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Protein Ontology report - TGF-beta 3
PR:000000184 - http://purl.obolibrary.org/obo/PR_000000184
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000184   
  PRO nameTGF-beta 3 
  Synonyms
PRO-Short-label: EXACT:TGFB3
Other: EXACT:TGF-beta-3
  Definition"A TGF-beta that is a translation product of the human TGFB3 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000046 TGF-beta
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 4                                        
         Sequence1                                                  Organism-Sequence 3                                        
         Modification5                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000184

TGF-beta 3

TGFB3


"A TGF-beta that is a translation product of the human TGFB3 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:P10600

transforming growth factor beta-3 (human)

hTGFB3


"A TGF-beta 3 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P10600]


organism-sequence



PR:P10600-1

transforming growth factor beta-3 isoform 1 (human)

hTGFB3/iso:1


"A TGF-beta 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036536

TGF-beta 3 isoform 1 cleaved 1 (human)

hTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in human. UniProtKB:P10600-1, 301-412." [PMID:18243111, PRO:CNA]

Yes

organism-sequence



PR:P10600-2

transforming growth factor beta-3 isoform h2 (human)

hTGFB3/iso:h2


"A transforming growth factor beta-3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10600-2." [PRO:DNx, UniProtKB:P10600]


organism-gene



PR:P16047

transforming growth factor beta-3 proprotein (chicken)

chick-TGFB3


"A TGF-beta 3 that is encoded in the genome of chicken." [PRO:CNA]


organism-gene



PR:P17125

transforming growth factor beta-3 (mouse)

mTGFB3


"A TGF-beta 3 that is encoded in the genome of mouse." [OMA:P17125, PRO:DAN]


organism-sequence



PR:P17125-1

transforming growth factor beta-3 isoform 1 (mouse)

mTGFB3/iso:1


"A TGF-beta 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036537

TGF-beta 3 isoform 1 cleaved 1 (mouse)

mTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in mouse. UniProtKB:P17125-1, 299-410." [PMID:1821856, PRO:CNA]

Yes

organism-modification



PR:000036538

TGF-beta 3 isoform 1 cleaved 3 (mouse)

mTGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1 cleaved 3 in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P17125-1, 30-298, 299-410." [PMID:1821856, PRO:CNA, PRO:DAN]

Yes

organism-gene



PR:Q07258

transforming growth factor beta-3 proprotein (rat)

rTGFB3


"A TGF-beta 3 that is encoded in the genome of rat." [OMA:Q07258, PRO:DNx]


sequence



PR:000000406

TGF-beta 3 isoform 1

TGFB3/iso:1


"A TGF-beta 3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P10600-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P10600-1

transforming growth factor beta-3 isoform 1 (human)

hTGFB3/iso:1


"A TGF-beta 3 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036536

TGF-beta 3 isoform 1 cleaved 1 (human)

hTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in human. UniProtKB:P10600-1, 301-412." [PMID:18243111, PRO:CNA]

Yes

organism-sequence



PR:P17125-1

transforming growth factor beta-3 isoform 1 (mouse)

mTGFB3/iso:1


"A TGF-beta 3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036537

TGF-beta 3 isoform 1 cleaved 1 (mouse)

mTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in mouse. UniProtKB:P17125-1, 299-410." [PMID:1821856, PRO:CNA]

Yes

organism-modification



PR:000036538

TGF-beta 3 isoform 1 cleaved 3 (mouse)

mTGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1 cleaved 3 in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P17125-1, 30-298, 299-410." [PMID:1821856, PRO:CNA, PRO:DAN]

Yes

modification



PR:000000634

TGF-beta 3 isoform 1 cleaved 1

TGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PRO:CNA]


organism-modification



PR:000036536

TGF-beta 3 isoform 1 cleaved 1 (human)

hTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in human. UniProtKB:P10600-1, 301-412." [PMID:18243111, PRO:CNA]

Yes

organism-modification



PR:000036537

TGF-beta 3 isoform 1 cleaved 1 (mouse)

mTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in mouse. UniProtKB:P17125-1, 299-410." [PMID:1821856, PRO:CNA]

Yes

modification



PR:000021910

TGF-beta 3 isoform 1, signal peptide removed form

TGFB3/iso:1/SigPep-


"A TGF-beta 3 isoform 1 that has had the signal peptide removed." [PRO:DNx]


modification



PR:000000635

TGF-beta 3 isoform 1 cleaved 2

TGFB3/iso:1/Clv:2


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by proteolytic cleavage to remove the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP)." [PMID:11821050]


modification



PR:000000636

TGF-beta 3 isoform 1 cleaved 3

TGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PRO:CNA]


organism-modification



PR:000036538

TGF-beta 3 isoform 1 cleaved 3 (mouse)

mTGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1 cleaved 3 in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P17125-1, 30-298, 299-410." [PMID:1821856, PRO:CNA, PRO:DAN]

Yes

modification



PR:000018294

TGF-beta 3 proteolytic cleavage product

TGFB3/ClvPrd


"A TGF-beta 3 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000634

TGF-beta 3 isoform 1 cleaved 1

TGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature peptide." [PRO:CNA]


organism-modification



PR:000036536

TGF-beta 3 isoform 1 cleaved 1 (human)

hTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in human. UniProtKB:P10600-1, 301-412." [PMID:18243111, PRO:CNA]

Yes

organism-modification



PR:000036537

TGF-beta 3 isoform 1 cleaved 1 (mouse)

mTGFB3/iso:1/Clv:1


"A TGF-beta 3 isoform 1 cleaved 1 in mouse. UniProtKB:P17125-1, 299-410." [PMID:1821856, PRO:CNA]

Yes

modification



PR:000000635

TGF-beta 3 isoform 1 cleaved 2

TGFB3/iso:1/Clv:2


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by proteolytic cleavage to remove the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP)." [PMID:11821050]


modification



PR:000000636

TGF-beta 3 isoform 1 cleaved 3

TGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1, signal peptide removed form that has been processed by subsequent cleavage at the dibasic cleavage site rendering the latency associated peptide (LAP) and the mature protein non-covalently bound." [PRO:CNA]


organism-modification



PR:000036538

TGF-beta 3 isoform 1 cleaved 3 (mouse)

mTGFB3/iso:1/Clv:3


"A TGF-beta 3 isoform 1 cleaved 3 in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P17125-1, 30-298, 299-410." [PMID:1821856, PRO:CNA, PRO:DAN]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036536 hTGFB3/iso:1/Clv:1
UniProtKB:P10600-1, 301-412
enablesGO:0005160 transforming growth factor beta receptor binding PMID:18243111
GO:0042803 protein homodimerization activity PMID:18243111
PR:000036537 mTGFB3/iso:1/Clv:1
UniProtKB:P17125-1, 299-410
acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:000036538 mTGFB3/iso:1/Clv:3
UniProtKB:P17125-1, 30-298, 299-410
acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856
PR:P10600-1 hTGFB3/iso:1 acts_upstream_of_or_withinGO:0007165 signal transduction PMID:3164476
GO:0007267 cell-cell signaling PMID:3164476
PR:P17125-1 mTGFB3/iso:1 acts_upstream_of_or_withinGO:0030879 mammary gland development PMID:1821856