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Protein Ontology report - TGF-beta receptor type-1 isoform 1
PR:000000185 - http://purl.obolibrary.org/obo/PR_000000185
 
  Protein Forms  Complex  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000185   
  PRO nameTGF-beta receptor type-1 isoform 1 
  Synonyms
PRO-Short-label: EXACT:TGFBR1/iso:1
  Definition"A TGF-beta receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] 
  PRO Categorysequence 
  ParentPR:000000047 TGF-beta receptor type-1
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Sequence1                                                  Organism-Sequence 2                                        
         Modification4                                                  Organism-Modification 3                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
sequence



PR:000000185

TGF-beta receptor type-1 isoform 1

TGFBR1/iso:1


"A TGF-beta receptor type-1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:P36897-1

TGF-beta receptor type-1 isoform 1 (human)

hTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA]

Yes

organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-sequence



PR:Q64729-1

TGF-beta receptor type-1 isoform 1 (mouse)

mTGFBR1/iso:1


"A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]


organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

modification



PR:000000522

TGF-beta receptor type-1 isoform 1, signal peptide removed form

TGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1 that has had the signal peptide removed." [PRO:CNA]


modification



PR:000000408

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form

TGFBR1/iso:1/SigPep-/PhosRes+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that includes at least one phosphorylated residue." [PRO:CNA]


modification



PR:000000523

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1

TGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated form in which the phosphorylation occurs within the GS-motif region (GSGSGLP and surrounding sequence) by TGFBR2. Phosphorylation of any of the Ser or Thr seems to be sufficient to transduce signal, however full activation is achieved when five of these residues are phosphorylated. Example: UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]


Yes
organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
organism-modification



PR:000036434

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (mouse)

mTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in mouse. UniProtKB:Q64729-1, 23-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:12065756, PRO:CNA]

Yes

modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


modification



PR:000003173

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated and ubiquitinated form

TGFBR1/iso:1/SigPep-/PhosUbiq+


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form that has been post-translationally modified to include phosphorylated and ubiquitinated residues." [PID:TGFB/TGFBR2/TGFBR1/WWP1/SMAD8, PRO:CNA]


organism-modification



PR:000036432

TGF-beta receptor type-1 isoform 1, signal peptide removed form (human)

hTGFBR1/iso:1/SigPep-


"A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 34-503." [PMID:8242743, PRO:CNA]

Yes

organism-modification



PR:000025959

TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human)

hTGFBR1/iso:1/SigPep-/Phos:1


"A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046]

Yes

Yes
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TGFBR1/iso:1 forms found in complexes   

TGFBR1/iso:1 Component
Complexes
PR:000000523 TGFBR1/iso:1/SigPep-/Phos:1 PR:000025975 transforming growth factor beta type I receptor homodimeric complex phosphorylated form
PR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PR:000025961 transforming growth factor beta type I receptor homodimeric complex phosphorylated form (human)
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Functional Annotation (GO-centric view) Switch to PRO Centric View     

Biological Process GO Term

Protein Forms & Complexes

Evidence
GO:0006468 protein phosphorylationPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578
PR:000036434 mTGFBR1/iso:1/SigPep-/Phos:1 PMID:12065756
GO:0007165 signal transductionPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8242743
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743
PR:P36897-1 hTGFBR1/iso:1 PMID:8242743
GO:0007181 transforming growth factor beta receptor complex assemblyPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743

Molecular Function GO Term

Protein Forms & Complexes

Evidence
GO:0005025 transforming growth factor beta receptor activity, type IPR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:7774578; PMID:8947046

Cellular Location GO Term

Protein Forms & Complexes

Evidence
GO:0005886 plasma membranePR:000025959 hTGFBR1/iso:1/SigPep-/Phos:1 PMID:8947046
PR:000036432 hTGFBR1/iso:1/SigPep- PMID:8242743