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Protein Ontology report - thrombospondin-2
PR:000000130 - http://purl.obolibrary.org/obo/PR_000000130
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000130   
  PRO namethrombospondin-2 
  Synonyms
PRO-Short-label: EXACT:THBS2
Gene-based: RELATED:TSP2
  Definition"A thrombospondin subgroup A that is a translation product of the human THBS2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000029 thrombospondin subgroup A
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification4                                                  Organism-Modification 9                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000130

thrombospondin-2

THBS2


"A thrombospondin subgroup A that is a translation product of the human THBS2 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35440

thrombospondin-2 (chicken)

chick-THBS2


"A thrombospondin-2 that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:P35442

thrombospondin-2 (human)

hTHBS2


"A thrombospondin-2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35442]


organism-sequence



PR:P35442-1

thrombospondin-2 isoform 1 (human)

hTHBS2/iso:1


"A thrombospondin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036491

thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-


"A thrombospondin-2 isoform 1, signal peptide removed form in human. UniProtKB:P35442-1, 19-1172." [PMID:1459996, PRO:CNA]

Yes

organism-modification



PR:000044787

thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in human. UniProtKB:P35442-1, 19-306." [PMID:17082774, PRO:DAN]

Yes

organism-modification



PR:000044788

thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in human. UniProtKB:P35442-1, 307-1172." [PMID:17082774, PRO:DAN]

Yes

organism-modification



PR:000063790

thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+


"A thrombospondin-2 (human) that has had the signal peptide removed and that includes at least one fucosylserine. UniProtKB:P35442, 19-1172, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173111]


organism-modification



PR:000064692

thrombospondin-2, signal peptide removed O-glycosylserine form (human)

hTHBS2/SigPep-/OGlycoSer+


"A thrombospondin-2 (human) that has had the signal peptide removed and that includes at least one O-glycosylated serine. UniProtKB:P35442, 19-1172, MOD:00002." [PRO:DNx, Reactome:R-HSA-5173234]


organism-modification



PR:000063790

thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+


"A thrombospondin-2 (human) that has had the signal peptide removed and that includes at least one fucosylserine. UniProtKB:P35442, 19-1172, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173111]


organism-modification



PR:000071125

thrombospondin-2 deaminated 1 (human)

hTHBS2/Deam:1


"A thrombospondin-2 (human) that has been deaminated on the residue at the position equivalent to Asn-875 of the amino acid sequence represented by UniProtKB:P35442. UniProtKB:P35442, Asn-875, MOD:00684." [IEDB_epitope:1799325, PRO:DNx]


organism-modification



PR:000085983

thrombospondin-2, signal peptide removed form (human)

hTHBS2/SigPep-


"A thrombospondin-2 (human) that has had the signal peptide removed. UniProtKB:P35442, 19-1172." [PRO:DNx, Reactome:R-HSA-5173187, Reactome:R-HSA-66520]


organism-modification



PR:000036491

thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-


"A thrombospondin-2 isoform 1, signal peptide removed form in human. UniProtKB:P35442-1, 19-1172." [PMID:1459996, PRO:CNA]

Yes

organism-modification



PR:000064692

thrombospondin-2, signal peptide removed O-glycosylserine form (human)

hTHBS2/SigPep-/OGlycoSer+


"A thrombospondin-2 (human) that has had the signal peptide removed and that includes at least one O-glycosylated serine. UniProtKB:P35442, 19-1172, MOD:00002." [PRO:DNx, Reactome:R-HSA-5173234]


organism-modification



PR:000063790

thrombospondin-2, signal peptide removed fucosylserine form (human)

hTHBS2/SigPep-/FucSer+


"A thrombospondin-2 (human) that has had the signal peptide removed and that includes at least one fucosylserine. UniProtKB:P35442, 19-1172, MOD:00812." [PRO:DNx, Reactome:R-HSA-5173111]


organism-gene



PR:Q03350

thrombospondin-2 (mouse)

mTHBS2


"A thrombospondin-2 that is encoded in the genome of mouse." [OMA:Q03350, PRO:DNx]


organism-sequence



PR:Q03350-1

thrombospondin-2 isoform 1 (mouse)

mTHBS2/iso:1


"A thrombospondin-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036492

thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in mouse. UniProtKB:Q03350-1, 19-306." [PMID:17082774, PRO:CNA]


organism-modification



PR:000036493

thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in mouse. UniProtKB:Q03350-1, 307-1172." [PMID:17082774, PRO:CNA]


sequence



PR:000000377

thrombospondin-2 isoform 1

THBS2/iso:1


"A thrombospondin-2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35442-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P35442-1

thrombospondin-2 isoform 1 (human)

hTHBS2/iso:1


"A thrombospondin-2 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036491

thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-


"A thrombospondin-2 isoform 1, signal peptide removed form in human. UniProtKB:P35442-1, 19-1172." [PMID:1459996, PRO:CNA]

Yes

organism-modification



PR:000044787

thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in human. UniProtKB:P35442-1, 19-306." [PMID:17082774, PRO:DAN]

Yes

organism-modification



PR:000044788

thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in human. UniProtKB:P35442-1, 307-1172." [PMID:17082774, PRO:DAN]

Yes

organism-sequence



PR:Q03350-1

thrombospondin-2 isoform 1 (mouse)

mTHBS2/iso:1


"A thrombospondin-2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036492

thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in mouse. UniProtKB:Q03350-1, 19-306." [PMID:17082774, PRO:CNA]


organism-modification



PR:000036493

thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in mouse. UniProtKB:Q03350-1, 307-1172." [PMID:17082774, PRO:CNA]


modification



PR:000000591

thrombospondin-2 isoform 1, signal peptide removed form

THBS2/iso:1/SigPep-


"A thrombospondin-2 isoform 1 that has had the signal peptide removed." [PRO:CNA]


organism-modification



PR:000036491

thrombospondin-2 isoform 1, signal peptide removed form (human)

hTHBS2/iso:1/SigPep-


"A thrombospondin-2 isoform 1, signal peptide removed form in human. UniProtKB:P35442-1, 19-1172." [PMID:1459996, PRO:CNA]

Yes

modification



PR:000000592

thrombospondin-2 isoform 1 cleaved 2

THBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 that has been proteolytically processed by ADAMTS1 to render an N-terminal domain product." [PMID:17082774]


organism-modification



PR:000036492

thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in mouse. UniProtKB:Q03350-1, 19-306." [PMID:17082774, PRO:CNA]


organism-modification



PR:000044787

thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in human. UniProtKB:P35442-1, 19-306." [PMID:17082774, PRO:DAN]

Yes

modification



PR:000000593

thrombospondin-2 isoform 1 cleaved 3

THBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 that has been proteolytically processed by ADAMTS1 to render a C-terminal domain product." [PMID:17082774]


organism-modification



PR:000036493

thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in mouse. UniProtKB:Q03350-1, 307-1172." [PMID:17082774, PRO:CNA]


organism-modification



PR:000044788

thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in human. UniProtKB:P35442-1, 307-1172." [PMID:17082774, PRO:DAN]

Yes

modification



PR:000025438

thrombospondin-2 proteolytic cleavage product

THBS2/ClvPrd


"A thrombospondin-2 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000592

thrombospondin-2 isoform 1 cleaved 2

THBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 that has been proteolytically processed by ADAMTS1 to render an N-terminal domain product." [PMID:17082774]


organism-modification



PR:000036492

thrombospondin-2 isoform 1 cleaved 2 (mouse)

mTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in mouse. UniProtKB:Q03350-1, 19-306." [PMID:17082774, PRO:CNA]


organism-modification



PR:000044787

thrombospondin-2 isoform 1 cleaved 2 (human)

hTHBS2/iso:1/Clv:2


"A thrombospondin-2 isoform 1 cleaved 2 in human. UniProtKB:P35442-1, 19-306." [PMID:17082774, PRO:DAN]

Yes

modification



PR:000000593

thrombospondin-2 isoform 1 cleaved 3

THBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 that has been proteolytically processed by ADAMTS1 to render a C-terminal domain product." [PMID:17082774]


organism-modification



PR:000036493

thrombospondin-2 isoform 1 cleaved 3 (mouse)

mTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in mouse. UniProtKB:Q03350-1, 307-1172." [PMID:17082774, PRO:CNA]


organism-modification



PR:000044788

thrombospondin-2 isoform 1 cleaved 3 (human)

hTHBS2/iso:1/Clv:3


"A thrombospondin-2 isoform 1 cleaved 3 in human. UniProtKB:P35442-1, 307-1172." [PMID:17082774, PRO:DAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036491 hTHBS2/iso:1/SigPep-
UniProtKB:P35442-1, 19-1172
enablesGO:0008201 heparin binding PMID:1459996
PR:000044787 hTHBS2/iso:1/Clv:2
UniProtKB:P35442-1, 19-306
acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774
located_inGO:0005615 extracellular space PMID:17082774
PR:000044788 hTHBS2/iso:1/Clv:3
UniProtKB:P35442-1, 307-1172
acts_upstream_of_or_withinGO:0016525 negative regulation of angiogenesis PMID:17082774
GO:0060055 angiogenesis involved in wound healing PMID:17082774