Gene
2
Organism-Gene
6
Sequence
2
Organism-Sequence
6
Modification
0
Organism-Modification
3
Term Hierarchy
Visualization
DAG:
OLS:
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Related Cross References
Db identifiers
PIRSF:PIRSF500454
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Protein Forms
Switch to
Extended View
Category
PRO Form Name
Short Name
Ann.
Has Annotation?
Comp.
In Complex?
family
PR:000000127
smad ubiquitination regulatory factor
ACVRL1
Yes
gene
PR:000000361
E3 ubiquitin-protein ligase SMURF1
SMURF1
organism-gene
PR:Q9CUN6
E3 ubiquitin-protein ligase SMURF1 (mouse)
mSMURF1
Yes
organism-sequence
PR:Q9CUN6-1
E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-modification
PR:000049754
E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse)
mSMURF1/Phos:1
organism-modification
PR:000049755
E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse)
mSMURF1/UnPhos:1
organism-gene
PR:Q9HCE7
E3 ubiquitin-protein ligase SMURF1 (human)
hSMURF1
Yes
organism-sequence
PR:Q9HCE7-1
E3 ubiquitin-protein ligase SMURF1 isoform Long (human)
hSMURF1/iso:Long
organism-sequence
PR:Q9HCE7-2
E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
organism-modification
PR:000075773
E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)
hSMURF1/Cyst:1
organism-gene
PR:Q9V853
E3 ubiquitin-protein ligase Smurf1 (fruit fly)
fly-SMURF1
sequence
PR:000000466
E3 ubiquitin-protein ligase SMURF1 isoform Short
SMURF1/iso:Short
organism-sequence
PR:Q9CUN6-1
E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)
mSMURF1/iso:Short
Yes
organism-sequence
PR:Q9HCE7-2
E3 ubiquitin-protein ligase SMURF1 isoform Short (human)
hSMURF1/iso:Short
Yes
gene
PR:000000362
E3 ubiquitin-protein ligase SMURF2
SMURF2
organism-gene
PR:A2A5Z6
E3 ubiquitin-protein ligase SMURF2 (mouse)
mSMURF2
organism-sequence
PR:A2A5Z6-1
E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1
organism-sequence
PR:A2A5Z6-2
E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse)
mSMURF2/iso:m2
organism-gene
PR:A9JRZ0
E3 ubiquitin-protein ligase SMURF2 (zebrafish)
z-SMURF2
organism-gene
PR:Q9HAU4
E3 ubiquitin-protein ligase SMURF2 (human)
hSMURF2
Yes
organism-sequence
PR:Q9HAU4-1
E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1
sequence
PR:000043363
E3 ubiquitin-protein ligase SMURF2 isoform 1
SMURF2/iso:1
organism-sequence
PR:A2A5Z6-1
E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)
mSMURF2/iso:1
organism-sequence
PR:Q9HAU4-1
E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)
hSMURF2/iso:1
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Functional Annotation (GO-centric view)
Switch to
PRO Centric View
Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0006511
ubiquitin-dependent protein catabolic process
PR:000000127
ACVRL1
PIRSF:PIRSF500454
PR:Q9HAU4
hSMURF2
PMID:14755250
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:12857866
GO:0007398
ectoderm development
PR:000000127
ACVRL1
PIRSF:PIRSF500454
GO:0009968
negative regulation of signal transduction
PR:000000127
ACVRL1
PIRSF:PIRSF500454
GO:0017015
regulation of transforming growth factor beta receptor signaling pathway
PR:Q9HAU4
hSMURF2
PMID:11016919
;
PMID:11158580
;
PMID:11163210
;
PMID:15862290
GO:0030514
negative regulation of BMP signaling pathway
PR:Q9CUN6
mSMURF1
PMID:14711801
PR:Q9HCE7
hSMURF1
PMID:10458166
GO:0036211
protein modification process
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:10458166
Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0004842
ubiquitin-protein transferase activity
PR:Q9HAU4
hSMURF2
PMID:14755250
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:10458166
GO:0005515
protein binding
PR:Q9HAU4
hSMURF2
PMID:14755250
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:11278251
;
PMID:16299379
Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005622
intracellular anatomical structure
PR:Q9CUN6-1
mSMURF1/iso:Short
PMID:14711801
PR:Q9HCE7-2
hSMURF1/iso:Short
PMID:10458166
