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Protein Ontology report - bone morphogenetic protein 4
PR:000000165 - http://purl.obolibrary.org/obo/PR_000000165
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000165   
  PRO namebone morphogenetic protein 4 
  Synonyms
PRO-Short-label: EXACT:BMP4
Gene-based: RELATED:BMP2B | Dvr-4 | DVR4
Other: EXACT:BMP-2B | BMP-4 | bone morphogenetic protein 2B
  Definition"A bone morphogenetic protein that is a translation product of the human BMP4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000034 bone morphogenetic protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  
PRO ID
Name
Short Name
Definition
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000165
bone morphogenetic protein 4
BMP4
"A bone morphogenetic protein that is a translation product of the human BMP4 gene or a 1:1 ortholog thereof." [PRO:CNA]
Yes
organism-gene


PR:P12644
bone morphogenetic protein 4 (human)
hBMP4
"A bone morphogenetic protein 4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P12644]

organism-sequence


PR:P12644-1
bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000046492
bone morphogenetic protein 4, signal peptide removed form (human)
hBMP4/SigPep-
"A bone morphogenetic protein 4 (human) that has had the signal peptide removed. UniProtKB:P12644, 20-408." [PRO:DNx, Reactome:R-HSA-2396280]

organism-modification


PR:000072771
bone morphogenetic protein 4, mature form (human)
hBMP4/mature
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:P12644, 293-408." [PRO:DNx, Reactome:R-HSA-8858573, Reactome:R-HSA-8956775]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

organism-modification


PR:000072771
bone morphogenetic protein 4, mature form (human)
hBMP4/mature
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed. UniProtKB:P12644, 293-408." [PRO:DNx, Reactome:R-HSA-8858573, Reactome:R-HSA-8956775]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

organism-modification


PR:000072824
bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+
"A bone morphogenetic protein 4 (human) that has had the signal peptide and propeptide removed, and that includes at least one phosphorylated residue. UniProtKB:P12644, 293-408, MOD:00696." [PRO:DNx, Reactome:R-HSA-8956944]

organism-gene


PR:P21275
bone morphogenetic protein 4 (mouse)
mBMP4
"A bone morphogenetic protein 4 that is encoded in the genome of mouse." [OMA:P21275, PRO:DNx]
Yes
organism-sequence


PR:000050192
bone morphogenetic protein 4 isoform m2 (mouse)
mBMP4/iso:m2
"A bone morphogenetic protein 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:PR:P21275-1, 83-408. This isoform is encoded from an alternative downstream start codon relative to that encoding for isoform 1." [PMID:20230640, PRO:HJD]

organism-sequence


PR:P21275-1
bone morphogenetic protein 4 isoform 1 (mouse)
mBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
organism-gene


PR:Q06826
bone morphogenetic protein 4 (rat)
rBMP4
"A bone morphogenetic protein 4 that is encoded in the genome of rat." [OMA:Q06826, PRO:DNx]

sequence


PR:000000386
bone morphogenetic protein 4 isoform 1
BMP4/iso:1
"A bone morphogenetic protein 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P12644-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]

organism-sequence


PR:P12644-1
bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of human." [PRO:CNA]
Yes
organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-sequence


PR:P21275-1
bone morphogenetic protein 4 isoform 1 (mouse)
mBMP4/iso:1
"A bone morphogenetic protein 4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
modification


PR:000000609
bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide and propeptide removed." [PMID:12805376]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
modification


PR:000021899
bone morphogenetic protein 4 isoform 1, signal peptide removed form
BMP4/iso:1/SigPep-
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide removed." [PRO:DNx]

modification


PR:000000609
bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1 that has had the signal peptide and propeptide removed." [PMID:12805376]

organism-modification


PR:000036511
bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in human. UniProtKB:P12644-1, 293-408." [PMID:11401399, PMID:12141440, PMID:12805376, PMID:14660436, PMID:14749725, PMID:9804553, PRO:CNA]
Yes
organism-modification


PR:000036512
bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
"A bone morphogenetic protein 4 isoform 1, mature form in mouse. UniProtKB:P21275-1, 293-408." [PMID:12631064, PMID:14623234, PMID:15381701, PRO:CNA]
Yes
modification


PR:000018287
bone morphogenetic protein 4 proteolytic cleavage product
BMP4/ClvPrd
"A bone morphogenetic protein 4 that has been processed by proteolytic cleavage." [PRO:DNx]

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:000000165 BMP4 PANTHER:PTHR11848
PR:P21275 mBMP4 PMID:14654219; PMID:15936012
GO:0001649 osteoblast differentiationPR:000036511 hBMP4/iso:1/mature PMID:14749725
PR:000036512 mBMP4/iso:1/mature PMID:15381701
GO:0001657 ureteric bud developmentPR:000036511 hBMP4/iso:1/mature PMID:12141440
PR:000036512 mBMP4/iso:1/mature PMID:12631064
GO:0001934 positive regulation of protein phosphorylationPR:000036511 hBMP4/iso:1/mature PMID:14749725
GO:0007498 mesoderm developmentPR:000036511 hBMP4/iso:1/mature PMID:9804553
PR:P12644-1 hBMP4/iso:1 PMID:9804553
GO:0030509 BMP signaling pathwayPR:000036511 hBMP4/iso:1/mature PMID:12805376
PR:000036512 mBMP4/iso:1/mature PMID:14623234
PR:P21275 mBMP4 PMID:14623234

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036511 hBMP4/iso:1/mature PMID:11401399; PMID:14660436
GO:0042803 protein homodimerization activityPR:000036511 hBMP4/iso:1/mature PMID:12805376

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036511 hBMP4/iso:1/mature PMID:12805376
GO:0005622 intracellular anatomical structurePR:P12644-1 hBMP4/iso:1 PMID:12805376