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Protein Ontology report - TGF-beta 2
PR:000000183 - http://purl.obolibrary.org/obo/PR_000000183
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza / PAF
  PRO ID
PR:000000183   
  PRO nameTGF-beta 2 
  Synonyms
PRO-Short-label: EXACT:TGFB2
Other: EXACT:BSC-1 cell growth inhibitor | cetermin | G-TSF | glioblastoma-derived T-cell suppressor factor | polyergin | TGF-beta-2
  Definition"A TGF-beta that is a translation product of the human TGFB2 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000046 TGF-beta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 3                                        
         Sequence2                                                  Organism-Sequence 5                                        
         Modification8                                                  Organism-Modification 7                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000183

TGF-beta 2

TGFB2


"A TGF-beta that is a translation product of the human TGFB2 gene or a 1:1 ortholog thereof." [PRO:CNA]

Yes

organism-gene



PR:P27090

transforming growth factor beta-2 proprotein (mouse)

mTGFB2


"A TGF-beta 2 that is encoded in the genome of mouse." [OMA:P27090, PRO:DNx]


organism-sequence



PR:P27090-1

transforming growth factor beta-2 isoform 1 (mouse)

mTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036531

TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]

Yes

organism-gene



PR:P61812

transforming growth factor beta-2 (human)

hTGFB2


"A TGF-beta 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P61812]


organism-sequence



PR:P61812-1

transforming growth factor beta-2 isoform A (human)

hTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036530

TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]

Yes

organism-modification



PR:000036532

TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]

Yes

organism-modification



PR:000036533

TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]

Yes

organism-sequence



PR:P61812-2

transforming growth factor beta-2 isoform B (human)

hTGFB2/iso:B


"A TGF-beta 2 isoform B that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036534

TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]

Yes

organism-modification



PR:000036535

TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]

Yes

organism-modification



PR:000069517

transforming growth factor beta-2 methylated 1 (human)

hTGFB2/Me:1


"A transforming growth factor beta-2 (human) that has been methylated on the residue at the position equivalent to Cys-4 of the amino acid sequence represented by UniProtKB:P61812. UniProtKB:P61812, Cys-4, MOD:00660." [IEDB_epitope:1019772, PRO:DNx]


organism-gene



PR:Q07257

transforming growth factor beta-2 proprotein (rat)

rTGFB2


"A TGF-beta 2 that is encoded in the genome of rat." [OMA:Q07257, PRO:DNx]


organism-sequence



PR:Q07257-1

transforming growth factor beta-2 proprotein isoform rTGF-beta2B (rat)

rTGFB2/iso:rTGF-beta2B


"A transforming growth factor beta-2 proprotein (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q07257-1." [PRO:DNx, UniProtKB:Q07257]


organism-sequence



PR:Q07257-2

transforming growth factor beta-2 isoform A (rat)

rTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of rat." [PRO:CNA]


sequence



PR:000000404

TGF-beta 2 isoform A

TGFB2/iso:A


"A TGF-beta 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61812-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P27090-1

transforming growth factor beta-2 isoform 1 (mouse)

mTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036531

TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]

Yes

organism-sequence



PR:P61812-1

transforming growth factor beta-2 isoform A (human)

hTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036530

TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]

Yes

organism-modification



PR:000036532

TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]

Yes

organism-modification



PR:000036533

TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]

Yes

organism-sequence



PR:Q07257-2

transforming growth factor beta-2 isoform A (rat)

rTGFB2/iso:A


"A TGF-beta 2 isoform A that is encoded in the genome of rat." [PRO:CNA]


modification



PR:000000629

TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A that has been processed by proteolytic cleavage and released from the latent complex. This form, cross-linked to an identical chain, is the active mature protein." [PMID:3476488]


organism-modification



PR:000036530

TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]

Yes

modification



PR:000021908

TGF-beta 2 isoform A, signal peptide removed form

TGFB2/iso:A/SigPep-


"A TGF-beta 2 isoform A that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000630

TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent removal of the C-terminal mature protein. This chain is referred as to the latency associated peptide (LAP)." [PRO:CNA]


organism-modification



PR:000036531

TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]

Yes

organism-modification



PR:000036532

TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]

Yes

modification



PR:000000631

TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:10224129]


organism-modification



PR:000036533

TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]

Yes

sequence



PR:000000405

TGF-beta 2 isoform B

TGFB2/iso:B


"A TGF-beta 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P61812-2 or a 1:1 ortholog thereof." [PMID:16868931, PMID:1777240, PMID:2850146, PRO:CNA, PRO:DAN]


organism-sequence



PR:P61812-2

transforming growth factor beta-2 isoform B (human)

hTGFB2/iso:B


"A TGF-beta 2 isoform B that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036534

TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]

Yes

organism-modification



PR:000036535

TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]

Yes

modification



PR:000000632

TGF-beta 2 isoform B cleaved 1

TGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PMID:1777240]


organism-modification



PR:000036534

TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]

Yes

modification



PR:000021909

TGF-beta 2 isoform B, signal peptide removed form

TGFB2/iso:B/SigPep-


"A TGF-beta 2 isoform B that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000633

TGF-beta 2 isoform B cleaved 2

TGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:1777240]


organism-modification



PR:000036535

TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]

Yes

modification



PR:000018293

TGF-beta 2 proteolytic cleavage product

TGFB2/ClvPrd


"A TGF-beta 2 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000629

TGF-beta 2 isoform A cleaved 1

TGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A that has been processed by proteolytic cleavage and released from the latent complex. This form, cross-linked to an identical chain, is the active mature protein." [PMID:3476488]


organism-modification



PR:000036530

TGF-beta 2 isoform A cleaved 1 (human)

hTGFB2/iso:A/Clv:1


"A TGF-beta 2 isoform A cleaved 1 in human. UniProtKB:P61812-1, 303-414." [PMID:15944186, PMID:16227582, PMID:2119582, PMID:3162913, PMID:3476488, PRO:CNA]

Yes

modification



PR:000000630

TGF-beta 2 isoform A cleaved 2

TGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent removal of the C-terminal mature protein. This chain is referred as to the latency associated peptide (LAP)." [PRO:CNA]


organism-modification



PR:000036531

TGF-beta 2 isoform A cleaved 2 (mouse)

mTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in mouse. UniProtKB:P27090-1, 20-302." [PMID:14985127, PRO:CNA]

Yes

organism-modification



PR:000036532

TGF-beta 2 isoform A cleaved 2 (human)

hTGFB2/iso:A/Clv:2


"A TGF-beta 2 isoform A cleaved 2 in human. UniProtKB:P61812-1, 20-302." [PMID:3162913, PRO:CNA]

Yes

modification



PR:000000631

TGF-beta 2 isoform A cleaved 3

TGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:10224129]


organism-modification



PR:000036533

TGF-beta 2 isoform A cleaved 3 (human)

hTGFB2/iso:A/Clv:3


"A TGF-beta 2 isoform A cleaved 3 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-1, 20-302, 303-414." [PMID:3162913, PMID:3476488, PRO:CNA]

Yes

modification



PR:000000632

TGF-beta 2 isoform B cleaved 1

TGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PMID:1777240]


organism-modification



PR:000036534

TGF-beta 2 isoform B cleaved 1 (human)

hTGFB2/iso:B/Clv:1


"A TGF-beta 2 isoform B cleaved 1 in human. UniProtKB:P61812-2, 331-442." [PMID:1777240, PRO:CNA]

Yes

modification



PR:000000633

TGF-beta 2 isoform B cleaved 2

TGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PMID:1777240]


organism-modification



PR:000036535

TGF-beta 2 isoform B cleaved 2 (human)

hTGFB2/iso:B/Clv:2


"A TGF-beta 2 isoform B cleaved 2 in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P61812-2, 20-330, 331-442." [PMID:1777240, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000000183 TGFB2 acts_upstream_of_or_withinGO:0008283 cell population proliferation PANTHER:PTHR11848
PR:000036530 hTGFB2/iso:A/Clv:1
UniProtKB:P61812-1, 303-414
acts_upstream_of_or_withinGO:0007179 transforming growth factor beta receptor signaling pathway PMID:3162913
GO:0008285 negative regulation of cell population proliferation PMID:15944186
enablesGO:0001540 amyloid-beta binding PMID:16227582
GO:0005160 transforming growth factor beta receptor binding PMID:16227582
GO:0042803 protein homodimerization activity PMID:2119582; PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036531 mTGFB2/iso:A/Clv:2
UniProtKB:P27090-1, 20-302
enablesGO:0005515 protein binding with PR:Q07475 D0H4S114 PMID:14985127
PR:000036532 hTGFB2/iso:A/Clv:2
UniProtKB:P61812-1, 20-302
located_inGO:0032991 protein-containing complex PMID:3162913
PR:000036533 hTGFB2/iso:A/Clv:3
UniProtKB:P61812-1, 20-302, 303-414
enablesGO:0042803 protein homodimerization activity PMID:3476488
located_inGO:0005615 extracellular space PMID:3162913
PR:000036534 hTGFB2/iso:B/Clv:1
UniProtKB:P61812-2, 331-442
located_inGO:0005615 extracellular space PMID:1777240
PR:000036535 hTGFB2/iso:B/Clv:2
UniProtKB:P61812-2, 20-330, 331-442
located_inGO:0005615 extracellular space PMID:1777240
PR:P61812-1 hTGFB2/iso:A enablesGO:0046982 protein heterodimerization activity PMID:2119582
PR:P61812-2 hTGFB2/iso:B enablesGO:0046982 protein heterodimerization activity PMID:17845732
located_inGO:0045177 apical part of cell PMID:17845732