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Protein Ontology report - lefty 1
PR:000000287 - http://purl.obolibrary.org/obo/PR_000000287
 
  Protein Forms  Annotations      
Ontology Information Show OBO stanza
  PRO ID
PR:000000287   
  PRO namelefty 1 
  Synonyms
PRO-Short-label: EXACT:LEFTY1
Gene-based: RELATED:LEFTB | LEFTYB | UNQ278/PRO317
Other: EXACT:protein lefty-1 | stimulated by retinoic acid gene 3 protein
RELATED:Ebaf | left-right determination factor B | Lefty | protein lefty-B | Stra3 | TGF-beta-4 | Tgfb4 | transforming growth factor beta-4
  Definition"A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA] 
  PRO Categorygene 
  ParentPR:000000102 lefty protein
  Terms by PRO Category
Organism-Independent Organism-Specific
         Category          Number of Terms          Category          Number of Terms
         Gene1                                                  Organism-Gene 1                                        
         Sequence1                                                  Organism-Sequence 2                                        
         Modification3                                                  Organism-Modification 4                                        
  Term Hierarchy
  Visualization
DAG: OLS:
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Protein Forms Switch to Compact View   

Category  

PRO ID

Name

Short Name

Definition

Ann. Has Annotation?

Comp. In Complex?
gene



PR:000000287

lefty 1

LEFTY1


"A lefty protein that is a translation product of the human LEFTY1 gene or a 1:1 ortholog thereof." [PRO:CNA]


organism-gene



PR:O75610

left-right determination factor 1 (human)

hLEFTY1


"A lefty 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:O75610]


organism-sequence



PR:O75610-1

left-right determination factor 1 isoform 1 (human)

hLEFTY1/iso:1


"A lefty 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036546

lefty 1 isoform 1 cleaved 1 (human)

hLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036548

lefty 1 isoform 1 cleaved 2 (human)

hLEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000077301

left-right determination factor 1 phosphorylated 1 (human)

hLEFTY1/Phos:1


"A left-right determination factor 1 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-61 of the amino acid sequence represented by UniProtKB:O75610. UniProtKB:O75610, Tyr-61, MOD:00048." [IEDB_epitope:2149845, PRO:DNx]


sequence



PR:000000450

lefty 1 isoform 1

LEFTY1/iso:1


"A lefty 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75610-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]


organism-sequence



PR:O75610-1

left-right determination factor 1 isoform 1 (human)

hLEFTY1/iso:1


"A lefty 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]


organism-modification



PR:000036546

lefty 1 isoform 1 cleaved 1 (human)

hLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036548

lefty 1 isoform 1 cleaved 2 (human)

hLEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

organism-sequence



PR:Q64280-1

left-right determination factor 1 isoform 1 (mouse)

mLEFTY1/iso:1


"A lefty 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]

Yes

organism-modification



PR:000036547

lefty 1 isoform 1 cleaved 1 (mouse)

mLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]

Yes

modification



PR:000000643

lefty 1 isoform 1 cleaved 1

LEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PMID:11278322, PMID:18039650]


organism-modification



PR:000036546

lefty 1 isoform 1 cleaved 1 (human)

hLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036547

lefty 1 isoform 1 cleaved 1 (mouse)

mLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]

Yes

modification



PR:000000644

lefty 1 isoform 1 cleaved 2

LEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PMID:11278322]


organism-modification



PR:000036548

lefty 1 isoform 1 cleaved 2 (human)

hLEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

modification



PR:000025431

lefty 1 proteolytic cleavage product

LEFTY1/ClvPrd


"A lefty 1 that has been processed by proteolytic cleavage." [PRO:DNx]


modification



PR:000000643

lefty 1 isoform 1 cleaved 1

LEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the first dibasic RxxR cleavage site within the propeptide region." [PMID:11278322, PMID:18039650]


organism-modification



PR:000036546

lefty 1 isoform 1 cleaved 1 (human)

hLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in human. UniProtKB:O75610-1, 77-366." [PMID:11278322, PRO:CNA]

Yes

organism-modification



PR:000036547

lefty 1 isoform 1 cleaved 1 (mouse)

mLEFTY1/iso:1/Clv:1


"A lefty 1 isoform 1 cleaved 1 in mouse. UniProtKB:Q64280-1, 77-368." [PMID:15004567, PMID:18039650, PRO:CNA]

Yes

modification



PR:000000644

lefty 1 isoform 1 cleaved 2

LEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 that is the C-terminal part after processing by proteolytic cleavage at the second dibasic RxxR cleavage site within the propeptide region." [PMID:11278322]


organism-modification



PR:000036548

lefty 1 isoform 1 cleaved 2 (human)

hLEFTY1/iso:1/Clv:2


"A lefty 1 isoform 1 cleaved 2 in human. UniProtKB:O75610-1, 135-366." [PMID:11278322, PRO:CNA]

Yes

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Functional Annotation (PRO-centric view) Switch to GO Centric View   
PRO Term GO Annotation Evidence
PR:000036546 hLEFTY1/iso:1/Clv:1
UniProtKB:O75610-1, 77-366
located_inGO:0005615 extracellular space PMID:11278322
PR:000036547 mLEFTY1/iso:1/Clv:1
UniProtKB:Q64280-1, 77-368
acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15004567
GO:0009948 anterior/posterior axis specification PMID:15004567
located_inGO:0005615 extracellular space PMID:18039650
PR:000036548 hLEFTY1/iso:1/Clv:2
UniProtKB:O75610-1, 135-366
acts_upstream_of_or_withinGO:0043406 positive regulation of MAP kinase activity PMID:11278322
located_inGO:0005615 extracellular space PMID:11278322
PR:Q64280-1 mLEFTY1/iso:1 acts_upstream_of_or_withinGO:0008285 negative regulation of cell population proliferation PMID:15004567
GO:0009948 anterior/posterior axis specification PMID:15004567