back to PRO homepage
  Home |   Linked Open Data |   Browse |  
Search

 |   Statistics |   Download
 RACE-PRO
 PRO tracker
 Community
 PRO Consortium
 Publications
 Documentation

Protein Ontology report - bone morphogenetic protein 2
PR:000000164 - http://purl.obolibrary.org/obo/PR_000000164
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000164   
  PRO namebone morphogenetic protein 2 
  Synonyms
PRO-Short-label: EXACT:BMP2
Gene-based: RELATED:BMP2A
Other: EXACT:BMP-2 | BMP-2A | bone morphogenetic protein 2A
  Definition"A bone morphogenetic protein that is a translation product of the human BMP2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000034 bone morphogenetic protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
Back to top
Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000164
bone morphogenetic protein 2
BMP2
"A bone morphogenetic protein that is a translation product of the human BMP2 gene or a 1:1 ortholog thereof." [PRO:CNA]
Yes
organism-gene


PR:P12643
bone morphogenetic protein 2 (human)
hBMP2
"A bone morphogenetic protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12643]

organism-sequence


PR:P12643-1
bone morphogenetic protein 2 isoform 1 (human)
hBMP2/iso:1
"A bone morphogenetic protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000026336
bone morphogenetic protein 2 isoform 1, mature form (human)
hBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396." [PRO:DNx, UniProtKB:P12643]
Yes
organism-modification


PR:000046491
bone morphogenetic protein 2, signal peptide removed form (human)
hBMP2/SigPep-
"A bone morphogenetic protein 2 (human) that has had the signal peptide removed. UniProtKB:P12643, 24-396." [PRO:DNx, Reactome:R-HSA-2396130]

organism-modification


PR:000026336
bone morphogenetic protein 2 isoform 1, mature form (human)
hBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396." [PRO:DNx, UniProtKB:P12643]
Yes
organism-gene


PR:P21274
bone morphogenetic protein 2 (mouse)
mBMP2
"A bone morphogenetic protein 2 that is encoded in the genome of mouse." [OMA:P21274, PRO:DNx]

organism-sequence


PR:000050190
bone morphogenetic protein 2 isoform m2 (mouse)
mBMP2/iso:m2
"A bone morphogenetic protein 2 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P21274-1, 59-394. This isoform is encoded from an alternative downstream start codon relative to that encoding for isoform 1. UniProtKB:P21274-1, 59-394." [PMID:20230640, PMID:30700748, PRO:HJD]

organism-sequence


PR:P21274-1
bone morphogenetic protein 2 isoform 1 (mouse)
mBMP2/iso:1
"A bone morphogenetic protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036510
bone morphogenetic protein 2 isoform 1, mature form (mouse)
mBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in mouse. UniProtKB:P21274-1, 281-394." [PMID:14623234, PMID:15110716, PMID:15565649, PMID:16109715, PRO:CNA]
Yes
organism-gene


PR:P49001
bone morphogenetic protein 2 (rat)
rBMP2
"A bone morphogenetic protein 2 that is encoded in the genome of rat." [OMA:P49001, PRO:DNx]

sequence


PR:000000385
bone morphogenetic protein 2 isoform 1
BMP2/iso:1
"A bone morphogenetic protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12643-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P12643-1
bone morphogenetic protein 2 isoform 1 (human)
hBMP2/iso:1
"A bone morphogenetic protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000026336
bone morphogenetic protein 2 isoform 1, mature form (human)
hBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396." [PRO:DNx, UniProtKB:P12643]
Yes
organism-sequence


PR:P21274-1
bone morphogenetic protein 2 isoform 1 (mouse)
mBMP2/iso:1
"A bone morphogenetic protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
Yes
organism-modification


PR:000036510
bone morphogenetic protein 2 isoform 1, mature form (mouse)
mBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in mouse. UniProtKB:P21274-1, 281-394." [PMID:14623234, PMID:15110716, PMID:15565649, PMID:16109715, PRO:CNA]
Yes
modification


PR:000000608
bone morphogenetic protein 2 isoform 1, mature form
BMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1 that has had the signal peptide and propeptide removed." [PMID:10074410]

organism-modification


PR:000026336
bone morphogenetic protein 2 isoform 1, mature form (human)
hBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396." [PRO:DNx, UniProtKB:P12643]
Yes
organism-modification


PR:000036510
bone morphogenetic protein 2 isoform 1, mature form (mouse)
mBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in mouse. UniProtKB:P21274-1, 281-394." [PMID:14623234, PMID:15110716, PMID:15565649, PMID:16109715, PRO:CNA]
Yes
modification


PR:000021898
bone morphogenetic protein 2 isoform 1, signal peptide removed form
BMP2/iso:1/SigPep-
"A bone morphogenetic protein 2 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000000608
bone morphogenetic protein 2 isoform 1, mature form
BMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1 that has had the signal peptide and propeptide removed." [PMID:10074410]

organism-modification


PR:000026336
bone morphogenetic protein 2 isoform 1, mature form (human)
hBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in human. UniProtKB:P12643-1, 283-396." [PRO:DNx, UniProtKB:P12643]
Yes
organism-modification


PR:000036510
bone morphogenetic protein 2 isoform 1, mature form (mouse)
mBMP2/iso:1/mature
"A bone morphogenetic protein 2 isoform 1, mature form in mouse. UniProtKB:P21274-1, 281-394." [PMID:14623234, PMID:15110716, PMID:15565649, PMID:16109715, PRO:CNA]
Yes
modification


PR:000018286
bone morphogenetic protein 2 proteolytic cleavage product
BMP2/ClvPrd
"A bone morphogenetic protein 2 that has been processed by proteolytic cleavage." [PRO:DNx]

Back to top
Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:000000164 BMP2 PANTHER:PTHR11848
PR:000026336 hBMP2/iso:1/mature PMID:2315314
PR:000036510 mBMP2/iso:1/mature PMID:15565649; PMID:16109715
PR:P12643-1 hBMP2/iso:1 PMID:2315314
GO:0007267 cell-cell signalingPR:000000164 BMP2 PANTHER:PTHR11848
PR:000026336 hBMP2/iso:1/mature PMID:2315314
PR:P12643-1 hBMP2/iso:1 PMID:2315314
GO:0030509 BMP signaling pathwayPR:000000164 BMP2 PANTHER:PTHR11848
PR:000036510 mBMP2/iso:1/mature PMID:14623234
PR:P21274-1 mBMP2/iso:1 PMID:14623234

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000026336 hBMP2/iso:1/mature PMID:2315314
GO:0042803 protein homodimerization activityPR:000026336 hBMP2/iso:1/mature PMID:10074410

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000026336 hBMP2/iso:1/mature PMID:2315314
PR:000036510 mBMP2/iso:1/mature PMID:15110716