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Protein Ontology report - smad ubiquitination regulatory factor
PR:000000127 - http://purl.obolibrary.org/obo/PR_000000127
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000127   
  PRO namesmad ubiquitination regulatory factor 
  Synonyms
Other: EXACT:smurf
  Definition"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA] 
  PRO Categoryfamily 
  ParentPR:000000016 HECT domain-containing E3 ubiquitin-protein ligase with WW domains
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Family1                                                  Organism-Family 0                                        
         Gene2                                                  Organism-Gene 6                                        
         Sequence2                                                  Organism-Sequence 6                                        
         Modification0                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500454
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
family



PR:000000127

smad ubiquitination regulatory factor

ACVRL1


"A HECT domain-containing E3 ubiquitin-protein ligase with WW domains that mediates smad ubiquitination." [PRO:CNA]

Yes

gene



PR:000000361

E3 ubiquitin-protein ligase SMURF1

SMURF1


"A smad ubiquitination regulatory factor that is a translation product of the human SMURF1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:Q9CUN6

E3 ubiquitin-protein ligase SMURF1 (mouse)

mSMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of mouse." [OMA:Q9CUN6, PRO:DNx]

Yes

organism-sequence



PR:Q9CUN6-1

E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)

mSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000049754

E3 ubiquitin-protein ligase SMURF1 phosphorylated 1 (mouse)

mSMURF1/Phos:1


"An E3 ubiquitin-protein ligase SMURF1 (mouse) that has been phosphorylated on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, MOD:00046." [MGI:1923038, PMID:27052174, PRO:HJD]


organism-modification



PR:000049755

E3 ubiquitin-protein ligase SMURF1 unphosphorylated 1 (mouse)

mSMURF1/UnPhos:1


"An E3 ubiquitin-protein ligase SMURF1 (mouse) that lacks phosphorylation on a Ser residue equivalent to Ser-148 of the amino acid sequence represented by UniProtKB:Q9CUN6. UniProtKB:Q9CUN6, Ser-148, PR:000026291." [MGI:1923038, PMID:27052174, PRO:HJD]


organism-gene



PR:Q9HCE7

E3 ubiquitin-protein ligase SMURF1 (human)

hSMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HCE7]

Yes

organism-sequence



PR:Q9HCE7-1

E3 ubiquitin-protein ligase SMURF1 isoform Long (human)

hSMURF1/iso:Long


"An E3 ubiquitin-protein ligase SMURF1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-1." [PRO:DNx, UniProtKB:Q9HCE7]


organism-sequence



PR:Q9HCE7-2

E3 ubiquitin-protein ligase SMURF1 isoform Short (human)

hSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000075773

E3 ubiquitin-protein ligase SMURF1 cysteinylated 1 (human)

hSMURF1/Cyst:1


"An E3 ubiquitin-protein ligase SMURF1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-725 of the amino acid sequence represented by UniProtKB:Q9HCE7-1. Example: UniProtKB:Q9HCE7-1, Cys-725, MOD:00765." [IEDB_epitope:1582149, PRO:DNx]


organism-gene



PR:Q9V853

E3 ubiquitin-protein ligase Smurf1 (fruit fly)

fly-SMURF1


"An E3 ubiquitin-protein ligase SMURF1 that is encoded in the genome of fruit fly." [PRO:DAN]


sequence



PR:000000466

E3 ubiquitin-protein ligase SMURF1 isoform Short

SMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HCE7-2 or a 1:1 ortholog thereof." [PRO:CNA]


organism-sequence



PR:Q9CUN6-1

E3 ubiquitin-protein ligase SMURF1 isoform Short (mouse)

mSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-sequence



PR:Q9HCE7-2

E3 ubiquitin-protein ligase SMURF1 isoform Short (human)

hSMURF1/iso:Short


"An E3 ubiquitin-protein ligase SMURF1 isoform Short that is encoded in the genome of human." [PRO:CNA]

Yes

gene



PR:000000362

E3 ubiquitin-protein ligase SMURF2

SMURF2


"A smad ubiquitination regulatory factor that is a translation product of the human SMURF2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:A2A5Z6

E3 ubiquitin-protein ligase SMURF2 (mouse)

mSMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of mouse." [OMA:A2A5Z6, PRO:DNx]


organism-sequence



PR:A2A5Z6-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)

mSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:A2A5Z6-2

E3 ubiquitin-protein ligase SMURF2 isoform m2 (mouse)

mSMURF2/iso:m2


"An E3 ubiquitin-protein ligase SMURF2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:A2A5Z6-2." [PRO:DNx, UniProtKB:A2A5Z6]


organism-gene



PR:A9JRZ0

E3 ubiquitin-protein ligase SMURF2 (zebrafish)

z-SMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of zebrafish." [OMA:A9JRZ0, PRO:DNx]


organism-gene



PR:Q9HAU4

E3 ubiquitin-protein ligase SMURF2 (human)

hSMURF2


"An E3 ubiquitin-protein ligase SMURF2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q9HAU4]

Yes

organism-sequence



PR:Q9HAU4-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)

hSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


sequence



PR:000043363

E3 ubiquitin-protein ligase SMURF2 isoform 1

SMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9HAU4-1 or a 1:1 ortholog thereof." [PRO:DNx]


organism-sequence



PR:A2A5Z6-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (mouse)

mSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of mouse." [PRO:DNx]


organism-sequence



PR:Q9HAU4-1

E3 ubiquitin-protein ligase SMURF2 isoform 1 (human)

hSMURF2/iso:1


"An E3 ubiquitin-protein ligase SMURF2 isoform 1 that is encoded in the genome of human." [PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006511 ubiquitin-dependent protein catabolic processPR:000000127 ACVRL1 PIRSF:PIRSF500454
PR:Q9HAU4 hSMURF2 PMID:14755250
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:12857866
GO:0007398 ectoderm developmentPR:000000127 ACVRL1 PIRSF:PIRSF500454
GO:0009968 negative regulation of signal transductionPR:000000127 ACVRL1 PIRSF:PIRSF500454
GO:0017015 regulation of transforming growth factor beta receptor signaling pathwayPR:Q9HAU4 hSMURF2 PMID:11016919; PMID:11158580; PMID:11163210; PMID:15862290
GO:0030514 negative regulation of BMP signaling pathwayPR:Q9CUN6 mSMURF1 PMID:14711801
PR:Q9HCE7 hSMURF1 PMID:10458166
GO:0036211 protein modification processPR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0004842 ubiquitin-protein transferase activityPR:Q9HAU4 hSMURF2 PMID:14755250
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166
GO:0005515 protein bindingPR:Q9HAU4 hSMURF2 PMID:14755250
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:11278251; PMID:16299379

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005622 intracellular anatomical structurePR:Q9CUN6-1 mSMURF1/iso:Short PMID:14711801
PR:Q9HCE7-2 hSMURF1/iso:Short PMID:10458166