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Protein Ontology report - transcription factor Sp1
PR:000000133 - http://purl.obolibrary.org/obo/PR_000000133
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000133   
  PRO nametranscription factor Sp1 
  Synonyms
PRO-Short-label: EXACT:SP1
Gene-based: RELATED:TSFP1
  Definition"A transcription factor Sp that is a translation product of the human SP1 gene or a 1:1 ortholog thereof. It comprises the exons that code for an N-terminal inhibitory domain, two serine/threonine stretches adjacent to activation domains and three zinc fingers." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000032 transcription factor Sp
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 5                                        
         Modification14                                                  Organism-Modification 14                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000133
transcription factor Sp1
SP1
"A transcription factor Sp that is a translation product of the human SP1 gene or a 1:1 ortholog thereof. It comprises the exons that code for an N-terminal inhibitory domain, two serine/threonine stretches adjacent to activation domains and three zinc fingers." [PRO:CNA]

organism-gene


PR:O89090
transcription factor Sp1 (mouse)
mSP1
"A transcription factor Sp1 that is encoded in the genome of mouse." [OMA:O89090, PRO:DNx]

organism-sequence


PR:O89090-1
transcription factor Sp1 isoform 1 (mouse)
mSP1/iso:1
"A transcription factor Sp1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O89090]

organism-sequence


PR:O89090-2
transcription factor Sp1 isoform m2 (mouse)
mSP1/iso:m2
"A transcription factor Sp1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O89090-2." [PRO:DNx, UniProtKB:O89090]

organism-gene


PR:P08047
transcription factor Sp1 (human)
hSP1
"A transcription factor Sp1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P08047]

organism-sequence


PR:P08047-1
transcription factor Sp1 isoform 1 (human)
hSP1/iso:1
"A transcription factor Sp1 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08047]
Yes
organism-modification


PR:000028672
transcription factor Sp1 isoform 1 acetylated 2 (human)
hSP1/iso:1/Ac:2
"A transcription factor Sp1 isoform 1 acetylated 2 in human. UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]

organism-modification


PR:000036496
transcription factor Sp1 isoform 1 acetylated 1 (human)
hSP1/iso:1/Ac:1
"A transcription factor Sp1 isoform 1 acetylated 1 in human." [PMID:15647279, PRO:CNA]
Yes
organism-modification


PR:000036497
transcription factor Sp1 isoform 1 cleaved 1 (human)
hSP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]
Yes
organism-modification


PR:000036498
transcription factor Sp1 isoform 1 O-glycosylated 1 (human)
hSP1/iso:1/OGlyco:1
"A transcription factor Sp1 isoform 1 O-glycosylated 1 in human. UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PMID:9343410, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036499
transcription factor Sp1 isoform 1 phosphorylated 1 (human)
hSP1/iso:1/Phos:1
"A transcription factor Sp1 isoform 1 phosphorylated 1 in human." [PMID:2170018, PMID:9525578, PRO:CNA]
Yes
organism-modification


PR:000036500
transcription factor Sp1 isoform 1 phosphorylated 2 (human)
hSP1/iso:1/Phos:2
"A transcription factor Sp1 isoform 1 phosphorylated 2 in human. UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193, PRO:CNA]
Yes
organism-modification


PR:000036501
transcription factor Sp1 isoform 1 phosphorylated 3 (human)
hSP1/iso:1/Phos:3
"A transcription factor Sp1 isoform 1 phosphorylated 3 in human. UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:17049555, PMID:18239466, PRO:CNA]
Yes
organism-modification


PR:000036502
transcription factor Sp1 isoform 1 phosphorylated 4 (human)
hSP1/iso:1/Phos:4
"A transcription factor Sp1 isoform 1 phosphorylated 4 in human." [PMID:18171990, PRO:CNA]
Yes
organism-modification


PR:000036503
transcription factor Sp1 isoform 1 sumoylated 1 (human)
hSP1/iso:1/Sumo:1
"A transcription factor Sp1 isoform 1 sumoylated 1 in human. UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261, PRO:CNA]
Yes
organism-sequence


PR:P08047-2
transcription factor Sp1 isoform h2 (human)
hSP1/iso:h2
"A transcription factor Sp1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-2." [PRO:DNx, UniProtKB:P08047]

organism-sequence


PR:P08047-3
transcription factor Sp1 isoform h3 (human)
hSP1/iso:h3
"A transcription factor Sp1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-3." [PRO:DNx, UniProtKB:P08047]

organism-modification


PR:000045654
transcription factor Sp1 phosphorylated 1 (human)
hSP1/Phos:1
"A transcription factor Sp1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-739 of the amino acid sequence represented by UniProtKB:P08047-1. Example: UniProtKB:P08047-1, Thr-739, MOD:00047." [iPTMnet:P08047, PMID:22266860]

organism-modification


PR:000049324
transcription factor Sp1, initiator methionine removed form (human)
hSP1/InitMet-
"A transcription factor Sp1 (human) that has had the initiator methionine removed. UniProtKB:P08047, 2-785." [PRO:DNx, Reactome:R-HSA-1592223]

organism-modification


PR:000069002
transcription factor Sp1 methylated 1 (human)
hSP1/Me:1
"A transcription factor Sp1 (human) that has been methylated on the residue at the position equivalent to Cys-755 of the amino acid sequence represented by UniProtKB:P08047-1. Example: UniProtKB:P08047-1, Cys-755, MOD:00660." [IEDB_epitope:1007012, PRO:DNx]

organism-modification


PR:000073305
transcription factor Sp1 deaminated 1 (human)
hSP1/Deam:1
"A transcription factor Sp1 (human) that has been deaminated on the residue at the position equivalent to Asn-244 of the amino acid sequence represented by UniProtKB:P08047-1. Example: UniProtKB:P08047-1, Asn-244, MOD:00684." [IEDB_epitope:1583104, PRO:DNx]

organism-modification


PR:000080651
transcription factor Sp1 cysteinylated 1 (human)
hSP1/Cyst:1
"A transcription factor Sp1 (human) that has been cysteinylated on the residue at the position equivalent to Cys-755 of the amino acid sequence represented by UniProtKB:P08047-1. Example: UniProtKB:P08047-1, Cys-755, MOD:00765." [IEDB_epitope:876858, PRO:DNx]

organism-gene


PR:Q01714
transcription factor Sp1 (rat)
rSP1
"A transcription factor Sp1 that is encoded in the genome of rat." [OMA:Q01714, PRO:DNx]

organism-gene


PR:Q90WR9
transcription factor (chicken)
chick-SP1
"A transcription factor Sp1 that is encoded in the genome of chicken." [OMA:Q90WR9, PRO:DAN]

sequence


PR:000000380
transcription factor Sp1 isoform 1
SP1/iso:1
"A transcription factor Sp1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P08047-1 or a 1:1 ortholog thereof." [PMID:10570957, PRO:CNA, PRO:DAN]

organism-sequence


PR:O89090-1
transcription factor Sp1 isoform 1 (mouse)
mSP1/iso:1
"A transcription factor Sp1 isoform 1 that is encoded in the genome of mouse." [PRO:DNx, UniProtKB:O89090]

organism-sequence


PR:P08047-1
transcription factor Sp1 isoform 1 (human)
hSP1/iso:1
"A transcription factor Sp1 isoform 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P08047]
Yes
organism-modification


PR:000028672
transcription factor Sp1 isoform 1 acetylated 2 (human)
hSP1/iso:1/Ac:2
"A transcription factor Sp1 isoform 1 acetylated 2 in human. UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]

organism-modification


PR:000036496
transcription factor Sp1 isoform 1 acetylated 1 (human)
hSP1/iso:1/Ac:1
"A transcription factor Sp1 isoform 1 acetylated 1 in human." [PMID:15647279, PRO:CNA]
Yes
organism-modification


PR:000036497
transcription factor Sp1 isoform 1 cleaved 1 (human)
hSP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]
Yes
organism-modification


PR:000036498
transcription factor Sp1 isoform 1 O-glycosylated 1 (human)
hSP1/iso:1/OGlyco:1
"A transcription factor Sp1 isoform 1 O-glycosylated 1 in human. UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PMID:9343410, PRO:CNA, PRO:DAN]
Yes
organism-modification


PR:000036499
transcription factor Sp1 isoform 1 phosphorylated 1 (human)
hSP1/iso:1/Phos:1
"A transcription factor Sp1 isoform 1 phosphorylated 1 in human." [PMID:2170018, PMID:9525578, PRO:CNA]
Yes
organism-modification


PR:000036500
transcription factor Sp1 isoform 1 phosphorylated 2 (human)
hSP1/iso:1/Phos:2
"A transcription factor Sp1 isoform 1 phosphorylated 2 in human. UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193, PRO:CNA]
Yes
organism-modification


PR:000036501
transcription factor Sp1 isoform 1 phosphorylated 3 (human)
hSP1/iso:1/Phos:3
"A transcription factor Sp1 isoform 1 phosphorylated 3 in human. UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:17049555, PMID:18239466, PRO:CNA]
Yes
organism-modification


PR:000036502
transcription factor Sp1 isoform 1 phosphorylated 4 (human)
hSP1/iso:1/Phos:4
"A transcription factor Sp1 isoform 1 phosphorylated 4 in human." [PMID:18171990, PRO:CNA]
Yes
organism-modification


PR:000036503
transcription factor Sp1 isoform 1 sumoylated 1 (human)
hSP1/iso:1/Sumo:1
"A transcription factor Sp1 isoform 1 sumoylated 1 in human. UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261, PRO:CNA]
Yes
modification


PR:000000490
transcription factor Sp1 isoform 1 acetylated form
SP1/iso:1/AcRes+
"A transcription factor Sp1 isoform 1 that includes at least one acetylated residue." [PRO:CNA]

modification


PR:000000596
transcription factor Sp1 isoform 1 acetylated 1
SP1/iso:1/Ac:1
"A transcription factor Sp1 isoform 1 acetylated form that has been acetylated by PCAF." [PRO:CNA]

organism-modification


PR:000036496
transcription factor Sp1 isoform 1 acetylated 1 (human)
hSP1/iso:1/Ac:1
"A transcription factor Sp1 isoform 1 acetylated 1 in human." [PMID:15647279, PRO:CNA]
Yes
modification


PR:000028671
transcription factor Sp1 isoform 1 acetylated 2
SP1/iso:1/Ac:2
"A transcription factor Sp1 isoform 1 that has been acetylated on a Lys residue within the conserved sequence SDHLSKHI in the most C-terminal zinc finger. Example: UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]

organism-modification


PR:000028672
transcription factor Sp1 isoform 1 acetylated 2 (human)
hSP1/iso:1/Ac:2
"A transcription factor Sp1 isoform 1 acetylated 2 in human. UniProtKB:P08047-1, Lys-703, MOD:00064." [PMID:16478997, PRO:PD]

modification


PR:000000492
transcription factor Sp1 isoform 1 glycosylated form
SP1/iso:1/GlycoRes+
"A transcription factor Sp1 isoform 1 that includes at least one glycosylated residue." [PRO:CNA]

modification


PR:000000598
transcription factor Sp1 isoform 1 O-glycosylated 1
SP1/iso:1/OGlyco:1
"A transcription factor Sp1 isoform 1 glycosylated form that has terminal O-linked N-acetylglucosamines. Example: UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PRO:CNA, PRO:DAN]

organism-modification


PR:000036498
transcription factor Sp1 isoform 1 O-glycosylated 1 (human)
hSP1/iso:1/OGlyco:1
"A transcription factor Sp1 isoform 1 O-glycosylated 1 in human. UniProtKB:P08047-1, Ser-491, MOD:00805." [PMID:11371615, PMID:9343410, PRO:CNA, PRO:DAN]
Yes
modification


PR:000000493
transcription factor Sp1 isoform 1 phosphorylated form
SP1/iso:1/PhosRes+
"A transcription factor Sp1 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000599
transcription factor Sp1 isoform 1 phosphorylated 1
SP1/iso:1/Phos:1
"A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs within the N-terminal activation domains by a DNA-dependent protein kinase." [PMID:2170018]

organism-modification


PR:000036499
transcription factor Sp1 isoform 1 phosphorylated 1 (human)
hSP1/iso:1/Phos:1
"A transcription factor Sp1 isoform 1 phosphorylated 1 in human." [PMID:2170018, PMID:9525578, PRO:CNA]
Yes
modification


PR:000000600
transcription factor Sp1 isoform 1 phosphorylated 2
SP1/iso:1/Phos:2
"A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at a Thr residue within the C-terminal region by casein kinase II. Example: UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193]

organism-modification


PR:000036500
transcription factor Sp1 isoform 1 phosphorylated 2 (human)
hSP1/iso:1/Phos:2
"A transcription factor Sp1 isoform 1 phosphorylated 2 in human. UniProtKB:P08047-1, Thr-579, MOD:00047." [PMID:9153193, PRO:CNA]
Yes
modification


PR:000000601
transcription factor Sp1 isoform 1 phosphorylated 3
SP1/iso:1/Phos:3
"A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at the Ser residue within the CyclinA/cdk2 phosphorylation site (QPSP sequence). Phosphorylation at this site induces removal of the inhibitory domain by proteolytic processing and activation of transcription activity. Example: UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:18239466]

organism-modification


PR:000036501
transcription factor Sp1 isoform 1 phosphorylated 3 (human)
hSP1/iso:1/Phos:3
"A transcription factor Sp1 isoform 1 phosphorylated 3 in human. UniProtKB:P08047-1, Ser-59, MOD:00046." [PMID:17049555, PMID:18239466, PRO:CNA]
Yes
modification


PR:000000602
transcription factor Sp1 isoform 1 phosphorylated 4
SP1/iso:1/Phos:4
"A transcription factor Sp1 isoform 1 phosphorylated form in which the phosphorylation occurs at the first serine/threonine stretch by ATM kinase in response to DNA damage." [PMID:18171990]

organism-modification


PR:000036502
transcription factor Sp1 isoform 1 phosphorylated 4 (human)
hSP1/iso:1/Phos:4
"A transcription factor Sp1 isoform 1 phosphorylated 4 in human." [PMID:18171990, PRO:CNA]
Yes
modification


PR:000000494
transcription factor Sp1 isoform 1 sumoylated form
SP1/iso:1/SumoLys+
"A transcription factor Sp1 isoform 1 that includes at least one sumoylated lysine." [PRO:CNA]

modification


PR:000000603
transcription factor Sp1 isoform 1 sumoylated 1
SP1/iso:1/Sumo:1
"A transcription factor Sp1 isoform 1 sumoylated form that has a SUMO protein covalently linked to a Lys residue at the consensus motif VKIE within the N-terminal inhibitory domain. Example: UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261]

organism-modification


PR:000036503
transcription factor Sp1 isoform 1 sumoylated 1 (human)
hSP1/iso:1/Sumo:1
"A transcription factor Sp1 isoform 1 sumoylated 1 in human. UniProtKB:P08047-1, Lys-16, MOD:01149." [PMID:16407261, PRO:CNA]
Yes
modification


PR:000000597
transcription factor Sp1 isoform 1 cleaved 1
SP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 that has had the N-terminal inhibitory domain released." [PMID:16407261]

organism-modification


PR:000036497
transcription factor Sp1 isoform 1 cleaved 1 (human)
hSP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]
Yes
modification


PR:000025441
transcription factor Sp1 proteolytic cleavage product
SP1/ClvPrd
"A transcription factor Sp1 that has been processed by proteolytic cleavage." [PRO:DNx]

modification


PR:000000597
transcription factor Sp1 isoform 1 cleaved 1
SP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 that has had the N-terminal inhibitory domain released." [PMID:16407261]

organism-modification


PR:000036497
transcription factor Sp1 isoform 1 cleaved 1 (human)
hSP1/iso:1/Clv:1
"A transcription factor Sp1 isoform 1 cleaved 1 in human. UniProtKB:P08047-1, 65-785." [PMID:16407261, PRO:CNA]
Yes
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0007179 transforming growth factor beta receptor signaling pathwayPR:000036496 hSP1/iso:1/Ac:1 PMID:15647279
GO:0042770 signal transduction in response to DNA damagePR:000036502 hSP1/iso:1/Phos:4 PMID:18171990

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0003677 DNA bindingPR:000036496 hSP1/iso:1/Ac:1 PMID:15647279
PR:000036498 hSP1/iso:1/OGlyco:1 PMID:11371615
PR:000036499 hSP1/iso:1/Phos:1 PMID:2170018
GO:0003700 DNA-binding transcription factor activityPR:000036497 hSP1/iso:1/Clv:1 PMID:16407261
PR:000036498 hSP1/iso:1/OGlyco:1 PMID:11371615
PR:000036500 hSP1/iso:1/Phos:2 PMID:9153193
PR:000036501 hSP1/iso:1/Phos:3 PMID:17049555; PMID:18239466
PR:000036503 hSP1/iso:1/Sumo:1 PMID:16407261

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005634 nucleusPR:000036496 hSP1/iso:1/Ac:1 PMID:15647279
PR:000036497 hSP1/iso:1/Clv:1 PMID:16407261
PR:000036498 hSP1/iso:1/OGlyco:1 PMID:11371615
PR:000036499 hSP1/iso:1/Phos:1 PMID:2170018; PMID:9525578
PR:000036500 hSP1/iso:1/Phos:2 PMID:9153193
PR:000036501 hSP1/iso:1/Phos:3 PMID:17049555; PMID:18239466
PR:000036502 hSP1/iso:1/Phos:4 PMID:18171990
PR:P08047-1 hSP1/iso:1 PMID:2170018