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Protein Ontology report - tumor necrosis factor
PR:000000134 - http://purl.obolibrary.org/obo/PR_000000134
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000134   
  PRO nametumor necrosis factor 
  Synonyms
PRO-Short-label: EXACT:TNF
Gene-based: RELATED:TNFA | TNFSF2
Other: EXACT:cachectin | TNF-a | TNF-alpha | TNFa | tumor necrosis factor alpha | tumor necrosis factor ligand superfamily member 2
  Definition"A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000033 tumor necrosis factor, TNF-like
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification7                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Related Cross References

  Db identifiers
PIRSF:PIRSF500467
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000134
tumor necrosis factor
TNF
"A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells." [PMID:11053079, PRO:CNA]

organism-gene


PR:P01375
tumor necrosis factor (human)
hTNF
"A tumor necrosis factor that is encoded in the genome of human." [PRO:DNx]

Yes
organism-sequence


PR:P01375-1
tumor necrosis factor isoform 1 (human)
hTNF/iso:1
"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
Yes
organism-modification


PR:000036507
tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
Yes
organism-modification


PR:000036508
tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
Yes
organism-modification


PR:000051774
tumor necrosis factor O-glycosylated 1 (human)
hTNF/OGlyco:1
"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G00031MO. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G00031MO." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]

organism-modification


PR:000051775
tumor necrosis factor O-glycosylated 2 (human)
hTNF/OGlyco:2
"A tumor necrosis factor (human) that has been O-glycosylated at the residue equivalent to Ser-80 of the amino acid sequence represented by UniProtKB:P01375-1, in which the glycan structure is represented by GlyTouCan:G56682BC. Example: UniProtKB:P01375-1, Ser-80, MOD:00002~GNO:G56682BC." [GlyGen:P01375-1, PMID:8631363, PRO:DNx]

organism-gene


PR:P06804
tumor necrosis factor (mouse)
mTNF
"A tumor necrosis factor that is encoded in the genome of mouse." [OMA:P06804, PRO:DNx]

organism-sequence


PR:P06804-1
tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1
"A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036505
tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
Yes
organism-modification


PR:000036506
tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
Yes
organism-gene


PR:P16599
tumor necrosis factor (rat)
rTNF
"A tumor necrosis factor that is encoded in the genome of rat." [OMA:P16599, PRO:DNx]

sequence


PR:000000381
tumor necrosis factor isoform 1
TNF/iso:1
"A tumor necrosis factor that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01375-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P01375-1
tumor necrosis factor isoform 1 (human)
hTNF/iso:1
"A tumor necrosis factor isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
Yes
organism-modification


PR:000036507
tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
Yes
organism-modification


PR:000036508
tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
Yes
organism-sequence


PR:P06804-1
tumor necrosis factor isoform 1 (mouse)
mTNF/iso:1
"A tumor necrosis factor isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036505
tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
Yes
organism-modification


PR:000036506
tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
Yes
modification


PR:000000496
tumor necrosis factor isoform 1 myristoylated form
TNF/iso:1/MyrRes+
"A tumor necrosis factor isoform 1 that includes at least one myristoylated residue." [PRO:CNA]

modification


PR:000000606
tumor necrosis factor isoform 1 myristoylated 1
TNF/iso:1/Myr:1
"A tumor necrosis factor isoform 1 myristoylated form that has been modified at the N-epsilon-NH2 groups of the most N-terminal Lys within the cytoplasmic domain. Example: UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651]

organism-modification


PR:000036507
tumor necrosis factor isoform 1 myristoylated 1 (human)
hTNF/iso:1/Myr:1
"A tumor necrosis factor isoform 1 myristoylated 1 in human. UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087." [PMID:1402651, PRO:CNA]
Yes
modification


PR:000000497
tumor necrosis factor isoform 1 phosphorylated form
TNF/iso:1/PhosRes+
"A tumor necrosis factor isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]

modification


PR:000000607
tumor necrosis factor isoform 1 phosphorylated 1
TNF/iso:1/Phos:1
"A tumor necrosis factor isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Ser within the ST[EK]S motif in the cytoplasmic domain. Example: UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166]

organism-modification


PR:000036508
tumor necrosis factor isoform 1 phosphorylated 1 (human)
hTNF/iso:1/Phos:1
"A tumor necrosis factor isoform 1 phosphorylated 1 in human. UniProtKB:P01375-1, Ser-2, MOD:00046." [PMID:10205166, PMID:8597870, PRO:CNA]
Yes
modification


PR:000000604
tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]

organism-modification


PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
Yes
organism-modification


PR:000036505
tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
Yes
modification


PR:000000605
tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]

organism-modification


PR:000036506
tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
Yes
modification


PR:000018285
tumor necrosis factor proteolytic cleavage product
TNF/ClvPrd
"A tumor necrosis factor that has been processed by proteolytic cleavage." [PRO:DNx]

modification


PR:000000604
tumor necrosis factor isoform 1 cleaved 1
TNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 that is the soluble C-terminal portion after processing by TNF alpha converting enzyme ADAM17." [PMID:12135369]

organism-modification


PR:000036504
tumor necrosis factor isoform 1 cleaved 1 (human)
hTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in human. UniProtKB:P01375-1, 77-233." [PMID:14512626, PMID:3856324, PRO:CNA]
Yes
organism-modification


PR:000036505
tumor necrosis factor isoform 1 cleaved 1 (mouse)
mTNF/iso:1/Clv:1
"A tumor necrosis factor isoform 1 cleaved 1 in mouse. UniProtKB:P06804-1, 80-235." [PMID:10089307, PMID:9305915, PRO:CNA]
Yes
modification


PR:000000605
tumor necrosis factor isoform 1 cleaved 2
TNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 that is the inactive soluble form after alternative protein processing. The resulting protein is 10 amino acids longer than the active form." [PMID:2777790, PRO:CNA, PRO:DAN]

organism-modification


PR:000036506
tumor necrosis factor isoform 1 cleaved 2 (mouse)
mTNF/iso:1/Clv:2
"A tumor necrosis factor isoform 1 cleaved 2 in mouse. UniProtKB:P06804-1, 70-235." [PMID:2777790, PRO:CNA]
Yes
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TNF forms found in complexes   

TNF Component
 Complexes
PR:P01375 hTNF PR:000028432 TNF-alpha:TNF-R1:TRAPP:RIP1:TRAF2 complex (human)
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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036504 hTNF/iso:1/Clv:1
UniProtKB:P01375-1, 77-233		 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
enablesGO:0005164 tumor necrosis factor receptor binding with PR:P19438 CD120a (human) PMID:14512626
GO:0042802 identical protein binding PMID:14512626
PR:000036505 mTNF/iso:1/Clv:1
UniProtKB:P06804-1, 80-235		 acts_upstream_of_or_withinGO:0006355 regulation of DNA-templated transcription PMID:9305915
located_inGO:0005615 extracellular space PMID:10089307
PR:000036506 mTNF/iso:1/Clv:2
UniProtKB:P06804-1, 70-235		 enablesNOT GO:0005125 cytokine activity PMID:2777790
located_inGO:0005576 extracellular region PMID:2777790
PR:000036507 hTNF/iso:1/Myr:1
UniProtKB:P01375-1, Lys-19/Lys-20, MOD:00087		 located_inGO:0016020 membrane PMID:1402651
PR:000036508 hTNF/iso:1/Phos:1
UniProtKB:P01375-1, Ser-2, MOD:00046		 located_inGO:0016020 membrane PMID:10205166
PR:P01375-1 hTNF/iso:1 acts_upstream_of_or_withinGO:0006915 apoptotic process PMID:3856324
located_inGO:0005886 plasma membrane PMID:3349526