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Protein Ontology report - lefty 2

PR:000000288 - http://purl.obolibrary.org/obo/PR_000000288

Protein Forms

Annotations

Ontology Information

Show OBO stanza

PRO ID

PR:000000288

PRO name

lefty 2

Synonyms

PRO-Short-label:	EXACT:	LEFTY2
Gene-based:	RELATED:	EBAF \| LEFTA \| LEFTYA \| PSEC0024 \| TGFB4
Other:	EXACT:	endometrial bleeding-associated factor \| left-right determination factor A \| protein lefty-2 \| protein lefty-A
	RELATED:	left-right determination factor B \| Leftb \| protein lefty-B \| TGF-beta-4 \| transforming growth factor beta-4

Definition

"A lefty protein that is a translation product of the human LEFTY2 gene or a 1:1 ortholog thereof." [PRO:CNA]

PRO Category

gene

Parent

PR:000000102 lefty protein

Terms by PRO Category

Organism-Independent		Organism-Specific
Category	Number of Terms	Category	Number of Terms
Gene	1	Organism-Gene	1
Sequence	1	Organism-Sequence	4
Modification	3	Organism-Modification	4

Term Hierarchy
Visualization

DAG:

OLS:

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Protein Forms

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Category

PRO Form Name

Short Name

Ann. Has Annotation?

Comp. In Complex?

gene

PR:000000288 lefty 2

LEFTY2

organism-gene

PR:O00292 left-right determination factor 2 (human)

hLEFTY2

organism-sequence

PR:000000452 lefty 2 sequence variant S342N (human)

hLEFTY2/var:S342N

Yes

organism-sequence

PR:O00292-1 left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1

Yes

organism-modification

PR:000036549 lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1

Yes

organism-modification

PR:000036550 lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2

Yes

organism-sequence

PR:O00292-2 left-right determination factor 2 isoform h2 (human)

hLEFTY2/iso:h2

organism-modification

PR:000048185 left-right determination factor 2, signal peptide removed form (human)

hLEFTY2/SigPep-

organism-modification

PR:000083292 left-right determination factor 2 phosphorylated 1 (human)

hLEFTY2/Phos:1

sequence

PR:000000451 lefty 2 isoform 1

LEFTY2/iso:1

organism-sequence

PR:O00292-1 left-right determination factor 2 isoform 1 (human)

hLEFTY2/iso:1

Yes

organism-modification

PR:000036549 lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1

Yes

organism-modification

PR:000036550 lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2

Yes

organism-sequence

PR:P57785-1 left-right determination factor 2 isoform 1 (mouse)

mLEFTY2/iso:1

modification

PR:000000645 lefty 2 isoform 1 cleaved 1

LEFTY2/iso:1/Clv:1

organism-modification

PR:000036549 lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1

Yes

modification

PR:000000646 lefty 2 isoform 1 cleaved 2

LEFTY2/iso:1/Clv:2

organism-modification

PR:000036550 lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2

Yes

modification

PR:000025432 lefty 2 proteolytic cleavage product

LEFTY2/ClvPrd

modification

PR:000000645 lefty 2 isoform 1 cleaved 1

LEFTY2/iso:1/Clv:1

organism-modification

PR:000036549 lefty 2 isoform 1 cleaved 1 (human)

hLEFTY2/iso:1/Clv:1

Yes

modification

PR:000000646 lefty 2 isoform 1 cleaved 2

LEFTY2/iso:1/Clv:2

organism-modification

PR:000036550 lefty 2 isoform 1 cleaved 2 (human)

hLEFTY2/iso:1/Clv:2

Yes

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Functional Annotation (PRO-centric view)

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PRO Term	GO Annotation		Evidence
PR:000000452 hLEFTY2/var:S342N Example: UniProtKB:O00292-1, Ser-342, CHEBI:50347	associated_with_disease_progression	DO:0050545 visceral heterotaxy	PMID:10053005
PR:000036549 hLEFTY2/iso:1/Clv:1 UniProtKB:O00292-1, 77-366	acts_upstream_of_or_within	GO:0007275 multicellular organism development	PMID:10053005
	acts_upstream_of_or_within	GO:0007309 oocyte axis specification	PMID:10053005
	located_in	GO:0005615 extracellular space	PMID:11278322
PR:000036550 hLEFTY2/iso:1/Clv:2 UniProtKB:O00292-1, 135-366	acts_upstream_of_or_within	GO:0043406 positive regulation of MAP kinase activity	PMID:11278322
	located_in	GO:0005615 extracellular space	PMID:11278322
PR:O00292-1 hLEFTY2/iso:1	acts_upstream_of_or_within	GO:0007275 multicellular organism development	PMID:10053005
PR:O00292-1 hLEFTY2/iso:1	acts_upstream_of_or_within	GO:0007309 oocyte axis specification	PMID:10053005