Protein Ontology

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Protein Ontology report - TGF-beta 2

PR:000000183 - http://purl.obolibrary.org/obo/PR_000000183

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PAF

PRO ID

PR:000000183

PRO name

TGF-beta 2

Synonyms

PRO-Short-label:	EXACT:	TGFB2
Other:	EXACT:	BSC-1 cell growth inhibitor \| cetermin \| G-TSF \| glioblastoma-derived T-cell suppressor factor \| polyergin \| TGF-beta-2

Definition

"A TGF-beta that is a translation product of the human TGFB2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000046 TGF-beta

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	3
Sequence	2	Organism-Sequence	5
Modification	8	Organism-Modification	7

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000183 TGF-beta 2

TGFB2

Yes

organism-gene

PR:P27090 transforming growth factor beta-2 proprotein (mouse)

mTGFB2

organism-sequence

PR:P27090-1 transforming growth factor beta-2 isoform 1 (mouse)

mTGFB2/iso:A

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-gene

PR:P61812 transforming growth factor beta-2 (human)

hTGFB2

organism-sequence

PR:P61812-1 transforming growth factor beta-2 isoform A (human)

hTGFB2/iso:A

Yes

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

organism-sequence

PR:P61812-2 transforming growth factor beta-2 isoform B (human)

hTGFB2/iso:B

Yes

organism-modification

PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1

Yes

organism-modification

PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2

Yes

organism-modification

PR:000069517 transforming growth factor beta-2 methylated 1 (human)

hTGFB2/Me:1

organism-gene

PR:Q07257 transforming growth factor beta-2 proprotein (rat)

rTGFB2

organism-sequence

PR:Q07257-1 transforming growth factor beta-2 proprotein isoform rTGF-beta2B (rat)

rTGFB2/iso:rTGF-beta2B

organism-sequence

PR:Q07257-2 transforming growth factor beta-2 isoform A (rat)

rTGFB2/iso:A

sequence

PR:000000404 TGF-beta 2 isoform A

TGFB2/iso:A

organism-sequence

PR:P27090-1 transforming growth factor beta-2 isoform 1 (mouse)

mTGFB2/iso:A

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-sequence

PR:P61812-1 transforming growth factor beta-2 isoform A (human)

hTGFB2/iso:A

Yes

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

organism-sequence

PR:Q07257-2 transforming growth factor beta-2 isoform A (rat)

rTGFB2/iso:A

modification

PR:000000629 TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

modification

PR:000021908 TGF-beta 2 isoform A, signal peptide removed form

TGFB2/iso:A/SigPep-

modification

PR:000000630 TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

modification

PR:000000631 TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

sequence

PR:000000405 TGF-beta 2 isoform B

TGFB2/iso:B

organism-sequence

PR:P61812-2 transforming growth factor beta-2 isoform B (human)

hTGFB2/iso:B

Yes

organism-modification

PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1

Yes

organism-modification

PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2

Yes

modification

PR:000000632 TGF-beta 2 isoform B cleaved 1

TGFB2/iso:B/Clv:1

organism-modification

PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1

Yes

modification

PR:000021909 TGF-beta 2 isoform B, signal peptide removed form

TGFB2/iso:B/SigPep-

modification

PR:000000633 TGF-beta 2 isoform B cleaved 2

TGFB2/iso:B/Clv:2

organism-modification

PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2

Yes

modification

PR:000018293 TGF-beta 2 proteolytic cleavage product

TGFB2/ClvPrd

modification

PR:000000629 TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1

organism-modification

PR:000036530 TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1

Yes

modification

PR:000000630 TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2

organism-modification

PR:000036531 TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2

Yes

organism-modification

PR:000036532 TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2

Yes

modification

PR:000000631 TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3

organism-modification

PR:000036533 TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3

Yes

modification

PR:000000632 TGF-beta 2 isoform B cleaved 1

TGFB2/iso:B/Clv:1

organism-modification

PR:000036534 TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1

Yes

modification

PR:000000633 TGF-beta 2 isoform B cleaved 2

TGFB2/iso:B/Clv:2

organism-modification

PR:000036535 TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000183 TGFB2	acts_upstream_of_or_within	GO:0008283 cell population proliferation	PANTHER:PTHR11848
PR:000036530 hTGFB2/iso:A/Clv:1 UniProtKB:P61812-1, 303-414	acts_upstream_of_or_within	GO:0007179 transforming growth factor beta receptor signaling pathway	PMID:3162913
	acts_upstream_of_or_within	GO:0008285 negative regulation of cell population proliferation	PMID:15944186
	enables	GO:0001540 amyloid-beta binding	PMID:16227582
		GO:0005160 transforming growth factor beta receptor binding	PMID:16227582
		GO:0042803 protein homodimerization activity	PMID:2119582; PMID:3476488
	located_in	GO:0005615 extracellular space	PMID:3162913
PR:000036531 mTGFB2/iso:A/Clv:2 UniProtKB:P27090-1, 20-302	enables	GO:0005515 protein binding with PR:Q07475 D0H4S114	PMID:14985127
PR:000036532 hTGFB2/iso:A/Clv:2 UniProtKB:P61812-1, 20-302	located_in	GO:0032991 protein-containing complex	PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3 UniProtKB:P61812-1, 20-302, 303-414	enables	GO:0042803 protein homodimerization activity	PMID:3476488
	located_in	GO:0005615 extracellular space	PMID:3162913
PR:000036534 hTGFB2/iso:B/Clv:1 UniProtKB:P61812-2, 331-442	located_in	GO:0005615 extracellular space	PMID:1777240
PR:000036535 hTGFB2/iso:B/Clv:2 UniProtKB:P61812-2, 20-330, 331-442	located_in	GO:0005615 extracellular space	PMID:1777240
PR:P61812-1 hTGFB2/iso:A	enables	GO:0046982 protein heterodimerization activity	PMID:2119582
PR:P61812-2 hTGFB2/iso:B	enables	GO:0046982 protein heterodimerization activity	PMID:17845732
PR:P61812-2 hTGFB2/iso:B	located_in	GO:0045177 apical part of cell	PMID:17845732