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Protein Ontology report - thrombospondin-4
PR:000000132 - http://purl.obolibrary.org/obo/PR_000000132
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000132   
  PRO namethrombospondin-4 
  Synonyms
PRO-Short-label: EXACT:THBS4
Gene-based: RELATED:TSP4
  Definition"A thrombospondin subgroup B that is a translation product of the human THBS4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000030 thrombospondin subgroup B
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification2                                                  Organism-Modification 6                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000132

thrombospondin-4

THBS4


"A thrombospondin subgroup B that is a translation product of the human THBS4 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P35443

thrombospondin-4 (human)

hTHBS4


"A thrombospondin-4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P35443]


organism-sequence



PR:P35443-1

thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

organism-modification



PR:000056389

thrombospondin-4 O-glycosylated 1 (human)

hTHBS4/OGlyco:1


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Ser-272 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G53434XO. Example: UniProtKB:P35443-1, Ser-272, MOD:00002~GNO:G53434XO." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056390

thrombospondin-4 O-glycosylated 2 (human)

hTHBS4/OGlyco:2


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-270 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P35443-1, Thr-270, MOD:00005~GNO:G43417UB." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056391

thrombospondin-4 O-glycosylated 3 (human)

hTHBS4/OGlyco:3


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-273 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G29068FM. Example: UniProtKB:P35443-1, Thr-273, MOD:00005~GNO:G29068FM." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000056392

thrombospondin-4 O-glycosylated 4 (human)

hTHBS4/OGlyco:4


"A thrombospondin-4 (human) that has been O-glycosylated at the residue equivalent to Thr-273 of the amino acid sequence represented by UniProtKB:P35443-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:P35443-1, Thr-273, MOD:00005~GNO:G43417UB." [GlyGen:P35443-1, PMID:30459171, PRO:DNx]


organism-modification



PR:000085893

thrombospondin-4, signal peptide removed form (human)

hTHBS4/SigPep-


"A thrombospondin-4 (human) that has had the signal peptide removed. UniProtKB:P35443, 27-961." [PRO:DNx, Reactome:R-HSA-66524]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

organism-gene



PR:P49744

thrombospondin-4 (rat)

rTHBS4


"A thrombospondin-4 that is encoded in the genome of rat." [OMA:P49744, PRO:DNx]


organism-gene



PR:Q8JGW0

thrombospondin-4-B (zebrafish)

z-THBS4


"A thrombospondin-4 that is encoded in the genome of zebrafish." [PRO:CNA]


organism-gene



PR:Q9Z1T2

thrombospondin-4 (mouse)

mTHBS4


"A thrombospondin-4 that is encoded in the genome of mouse." [OMA:Q9Z1T2, PRO:DNx]


organism-sequence



PR:Q9Z1T2-1

thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


sequence



PR:000000379

thrombospondin-4 isoform 1

THBS4/iso:1


"A thrombospondin-4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P35443-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P35443-1

thrombospondin-4 isoform 1 (human)

hTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

organism-sequence



PR:Q9Z1T2-1

thrombospondin-4 isoform 1 (mouse)

mTHBS4/iso:1


"A thrombospondin-4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


modification



PR:000000595

thrombospondin-4 isoform 1, signal peptide removed form

THBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1 that has had the signal peptide removed." [PMID:8654563]


organism-modification



PR:000026337

thrombospondin-4 isoform 1, signal peptide removed form (human)

hTHBS4/iso:1/SigPep-


"A thrombospondin-4 isoform 1, signal peptide removed form in human. UniProtKB:P35443-1, 27-961." [PRO:DNx, UniProtKB:P35443]

Yes

modification



PR:000025440

thrombospondin-4 proteolytic cleavage product

THBS4/ClvPrd


"A thrombospondin-4 that has been processed by proteolytic cleavage." [PRO:DNx]


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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006930 substrate-dependent cell migration, cell extensionPR:000026337 hTHBS4/iso:1/SigPep- PMID:7490284

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005509 calcium ion bindingPR:000026337 hTHBS4/iso:1/SigPep- PMID:7852353
GO:0008201 heparin bindingPR:000026337 hTHBS4/iso:1/SigPep- PMID:7852353

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0031012 extracellular matrixPR:000026337 hTHBS4/iso:1/SigPep- PMID:7490284