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Protein Ontology report - bone morphogenetic protein 4
PR:000000165 - http://purl.obolibrary.org/obo/PR_000000165
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000165   
  PRO namebone morphogenetic protein 4 
  Synonyms
PRO-Short-label: EXACT:BMP4
Gene-based: RELATED:BMP2B | Dvr-4 | DVR4
Other: EXACT:BMP-2B | BMP-4 | bone morphogenetic protein 2B
  Definition"A bone morphogenetic protein that is a translation product of the human BMP4 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000034 bone morphogenetic protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification3                                                  Organism-Modification 5                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms  Switch to Extended View   

Category  
PRO Form Name
Short Name
Ann. Has Annotation?

Comp. In Complex?
gene


PR:000000165 bone morphogenetic protein 4
BMP4
Yes
organism-gene


PR:P12644 bone morphogenetic protein 4 (human)
hBMP4

organism-sequence


PR:P12644-1 bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
Yes
organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-modification


PR:000046492 bone morphogenetic protein 4, signal peptide removed form (human)
hBMP4/SigPep-

organism-modification


PR:000072771 bone morphogenetic protein 4, mature form (human)
hBMP4/mature

organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-modification


PR:000072824 bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+

organism-modification


PR:000072771 bone morphogenetic protein 4, mature form (human)
hBMP4/mature

organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-modification


PR:000072824 bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+

organism-modification


PR:000072824 bone morphogenetic protein 4, mature phosphorylated form (human)
hBMP4/mature/PhosRes+

organism-gene


PR:P21275 bone morphogenetic protein 4 (mouse)
mBMP4
Yes
organism-sequence


PR:000050192 bone morphogenetic protein 4 isoform m2 (mouse)
mBMP4/iso:m2

organism-sequence


PR:P21275-1 bone morphogenetic protein 4 isoform 1 (mouse)
mBMP4/iso:1

organism-modification


PR:000036512 bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
Yes
organism-gene


PR:Q06826 bone morphogenetic protein 4 (rat)
rBMP4

sequence


PR:000000386 bone morphogenetic protein 4 isoform 1
BMP4/iso:1

organism-sequence


PR:P12644-1 bone morphogenetic protein 4 isoform 1 (human)
hBMP4/iso:1
Yes
organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-sequence


PR:P21275-1 bone morphogenetic protein 4 isoform 1 (mouse)
mBMP4/iso:1

organism-modification


PR:000036512 bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
Yes
modification


PR:000000609 bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature

organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-modification


PR:000036512 bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
Yes
modification


PR:000021899 bone morphogenetic protein 4 isoform 1, signal peptide removed form
BMP4/iso:1/SigPep-

modification


PR:000000609 bone morphogenetic protein 4 isoform 1, mature form
BMP4/iso:1/mature

organism-modification


PR:000036511 bone morphogenetic protein 4 isoform 1, mature form (human)
hBMP4/iso:1/mature
Yes
organism-modification


PR:000036512 bone morphogenetic protein 4 isoform 1, mature form (mouse)
mBMP4/iso:1/mature
Yes
modification


PR:000018287 bone morphogenetic protein 4 proteolytic cleavage product
BMP4/ClvPrd

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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term
Protein Forms & Complexes
Evidence
GO:0001501 skeletal system developmentPR:000000165 BMP4 PANTHER:PTHR11848
PR:P21275 mBMP4 PMID:14654219; PMID:15936012
GO:0001649 osteoblast differentiationPR:000036511 hBMP4/iso:1/mature PMID:14749725
PR:000036512 mBMP4/iso:1/mature PMID:15381701
GO:0001657 ureteric bud developmentPR:000036511 hBMP4/iso:1/mature PMID:12141440
PR:000036512 mBMP4/iso:1/mature PMID:12631064
GO:0001934 positive regulation of protein phosphorylationPR:000036511 hBMP4/iso:1/mature PMID:14749725
GO:0007498 mesoderm developmentPR:000036511 hBMP4/iso:1/mature PMID:9804553
PR:P12644-1 hBMP4/iso:1 PMID:9804553
GO:0030509 BMP signaling pathwayPR:000036511 hBMP4/iso:1/mature PMID:12805376
PR:000036512 mBMP4/iso:1/mature PMID:14623234
PR:P21275 mBMP4 PMID:14623234

Molecular Function GO Term
Protein Forms & Complexes
Evidence
GO:0005102 signaling receptor bindingPR:000036511 hBMP4/iso:1/mature PMID:11401399; PMID:14660436
GO:0042803 protein homodimerization activityPR:000036511 hBMP4/iso:1/mature PMID:12805376

Cellular Location GO Term
Protein Forms & Complexes
Evidence
GO:0005615 extracellular spacePR:000036511 hBMP4/iso:1/mature PMID:12805376
GO:0005622 intracellular anatomical structurePR:P12644-1 hBMP4/iso:1 PMID:12805376